The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
A Genetic Program Promotes C. elegans Longevity at Cold Temperatures via a Thermosensitive TRP Channel
Open accessAbstract
Summary Both poikilotherms and homeotherms live longer at lower body temperatures, highlighting a general role of temperature reduction in lifespan extension. However, the underlying mechanisms remain unclear. One prominent model is that cold temperatures reduce the rate of chemical reactions, thereby slowing the rate of aging. This view suggests that cold-dependent lifespan extension is simply a passive thermodynamic process. Here, we challenge this view in C. elegans by showing that genetic programs actively promote longevity at cold temperatures. We find that TRPA-1, a cold-sensitive TRP channel, detects temperature drop in the environment to extend lifespan. This effect requires cold-induced, TRPA-1-mediated calcium influx and a calcium-sensitive PKC which signals to the transcription factor DAF-16/FOXO. Human TRPA1 can functionally substitute for worm TRPA-1 in promoting longevity. Our results reveal a new function for TRP channels, link calcium signaling to longevity, and importantly, demonstrate that genetic programs contribute to lifespan extension at cold temperatures.
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Cites
Extending Healthy Life Span—From Yeast to Humans
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Tissue-Specific Activities of C. elegans DAF-16 in the Regulation of Lifespan
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Transgenic Mice with a Reduced Core Body Temperature Have an Increased Life Span
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Cited by
SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans
Blackwell, T. K., Steinbaugh, M. J., Hourihan, J. M., Ewald, C. Y., & Isik, M. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.008 · Cited by 622
Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS)
Ristow, M., & Schmeisser, K. (2014) · Dose-Response · doi:10.2203/dose-response.13-035.ristow · Cited by 534
TRPA1 channels: molecular sentinels of cellular stress and tissue damage
Viana, F. (2016) · The Journal of Physiology · doi:10.1113/jp270935 · Cited by 210
How Caenorhabditis elegans Senses Mechanical Stress, Temperature, and Other Physical Stimuli
Goodman, M. B., & Sengupta, P. (2019) · Genetics · doi:10.1534/genetics.118.300241 · Cited by 131
Cell non-autonomous regulation of health and longevity
Miller, H. A., Dean, E. S., Pletcher, S. D., & Leiser, S. F. (2020) · eLife · doi:10.7554/elife.62659 · Cited by 102
Metadata
- Authors
- Xiao, R., Zhang, B., Dong, Y., Gong, J., Xu, T., Liu, J., & Xu, X. Z. S.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2013-02
- Volume
- 152
- Issue
- 4
- Pages
- 806-817
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2159575874
- Cited by
- 254
- References
- 8
- FWCI
- 7.15
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Xiao, R., Zhang, B., Dong, Y., Gong, J., Xu, T., Liu, J., & Xu, X. Z. S. (2013). A Genetic Program Promotes C. elegans Longevity at Cold Temperatures via a Thermosensitive TRP Channel. Cell. https://doi.org/10.1016/j.cell.2013.01.020
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