The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Identification of Early Replicating Fragile Sites that Contribute to Genome Instability
Open accessAbstract
Summary DNA double strand breaks (DSBs) in B lymphocytes arise stochastically during replication or as a result of targeted DNA damage by activation induced cytidine deaminase (AID). Here we identify recurrent, early replicating and AID independent DNA lesions, termed early replication fragile sites (ERFS), by genome-wide localization of DNA repair proteins in B cells subjected to replication stress. ERFS colocalize with highly expressed gene clusters and are enriched for repetitive elements and CpG dinucleotides. Although distinct from late-replicating common fragile sites (CFS), the stability of ERFSs and CFSs is similarly dependent on the replication-stress response kinase ATR. ERFSs break spontaneously during replication, but their fragility is increased by hydroxyurea, ATR inhibition or deregulated c-Myc expression. Moreover, greater than 50% of recurrent amplifications/deletions in human diffuse large B cell lymphoma map to ERFSs. In summary, we have identified a source of spontaneous DNA lesions that drives instability at preferred genomic sites.
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Cites
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Metadata
- Authors
- Barlow, J. H., Faryabi, R. B., Callén, E., Wong, N., Malhowski, A., Chen, H. T., Gutierrez-Cruz, G., Sun, H.-W., McKinnon, P., Wright, G., Casellas, R., Robbiani, D. F., Staudt, L., Fernandez-Capetillo, O., & Nussenzweig, A.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 152
- Issue
- 3
- Pages
- 620-632
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2113896971
- Cited by
- 444
- References
- 65
- FWCI
- 19.90
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Barlow, J. H., Faryabi, R. B., Callén, E., Wong, N., Malhowski, A., Chen, H. T., Gutierrez-Cruz, G., Sun, H.-W., McKinnon, P., Wright, G., Casellas, R., Robbiani, D. F., Staudt, L., Fernandez-Capetillo, O., & Nussenzweig, A. (2013). Identification of Early Replicating Fragile Sites that Contribute to Genome Instability. Cell. https://doi.org/10.1016/j.cell.2013.01.006
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