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Cited by 131Ion Channels and ReceptorsNeurobiology and Insect Physiology ResearchGenetics, Aging, and Longevity in Model Organisms

How Caenorhabditis elegans Senses Mechanical Stress, Temperature, and Other Physical Stimuli

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Goodman, Miriam B, Sengupta, Piali·2019·Genetics
DOI 10.1534/genetics.118.300241PMC PMC6499529
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Abstract

Caenorhabditis elegans lives in a complex habitat in which they routinely experience large fluctuations in temperature, and encounter physical obstacles that vary in size and composition. Their habitat is shared by other nematodes, by beneficial and harmful bacteria, and nematode-trapping fungi. Not surprisingly, these nematodes can detect and discriminate among diverse environmental cues, and exhibit sensory-evoked behaviors that are readily quantifiable in the laboratory at high resolution. Their ability to perform these behaviors depends on <100 sensory neurons, and this compact sensory nervous system together with powerful molecular genetic tools has allowed individual neuron types to be linked to specific sensory responses. Here, we describe the sensory neurons and molecules that enable C. elegans to sense and respond to physical stimuli. We focus primarily on the pathways that allow sensation of mechanical and thermal stimuli, and briefly consider this animal’s ability to sense magnetic and electrical fields, light, and relative humidity. As the study of sensory transduction is critically dependent upon the techniques for stimulus delivery, we also include a section on appropriate laboratory methods for such studies. This chapter summarizes current knowledge about the sensitivity and response dynamics of individual classes of C. elegans mechano- and thermosensory neurons from in vivo calcium imaging and whole-cell patch-clamp electrophysiology studies. We also describe the roles of conserved molecules and signaling pathways in mediating the remarkably sensitive responses of these nematodes to mechanical and thermal cues. These studies have shown that the protein partners that form mechanotransduction channels are drawn from multiple superfamilies of ion channel proteins, and that signal transduction pathways responsible for temperature sensing in C. elegans share many features with those responsible for phototransduction in vertebrates.

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  • Many biological processes vary considerably over 4-5 °C, well within the range of what is normally considered room temperature.

    “because many biological processes vary considerably over 4-5 • C [40,55-59], well within the range of what is normally considered room temperature.”

    From A feature and not a bug: Replication failures can lead to new biology (2026) · cites this paper as [57]

    The Thermosensation section says temperature regulates biochemical reaction rates, and the Behavioral responses to thermal stimuli section describes changes in C. elegans behavior across differences of a few degrees (page numbers unavailable). These passages support temperature sensitivity, but do not establish that many biological processes vary considerably over specifically 4–5 °C or define that interval as room temperature. (LLM, conf=0.83)

    Experimental — accuracy not yet measured

