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ISWI Remodelers Slide Nucleosomes with Coordinated Multi-Base-Pair Entry Steps and Single-Base-Pair Exit Steps
Open accessAbstract
SUMMARY ISWI-family enzymes remodel chromatin by sliding nucleosomes along DNA, but the nucleosome translocation mechanism remains unclear. Here we use single-molecule FRET to probe nucleosome translocation by ISWI-family remodelers. Distinct ISWI-family members translocate nucleosomes with a similar stepping pattern maintained by the catalytic subunit of the enzyme. Nucleosome remodeling begins with a 7-bp step of DNA translocation followed by 3-bp subsequent steps towards the exit side of nucleosomes. These multi-bp, compound steps are comprised of 1-bp substeps. DNA movement on the entry side of the nucleosome occurs only after 7 bp of exit-side translocation and each entry-side step draws in a 3-bp equivalent of DNA that allows three additional base pairs to be moved to the exit side. Our results suggest a remodeling mechanism with precise coordination at different nucleosomal sites featuring DNA translocation towards the exit side in 1-bp steps preceding multi-bp steps of DNA movement on the entry side.
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Cited by
Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes
Clapier, C. R., Iwasa, J., Cairns, B. R., & Peterson, C. L. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.26 · Cited by 1,305
Post-Translational Modifications of Histones That Influence Nucleosome Dynamics
Bowman, G. D., & Poirier, M. G. (2015) · Chemical Reviews · doi:10.1021/cr500350x · Cited by 502
Multiplexed Profiling of Single Extracellular Vesicles
Lee, K., Fraser, K., Ghaddar, B., Yang, K., Kim, E., Balaj, L., Chiocca, E. A., Breakefield, X. O., Lee, H., & Weissleder, R. (2018) · ACS Nano · doi:10.1021/acsnano.7b07060 · Cited by 369
Asymmetric Unwrapping of Nucleosomes under Tension Directed by DNA Local Flexibility
Ngo, T. T. M., Zhang, Q., Zhou, R., Yodh, J. G., & Ha, T. (2015) · Cell · doi:10.1016/j.cell.2015.02.001 · Cited by 323
Metadata
- Authors
- Deindl, S., Hwang, W. L., Hota, S. K., Blosser, T. R., Prasad, P., Bartholomew, B., & Zhuang, X.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 152
- Issue
- 3
- Pages
- 442-452
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2051656825
- Cited by
- 179
- References
- 0
- FWCI
- 6.86
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Deindl, S., Hwang, W. L., Hota, S. K., Blosser, T. R., Prasad, P., Bartholomew, B., & Zhuang, X. (2013). ISWI Remodelers Slide Nucleosomes with Coordinated Multi-Base-Pair Entry Steps and Single-Base-Pair Exit Steps. Cell. https://doi.org/10.1016/j.cell.2012.12.040
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