β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis

Rosenbluh, Joseph, Nijhawan, Deepak, Cox, Andrew G., Li, Xingnan, Neal, James T., Schafer, Eric J., Zack, Travis I., Wang, Xiaoxing +13 more·2012·Cell

DOI 10.1016/j.cell.2012.11.026

Cited by (759)

Items 301–400 of 759

Two Opposing Faces of Retinoic Acid: Induction of Stemness or Induction of Differentiation Depending on Cell-Type
Belén Mezquita, Cristóbal Mezquita · 2019 · Biomolecules
YAP/TAZ Are Required to Suppress Osteogenic Differentiation of Vascular Smooth Muscle Cells
Lei Wang, Ramesh Chennupati, Young‐June Jin, Rui Li, Shengpeng Wang, Stefan Günther, Stefan Offermanns · 2020 · iScience
The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling
Shen, Chen, Nayak, Anmada, Neitzel, Leif R., Adams, Amber A., Silver-Isenstadt, Maya, Sawyer, Leah M., Benchabane, Hassina, Wang, Huilan, Bunnag, Nawat, Li, Bin et al. · 2021 · Nature Communications
Pancreatic cancer: molecular pathogenesis and emerging therapeutic strategies
Enrique Rozengurt, Guido Eibl · 2026 · Signal Transduction and Targeted Therapy
Nemo‐Like Kinase (NLK) Inhibits the Progression of NSCLC via Negatively Modulating WNT Signaling Pathway
Liting Lv, Chunhua Wan, Buyou Chen, Mei Li, Yifei Liu, Tingting Ni, Yi Yang, Yanhua Liu, Xia Cong, Guoxin Mao et al. · 2013 · Journal of Cellular Biochemistry
BCL9 provides multi-cellular communication properties in colorectal cancer by interacting with paraspeckle proteins
Meng Jiang, Yue Kang, Tomasz Sewastianik, Jiao Wang, Helen Tanton, Keith Alder, Peter S. Dennis, Xin Yu, Zhongqiu Wang, Ruiyang Liu et al. · 2020 · Nature Communications
Shisa3 is Associated with Prolonged Survival Through Promoting β-Catenin Degradation in Lung Cancer
Chun-Chieh Chen, Hsuan‐Yu Chen, Kang‐Yi Su, Qi-Sheng Hong, Bo‐Shiun Yan, Ching‐Hsien Chen, Szu‐Hua Pan, Yih‐Leong Chang, Chia-Jen Wang, Pei-Fang Hung et al. · 2014 · American Journal of Respiratory and Critical Care Medicine
WNT7A Promotes EGF-Induced Migration of Oral Squamous Cell Carcinoma Cells by Activating β-Catenin/MMP9-Mediated Signaling
Hui Xie, Yadong Ma, Jun Li, Huixia Chen, Yongfu Xie, Minzhen Chen, Xuyang Zhao, Sijie Tang, Shuo Zhao, Yujie Zhang et al. · 2020 · Frontiers in Pharmacology
Role Of YAP Signaling in Regulation of Programmed Cell Death and Drug Resistance in Cancer
Wei Zhou, Adrian Lim, Mouad Edderkaoui, Arsen Osipov, Heshui Wu, Qiang Wang, Stephen Jacob Pandol · 2023 · International Journal of Biological Sciences
Emerging roles of Hippo signaling in inflammation and YAP-driven tumor immunity
Yuhang Zhou, Tingting Huang, Jinglin Zhang, Alfred S.L. Cheng, Jun Qing Yu, Wei Kang, Ka Fai To · 2018 · Cancer Letters
PPARδ Interacts with the Hippo Coactivator YAP1 to Promote SOX9 Expression and Gastric Cancer Progression
Shumei Song, Zhenning Wang, Yuan Li, Lang Ma, Jiankang Jin, Ailing W. Scott, Yan Xu, Jeannelyn Santiano Estrella, Yongxi Song, Bin Liu et al. · 2019 · Molecular Cancer Research
Deciphering mechanical cues in the microenvironment: from non-malignant settings to tumor progression
Yicheng Zhu, Jiaoshun Chen, Chen Chen, Rong Tang, Jin Xu, Si Shi, Xianjun Yu · 2025 · Biomarker Research
MUC1-C Represses the Crumbs Complex Polarity Factor CRB3 and Downregulates the Hippo Pathway