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  1. Akella J. S. Wloga D. Kim J. Starostina N. G. Lyons-Abbott S., 2010 MEC-17 is an alpha-tubulin acetyltransferase. Nature 467: 218– 222. 10.1038/nature09324 20829795 PMC2938957 · DOI · Paper page
  2. Albeg A. Smith C. J. Chatzigeorgiou M. Feitelson D. G. Hall D. H., 2011 C. elegans multi-dendritic sensory neurons: morphology and function. Mol. Cell. Neurosci. 46: 308– 317. 10.1016/j.mcn.2010.10.001 20971193 PMC3018541 · DOI
  3. Albrecht D. R. Bargmann C. I., 2011 High-content behavioral analysis of Caenorhabditis elegans in precise spatiotemporal chemical environments. Nat. Methods 8: 599– 605. 10.1038/nmeth.1630 21666667 PMC3152576 · DOI
  4. Anderson J. L. Albergotti L. Ellebracht B. Huey R. B. Phillips P. C., 2011 Does thermoregulatory behavior maximize reproductive fitness of natural isolates of Caenorhabditis elegans? BMC Evol. Biol. 11: 157 10.1186/1471-2148-11-157 21645395 PMC3141425 · DOI
  5. Angilletta M. J., 2009 Thermal Adaptation: A Theoretical and Empirical Synthesis. Oxford University Press, Oxford 10.1093/acprof:oso/9780198570875.001.1 · DOI
  6. Anishkin A. Kung C., 2013 Stiffened lipid platforms at molecular force foci. Proc. Natl. Acad. Sci. USA 110: 4886– 4892. 10.1073/pnas.1302018110 23476066 PMC3612676 · DOI
  7. Anishkin A. Loukin S. H. Teng J. Kung C., 2014 Feeling the hidden mechanical forces in lipid bilayer is an original sense. Proc. Natl. Acad. Sci. USA 111: 7898– 7905. 10.1073/pnas.1313364111 24850861 PMC4050596 · DOI
  8. Aoki I. Mori I., 2015 Molecular biology of thermosensory transduction in C. elegans. Curr. Opin. Neurobiol. 34: 117– 124. 10.1016/j.conb.2015.03.011 25840145 · DOI
  9. Aoki I. Tateyama M. Shimomura T. Ihara K. Kubo Y., 2018 SLO potassium channels antagonize premature decision making in C. elegans. Commun Biol 1: 123 10.1038/s42003-018-0124-5 30272003 PMC6123717 · DOI
  10. Arnadóttir J. Chalfie M., 2010 Eukaryotic mechanosensitive channels. Annu. Rev. Biophys. 39: 111– 137. 10.1146/annurev.biophys.37.032807.125836 20192782 · DOI
  11. Arnadottir J. O’Hagan R. Chen Y. Goodman M. B. Chalfie M., 2011 The DEG/ENaC protein MEC-10 regulates the transduction channel complex in Caenorhabditis elegans touch receptor neurons. J. Neurosci. 31: 12695– 12704. 10.1523/JNEUROSCI.4580-10.2011 21880930 PMC3172708 · DOI
  12. Bainbridge C. Rodriguez A. Schuler A. Cisneros M. Vidal-Gadea A. G., 2016 Magnetic orientation in C. elegans relies on the integrity of the villi of the AFD magnetosensory neurons. J. Physiol. Paris 110: 76– 82. 10.1016/j.jphysparis.2016.12.002 27940210 · DOI
  13. Baker C. V. Modrell M. S. Gillis J. A., 2013 The evolution and development of vertebrate lateral line electroreceptors. J. Exp. Biol. 216: 2515– 2522. 10.1242/jeb.082362 23761476 PMC4988487 · DOI
  14. Bargmann C. I. Horvitz H. R., 1991 Chemosensory neurons with overlapping functions direct chemotaxis to multiple chemicals in C. elegans. Neuron 7: 729– 742. 10.1016/0896-6273(91)90276-6 1660283 · DOI · Paper page
  15. Bargmann C. I. Hartwieg E. Horvitz H. R., 1993 Odorant-selective genes and neurons mediate olfaction in C. elegans. Cell 74: 515– 527. 10.1016/0092-8674(93)80053-H 8348618 · DOI
  16. Barr M. M. DeModena J. Braun D. Nguyen C. Q. Hall D. H., 2001 The Caenorhabditis elegans autosomal dominant polycystic kidney disease gene homologs lov-1 and pkd-2 act in the same pathway. Curr. Biol. 11: 1341– 1346. 10.1016/S0960-9822(01)00423-7 11553327 · DOI
