Causes and consequences of replication stress

The DNA-damage response in human biology and disease

Jackson, S. P., & Bartek, J. (2009) · Nature · doi:10.1038/nature08467 · Cited by 6,092 · see citing works

The DNA Damage Response: Making It Safe to Play with Knives

Ciccia, A., & Elledge, S. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.019 · Cited by 4,368 · see citing works

Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

Shi, Y., Lan, F., Matson, C., Mulligan, P., Whetstine, J. R., Cole, P. A., Casero, R. A., & Shi, Y. (2004) · Cell · doi:10.1016/j.cell.2004.12.012 · Cited by 4,051 · see citing works

Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

Zou, L., & Elledge, S. J. (2003) · Science · doi:10.1126/science.1083430 · Cited by 2,693 · see citing works

Genomic instability — an evolving hallmark of cancer

Negrini, S., Gorgoulis, V. G., & Halazonetis, T. D. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2858 · Cited by 2,397 · see citing works

An Oncogene-Induced DNA Damage Model for Cancer Development

Halazonetis, T. D., Gorgoulis, V. G., & Bartek, J. (2008) · Science · doi:10.1126/science.1140735 · Cited by 1,851 · see citing works

DNA Damage Sensing by the ATM and ATR Kinases

Marechal, A., & Zou, L. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012716 · Cited by 1,514 · see citing works

DNA secondary structures: stability and function of G-quadruplex structures

Bochman, M. L., Paeschke, K., & Zakian, V. A. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3296 · Cited by 1,449 · see citing works

Ciliopathies

Hildebrandt, F., Benzing, T., & Katsanis, N. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1010172 · Cited by 1,331 · see citing works

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

Schlacher, K., Christ, N., Siaud, N., Egashira, A., Wu, H., & Jasin, M. (2011) · Cell · doi:10.1016/j.cell.2011.03.041 · Cited by 1,258 · see citing works

Structural Variation in the Human Genome and its Role in Disease

Stankiewicz, P., & Lupski, J. R. (2010) · Annual Review of Medicine · doi:10.1146/annurev-med-100708-204735 · Cited by 1,201 · see citing works

R Loops: From Transcription Byproducts to Threats to Genome Stability

Aguilera, A., & García‐Muse, T. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.04.009 · Cited by 1,029 · see citing works

<i>ATR</i> disruption leads to chromosomal fragmentation and early embryonic lethality

Brown, E. J., & Baltimore, D. (2000) · Genes &amp; Development · doi:10.1101/gad.14.4.397 · Cited by 951 · see citing works

A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2

Schlacher, K., Wu, H., & Jasin, M. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.05.015 · Cited by 936 · see citing works

Replication stress links structural and numerical cancer chromosomal instability

Burrell, R. A., McClelland, S. E., Endesfelder, D., Groth, P., Weller, M.-C., Shaikh, N., Domingo, E., Kanu, N., Dewhurst, S. M., Gronroos, E. C., et al. (2013) · Nature · doi:10.1038/nature11935 · Cited by 868 · see citing works

Nucleotide deficiency promotes genomic instability in early stages of cancer development

Bester, A. C., Roniger, M., Oren, Y. S., Im, M. M., Sarni, D., Chaoat, M., Bensimon, A., Zamir, G., Shewach, D. S., & Kerem, B. (2011) · Cell · doi:10.1016/j.cell.2011.03.044 · Cited by 858 · see citing works

Fork Reversal and ssDNA Accumulation at Stalled Replication Forks Owing to Checkpoint Defects

Sogo, J. M., Lopes, M., & Foiani, M. (2002) · Science · doi:10.1126/science.1074023 · Cited by 824 · see citing works

Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair

Petermann, E., Orta, M. L., Issaeva, N., Schultz, N., & Helleday, T. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.01.021 · Cited by 815 · see citing works

Inactivation of the SR Protein Splicing Factor ASF/SF2 Results in Genomic Instability

Xialu Li, C., & Manley, J. L. (2005) · Cell · doi:10.1016/j.cell.2005.06.008 · Cited by 772 · see citing works

Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint

Byun, T. S., Pacek, M., Yee, M.-C., Walter, J. C., & Cimprich, K. A. (2005) · Genes &amp; Development · doi:10.1101/gad.1301205 · Cited by 767 · see citing works

Cotranscriptionally Formed DNA:RNA Hybrids Mediate Transcription Elongation Impairment and Transcription-Associated Recombination

Huertas, P., & Aguilera, A. (2003) · Molecular Cell · doi:10.1016/j.molcel.2003.08.010 · Cited by 750 · see citing works

The DNA replication checkpoint response stabilizes stalled replication forks

Lopes, M., Cotta‐Ramusino, C., Pellicioli, A., Liberi, G., Plevani, P., Muzi-Falconi, M., Newlon, C. S., & Foiani, M. (2001) · Nature · doi:10.1038/35087613 · Cited by 749 · see citing works

The MRE11 complex: starting from the ends

Stracker, T. H., & Petrini, J. H. J. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3047 · Cited by 734 · see citing works

Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infection

Crow, Y. J., Leitch, A., Hayward, B. E., Garner, A., Parmar, R., Griffith, E., Ali, M., Semple, C. A. M., Aicardi, J. F., Babul‐Hirji, R., et al. (2006) · Nature Genetics · doi:10.1038/ng1842 · Cited by 670 · see citing works

Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint

Tercero, J. A., & Diffley, J. F. X. (2001) · Nature · doi:10.1038/35087607 · Cited by 667 · see citing works

Dormant origins licensed by excess Mcm2–7 are required for human cells to survive replicative stressPreprint

Ge, X. Q., Jackson, D. A., & Blow, J. J. (2007) · Genes & Development · doi:10.1101/gad.457807 · Cited by 605 · see citing works

Multiple mechanisms control chromosome integrity after replication fork uncoupling and restart at irreparable UV lesions

Lopes, M., Foiani, M., & Sogo, J. M. (2006) · Molecular Cell · doi:10.1016/j.molcel.2005.11.015 · Cited by 563 · see citing works

ATR Regulates Fragile Site Stability

Casper, A. M., Nghiem, P., Arlt, M. F., & Glover, T. W. (2002) · Cell · doi:10.1016/s0092-8674(02)01113-3 · Cited by 559 · see citing works

A Genome-wide siRNA Screen Reveals Diverse Cellular Processes and Pathways that Mediate Genome Stability

Paulsen, R. D., Soni, D. V., Wollman, R., Hahn, A. T., Yee, M., Guan, A. S., Hesley, J., Miller, S. C., Cromwell, E. F., Solow-Cordero, D. E., et al. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.06.021 · Cited by 554 · see citing works

Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription

Tuduri, S., Crabbé, L., Conti, C., Tourrière, H., Holtgreve-Grez, H., Jauch, A. S., Pantesco, V., Vos, J. D., Thomas, A., Theillet, C. G., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1984 · Cited by 553 · see citing works

Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathwayPreprint

Kim, H., & D’Andrea, A. D. (2012) · Genes & Development · doi:10.1101/gad.195248.112 · Cited by 510 · see citing works

Topoisomerase I poisoning results in PARP-mediated replication fork reversal

Chaudhuri, A. R., Hashimoto, Y., Herrador, R., Neelsen, K. J., Fachinetti, D., Bermejo, R., Cocito, A., Costanzo, V., & Lopes, M. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2258 · Cited by 499 · see citing works

Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice

Langevin, F., Crossan, G. P., Rosado, I. V., Arends, M. J., & Patel, K. J. (2011) · Nature · doi:10.1038/nature10192 · Cited by 499 · see citing works

Mechanisms of trinucleotide repeat instability during human development

McMurray, C. T. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2828 · Cited by 496 · see citing works

Eukaryotic Chromosome DNA Replication: Where, When, and How?