Maroof Alam, Audrey Bouillez, Ashujit Tagde, Rehan Ahmad, Hasan N. Rajabi, Takahiro Maeda, Masayuki Hiraki, Yozo Suzuki, Donald W. Kufe · 2016 · Molecular Cancer Research
Targeting the YAP-TEAD interaction interface for therapeutic intervention in glioblastoma
Jacquelyn T. Saunders, Brent Holmes, Angelica Benavides-Serrato, Sunil Kumar, Robert N. Nishimura, Joseph Gera · 2021 · Journal of Neuro-Oncology
Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer
Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko F. Duke, Jennifer Chen, Iris Fung, Jacqueline Watson et al. · 2021 · Nature Communications
YAP/TAZ signalling in colorectal cancer: lessons from consensus molecular subtypes
Mouillet-Richard, Sophie, Laurent-Puig, Pierre · 2020 · Cancers
The Hippo effector TAZ ( WWTR1 ) transforms myoblasts and TAZ abundance is associated with reduced survival in embryonal rhabdomyosarcoma
Abdalla D. Mohamed, Congshan Sun, Vanessa De Mello, Joanna Selfe, Edoardo Missiaglia, JANET M. SHIPLEY, Graeme I. Murray, Peter S. Zammit, Henning Wackerhage · 2016 · The Journal of Pathology
Emerging role of Hippo signalling pathway in bladder cancer
Jianling Xia, Ming Zeng, Hua Zhu, Xiangjian Chen, Zhiliang Weng, Shi Li · 2017 · Journal of Cellular and Molecular Medicine
RHOA GTPase Controls YAP-Mediated EREG Signaling in Small Intestinal Stem Cell Maintenance
Ming Liu, Zheng Zhang, Leesa L. Sampson, Xuan Zhou, Kodandaramireddy Nalapareddy, Yuxin Feng, Shailaja Akunuru, Jaime Meléndez, Ashley Kuenzi Davis, Feng Bi et al. · 2017 · Stem Cell Reports
Targeting Wnt/tenascin C-mediated cross talk between pancreatic cancer cells and stellate cells via activation of the metastasis suppressor NDRG1
Bekesho Geleta, Faten Shehadeh-Tout, Syer Choon Lim, Sumit Sahni, Patric J. Jansson, Minoti Vivek Apte, Des Raymond Richardson, Žaklina Kovačević · 2022 · Journal of Biological Chemistry
A p300/GATA6 axis determines differentiation and Wnt dependency in pancreatic cancer models
Zheng Zhong, Nathan Harmston, Kris C. Wood, Babita Madan, David M. Virshup · 2022 · Journal of Clinical Investigation
Downregulation of miR‐375 in aldosterone‐producing adenomas promotes tumour cell growth via MTDH
Juan He, Yanan Cao, Tingwei Su, Yiran Jiang, Lei Jiang, Weiwei Zhou, Cui Zhang, Weiqing Wang, Guang Ning · 2015 · Clinical Endocrinology
Organ Size Control Is Dominant over Rb Family Inactivation to Restrict Proliferation In Vivo
Ursula Ehmer, Anne‐Flore Zmoos, Raymond K. Auerbach, Dedeepya Vaka, Atul Janardhan Butte, Mark A. Kay, Julien Sage · 2014 · Cell Reports
The cellular prion protein PrPcis a partner of the Wnt pathway in intestinal epithelial cells
Laura Besnier, Philippe Cardot, Barbara Da Rocha, Anthony Y. Simon, Damarys Loew, Christophe Klein, Béatrice Riveau, Michel Lacasa, Caroline Clair, Monique Rousset et al. · 2015 · Molecular Biology of the Cell
Context-dependent transcriptional regulations of YAP/TAZ in cancer
Yibo Guo, Juan Luo, Hailin Zou, Chenxin Liu, Liang Deng, Peng Li · 2021 · Cancer Letters
HER2-mTOR signaling–driven breast cancer cells require ER-associated degradation to survive
Singh, Navneet, Joshi, Rashika, Komurov, Kakajan · 2015 · Science Signaling