  17. Barr M. M. Garcia L. R. Portman D. S., 2018 Sexual dimorphism and sex differences in Caenorhabditis elegans neuronal development and behavior. Genetics 208: 909– 935. 10.1534/genetics.117.300294 29487147 PMC5844341 · DOI
  18. Beverly M. Anbil S. Sengupta P., 2011 Degeneracy and neuromodulation among thermosensory neurons contribute to robust thermosensory behaviors in Caenorhabditis elegans. J. Neurosci. 31: 11718– 11727. 10.1523/JNEUROSCI.1098-11.2011 21832201 PMC3167209 · DOI
  19. Bhatla N. Horvitz H. R., 2015 Light and hydrogen peroxide inhibit C. elegans feeding through gustatory receptor orthologs and pharyngeal neurons. Neuron 85: 804– 818. 10.1016/j.neuron.2014.12.061 25640076 PMC4408612 · DOI
  20. Biron D. Shibuya M. Gabel C. Wasserman S. M. Clark D. A., 2006 A diacylglycerol kinase modulates long-term thermotactic behavioral plasticity in C. elegans. Nat. Neurosci. 9: 1499– 1505. 10.1038/nn1796 17086178 · DOI
  21. Biron D. Wasserman S. Thomas J. H. Samuel A. D. Sengupta P., 2008 An olfactory neuron responds stochastically to temperature and modulates Caenorhabditis elegans thermotactic behavior. Proc. Natl. Acad. Sci. USA 105: 11002– 11007. 10.1073/pnas.0805004105 18667708 PMC2504807 · DOI
  22. Blakemore R., 1975 Magnetotactic bacteria. Science 190: 377– 379. 10.1126/science.170679 170679 · DOI
  23. Boscardin E. Alijevic O. Hummler E. Frateschi S. Kellenberger S., 2016 The function and regulation of acid-sensing ion channels (ASICs) and the epithelial Na(+) channel (ENaC): IUPHAR Review 19. Br. J. Pharmacol. 173: 2671– 2701. 10.1111/bph.13533 27278329 PMC4995293 · DOI
  24. Bounoutas A. O’Hagan R. Chalfie M., 2009 The multipurpose 15-protofilament microtubules in C. elegans have specific roles in mechanosensation. Curr. Biol. 19: 1362– 1367. 10.1016/j.cub.2009.06.036 19615905 PMC2757273 · DOI
  25. Bozorgmehr T. Ardiel E. L. McEwan A. H. Rankin C. H., 2013 Mechanisms of plasticity in a Caenorhabditis elegans mechanosensory circuit. Front. Physiol. 4: 88 10.3389/fphys.2013.00088 23986713 PMC3750945 · DOI
  26. Bretscher A. J. Kodama-Namba E. Busch K. E. Murphy R. J. Soltesz Z., 2011 Temperature, oxygen, and salt-sensing neurons in C. elegans are carbon dioxide sensors that control avoidance behavior. Neuron 69: 1099– 1113. 10.1016/j.neuron.2011.02.023 21435556 PMC3115024 · DOI
  27. Bullock T. H. Diecke F. P., 1956 Properties of an infra-red receptor. J. Physiol. 134: 47– 87. 10.1113/jphysiol.1956.sp005624 13377311 PMC1359182 · DOI
  28. Chalasani S. H. Chronis N. Tsunozaki M. Gray J. M. Ramot D., 2007 Dissecting a circuit for olfactory behaviour in Caenorhabditis elegans. Nature 450: 63– 70 [corrigenda: Nature 533: 130 (2016)] 10.1038/nature06292 17972877 · DOI
  29. Chalasani S. H. Chronis N. Tsunozaki M. Gray J. M. Ramot D., 2016 Corrigendum: dissecting a circuit for olfactory behaviour in Caenorhabditis elegans. Nature 533: 130 10.1038/nature16515 26789243 · DOI
  30. Chalfie M. Au M., 1989 Genetic control of differentiation of the Caenorhabditis elegans touch receptor neurons. Science 243: 1027– 1033. 10.1126/science.2646709 2646709 · DOI
  31. Chalfie M. Sulston J., 1981 Developmental genetics of the mechanosensory neurons of Caenorhabditis elegans. Dev. Biol. 82: 358– 370. 10.1016/0012-1606(81)90459-0 7227647 · DOI
  32. Chalfie M. Thomson J. N., 1979 Organization of neuronal microtubules in the nematode Caenorhabditis elegans. J. Cell Biol. 82: 278– 289. 10.1083/jcb.82.1.278 479300 PMC2110421 · DOI