Masai, H., Matsumoto, S., You, Z., Yoshizawa-Sugata, N., & Oda, M. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.052308.103205 · Cited by 494 · see citing works

Causes of genome instability

Aguilera, A., & García-Muse, T. (2013) · Annual Review of Genetics · doi:10.1146/annurev-genet-111212-133232 · Cited by 476 · see citing works

Pif1 family helicases suppress genome instability at G-quadruplex motifs

Paeschke, K., Bochman, M. L., Garcia, P. D., Ćejka, P., Friedman, K. L., Kowalczykowski, S. C., & Zakian, V. A. (2013) · Nature · doi:10.1038/nature12149 · Cited by 471 · see citing works

Enzymatic Removal of Ribonucleotides from DNA Is Essential for Mammalian Genome Integrity and Development

Reijns, M. A. M., Rabe, B., Rigby, R. E., Mill, P., Astell, K. R., Lettice, L. A., Boyle, S., Leitch, A., Keighren, M., Kilanowski, F., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.011 · Cited by 466 · see citing works

Erratum: Corrigendum: Replication stress links structural and numerical cancer chromosomal instability

Burrell, R. A., McClelland, S. E., Endesfelder, D., Groth, P., Weller, M.-C., Shaikh, N., Domingo, E., Kanu, N., Dewhurst, S. M., Gronroos, E. C., et al. (2013) · Nature · doi:10.1038/nature12369 · Cited by 451 · see citing works

Analysis of protein dynamics at active, stalled, and collapsed replication forksPreprint

Sirbu, B. M., Couch, F. B., Feigerle, J. T., Bhaskara, S., Hiebert, S. W., & Cortez, D. (2011) · Genes & Development · doi:10.1101/gad.2053211 · Cited by 442 · see citing works

Identification of Early Replicating Fragile Sites that Contribute to Genome Instability

Barlow, J. H., Faryabi, R. B., Callén, E., Wong, N., Malhowski, A. J., Chen, H. T., Gutierrez-Cruz, G., Sun, H., McKinnon, P. J., Wright, G. W., et al. (2013) · Cell · doi:10.1016/j.cell.2013.01.006 · Cited by 433 · see citing works

ATR phosphorylates SMARCAL1 to prevent replication fork collapsePreprint

Couch, F. B., Bansbach, C. E., Driscoll, R., Luzwick, J. W., Glick, G. G., Betous, R., Carroll, C. M., Jung, S. Y., Qin, J., Cimprich, K. A., et al. (2013) · Genes & Development · doi:10.1101/gad.214080.113 · Cited by 409 · see citing works

RNase H and Multiple RNA Biogenesis Factors Cooperate to Prevent RNA:DNA Hybrids from Generating Genome Instability

Wahba, L., Amon, J. D., Koshland, D. E., & Vuica‐Ross, M. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.10.017 · Cited by 401 · see citing works

Genome instability due to ribonucleotide incorporation into DNA

McElhinny, S. A. N., Kumar, D., Clark, A. B., Watt, D. L., Watts, B. E., Lundström, E.-B., Johansson, E., Chabes, A., & Kunkel, T. A. (2010) · Nature Chemical Biology · doi:10.1038/nchembio.424 · Cited by 395 · see citing works

The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks

Hanada, K., Budzowska, M., Davies, S. L., van Drunen, E., Onizawa, H., Beverloo, H. B., Maas, A., Essers, J., Hickson, I. D., & Kanaar, R. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1313 · Cited by 392 · see citing works

DNA adducts from acetaldehyde: implications for alcohol-related carcinogenesis

Brooks, P. J., & Theruvathu, J. A. (2005) · Alcohol · doi:10.1016/j.alcohol.2005.03.009 · Cited by 382 · see citing works

Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors

Murga, M., Campaner, S., Lopez-Contreras, A. J., Toledo, L. I., Soria, R., Montaña, M. F., D'Artista, L., Schleker, T., Guerra, C., Garcia, E., et al. (2011) · Nature Structural &amp; Molecular Biology · doi:10.1038/nsmb.2189 · Cited by 381 · see citing works

Regulation of PCNA–protein interactions for genome stability

Mailand, N., Gibbs‐Seymour, I., & Bekker‐Jensen, S. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3562 · Cited by 375 · see citing works

Exome Capture Reveals ZNF423 and CEP164 Mutations, Linking Renal Ciliopathies to DNA Damage Response Signaling

Chaki, M., Airik, R., Ghosh, A. K., Giles, R. H., Chen, R., Slaats, G. G. G., Wang, H., Hurd, T. W., Zhou, W., Cluckey, A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.028 · Cited by 374 · see citing works

Excess Mcm2–7 license dormant origins of replication that can be used under conditions of replicative stress

Woodward, A. M., Göhler, T., Luciani, M. G., Oehlmann, M., Ge, X., Gartner, A., Jackson, D. A., & Blow, J. J. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200602108 · Cited by 369 · see citing works

A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging

Murga, M., Bunting, S. F., Montaña, M. F., Soria, R., Mulero, F., Cañamero, M., Lee, Y., McKinnon, P. J., Nussenzweig, A., & Fernández-Capetillo, Ó. (2009) · Nature Genetics · doi:10.1038/ng.420 · Cited by 351 · see citing works

Pathways of mammalian replication fork restart

Petermann, E., & Helleday, T. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2974 · Cited by 340 · see citing works

RNase H2-Initiated Ribonucleotide Excision Repair

Sparks, J. L., Chon, H., Cerritelli, S. M., Kunkel, T. A., Johansson, E., Crouch, R. J., & Burgers, P. M. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.06.035 · Cited by 339 · see citing works

Dynamics of DNA Replication in Mammalian Somatic Cells

Anglana, M., Apiou, F., Bensimon, A., & Debatisse, M. (2003) · Cell · doi:10.1016/s0092-8674(03)00569-5 · Cited by 339 · see citing works

DNA polymerase stabilization at stalled replication forks requires Mec1 and the RecQ helicase Sgs1

Cobb, J. A., Bjergbæk, L., Shimada, K., Frei, C., & Gasser, S. M. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg391 · Cited by 333 · see citing works

A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice

Shima, N., Alcaraz, A., Liachko, I., Buske, T. R., Andrews, C. A., Munroe, R. J., Hartford, S. A., Tye, B., & Schimenti, J. C. (2006) · Nature Genetics · doi:10.1038/ng1936 · Cited by 318 · see citing works

Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication

Sørensen, C. S., & Syljuåsen, R. G. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr697 · Cited by 316 · see citing works

ATR signalling: more than meeting at the fork

Nam, E. A., & Cortez, D. (2011) · Biochemical Journal · doi:10.1042/bj20102162 · Cited by 316 · see citing works

Cyclin-Dependent Kinase Suppression by WEE1 Kinase Protects the Genome through Control of Replication Initiation and Nucleotide Consumption

Beck, H., Nähse, V., Larsen, M. S. Y., O’Hanlon, K. A., Patzke, S., Holmberg, C., Mejlvang, J., Groth, A., Nielsen, O., Syljuåsen, R. G., et al. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00412-12 · Cited by 303 · see citing works

Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling

Griffith, E., Walker, S., Martin, C.-A., Vagnarelli, P., Stiff, T., Vernay, B., Sanna, N. A., Saggar, A., Hamel, B. C. J., Earnshaw, W. C., et al. (2007) · Nature Genetics · doi:10.1038/ng.2007.80 · Cited by 301 · see citing works

SMARCAL1 catalyzes fork regression and Holliday junction migration to maintain genome stability during DNA replicationPreprint

Betous, R., Mason, A. C., Rambo, R. P., Bansbach, C. E., Badu-Nkansah, A., Sirbu, B. M., Eichman, B. F., & Cortez, D. (2012) · Genes & Development · doi:10.1101/gad.178459.111 · Cited by 298 · see citing works

Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress

Jones, R. M., Mortusewicz, O., Afzal, I., Lorvellec, M., García, P., Helleday, T., & Petermann, E. (2012) · Oncogene · doi:10.1038/onc.2012.387 · Cited by 297 · see citing works

The RecQ DNA Helicases in DNA Repair

Bernstein, K. A., Gangloff, S., & Rothstein, R. J. (2010) · Annual Review of Genetics · doi:10.1146/annurev-genet-102209-163602 · Cited by 297 · see citing works

Regulatory Control of the Resolution of DNA Recombination Intermediates during Meiosis and Mitosis