The Hippo Pathway and YAP Signaling: Emerging Concepts in Regulation, Signaling, and Experimental Targeting Strategies With Implications for Hepatobiliary Malignancies
Nathan W. Werneburg, Gregory James Gores, Rory L. Smoot · 2019 · Gene Expression
The Hippo signal transduction pathway in soft tissue sarcomas
Abdalla D. Mohamed, Annie Tremblay, Graeme I. Murray, Henning Wackerhage · 2015 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
Src and STAT3 inhibitors synergize to promote tumor inhibition in renal cell carcinoma
Hui-Wen Lue, Brook C. Cole, Soumya Alige Mahabala Rao, Jennifer Podolak, Ahna Van Gaest, Carly J. King, Christopher A. Eide, Beth Wilmot, Changhui Xue, Paul T. Spellman et al. · 2015 · Oncotarget
The role of extracellular biophysical cues in modulating the Hippo-YAP pathway
Jung‐Soon Mo · 2017 · BMB Reports
Knockdown of YAP1 inhibits the proliferation of osteosarcoma cells in vitro and in vivo
Zhi Yang, MING ZHANG, Ke Xu, Lin Liu, Weikun Hou, Yuanzhen Cai, Peng Xu, Jianfeng Yao · 2014 · Oncology Reports
Substratum stiffness tunes proliferation downstream of Wnt3a in part by regulating integrin-linked kinase and frizzled-1
Siyang Han, Mei-Fong Pang, Celeste M. Nelson · 2018 · Journal of Cell Science
Epidermal YAP activity drives canonical WNT16/β-catenin signaling to promote keratinocyte proliferation in vitro and in the murine skin
Veronica Mendoza‐Reinoso, Annemiek Beverdam · 2018 · Stem Cell Research
Tyrosine kinase SRC-induced YAP1-KLF5 module regulates cancer stemness and metastasis in triple-negative breast cancer
Hailin Zou, Juan Luo, Yibo Guo, Tongyu Tong, Yuchen Liu, Yun Chen, Yunjun Xiao, Liping Ye, Chengming Zhu, Liang Deng et al. · 2023 · Cellular and Molecular Life Sciences
Enhanced osteogenic differentiation of MC3T3‐E1 cells on grid‐topographic surface and evidence for involvement of YAP mediator
Yingying Zhang, He Gong, Yan Sun, Yan Huang, Yubo Fan · 2016 · Journal of Biomedical Materials Research Part A
FoxO6 regulates Hippo signaling and growth of the craniofacial complex
Zhao Qing Sun, Clarissa Souza Gomes da Fontoura, Myriam Moreno, Nathan E. Holton, Mason Sweat, Yan Y. Sweat, Myoung Keun Lee, Jed Arbon, Felicitas B. Bidlack, Daniel R. Thedens et al. · 2018 · PLoS Genetics
YAP ping about and not forgetting TAZ
Bernard Andrew Callus, Megan Finch‐Edmondson, Sue Fletcher, Steve Donald Wilton · 2018 · FEBS Letters
Regulation of organogenesis and stem cell properties by T-box transcription factors
Yasuo Takashima, Atsushi Suzuki · 2013 · Cellular and Molecular Life Sciences
The 1918 Influenza Virus PB2 Protein Enhances Virulence through the Disruption of Inflammatory and Wnt-Mediated Signaling in Mice
Adriana Forero, Jennifer Tisoncik-Go, Tokiko Watanabe, Gongxun Zhong, Masato Hatta, Nicolas Tchitchek, Christian Selinger, Jean Chang, Kristi Barker, Juliet M. Morrison et al. · 2015 · Journal of Virology
Targeting YAP/TAZ-TEAD protein-protein interactions using fragment-based and computational modeling approaches
Hung Yi Kristal Kaan, Adelene Y. L. Sim, Siew Kim Joyce Tan, Chandra Shekhar Verma, Haiwei Song · 2017 · PLoS ONE
Transcriptional regulation of effector and memory CD8+ T cell fates
James E. D. Thaventhiran, Douglas T. Fearon, Luca Gattinoni · 2013 · Current Opinion in Immunology