  33. Chalfie M. Thomson J. N., 1982 Structural and functional diversity in the neuronal microtubules of Caenorhabditis elegans. J. Cell Biol. 93: 15– 23. 10.1083/jcb.93.1.15 7068753 PMC2112106 · DOI
  34. Chalfie M. Sulston J. E. White J. G. Southgate E. Thomson J. N., 1985 The neural circuit for touch sensitivity in Caenorhabditis elegans. J. Neurosci. 5: 956– 964. 10.1523/JNEUROSCI.05-04-00956.1985 3981252 PMC6565008 · DOI · Paper page
  35. Chalfie M. Dean E. Reilly E. Buck K. Thomson J. N., 1986 Mutations affecting microtubule structure in Caenorhabditis elegans. J. Cell Sci. Suppl. 5: 257– 271. 10.1242/jcs.1986.Supplement_5.17 3477555 · DOI
  36. Chalfie M. Hart A. C. Rankin C. H. Goodman M. B., 2014 Assaying mechanosensation. (July 31, 2014), WormBook, ed. The C. elegans Research Community, WormBook, /10.1895/wormbook.1.172.1. http://www​.wormbook.org 10.1895/wormbook.1.172.1 PMC4448936 25093996 · DOI
  37. Chao Y. C. Chen C. C. Lin Y. C. Breer H. Fleischer J., 2015 Receptor guanylyl cyclase-G is a novel thermosensory protein activated by cool temperatures. EMBO J. 34: 294– 306. 10.15252/embj.201489652 25452496 PMC4339118 · DOI
  38. Chatzigeorgiou M. Schafer W. R., 2011 Lateral facilitation between primary mechanosensory neurons controls nose touch perception in C. elegans. Neuron 70: 299– 309. 10.1016/j.neuron.2011.02.046 21521615 PMC3145979 · DOI
  39. Chatzigeorgiou M. Yoo S. Watson J. D. Lee W. H. Spencer W. C., 2010 Specific roles for DEG/ENaC and TRP channels in touch and thermosensation in C. elegans nociceptors. Nat. Neurosci. 13: 861– 868. 10.1038/nn.2581 20512132 PMC2975101 · DOI
  40. Chen X. Chalfie M., 2014 Modulation of C. elegans touch sensitivity is integrated at multiple levels. J. Neurosci. 34: 6522– 6536. 10.1523/JNEUROSCI.0022-14.2014 24806678 PMC4012311 · DOI
  41. Chen X. Chalfie M., 2015 Regulation of mechanosensation in C. elegans through ubiquitination of the MEC-4 mechanotransduction channel. J. Neurosci. 35: 2200– 2212. 10.1523/JNEUROSCI.4082-14.2015 25653375 PMC4315841 · DOI
  42. Chen Y. Bharill S. O’Hagan R. Isacoff E. Y. Chalfie M., 2016a MEC-10 and MEC-19 reduce the neurotoxicity of the MEC-4(d) DEG/ENaC channel in Caenorhabditis elegans. G3 (Bethesda) 6: 1121– 1130. 10.1534/g3.115.023507 27172609 PMC4825646 · DOI
  43. Chen Y. C. Chen H. J. Tseng W. C. Hsu J. M. Huang T. T., 2016b A C. elegans thermosensory circuit regulates longevity through crh-1/CREB-dependent flp-6 neuropeptide signaling. Dev. Cell 39: 209– 223. 10.1016/j.devcel.2016.08.021 27720609 · DOI
  44. Chi C. A. Clark D. A. Lee S. Biron D. Luo L., 2007 Temperature and food mediate long-term thermotactic behavioral plasticity by association-independent mechanisms in C. elegans. J. Exp. Biol. 210: 4043– 4052. 10.1242/jeb.006551 17981872 · DOI
  45. Cho Y. Porto D. A. Hwang H. Grundy L. J. Schafer W. R., 2017 Automated and controlled mechanical stimulation and functional imaging in vivo in C. elegans. Lab Chip 17: 2609– 2618 (erratum: Lab Chip 17: 3935) 10.1039/C7LC00465F 28660945 PMC5575793 · DOI
  46. Chrisman S. D. Waite C. B. Scoville A. G. Carnell L., 2016 C. elegans demonstrates distinct behaviors within a fixed and uniform electric field. PLoS One 11: e0151320 10.1371/journal.pone.0151320 26998749 PMC4801214 · DOI
  47. Clark D. A. Biron D. Sengupta P. Samuel A. D., 2006 The AFD sensory neurons encode multiple functions underlying thermotactic behavior in Caenorhabditis elegans. J. Neurosci. 26: 7444– 7451. 10.1523/JNEUROSCI.1137-06.2006 16837592 PMC6674189 · DOI