Matos, J., Blanco, M. G., Maslen, S., Skehel, M. J., & West, S. C. (2011) · Cell · doi:10.1016/j.cell.2011.08.032 · Cited by 294 · see citing works

dNTP pools determine fork progression and origin usage under replication stress

Poli, J., Tsaponina, O., Crabbé, L., Keszthelyi, A., Pantesco, V., Chabes, A., Lengronne, A., & Pasero, P. (2012) · The EMBO Journal · doi:10.1038/emboj.2011.470 · Cited by 293 · see citing works

Mutagenic Processing of Ribonucleotides in DNA by Yeast Topoisomerase I

Kim, N., Huang, S.-Y. N., Williams, J. S., Li, Y. C., Clark, A. B., Cho, J.-E., Kunkel, T. A., Pommier, Y., & Jinks-Robertson, S. (2011) · Science · doi:10.1126/science.1205016 · Cited by 291 · see citing works

ERCC1 and MUS81–EME1 promote sister chromatid separation by processing late replication intermediates at common fragile sites during mitosis

Naim, V., Wilhelm, T., Debatisse, M., & Rosselli, F. (2013) · Nature Cell Biology · doi:10.1038/ncb2793 · Cited by 282 · see citing works

Exo1 Processes Stalled Replication Forks and Counteracts Fork Reversal in Checkpoint-Defective Cells

Cotta‐Ramusino, C., Fachinetti, D., Lucca, C., Doksani, Y., Lopes, M., Sogo, J. M., & Foiani, M. (2005) · Molecular Cell · doi:10.1016/j.molcel.2004.11.032 · Cited by 281 · see citing works

Transcription-replication encounters, consequences and genomic instability

Helmrich, A., Ballarino, M., Nudler, E., & Tora, L. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2543 · Cited by 267 · see citing works

MUS81 promotes common fragile site expression

Ying, S., Minocherhomji, S., Chan, K., Palmai‐Pallag, T., Chu, W. K., Wass, T., Mankouri, H. W., Liu, Y., & Hickson, I. D. (2013) · Nature Cell Biology · doi:10.1038/ncb2773 · Cited by 264 · see citing works

A requirement for MCM7 and Cdc45 in chromosome unwinding during eukaryotic DNA replication

Pacek, M., & Walter, J. C. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600369 · Cited by 254 · see citing works

Common fragile sites: mechanisms of instability revisited

Debatisse, M., Tallec, B. L., Letessier, A., Dutrillaux, B., & Brison, O. (2011) · Trends in Genetics · doi:10.1016/j.tig.2011.10.003 · Cited by 252 · see citing works

The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forksPreprint

Bansbach, C. E., Betous, R., Lovejoy, C. A., Glick, G. G., & Cortez, D. (2009) · Genes & Development · doi:10.1101/gad.1839909 · Cited by 252 · see citing works

Chk1 is haploinsufficient for multiple functions critical to tumor suppression

Lam, M. H., Liu, Q., Elledge, S. J., & Rosen, J. M. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.06.015 · Cited by 247 · see citing works

FAN1 mutations cause karyomegalic interstitial nephritis, linking chronic kidney failure to defective DNA damage repair

Zhou, W., Otto, E. A., Cluckey, A., Airik, R., Hurd, T. W., Chaki, M., Diaz, K. A., Lach, F. P., Bennett, G. R., Gee, H. Y., et al. (2012) · Nature Genetics · doi:10.1038/ng.2347 · Cited by 241 · see citing works

The structural determinants of checkpoint activation

MacDougall, C. A., Byun, T. S., Van, C., Yee, M.-C., & Cimprich, K. A. (2007) · Genes &amp; Development · doi:10.1101/gad.1522607 · Cited by 240 · see citing works

Senataxin Associates with Replication Forks to Protect Fork Integrity across RNA-Polymerase-II-Transcribed Genes

Alzu, A., Bermejo, R., Begnis, M., Lucca, C., Piccini, D., Carotenuto, W., Saponaro, M., Brambati, A., Cocito, A., Foiani, M., et al. (2012) · Cell · doi:10.1016/j.cell.2012.09.041 · Cited by 234 · see citing works

R-loop-mediated genome instability in mRNA cleavage and polyadenylation mutantsPreprint

Stirling, P. C., Chan, Y. A., Minaker, S. W., Aristizabal, M. J., Barrett, I. J., Sipahimalani, P., Kobor, M. S., & Hieter, P. (2012) · Genes & Development · doi:10.1101/gad.179721.111 · Cited by 225 · see citing works

Combining ATR Suppression with Oncogenic Ras Synergistically Increases Genomic Instability, Causing Synthetic Lethality or Tumorigenesis in a Dosage-Dependent Manner

Gilad, O., Nabet, B. Y., Ragland, R. L., Schoppy, D. W., Smith, K. D., Durham, A. C., & Brown, E. J. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-2286 · Cited by 225 · see citing works

The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restartPreprint

Ciccia, A., Bredemeyer, A. L., Sowa, M. E., Terret, M., Jallepalli, P. V., Harper, J. W., & Elledge, S. J. (2009) · Genes & Development · doi:10.1101/gad.1832309 · Cited by 217 · see citing works

The Replication Checkpoint Protects Fork Stability by Releasing Transcribed Genes from Nuclear Pores

Bermejo, R., Capra, T., Jossen, R., Colosio, A., Frattini, C., Carotenuto, W., Cocito, A., Doksani, Y., Klein, H. L., Gómez‐González, B., et al. (2011) · Cell · doi:10.1016/j.cell.2011.06.033 · Cited by 215 · see citing works

Stalled Fork Rescue via Dormant Replication Origins in Unchallenged S Phase Promotes Proper Chromosome Segregation and Tumor Suppression

Kawabata, T., Luebben, S. W., Yamaguchi, S., Ilves, I., Matise, I., Buske, T. R., Botchan, M. R., & Shima, N. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.02.006 · Cited by 206 · see citing works

Preventing Replication Stress to Maintain Genome Stability: Resolving Conflicts between Replication and Transcription

Bermejo, R., Lai, M. S., & Foiani, M. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.03.001 · Cited by 194 · see citing works

Targeting ATR in DNA damage response and cancer therapeutics

Fokas, E., Prevo, R., Hammond, E. M., Brunner, T. B., McKenna, W. G., & Muschel, R. J. (2013) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2013.03.002 · Cited by 192 · see citing works

Senataxin, Defective in the Neurodegenerative Disorder Ataxia with Oculomotor Apraxia 2, Lies at the Interface of Transcription and the DNA Damage Response

Yüce, Ö., & West, S. C. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.01195-12 · Cited by 189 · see citing works

Common Fragile Site Profiling in Epithelial and Erythroid Cells Reveals that Most Recurrent Cancer Deletions Lie in Fragile Sites Hosting Large Genes

Tallec, B. L., Millot, G. A., Blin, M., Brison, O., Dutrillaux, B., & Debatisse, M. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.07.003 · Cited by 188 · see citing works

Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates

Neelsen, K. J., Zanini, I. M. Y., Herrador, R., & Lopes, M. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201212058 · Cited by 188 · see citing works

Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway

Rosado, I. V., Langevin, F., Crossan, G. P., Takata, M., & Patel, K. J. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2173 · Cited by 184 · see citing works

Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR

Schoppy, D. W., Ragland, R. L., Gilad, O., Shastri, N., Peters, A. A., Murga, M., Fernández-Capetillo, Ó., Diehl, J. A., & Brown, E. J. (2011) · Journal of Clinical Investigation · doi:10.1172/jci58928 · Cited by 180 · see citing works

Replication Stress-Induced Genome Instability: The Dark Side of Replication Maintenance by Homologous Recombination

Carr, A. M., & Lambert, S. (2013) · Journal of Molecular Biology · doi:10.1016/j.jmb.2013.04.023 · Cited by 179 · see citing works

RNase H and Postreplication Repair Protect Cells from Ribonucleotides Incorporated in DNA

Lazzaro, F., Novarina, D., Amara, F., Watt, D. L., Stone, J. E., Costanzo, V., Burgers, P., Kunkel, T. A., Plevani, P., & Muzi-Falconi, M. (2012) · Molecular Cell · doi:10.1016/j.molcel.2011.12.019 · Cited by 177 · see citing works