Yes-Associated Protein Inhibits Transcription of Myocardin and Attenuates Differentiation of Vascular Smooth Muscle Cell from Cardiovascular Progenitor Cell Lineage
Lunchang Wang, Ping Qiu, Jiao Jiao, Hiroyuki Hirai, Wei Xiong, Jifeng Zhang, Tianqing Zhu, Peter X. Ma, Y. Eugene Chen, Bo Yang · 2016 · Stem Cells
Use of signals of positive and negative selection to distinguish cancer genes and passenger genes
László Bányai, Mária Trexler, Krisztina Kerekes, Orsolya Csuka, László Patthy · 2021 · eLife
Multi-Functional Regulation by YAP/TAZ Signaling Networks in Tumor Progression and Metastasis
Hannah L. Thrash, Ann Marie Pendergast · 2023 · Cancers
Mechanotransduction and Cytoskeleton Remodeling Shaping YAP1 in Gastric Tumorigenesis
Jinglin Zhang, Yuhang Zhou, Patrick Ming‐Kuen Tang, Alfred S.L. Cheng, Jun Qing Yu, Ka Fai To, Wei Kang · 2019 · International Journal of Molecular Sciences
Role of Muscarinic Acetylcholine Signaling in Gastrointestinal Cancers
Mitsuru Konishi, Yoku Hayakawa, Kazuhiko Koike · 2019 · Biomedicines
Inhibitors Targeting YAP in Gastric Cancer: Current Status and Future Perspectives
Jiaxin Yong, Yuan Li, Sihan Lin, Zhenning Wang, Yan Hua Xu · 2021 · Drug Design Development and Therapy
Dihydroartemisinin broke the tumor immunosuppressive microenvironment by inhibiting YAP1 expression to enhance anti‐PD ‐1 efficacy
Qing Peng, Shenghao Li, Xinli Shi, Yinglin Guo, Liyuan Hao, Zhiqin Zhang, Jingmin Ji, Yanmeng Zhao, Caige Li, Yu Xue et al. · 2022 · Phytotherapy Research
Protein Kinase PKN1 Represses Wnt/β-Catenin Signaling in Human Melanoma Cells
Richard G. James, Katherine A. Bosch, Rima M. Kulikauskas, Pei‐Tzu Yang, Nick C. Robin, Rachel A. Toroni, Travis L. Biechele, Jason D. Berndt, Priska D. von Haller, Jimmy K. Eng et al. · 2013 · Journal of Biological Chemistry
Mapping the STK4/Hippo signaling network in prostate cancer cell
Damien B. Ready, Kader Yagiz, Pooneh Amin, Yüksel Yıldız, Vincent Anthony Funari, Serdar Bozdag, Bekir Cinar · 2017 · PLoS ONE
All-trans-retinoic acid activates the pro-invasive Src-YAP-Interleukin 6 axis in triple-negative MDA-MB-231 breast cancer cells while cerivastatin reverses this action
Belén Mezquita, Pau Mezquita, Montserrat Pau, Laura Gasa, Lourdes Navarro, Mireia Samitier, Miquel Pons, Cristóbal Mezquita · 2018 · Scientific Reports
MK5 Regulates YAP Stability and Is a Molecular Target in YAP-Driven Cancers
Jimyung Seo, Min Hwan Kim, Hyowon Hong, Hyunsoo Cho, Seongyeol Park, Sang Kyum Kim, Joon Kim · 2019 · Cancer Research
Intestinal multicellular organoids to study colorectal cancer
Musa Idris, Maria M. Alves, Robert M.W. Hofstra, Maxime M. Mahé, Veerle Melotte · 2021 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
Blending Hippo and WNT: Sharing Messengers and Regulation
Becky Pinjou Tsai, Nate P. Hoverter, Marian L. Waterman · 2012 · Cell
Multiple roles and context-specific mechanisms underlying YAP and TAZ-mediated resistance to anti-cancer therapy
Francesca Reggiani, Giulia Gobbi, Alessia Ciarrocchi, Davide Carlo Ambrosetti, Valentina Sancisi · 2020 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
A growing role for the Hippo signaling pathway in the heart
Yu Zhang, Dominic P. Del Re · 2017 · Journal of Molecular Medicine
Osteal Tissue Macrophages Are Involved in Endplate Osteosclerosis through the OSM-STAT3/YAP1 Signaling Axis in Modic Changes