  48. Clark D. A. Gabel C. V. Gabel H. Samuel A. D., 2007a Temporal activity patterns in thermosensory neurons of freely moving Caenorhabditis elegans encode spatial thermal gradients. J. Neurosci. 27: 6083– 6090. 10.1523/JNEUROSCI.1032-07.2007 17553981 PMC6672141 · DOI
  49. Clark D. A. Gabel C. V. Lee T. M. Samuel A. D., 2007b Short-term adaptation and temporal processing in the cryophilic response of Caenorhabditis elegans. J. Neurophysiol. 97: 1903– 1910. 10.1152/jn.00892.2006 17151225 · DOI
  50. Clites B. L. Pierce J. T., 2017 Identifying cellular and molecular mechanisms for magnetosensation. Annu. Rev. Neurosci. 40: 231– 250. 10.1146/annurev-neuro-072116-031312 28772099 PMC5588146 · DOI
  51. Coburn C. M. Mori I. Ohshima Y. Bargmann C. I., 1998 A cyclic nucleotide-gated channel inhibits sensory axon outgrowth in larval and adult Caenorhabditis elegans: a distinct pathway for maintenance of sensory axon structure. Development 125: 249– 258. 9486798
  52. Cohen E. Yemini E. Schafer W. Feitelson D. G. Treinin M., 2012 Locomotion analysis identifies roles of mechanosensory neurons in governing locomotion dynamics of C. elegans. J. Exp. Biol. 215: 3639– 3648. 10.1242/jeb.075416 22811252 · DOI
  53. Colbert H. A. Smith T. L. Bargmann C. I., 1997 OSM-9, a novel protein with structural similarity to channels, is required for olfaction, mechanosensation, and olfactory adaptation in Caenorhabditis elegans. J. Neurosci. 17: 8259– 8269. 10.1523/JNEUROSCI.17-21-08259.1997 9334401 PMC6573730 · DOI
  54. Cueva J. G. Hsin J. Huang K. C. Goodman M. B., 2012 Posttranslational acetylation of alpha-tubulin constrains protofilament number in native microtubules. Curr. Biol. 22: 1066– 1074. 10.1016/j.cub.2012.05.012 22658592 PMC3670109 · DOI
  55. Czech-Damal N. U. Dehnhardt G. Manger P. Hanke W., 2013 Passive electroreception in aquatic mammals. J. Comp. Physiol. A Neuroethol. Sens. Neural Behav. Physiol. 199: 555– 563. 10.1007/s00359-012-0780-8 23187861 · DOI
  56. Delmas P. Hao J. Rodat-Despoix L., 2011 Molecular mechanisms of mechanotransduction in mammalian sensory neurons. Nat. Rev. Neurosci. 12: 139– 153. 10.1038/nrn2993 21304548 · DOI
  57. Ding G. Zou W. Zhang H. Xue Y. Cai Y., 2015 In vivo tactile stimulation-evoked responses in Caenorhabditis elegans amphid sheath glia. PLoS One 10: e0117114 10.1371/journal.pone.0117114 25671616 PMC4325002 · DOI
  58. Doroquez D. B. Berciu C. Anderson J. R. Sengupta P. Nicastro D., 2014 A high-resolution morphological and ultrastructural map of anterior sensory cilia and glia in Caenorhabditis elegans. eLife 3: e01948 10.7554/eLife.01948 24668170 PMC3965213 · DOI
  59. Du H. Gu G. William C. M. Chalfie M., 1996 Extracellular proteins needed for C. elegans mechanosensation. Neuron 16: 183– 194. 10.1016/S0896-6273(00)80035-5 8562083 · DOI
  60. Dusenbery D. B. Sheridan R. E. Russell R. L., 1975 Chemotaxis-defective mutants of the nematode Caenorhabditis elegans. Genetics 80: 297– 309. 1132687 PMC1213328
  61. Eastwood A. L. Goodman M. B., 2012 Insight into DEG/ENaC channel gating from genetics and structure. Physiology (Bethesda) 27: 282– 290. 23026751 PMC4012085
  62. Eastwood A. L. Sanzeni A. Petzold B. C. Park S. J. Vergassola M., 2015 Tissue mechanics govern the rapidly adapting and symmetrical response to touch. Proc. Natl. Acad. Sci. USA 112: E6955– E6963 [corrigenda: Proc. Natl. Acad. Sci. USA 113: E2471 (2016)] 10.1073/pnas.1514138112 26627717 PMC4687575 · DOI