Separate roles for the DNA damage checkpoint protein kinases in stabilizing DNA replication forksPreprint

Segurado, M., & Diffley, J. F. X. (2008) · Genes & Development · doi:10.1101/gad.477208 · Cited by 171 · see citing works

Substrate-Selective Repair and Restart of Replication Forks by DNA Translocases

Betous, R., Couch, F. B., Mason, A. C., Eichman, B. F., Mañosas, M., & Cortez, D. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.05.002 · Cited by 164 · see citing works

The Intra-S Phase Checkpoint Targets Dna2 to Prevent Stalled Replication Forks from Reversing

Hu, J., Sun, L., Shen, F., Chen, Y., Yu, H., Liu, Y., Zhang, M., Hu, Y., Wang, Q., Xu, W. F., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.030 · Cited by 164 · see citing works

Replisome Stability at Defective DNA Replication Forks Is Independent of S Phase Checkpoint Kinases

Piccoli, G. D., Katou, Y., Itoh, T., Nakato, R., Shirahige, K., & Labib, K. P. M. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.01.007 · Cited by 159 · see citing works

Topoisomerase 1-Mediated Removal of Ribonucleotides from Nascent Leading-Strand DNA

Williams, J. S., Smith, D. J., Marjavaara, L., Lujan, S. A., Chabes, A., & Kunkel, T. A. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.12.021 · Cited by 157 · see citing works

A Role for the MRN Complex in ATR Activation via TOPBP1 Recruitment

Duursma, A. M., Driscoll, R., Elias, J. E., & Cimprich, K. A. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.03.006 · Cited by 153 · see citing works

Dormant Origins, the Licensing Checkpoint, and the Response to Replicative StressesPreprint

McIntosh, D., & Blow, J. J. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012955 · Cited by 151 · see citing works

How unfinished business from S‐phase affects mitosis and beyond

Mankouri, H. W., Huttner, D., & Hickson, I. D. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.211 · Cited by 149 · see citing works

Cdc45 Is a Critical Effector of Myc-Dependent DNA Replication Stress

Srinivasan, S. V., Dominguez-Sola, D., Wang, L. C., Hyrien, O., & Gautier, J. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.04.002 · Cited by 148 · see citing works

NEK8 Links the ATR-Regulated Replication Stress Response and S Phase CDK Activity to Renal Ciliopathies

Choi, H. J. C., Lin, J., Vannier, J., Slaats, G. G. G., Kile, A. C., Paulsen, R. D., Manning, D. K., Beier, D. R., Giles, R. H., Boulton, S. J., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.08.006 · Cited by 142 · see citing works

The annealing helicase HARP protects stalled replication forksPreprint

Yuan, J., Ghosal, G., & Chen, J. (2009) · Genes & Development · doi:10.1101/gad.1836409 · Cited by 141 · see citing works

Two Distinct Modes of ATR Activation Orchestrated by Rad17 and Nbs1

Shiotani, B., Nguyen, H. D., Håkansson, P., Maréchal, A., Tse, A., Tahara, H., & Zou, L. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.04.018 · Cited by 137 · see citing works

Stepwise Activation of the ATR Signaling Pathway upon Increasing Replication Stress Impacts Fragile Site Integrity

Koundrioukoff, S., Carignon, S., Técher, H., Letessier, A., Brison, O., & Debatisse, M. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003643 · Cited by 137 · see citing works

The annealing helicase HARP is recruited to DNA repair sites via an interaction with RPAPreprint

Yusufzai, T. M., Kong, X., Yokomori, K., & Kadonaga, J. T. (2009) · Genes & Development · doi:10.1101/gad.1831509 · Cited by 134 · see citing works

ATR and H2AX cooperate in maintaining genome stability under replication stress

Chanoux, R. A., Yin, B., Urtishak, K. A., Asare, A., Bassing, C. H., & Brown, E. J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m806739200 · Cited by 130 · see citing works

Replication stress and mechanisms of CNV formation

Arlt, M. F., Wilson, T. E., & Glover, T. W. (2012) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2012.01.009 · Cited by 125 · see citing works

UV stalled replication forks restart by re-priming in human fibroblasts

Elvers, I., Johansson, F., Groth, P., Erixon, K., & Helleday, T. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr420 · Cited by 120 · see citing works

The balancing act of DNA repeat expansions

Kim, J. C., & Mirkin, S. M. (2013) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2013.04.009 · Cited by 119 · see citing works

Identification of the First ATRIP–Deficient Patient and Novel Mutations in ATR Define a Clinical Spectrum for ATR–ATRIP Seckel Syndrome

Ogi, T., Walker, S., Stiff, T., Hobson, E., Limsirichaikul, S., Carpenter, G., Prescott, K., Suri, M., Byrd, P. J., Matsuse, M., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002945 · Cited by 117 · see citing works

An extra allele of Chk1 limits oncogene-induced replicative stress and promotes transformation

Lopez-Contreras, A. J., Gutierrez‐Martinez, P., Specks, J., Rodrigo-Perez, S., & Fernández-Capetillo, Ó. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20112147 · Cited by 114 · see citing works

Genome-Organizing Factors Top2 and Hmo1 Prevent Chromosome Fragility at Sites of S phase Transcription

Bermejo, R., Capra, T., González‐Huici, V., Fachinetti, D., Cocito, A., Natoli, G., Katou, Y., Mori, H., Kurokawa, K., Shirahige, K., et al. (2009) · Cell · doi:10.1016/j.cell.2009.06.022 · Cited by 113 · see citing works

RNF4 and PLK1 are required for replication fork collapse in ATR-deficient cellsPreprint

Ragland, R. L., Patel, S., Rivard, R. S., Smith, K. D., Peters, A. A., Bielinsky, A., & Brown, E. J. (2013) · Genes & Development · doi:10.1101/gad.223180.113 · Cited by 113 · see citing works

Identification of SMARCAL1 as a Component of the DNA Damage Response

Postow, L., Woo, E. M., Chait, B. T., & Funabiki, H. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.048330 · Cited by 112 · see citing works

Analysis of DNA replication profiles in budding yeast and mammalian cells using DNA combing

Bianco, J. N., Poli, J., Saksouk, J., Bacal, J., Silva, M. J., Yoshida, K., Lin, Y., Tourrière, H., Lengronne, A., & Pasero, P. (2012) · Methods · doi:10.1016/j.ymeth.2012.04.007 · Cited by 111 · see citing works

Tissue regenerative delays and synthetic lethality in adult mice after combined deletion of Atr and Trp53

Ruzankina, Y., Schoppy, D. W., Asare, A., Clark, C. E., Vonderheide, R. H., & Brown, E. J. (2009) · Nature Genetics · doi:10.1038/ng.441 · Cited by 104 · see citing works

Impediments to replication fork movement: stabilisation, reactivation and genome instability

Lambert, S., & Carr, A. M. (2013) · Chromosoma · doi:10.1007/s00412-013-0398-9 · Cited by 99 · see citing works

Initiation of Genome Instability and Preneoplastic Processes through Loss of Fhit Expression

Saldivar, J. C., Miuma, S., Bene, J., Hosseini, S. A., Shibata, H., Sun, J., Wheeler, L. J., Mathews, C. K., & Huebner, K. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003077 · Cited by 96 · see citing works

Common fragile sites are characterized by histone hypoacetylation

Jiang, Y., Lucas, I., Young, D. J., Davis, E. M., Karrison, T. G., Rest, J. S., & Beau, M. M. L. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp410 · Cited by 94 · see citing works

The role of the DNA damage response pathways in brain development and microcephaly: Insight from human disorders

O’Driscoll, M., & Jeggo, P. A. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.03.018 · Cited by 92 · see citing works

Wolf–Hirschhorn syndrome candidate 1 is involved in the cellular response to DNA damage

Hajdú, I., Ciccia, A., Lewis, S. M., & Elledge, S. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110081108 · Cited by 91 · see citing works

Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1Preprint

Sivasubramaniam, S., Sun, X., Pan, Y.-R., Wang, S., & Lee, E. Y.-H. P. (2008) · Genes & Development · doi:10.1101/gad.1627708 · Cited by 91 · see citing works