Jiasheng Wang, Zeyu Zheng, Bao Hua Huang, Hao Wu, Xuyang Zhang, Yilei Chen, Junhui Liu, Zhi Shan, Shunwu Fan, Jian Chen et al. · 2020 · The Journal of Immunology
Hippo signaling: bridging the gap between cancer and neurodegenerative disorders
Amit Singh, Neha Gogia, Anuradha Venkatakrishnan Chimata, Prajakta Deshpande, Aditi Singh · 2020 · Neural Regeneration Research
BAG3 Proteomic Signature under Proteostasis Stress
Christof Hiebel, Elisabeth Stürner, Meike Hoffmeister, Georg Tascher, Mario Schwarz, Heike Nagel, Christian Behrends, Christian Münch, Christian Behl · 2020 · Cells
HTLV-1 activates YAP via NF-κB/p65 to promote oncogenesis
Tiejun Zhao, Zhilong Wang, Jinyong Fang, Wenzhao Cheng, Yiling Zhang, Jinhua Huang, Lingling Xu, Hongwei Gou, Linghui Zeng, Zhigang Jin et al. · 2022 · Proceedings of the National Academy of Sciences
Nicotine Activates YAP1 through nAChRs Mediated Signaling in Esophageal Squamous Cell Cancer (ESCC)
Yue Zhao, Wei Zhou, Liyan Xue, Weimin Zhang, Qimin Zhan · 2014 · PLoS ONE
A Preclinical Evaluation of Antimycin A as a Potential Antilung Cancer Stem Cell Agent
Chi‐Tai Yeh, Chun‐Li Su, Chi‐Ying F. Huang, Justin Kung-Yi Lin, Wei‐Hwa Lee, Peter Mu‐Hsin Chang, Yu-Lun Kuo, Yu-Wen Liu, Liang-Shun Wang, Chih‐Hsiung Wu et al. · 2013 · Evidence-based Complementary and Alternative Medicine
MicroRNA-1285 inhibits malignant biological behaviors of human pancreatic cancer cells by negative regulation of YAP1
He Huang, G. Xiong, Pan Shen, Z Cao, L. Zheng, Tianzhu Zhang, Yingying Zhao · 2017 · Neoplasma
A brief review: some compounds targeting YAP against malignancies
Zhenxue Tang, Qingxia Ma, Luyao Wang, Chaolong Liu, Hui Gao, Zhihong Yang, Zhantao Liu, Huimin Zhang, Lixia Ji, Guohui Jiang · 2019 · Future Oncology
The Hippo Pathway in Cardiac Regeneration and Homeostasis: New Perspectives for Cell-Free Therapy in the Injured Heart
Mingjie Zheng, Joan Jacob, Shao-Hsi Hung, Jun Wang · 2020 · Biomolecules
Src Family Tyrosine Kinases in Intestinal Homeostasis, Regeneration and Tumorigenesis
Audrey Sirvent, Rudy Mevizou, Dana Naim, Marie Lafitte, Serge Roche · 2020 · Cancers
HOXA13 promotes colon cancer progression through β-catenin-dependent WNT pathway
Yan Jennifer Gu, Jun Gu, Kaicheng Shen, Hongxu Zhou, Jie Hao, Fu Li, Hua Tao Yu, Yueqi Chen, Jianjun Li, Yifei Li et al. · 2020 · Experimental Cell Research
Casein Kinase 1α as a Regulator of Wnt-Driven Cancer
Chen Shen, Anmada Nayak, Ricardo A. Meléndez, Daniel T. Wynn, Joshua Jackson, Ethan N. Lee, Yashi F. Ahmed, David J. Robbins · 2020 · International Journal of Molecular Sciences
The Hippo–YAP Signaling as Guardian in the Pool of Intestinal Stem Cells
Yoojin Seo, So‐Yeon Park, Hyung‐Sik Kim, Jeong‐Seok Nam · 2020 · Biomedicines
R-2HG downregulates ERα to inhibit cholangiocarcinoma via the FTO/m6A-methylated ERα/miR16-5p/YAP1 signal pathway
Yuan Gao, Xiwu Ouyang, Li Zuo, Yao Xiao, Yin Sun, Chawnshang Chang, Xihu Qin, Shuyuan Yeh · 2021 · Molecular Therapy — Oncolytics
Crosstalk between KRAS, SRC and YAP Signaling in Pancreatic Cancer: Interactions Leading to Aggressive Disease and Drug Resistance
Enrique Rozengurt, Guido Eibl · 2021 · Cancers
YAP and TAZ: Monocorial and bicorial transcriptional co-activators in human cancers