  63. Edwards S. L. Charlie N. K. Milfort M. C. Brown B. S. Gravlin C. N., 2008 A novel molecular solution for ultraviolet light detection in Caenorhabditis elegans. PLoS Biol. 6: e198 10.1371/journal.pbio.0060198 18687026 PMC2494560 · DOI
  64. Elmi M. Pawar V. M. Shaw M. Wong D. Zhan H., 2017 Determining the biomechanics of touch sensation in C. elegans. Sci. Rep. 7: 12329 10.1038/s41598-017-12190-0 28951574 PMC5615042 · DOI
  65. Emtage L. Gu G. Hartwieg E. Chalfie M., 2004 Extracellular proteins organize the mechanosensory channel complex in C. elegans touch receptor neurons. Neuron 44: 795– 807. 10.1016/j.neuron.2004.11.010 15572111 · DOI
  66. Fukushige T. Yasuda H. Siddiqui S. S., 1995 Selective expression of the tba-1 alpha tubulin gene in a set of mechanosensory and motor neurons during the development of Caenorhabditis elegans. Biochim. Biophys. Acta 1261: 401– 416. 10.1016/0167-4781(95)00028-F 7742369 · DOI
  67. Fukushige T. Siddiqui Z. K. Chou M. Culotti J. G. Gogonea C. B., 1999 MEC-12, an alpha-tubulin required for touch sensitivity in C. elegans. J. Cell Sci. 112: 395– 403. 9885292
  68. Gabel C. V. Gabel H. Pavlichin D. Kao A. Clark D. A., 2007 Neural circuits mediate electrosensory behavior in Caenorhabditis elegans. J. Neurosci. 27: 7586– 7596. 10.1523/JNEUROSCI.0775-07.2007 17626220 PMC6672606 · DOI
  69. Garrity P. A. Goodman M. B. Samuel A. D. Sengupta P., 2010 Running hot and cold: behavioral strategies, neural circuits, and the molecular machinery for thermotaxis in C. elegans and Drosophila. Genes Dev. 24: 2365– 2382. 10.1101/gad.1953710 21041406 PMC2964747 · DOI · Paper page
  70. Geffeney S. L. Cueva J. G. Glauser D. A. Doll J. C. Lee T. H., 2011 DEG/ENaC but not TRP channels are the major mechanoelectrical transduction channels in a C. elegans nociceptor. Neuron 71: 845– 857. 10.1016/j.neuron.2011.06.038 21903078 PMC3170654 · DOI
  71. Ghosh, D. D., X. Jin, and M. N. Nitabach, 2017 C. elegans discriminate colors without eyes or opsins. 10.1101/092072 · DOI
  72. Ghosh R. Mohammadi A. Kruglyak L. Ryu W. S., 2012 Multiparameter behavioral profiling reveals distinct thermal response regimes in Caenorhabditis elegans. BMC Biol. 10: 85 10.1186/1741-7007-10-85 23114012 PMC3520762 · DOI
  73. Glauser D. A. Chen W. C. Agin R. Macinnis B. L. Hellman A. B., 2011 Heat avoidance is regulated by transient receptor potential (TRP) channels and a neuropeptide signaling pathway in Caenorhabditis elegans. Genetics 188: 91– 103. 10.1534/genetics.111.127100 21368276 PMC3120139 · DOI
  74. Gong, J., Y. Yuan, A. Ward, L. Kang, B. Zhang et al., 2016 The C. elegans taste receptor homolog LITE-1 is a photoreceptor. Cell 167: 1252–1263.e10 [corrigenda: Cell 168: 325 (2017)] DOI: 10.1016/j.cell.2016.10.053 PMC5388352 27863243 · DOI
  75. Goodman, M. B., 2006 Mechanosensation (January 06, 2006), WormBook, ed. The C. elegans Research Community, WormBook, /10.1895/wormbook.1.62.1. http://www.wormbook.org · DOI
  76. Goodman M. B. Sengupta P., 2018 The extraordinary AFD thermosensor of C. elegans. Pflugers Arch. 470: 839– 849. 10.1007/s00424-017-2089-5 29218454 PMC5945307 · DOI · Paper page
  77. Goodman M. B. Ernstrom G. G. Chelur D. S. O’Hagan R. Yao C. A., 2002 MEC-2 regulates C. elegans DEG/ENaC channels needed for mechanosensation. Nature 415: 1039– 1042. 10.1038/4151039a 11875573 · DOI