Surviving chromosome replication: the many roles of the S-phase checkpoint pathway

Labib, K. P. M., & Piccoli, G. D. (2011) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2011.0071 · Cited by 89 · see citing works

Friedreich's ataxia–associated GAA repeats induce replication-fork reversal and unusual molecular junctions

Follonier, C., Oehler, J., Herrador, R., & Lopes, M. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2520 · Cited by 88 · see citing works

Codanin‐1, mutated in the anaemic disease CDAI, regulates Asf1 function in S‐phase histone supply

Ask, K., Jasencakova, Z., Ménard, P., Feng, Y., Almouzni, G., & Groth, A. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.55 · Cited by 86 · see citing works

Pyrimidine pool imbalance induced by BLM helicase deficiency contributes to genetic instability in Bloom syndrome

CHABOSSEAU, P. L., Buhagiar‐Labarchède, G., Onclercq, R., Lambert, S., Debatisse, M., Brison, O., & Amor-Guéret, M. (2011) · Nature Communications · doi:10.1038/ncomms1363 · Cited by 84 · see citing works

RAD6-RAD18-RAD5-pathway-dependent tolerance to chronic low-dose ultraviolet light

Hishida, T., Kubota, Y., Carr, A. M., & Iwasaki, H. (2009) · Nature · doi:10.1038/nature07580 · Cited by 77 · see citing works

Thresholds of replication stress signaling in cancer development and treatment

Bártek, J., Mistrík, M., & Bártková, J. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2220 · Cited by 74 · see citing works

Erratum To: Codanin‐1, mutated in the anaemic disease CDAI, regulates Asf1 function in S‐phase histone supply

Ask, K., Jasencakova, Z., Ménard, P., Feng, Y., Almouzni, G., & Groth, A. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.187 · Cited by 74 · see citing works

Laminopathies

Broers, J. L. V., Hutchison, C., & Ramaekers, F. C. S. (2004) · The Journal of Pathology · doi:10.1002/path.1655 · Cited by 70 · see citing works

The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks

Lee, J., & Dunphy, W. G. (2013) · Molecular Biology of the Cell · doi:10.1091/mbc.e13-01-0025 · Cited by 68 · see citing works

Meier-Gorlin syndrome mutations disrupt an Orc1 CDK inhibitory domain and cause centrosome reduplicationPreprint

Hossain, M. J., & Stillman, B. (2012) · Genes & Development · doi:10.1101/gad.197178.112 · Cited by 64 · see citing works

Penetrance of biallelic SMARCAL1 mutations is associated with environmental and genetic disturbances of gene expression

Baradaran‐Heravi, A., Cho, K. S., Tolhuis, B., Sanyal, M., Morozova, O., Morimoto, M., Elizondo, L. I., Bridgewater, D. J., Lubieniecka, J. M., Beirnes, K., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds083 · Cited by 60 · see citing works

Causes and consequences of ribonucleotide incorporation into nuclear DNA

Dalgaard, J. Z. (2012) · Trends in Genetics · doi:10.1016/j.tig.2012.07.008 · Cited by 48 · see citing works

Characterizing the functional consequences of haploinsufficiency of NELF-A (WHSC2) and SLBP identifies novel cellular phenotypes in Wolf–Hirschhorn syndrome

Kerzendorfer, C., Hannes, F., Colnaghi, R., Abramowicz, I., Carpenter, G., Vermeesch, J. R., & O’Driscoll, M. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds033 · Cited by 48 · see citing works

Nurturing the genome

González-Suárez, I., & Gonzalo, S. (2010) · Nucleus · doi:10.4161/nucl.1.2.10797 · Cited by 45 · see citing works

The Preference for Error-Free or Error-Prone Postreplication Repair in Saccharomyces cerevisiae Exposed to Low-Dose Methyl Methanesulfonate Is Cell Cycle Dependent

Huang, D., Piening, B., & Paulovich, A. G. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01392-12 · Cited by 43 · see citing works

Two replication fork maintenance pathways fuse inverted repeats to rearrange chromosomes

Hu, L., Kim, T. M., Son, M. Y., Kim, S.-A., Holland, C., Tateishi, S., Kim, D. H., Yew, P. R., Montagna, C., Dumitrache, L. C., et al. (2013) · Nature · doi:10.1038/nature12500 · Cited by 42 · see citing works

Senataxin protects the genome

Lavin, M. F., Yeo, A. J., & Bécherel, O. J. (2013) · Rare Diseases · doi:10.4161/rdis.25230 · Cited by 33 · see citing works

Meier–Gorlin syndrome and Wolf–Hirschhorn syndrome: Two developmental disorders highlighting the importance of efficient DNA replication for normal development and neurogenesis

Kerzendorfer, C., Colnaghi, R., Abramowicz, I., Carpenter, G., & O’Driscoll, M. (2013) · DNA repair · doi:10.1016/j.dnarep.2013.04.016 · Cited by 23 · see citing works

Common Fragile Site Tumor Suppressor Genes and Corresponding MouseModels of Cancer

Drusco, A., Pekarsky, Y., Costinean, S., Antenucci, A., Conti, L., Volinia, S., Aqeilan, R. I., Huebner, K., & Zanesi, N. A. O. (2010) · BioMed Research International · doi:10.1155/2011/984505 · Cited by 22 · see citing works

ROS and the DNA damage response in cancer

Srinivas, U. S., Tan, B. W. Q., Vellayappan, B. A., & Jeyasekharan, A. D. (2019) · Redox Biology · doi:10.1016/j.redox.2018.101084 · Cited by 2,144 · see citing works

Targeting the DNA Damage Response in Cancer

O’Connor, M. J. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.10.040 · Cited by 1,551 · see citing works

Cell cycle control in cancer

Matthews, H. K., Bertoli, C., & de Bruin, R. A. M. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00404-3 · Cited by 1,506 · see citing works

DNA double-strand break repair-pathway choice in somatic mammalian cells

Scully, R., Panday, A., Elango, R., & Willis, N. A. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0152-0 · Cited by 1,445 · see citing works

DNA damage and the balance between survival and death in cancer biology

Roos, W. P., Thomas, A. D., & Kaina, B. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2015.2 · Cited by 1,189 · see citing works

Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas

Knijnenburg, T., Wang, L., Zimmermann, M. T., Chambwe, N., Gao, G. F., Cherniack, A. D., Fan, H., Shen, H., Way, G. P., Greene, C. S., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.076 · Cited by 1,126 · see citing works

The essential kinase ATR: ensuring faithful duplication of a challenging genome

Saldivar, J. C., Cortez, D., & Cimprich, K. A. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.67 · Cited by 829 · see citing works

The control of DNA repair by the cell cycle

Hustedt, N., & Durocher, D. (2017) · Nature Cell Biology · doi:10.1038/ncb3452 · Cited by 738 · see citing works

BRD4 and Cancer: going beyond transcriptional regulation

Donati, B., Lorenzini, E., & Ciarrocchi, A. (2018) · Molecular Cancer · doi:10.1186/s12943-018-0915-9 · Cited by 724 · see citing works

Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells

Zellweger, R., Dalcher, D., Mutreja, K., Berti, M., Schmid, J. A., Herrador, R., Vindigni, A., & Lopes, M. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201406099 · Cited by 660 · see citing works

PARP and PARG inhibitors in cancer treatmentPreprint

Slade, D. (2020) · Genes & Development · doi:10.1101/gad.334516.119 · Cited by 666 · see citing works

Transcription-Replication Conflict Orientation Modulates R-Loop Levels and Activates Distinct DNA Damage Responses

Hamperl, S., Bocek, M. J., Saldivar, J. C., Swigut, T., & Cimprich, K. A. (2017) · Cell · doi:10.1016/j.cell.2017.07.043 · Cited by 639 · see citing works

A Genetic Map of the Response to DNA Damage in Human Cells

Olivieri, M., Cho, T., Álvarez-Quilón, A., Li, K., Schellenberg, M. J., Zimmermann, M., Hustedt, N., Rossi, S. E., Adam, S., Melo, H., et al. (2020) · Cell · doi:10.1016/j.cell.2020.05.040 · Cited by 551 · see citing works