Federica Lo Sardo, Valeria Canu, Marcello Maugeri‐Saccà, Sabrina Strano, Giovanni Blandino · 2022 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
The role of YAP1 in survival prediction, immune modulation, and drug response: A pan-cancer perspective
Xueqing Hu, Yingru Zhang, Hao Nao Yu, Yiyang Zhao, Xiaoting Sun, Qi Li, Yan Wang · 2022 · Frontiers in Immunology
Competence for neural crest induction is controlled by hydrostatic pressure through Yap
Delan N. Alasaadi, Lucas Alvizi, Jonas Hartmann, Namid Stillman, Prachiti Moghe, Takashi Hiiragi, Roberto Mayor · 2024 · Nature Cell Biology
HMGA1 Interacts with β-Catenin to Positively Regulate Wnt/β-Catenin Signaling in Colorectal Cancer Cells
Junjie Xing, Guangwen Cao, Chuangang Fu · 2014 · Pathology & Oncology Research
Myt1 and Myt1l transcription factors limit proliferation in GBM cells by repressing YAP1 expression
Tiffany A. Melhuish, Izabela Kowalczyk, Arkadi Manukyan, Ying Zhang, Anant Shah, Roger Abounader, David Wotton · 2018 · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
A novel YAP1/SLC35B4 regulatory axis contributes to proliferation and progression of gastric carcinoma
Jun Liu, Xinhui Zhao, Ke Wang, Xiang Zhang, Yanping Yu, Yongzhi Lv, Shun Zhang, Long Zhang, Yuan Guo, Yunlong Li et al. · 2019 · Cell Death and Disease
Nuclear receptor CAR-mediated liver cancer and its species differences
Ryota Shizu, Kouichi Yoshinari · 2020 · Expert Opinion on Drug Metabolism & Toxicology
YES1 amplification confers trastuzumab–emtansine (T-DM1) resistance in HER2-positive cancer
Lei Wang, Quanren Wang, Piaopiao Xu, Fu Li, Yun Li, Haoyu Fu, Haitian Quan, Liguang Lou · 2020 · British Journal of Cancer
The YAP-Interacting Phosphatase SHP2 Can Regulate Transcriptional Coactivity and Modulate Sensitivity to Chemotherapy in Cholangiocarcinoma
EeeLN H. Buckarma, Nathan W. Werneburg, Caitlin B. Conboy, Ayano Kabashima, Daniel R. O’Brien, Chen Wang, Sumera Irie Ilyas, Rory L. Smoot · 2020 · Molecular Cancer Research
Recent advances of miRNAs in the development and clinical application of gastric cancer
Si Wu, Qiong Wu, Yong-Quan Shi · 2020 · Chinese Medical Journal
The Hippo Signaling Pathway: The Trader of Tumor Microenvironment
Duo Yang, Na Zhang, Meihua Li, Tao Hong, Wei Meng, Taohui Ouyang · 2021 · Frontiers in Oncology
N-cadherin functions as a growth suppressor in a model of K-ras-induced PanIN
Yanrong Su, Jian Li, Chanjuan Shi, Ralph H. Hruban, Glenn L. Radice · 2015 · Oncogene
Tumor mechanosensing and its therapeutic potential
Antonios N. Gargalionis, Efthimia K. Basdra, Athanasios G. Papavassiliou · 2018 · Journal of Cellular Biochemistry
The transcriptional coactivator WBP2 primes triple-negative breast cancer cells for responses to Wnt signaling via the JNK/Jun kinase pathway
Zilin Li, Shen Kiat Lim, Liang Xu, Yoon Pin Lim · 2018 · Journal of Biological Chemistry
Angiotensin-converting enzyme 2 activation suppresses pulmonary vascular remodeling by inducing apoptosis through the Hippo signaling pathway in rats with pulmonary arterial hypertension
Daole Yan, Gang Li, Yaozhong Zhang, Yinglong Liu · 2019 · Clinical and Experimental Hypertension
LKB1 and YAP phosphorylation play important roles in Celastrol-induced β-catenin degradation in colorectal cancer
Shuren Wang, Kai Ma, Cuiqi Zhou, Yu Wang, Guanghui Hu, Lechuang Chen, Zhuo Li, Chenfei Hu, Qing Xu, Hongxia Zhu et al. · 2019 · Therapeutic Advances in Medical Oncology
Targeting Hippo signaling pathway by phytochemicals in cancer therapy
Milad Moloudizargari, Mohammad Hossein Asghari, Seyed Fazel Nabavi, Diana Gulei, Ioana Berindan‐Neagoe, Anupam Bishayee, Seyed Mohammad Nabavi · 2020 · Seminars in Cancer Biology
AXL activates YAP through the EGFR–LATS1/2 axis and confers resistance to EGFR-targeted drugs in head and neck squamous cell carcinoma
Kento Okamoto, Toshinori Ando, Hiroki Izumi, Susumu S. Kobayashi, Tomoaki Shintani, Jorge Silvio Gutkind, Souichi Yanamoto, Mutsumi Miyauchi, Mikihito Kajiya · 2023 · Oncogene
Targeting ABCA12-controlled ceramide homeostasis inhibits breast cancer stem cell function and chemoresistance
Jihong Cui, John R. Christin, Julie A. Reisz, Francesca Isabelle Cendali, Rahul Sanawar, Marcelo Coutinho de Miranda, Angelo D’Alessandro, Wenjun Guo · 2023 · Science Advances
The roles of Hippo/YAP signaling pathway in physical therapy
Chunran Pan, Xiaoxia Hao, Xiaofeng Deng, Fan Lü, Jiawei Liu, Wenjie Hou, Tao Xu · 2024 · Cell Death Discovery
YAP1 inhibits circRNA-000425 expression and thus promotes oncogenic activities of miR-17 and miR-106
Zhen Liu, Shanshan Huang, Yuan Cao, Yangyang Yao, Junhe Li, Jun Chen, Bailing Jiang, Xiang Yuan, Xiaojun Xiang, Jianping Xiong et al. · 2018 · Biochemical and Biophysical Research Communications
Translational genomics of sinonasal cancers
Mario A. J. A. Hermsen, Cristina Riobello, Rocío García‐Marín, Virginia N. Cabal, Laura Suárez–Fernández, Fernando López, José Luís Llorente · 2019 · Seminars in Cancer Biology
Regulation and functions of the Hippo pathway in stemness and differentiation
Xiaolei Cao, Chenliang Wang, Jiyang Liu, Bin Zhao · 2020 · Acta Biochimica et Biophysica Sinica
Implications of Epithelial–Mesenchymal Plasticity for Heterogeneity in Colorectal Cancer
Lloyd A. Pereira, John Martin Mariadason, Ross D. Hannan, Amardeep S. Dhillon · 2015 · Frontiers in Oncology
LKB1 inhibits the proliferation of gastric cancer cells by suppressing the nuclear translocation of Yap and β-catenin
Liangang Ma, Shibo Bian, Jianxin Cui, Hongqing Xi, Kecheng Zhang, Hongzhen Qin, Xiaoming Zhu, Lin Chen · 2016 · International Journal of Molecular Medicine
miR-193b regulates tumorigenesis in liposarcoma cells via PDGFR, TGFβ, and Wnt signaling
Ying Zhang Mazzu, Yulan Hu, Yawei Shen, Thomas Tuschl, Samuel Singer · 2019 · Scientific Reports
Posttranslational modifications of YAP/TAZ: molecular mechanisms and therapeutic opportunities
Zhenxiong Zhang, Peiheng He, Yang Li, Jun Gong, Renyi Qin, Wang Z. Min · 2025 · Cellular & Molecular Biology Letters
AML Subtype Is a Major Determinant of the Association between Prognostic Gene Expression Signatures and Their Clinical Significance
Caroline R.M. Wiggers, Mirna Lilian Baak, Edwin Sonneveld, Edward E. S. Nieuwenhuis, Marije Bartels, Menno P. Creyghton · 2019 · Cell Reports
Targeting the Hippo/ YAP / TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers
Alexander Howard, Jodie Bojko, Benjamin P. Flynn, Sophie Bowen, Ute Jungwirth, Gernot Walko · 2022 · Experimental Dermatology