Synthetic Lethality and Cancer Therapy: Lessons Learned from the Development of PARP Inhibitors

Lord, C. J., Tutt, A. N. J., & Ashworth, A. (2014) · Annual Review of Medicine · doi:10.1146/annurev-med-050913-022545 · Cited by 476 · see citing works

Inflammation-induced DNA damage, mutations and cancer

Kay, J. E., Thadhani, E., Samson, L. D., & Engelward, B. P. (2019) · DNA repair · doi:10.1016/j.dnarep.2019.102673 · Cited by 481 · see citing works

Hallmarks of DNA replication stress

Saxena, S., & Zou, L. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.05.004 · Cited by 442 · see citing works

SAMHD1 acts at stalled replication forks to prevent interferon induction

Coquel, F., Silva, M. J., Técher, H., Zadorozhny, K., Sharma, S., Nieminuszczy, J., Mettling, C., Dardillac, E., Barthe, A., Schmitz, A.-L., et al. (2018) · Nature · doi:10.1038/s41586-018-0050-1 · Cited by 436 · see citing works

Stem cell competition orchestrates skin homeostasis and ageing

Liu, N., Matsumura, H., Kato, T., Ichinose, S., Takada, A., Namiki, T., Asakawa, K., Morinaga, H., Mohri, Y., De Arcangelis, A., et al. (2019) · Nature · doi:10.1038/s41586-019-1085-7 · Cited by 422 · see citing works

The MRE11–RAD50–NBS1 Complex Conducts the Orchestration of Damage Signaling and Outcomes to Stress in DNA Replication and Repair

Syed, A., & Tainer, J. A. (2018) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-062917-012415 · Cited by 390 · see citing works

The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer

Alves-Fernandes, D. K., & Jasiulionis, M. G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133153 · Cited by 385 · see citing works

The Replication Checkpoint Prevents Two Types of Fork Collapse without Regulating Replisome Stability

Dungrawala, H., Rose, K. L., Bhat, K. P., Mohni, K. N., Glick, G. G., Couch, F. B., & Cortez, D. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.07.030 · Cited by 376 · see citing works

ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A

Williamson, C. T., Miller, R., Pemberton, H. N., Jones, S. E., Campbell, J., Konde, A., Badham, N., Rafiq, R., Brough, R., Gulati, A., et al. (2016) · Nature Communications · doi:10.1038/ncomms13837 · Cited by 382 · see citing works

ATR/CHK1 inhibitors and cancer therapy

Qiu, Z., Oleinick, N. L., & Zhang, J. (2017) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2017.09.043 · Cited by 378 · see citing works

Targeting replication stress in cancer therapy

da Costa, A. A. B. A., Chowdhury, D., Shapiro, G. I., D’Andrea, A. D., & Konstantinopoulos, P. A. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00558-5 · Cited by 380 · see citing works

Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models

Kim, H., Xu, H., George, E. M., Hallberg, D. L., Kumar, S., Jagannathan, V., Medvedev, S., Kinose, Y., Devins, K. M., Verma, P., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17127-2 · Cited by 370 · see citing works

RPA and RAD51: fork reversal, fork protection, and genome stability

Bhat, K. P., & Cortez, D. (2018) · Nature Structural & Molecular Biology · doi:10.1038/s41594-018-0075-z · Cited by 347 · see citing works

DNA2 drives processing and restart of reversed replication forks in human cells

Thangavel, S., Berti, M., Levikova, M., Pinto, C., Gomathinayagam, S., Vujanovic, M., Zellweger, R., Moore, H. R., Lee, E. H., Hendrickson, E. A., et al. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201406100 · Cited by 341 · see citing works

Forging Ahead through Darkness: PCNA, Still the Principal Conductor at the Replication Fork

Choe, K. N., & Moldovan, G.-L. (2017) · Molecular Cell · doi:10.1016/j.molcel.2016.12.020 · Cited by 325 · see citing works

CDK12 regulates DNA repair genes by suppressing intronic polyadenylation

Dubbury, S. J., Boutz, P. L., & Sharp, P. A. (2018) · Nature · doi:10.1038/s41586-018-0758-y · Cited by 318 · see citing works

Distinct but Concerted Roles of ATR, DNA-PK, and Chk1 in Countering Replication Stress during S Phase

Buisson, R., Boisvert, J. L., Benes, C. H., & Zou, L. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.07.029 · Cited by 316 · see citing works

A mitosis-specific and R loop–driven ATR pathway promotes faithful chromosome segregation

Kabeche, L., Nguyen, H. D., Buisson, R., & Zou, L. (2017) · Science · doi:10.1126/science.aan6490 · Cited by 303 · see citing works

Exploiting replicative stress to treat cancer

Dobbelstein, M., & Sørensen, C. S. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4553 · Cited by 300 · see citing works

Resistance to PARP inhibitors by SLFN11 inactivation can be overcome by ATR inhibition

Murai, J., Feng, Y., Yu, G. K., Ru, Y., Tang, S.-W., Shen, Y., & Pommier, Y. G. (2016) · Oncotarget · doi:10.18632/oncotarget.12266 · Cited by 298 · see citing works

Targeting the ATR/CHK1 Axis with PARP Inhibition Results in Tumor Regression in BRCA -Mutant Ovarian Cancer Models

Kim, H., George, E. M., Ragland, R. L., Rafail, S., Zhang, R., Krepler, C., Morgan, M. A., Herlyn, M., Brown, E. J., & Simpkins, F. A. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-2273 · Cited by 294 · see citing works

SIRT2: Controversy and multiple roles in disease and physiology

Wang, Y., Yang, J., Hong, T., Chen, X., & Cui, L. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100961 · Cited by 289 · see citing works

ATR inhibition induces synthetic lethality and overcomes chemoresistance in TP53- or ATM-defective chronic lymphocytic leukemia cells

Kwok, M., Davies, N., Agathanggelou, A., Smith, E., Oldreive, C., Petermann, E., Stewart, G. S., Brown, J., Lau, A., Pratt, G., et al. (2015) · Blood · doi:10.1182/blood-2015-05-644872 · Cited by 281 · see citing works

The impact of replication stress on replication dynamics and DNA damage in vertebrate cells

Técher, H., Koundrioukoff, S., Nicolas, A. G., & Debatisse, M. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.46 · Cited by 271 · see citing works

Targeted and Persistent 8-Oxoguanine Base Damage at Telomeres Promotes Telomere Loss and Crisis

Fouquerel, E., Barnes, R. P., Uttam, S., Watkins, S. C., Bruchez, M. P., & Opresko, P. L. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.04.024 · Cited by 275 · see citing works

SLFN11 Blocks Stressed Replication Forks Independently of ATR

Murai, J., Tang, S.-W., Leo, E., Baechler, S. A., Redon, C. E., Zhang, H., Al Abo, M., Rajapakse, V. N., Nakamura, E., Jenkins, L. M. M., et al. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.01.012 · Cited by 275 · see citing works

Molecular Pathways: Targeting ATR in Cancer Therapy

Karnitz, L. M., & Zou, L. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-0479 · Cited by 267 · see citing works

Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1

Nguyen, H. D., Yadav, T., Giri, S., Sáez, B., Graubert, T. A., & Zou, L. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.01.029 · Cited by 268 · see citing works

Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds

Zimmer, J., Tacconi, E. M. C., Folio, C., Badie, S., Porru, M., Klare, K., Tumiati, M., Markkanen, E., Halder, S., Ryan, A., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2015.12.004 · Cited by 261 · see citing works

The Ageing Brain: Molecular and Cellular Basis of Neurodegeneration

Azam, S., Haque, M. E., Balakrishnan, R., Kim, I., & Choi, D. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.683459 · Cited by 257 · see citing works

ETAA1 acts at stalled replication forks to maintain genome integrity

Bass, T. E., Luzwick, J. W., Kavanaugh, G. M., Carroll, C. M., Dungrawala, H., Glick, G. G., Feldkamp, M. D., Putney, R., Chazin, W., & Cortez, D. (2016) · Nature Cell Biology · doi:10.1038/ncb3415 · Cited by 258 · see citing works

Replication stress: getting back on track

Berti, M., & Vindigni, A. (2016) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3163 · Cited by 249 · see citing works

Activation of the ATR kinase by the RPA-binding protein ETAA1

Haahr, P., Hoffmann, S., Tollenaere, M. A. X., Ho, T., Toledo, L. I., Mann, M., Bekker‐Jensen, S., Räschle, M., & Mailand, N. (2016) · Nature Cell Biology · doi:10.1038/ncb3422 · Cited by 255 · see citing works

RAD51 Gene Family Structure and Function

Bonilla, B., Hengel, S. R., Grundy, M. K., & Bernstein, K. A. (2020) · Annual Review of Genetics · doi:10.1146/annurev-genet-021920-092410 · Cited by 259 · see citing works

MRE11-RAD50-NBS1 complex alterations and DNA damage response: implications for cancer treatment

Bian, L., Meng, Y., Zhang, M., & Li, D. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1100-5 · Cited by 252 · see citing works

DNA Fiber Analysis: Mind the Gap!

Quinet, A., Carvajal-Maldonado, D., Lemacon, D. S., & Vindigni, A. (2017) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2017.03.019 · Cited by 240 · see citing works

Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features

Lessel, D., Vaz, B., Halder, S., Lockhart, P. J., Marinovic‐Terzić, I., López-Mosqueda, J., Philipp, M., Sim, J. C. H., Smith, K. R., Oehler, J., et al. (2014) · Nature Genetics · doi:10.1038/ng.3103 · Cited by 234 · see citing works

Targeting the ATR-CHK1 Axis in Cancer Therapy

Rundle, S., Bradbury, A., Drew, Y., & Curtin, N. J. (2017) · Cancers · doi:10.3390/cancers9050041 · Cited by 235 · see citing works

Exploiting DNA Replication Stress for Cancer Treatment

Ubhi, T., & Brown, G. W. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-3631 · Cited by 227 · see citing works

Genetic variants associated with mosaic Y chromosome loss highlight cell cycle genes and overlap with cancer susceptibility

Wright, D. J., Day, F. R., Kerrison, N. D., Zink, F., Cardona, A., Sulem, P., Thompson, D. J., Sigurjónsdóttir, S., Gudbjartsson, D. F., Helgason, A., et al. (2017) · Nature Genetics · doi:10.1038/ng.3821 · Cited by 225 · see citing works

APOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA Replication

Hoopes, J. I., Cortez, L. M., Mertz, T. M., Malc, E. P., Mieczkowski, P. A., & Roberts, S. A. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.01.021 · Cited by 224 · see citing works

Preventing replication fork collapse to maintain genome integrity

Cortez, D. (2015) · DNA Repair · doi:10.1016/j.dnarep.2015.04.026 · Cited by 223 · see citing works

Quantitative Phosphoproteomics of the Ataxia Telangiectasia-Mutated (ATM) and Ataxia Telangiectasia-Mutated and Rad3-related (ATR) Dependent DNA Damage Response in Arabidopsis thaliana*

Roitinger, E., Hofer, M., Köcher, T., Pichler, P., Novatchkova, M., Yang, J., Schlögelhofer, P., & Mechtler, K. (2015) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m114.040352 · Cited by 216 · see citing works

Inflammation and DNA damage: cause, effect or both

Pezone, A., Olivieri, F., Napoli, M. V., Procopio, A., Avvedimento, E. V., & Gabrielli, A. (2023) · Nature Reviews Rheumatology · doi:10.1038/s41584-022-00905-1 · Cited by 212 · see citing works

Nuclear Deformation Causes DNA Damage by Increasing Replication Stress

Shah, P., Hobson, C. M., Cheng, S., Colville, M. J., Paszek, M. J., Superfine, R., & Lammerding, J. (2020) · Current Biology · doi:10.1016/j.cub.2020.11.037 · Cited by 212 · see citing works

DNA replication stress: Causes, resolution and disease

Mazouzi, A., Velimezi, G., & Loizou, J. I. (2014) · Experimental Cell Research · doi:10.1016/j.yexcr.2014.09.030 · Cited by 211 · see citing works

Cancer, metastasis, and the epigenome

Kiri, S., & Ryba, T. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02069-w · Cited by 214 · see citing works

Impact of genomic damage and ageing on stem cell function

Behrens, A., van Deursen, J. M., Rudolph, K. L., & Schumacher, B. (2014) · Nature Cell Biology · doi:10.1038/ncb2928 · Cited by 207 · see citing works

Interplay between Fanconi anemia and homologous recombination pathways in genome integrity

Michl, J., Zimmer, J., & Tarsounas, M. (2016) · The EMBO Journal · doi:10.15252/embj.201693860 · Cited by 204 · see citing works

Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination sites

Promonet, A., Padioleau, I., Liu, Y., Sanz, L. A., Biernacka, A., Schmitz, A.-L., Skrzypczak, M., Sarrazin, A., Mettling, C., Rowicka, M., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17858-2 · Cited by 196 · see citing works

HLTF’s Ancient HIRAN Domain Binds 3′ DNA Ends to Drive Replication Fork Reversal

Kile, A. C., Chavez, D., Bacal, J., Eldirany, S. A., Korzhnev, D. M., Bezsonova, I., Eichman, B. F., & Cimprich, K. A. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.05.013 · Cited by 203 · see citing works

FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair

Kais, Z., Rondinelli, B., Holmes, A. L., O’Leary, C., Kozono, D., D’Andrea, A. D., & Ceccaldi, R. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.05.031 · Cited by 198 · see citing works

Multiomic Analysis of the UV-Induced DNA Damage Response

Boeing, S., Williamson, L. M., Encheva, V., Gori, I., Saunders, R. E., Instrell, R., Aygün, O., Rodríguez‐Martínez, M., Weems, J. C., Kelly, G. P., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.04.047 · Cited by 199 · see citing works

Clustered DNA Double-Strand Breaks: Biological Effects and Relevance to Cancer Radiotherapy

Nickoloff, J. A., Sharma, N., & Taylor, L. E. (2020) · Genes · doi:10.3390/genes11010099 · Cited by 198 · see citing works

HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis

Bai, G., Kermi, C., Stoy, H., Schiltz, C. J., Bacal, J., Zaino, A. M., Hadden, M. K., Eichman, B. F., Lopes, M., & Cimprich, K. A. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.04.031 · Cited by 198 · see citing works

BOD1L Is Required to Suppress Deleterious Resection of Stressed Replication Forks

Higgs, M. R., Reynolds, J. J., Winczura, A., Blackford, A. N., Borel, V., Miller, E. S., Zlatanou, A., Nieminuszczy, J., Ryan, E. L., Davies, N. J., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.06.007 · Cited by 194 · see citing works

Redox-sensitive alteration of replisome architecture safeguards genome integrity

Somyajit, K., Gupta, R., Polášek-Sedláčková, H., Neelsen, K. J., Ochs, F., Rask, M., Choudhary, C., & Lukas, J. (2017) · Science · doi:10.1126/science.aao3172 · Cited by 190 · see citing works

Virus DNA Replication and the Host DNA Damage Response

Weitzman, M. D., & Fradet‐Turcotte, A. (2018) · Annual Review of Virology · doi:10.1146/annurev-virology-092917-043534 · Cited by 190 · see citing works

Cell cycle proliferation decisions: the impact of single cell analyses

Matson, J. P., & Cook, J. G. (2016) · FEBS Journal · doi:10.1111/febs.13898 · Cited by 183 · see citing works

Replication Stress Drives Constitutive Activation of the DNA Damage Response and Radioresistance in Glioblastoma Stem-like Cells

Carruthers, R., Ahmed, S. U., Ramachandran, S., Strathdee, K. E., Kurian, K. M., Hedley, A., Gomez-Roman, N., Kalna, G., Neilson, M., Gilmour, L., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-0569 · Cited by 180 · see citing works

ATR Inhibitors VE-821 and VX-970 Sensitize Cancer Cells to Topoisomerase I Inhibitors by Disabling DNA Replication Initiation and Fork Elongation Responses

Jossé, R., Martin, S. E., Guha, R., Ormanoglu, P., Pfister, T. D., Reaper, P. M., Barnes, C. S., Jones, J. L., Charlton, P., Pollard, J. R., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-3369 · Cited by 176 · see citing works

Phase I Study of ATR Inhibitor M6620 in Combination With Topotecan in Patients With Advanced Solid Tumors

Thomas, A., Redon, C. E., Sciuto, L. C., Padiernos, E., Ji, J. J., Lee, M.-J., Yuno, A., Lee, S., Zhang, Y., Tran, L. T.-N., et al. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2017.76.6915 · Cited by 173 · see citing works

Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress

Thomas, A., Takahashi, N., Rajapakse, V. N., Zhang, X., Sun, Y., Ceribelli, M., Wilson, K. M., Zhang, Y., Beck, E., Sciuto, L. C., et al. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.02.014 · Cited by 173 · see citing works

Schlafen 11 (SLFN11), a restriction factor for replicative stress induced by DNA-targeting anti-cancer therapies

Murai, J., Thomas, A., Miettinen, M., & Pommier, Y. (2019) · Pharmacology &amp; Therapeutics · doi:10.1016/j.pharmthera.2019.05.009 · Cited by 172 · see citing works

DNA damage response inhibitors: Mechanisms and potential applications in cancer therapy

Carrassa, L., & Damia, G. L. M. (2017) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2017.08.013 · Cited by 170 · see citing works

Endogenous Replication Stress in Mother Cells Leads to Quiescence of Daughter Cells

Arora, M., Moser, J. C., Phadke, H., Basha, A. A., & Spencer, S. L. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.04.055 · Cited by 165 · see citing works

Exploring the links between cancer and placenta development

Costanzo, V., Bardelli, A., Siena, S., & Abrignani, S. (2018) · Open Biology · doi:10.1098/rsob.180081 · Cited by 168 · see citing works

DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer

Kanu, N., Cerone, M. A., Goh, G., Zalmas, L., Bártková, J., Dietzen, M., McGranahan, N., Rogers, R. F., Law, E. K., Gromova, I., et al. (2016) · Genome biology · doi:10.1186/s13059-016-1042-9 · Cited by 165 · see citing works

R-loop proximity proteomics identifies a role of DDX41 in transcription-associated genomic instability

Mosler, T., Conte, F., Longo, G. M. C., Mikičić, I., Kreim, N., Möckel, M. M., Petrosino, G., Flach, J., Barau, J., Luke, B., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-27530-y · Cited by 165 · see citing works

miRNA dysregulation is an emerging modulator of genomic instability

Cardoso, A. P. F., Banerjee, M., Nail, A. N., Lykoudi, A., & States, J. C. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.05.004 · Cited by 169 · see citing works

p53 at the crossroad of DNA replication and ribosome biogenesis stress pathways

Lindström, M. S., Bártek, J., & Maya‐Mendoza, A. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-00999-w · Cited by 161 · see citing works

The causes of replication stress and their consequences on genome stability and cell fate

Magdalou, I., López, B. S., Pasero, P., & Lambert, S. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.04.035 · Cited by 157 · see citing works

mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability

Valvezan, A. J., Turner, M., Belaïd, A., Lam, H. C., Miller, S. K., McNamara, M. C., Baglini, C. V., Housden, B. E., Perrimon, N., Kwiatkowski, D. J., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.09.013 · Cited by 160 · see citing works

DNA-PKcs: A Multi-Faceted Player in DNA Damage Response

Yue, X., Bai, C., Xie, D., Ma, T., & Zhou, P. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.607428 · Cited by 160 · see citing works

Fork Cleavage-Religation Cycle and Active Transcription Mediate Replication Restart after Fork Stalling at Co-transcriptional R-Loops

Chappidi, N., Naščáková, Z., Boleslavska, B., Zellweger, R., Işık, E., Andrš, M., Menon, S., Dobrovolná, J., Pogliano, C. B., Matos, J., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.10.026 · Cited by 159 · see citing works

TRIP13 regulates DNA repair pathway choice through REV7 conformational change

Clairmont, C. S., Sarangi, P., Ponnienselvan, K., Galli, L. D., Csete, I. S., Moreau, L. A., Adelmant, G., Chowdhury, D., Marto, J. A., & D’Andrea, A. D. (2020) · Nature Cell Biology · doi:10.1038/s41556-019-0442-y · Cited by 156 · see citing works

Targeting the replication stress response in cancer

Forment, J. V., & O’Connor, M. J. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.03.005 · Cited by 159 · see citing works

Ataxia telangiectasia and Rad3-related inhibitors and cancer therapy: where we stand

Mei, L., Zhang, J., He, K., & Zhang, J. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0733-6 · Cited by 157 · see citing works

Genome integrity and disease prevention in the nervous systemPreprint

McKinnon, P. J. (2017) · Genes & Development · doi:10.1101/gad.301325.117 · Cited by 155 · see citing works

Nuclear F-Actin Counteracts Nuclear Deformation and Promotes Fork Repair during Replication Stress

Lamm, N., Read, M. N., Nobis, M., Van Ly, D., Page, S. G., Masamsetti, V. P., Timpson, P., Biro, M., & Cesare, A. J. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-00605-6 · Cited by 156 · see citing works

Advances in understanding DNA processing and protection at stalled replication forks

Rickman, K. A., & Smogorzewska, A. (2019) · The Journal of Cell Biology · doi:10.1083/jcb.201809012 · Cited by 153 · see citing works

BRD4 prevents the accumulation of R-loops and protects against transcription–replication collision events and DNA damage

Lam, F. C., Kong, Y. W., Huang, Q., Vu‐Han, T., Maffa, A., Kasper, E. M., & Yaffe, M. B. (2020) · Nature Communications · doi:10.1038/s41467-020-17503-y · Cited by 154 · see citing works

Linking Oxidative Stress and DNA Damage to Changes in the Expression of Extracellular Matrix Components

Martins, S. G., Zilhão, R., Þorsteinsdóttir, S., & Carlos, A. R. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.673002 · Cited by 160 · see citing works

ATM-Dependent Phosphorylation of All Three Members of the MRN Complex: From Sensor to Adaptor

Lavin, M. F., Kozlov, S., Gatei, M. H., & Kijas, A. W. (2015) · Biomolecules · doi:10.3390/biom5042877 · Cited by 152 · see citing works

Reality CHEK: Understanding the biology and clinical potential of CHK1

Neizer‐Ashun, F., & Bhattacharya, R. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.09.016 · Cited by 149 · see citing works

Signaling Pathways of Replication Stress in Yeast

Pardo, B., Crabbé, L., & Pasero, P. (2016) · FEMS Yeast Research · doi:10.1093/femsyr/fow101 · Cited by 146 · see citing works

ATRX Promotes DNA Repair Synthesis and Sister Chromatid Exchange during Homologous Recombination

Juhász, S., Elbakry, A., Mathes, A., & Löbrich, M. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.05.014 · Cited by 150 · see citing works

Signaling at Stalled Replication Forks

Mordes, D. A., & Cortez, D. (2009) · Springer eBooks · doi:10.1007/978-90-481-2561-6_2

GENOME STABILITY MECHANISMS DURING REPLICATION STRESS AND DNA DAMAGE RESPONSE IN PROLIFERATING CELLS

Seol, J.-M., Kwon, E.-B., Moon, T.-H., Nam, S.-Y., & Jin, K.-H. (2026) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.22693628

Stalled Replication Forks under Replication Stress: Cellular Responses, Repair Mechanisms and Therapeutic Implications

Wang, Y. (2026) · Theoretical and Natural Science · doi:10.54254/2753-8818/2026.36489

The Adaptive Mechanisms and Checkpoint Responses to a Stressed DNA Replication Fork

Saldanha, J., Rageul, J., Patel, J. A., & Kim, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310488 · Cited by 26 · see citing works

Signaling of DNA Replication Stress Through the ATR Checkpoint

Shiotani, B., & Zou, L. (2016) · Springer eBooks · doi:10.1007/978-4-431-55873-6_16