  78. Goodman M. B. Klein M. Lasse S. Luo L. Mori I., 2014 Thermotaxis navigation behavior (February 20, 2014), WormBook, ed. The C. elegans Research Community, WormBook, /10.1895/wormbook.1.168.1. http://www​.wormbook.org 10.1895/wormbook.1.168.1 PMC5410636 24563245 · DOI
  79. Gordus A. Pokala N. Levy S. Flavell S. W. Bargmann C. I., 2015 Feedback from network states generates variability in a probabilistic olfactory circuit. Cell 161: 215– 227. 10.1016/j.cell.2015.02.018 25772698 PMC4821011 · DOI
  80. Gray J. M. Hill J. J. Bargmann C. I., 2005 A circuit for navigation in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 102: 3184– 3191. 10.1073/pnas.0409009101 15689400 PMC546636 · DOI · Paper page
  81. Greene S. E. Komeili A., 2012 Biogenesis and subcellular organization of the magnetosome organelles of magnetotactic bacteria. Curr. Opin. Cell Biol. 24: 490– 495. 10.1016/j.ceb.2012.05.008 22726584 PMC3660231 · DOI
  82. Guo Z. V. Hart A. C. Ramanathan S., 2009 Optical interrogation of neural circuits in Caenorhabditis elegans. Nat. Methods 6: 891– 896. 10.1038/nmeth.1397 19898486 PMC3108858 · DOI
  83. Halevi S. McKay J. Palfreyman M. Yassin L. Eshel M., 2002 The C. elegans ric-3 gene is required for maturation of nicotinic acetylcholine receptors. EMBO J. 21: 1012– 1020. 10.1093/emboj/21.5.1012 11867529 PMC125878 · DOI
  84. Hall D. H. Lints R. Altun Z., 2006 Nematode neurons: anatomy and anatomical methods in Caenorhabditis elegans. Int. Rev. Neurobiol. 69: 1– 35. 16492460
  85. Han B. Kim D. Ko U. H. Shin J. H., 2012 A sorting strategy for C. elegans based on size-dependent motility and electrotaxis in a micro-structured channel. Lab Chip 12: 4128– 4134. 10.1039/c2lc40209b 22864253 · DOI
  86. Han B. Dong Y. Zhang L. Liu Y. Rabinowitch I., 2017 Dopamine signaling tunes spatial pattern selectivity in C. elegans. eLife 6: e22896 10.7554/eLife.22896 28349862 PMC5370180 · DOI
  87. Hart A. C. Sims S. Kaplan J. M., 1995 Synaptic code for sensory modalities revealed by C. elegans GLR-1 glutamate receptor. Nature 378: 82– 85. 10.1038/378082a0 7477294 · DOI
  88. Haselwandter C. A. MacKinnon R., 2018 Piezo’s membrane footprint and its contribution to mechanosensitivity. eLife 7: e41968 10.7554/eLife.41968 30480546 PMC6317911 · DOI
  89. Hawk J. D. Calvo A. C. Liu P. Almoril-Porras A. Aljobeh A., 2018 Integration of plasticity mechanisms within a single sensory neuron of C. elegans actuates a memory. Neuron 97: 356– 367.e4. 10.1016/j.neuron.2017.12.027 29307713 PMC5806692 · DOI
  90. Hedgecock E. M. Russell R. L., 1975 Normal and mutant thermotaxis in the nematode Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 72: 4061– 4065. 10.1073/pnas.72.10.4061 1060088 PMC433138 · DOI
  91. Hilliard M. A. Apicella A. J. Kerr R. Suzuki H. Bazzicalupo P., 2005 In vivo imaging of C. elegans ASH neurons: cellular response and adaptation to chemical repellents. EMBO J. 24: 63– 72. 10.1038/sj.emboj.7600493 15577941 PMC544906 · DOI
  92. Hoffstaetter L. J. Bagriantsev S. N. Gracheva E. O., 2018 TRPs et al.: a molecular toolkit for thermosensory adaptations. Pflugers Arch. 470: 745– 759. 10.1007/s00424-018-2120-5 29484488 PMC5945325 · DOI
  93. Inada H. Ito H. Satterlee J. Sengupta P. Matsumoto K., 2006 Identification of guanylyl cyclases that function in thermosensory neurons of Caenorhabditis elegans. Genetics 172: 2239– 2252. 10.1534/genetics.105.050013 16415369 PMC1456394 · DOI
  94. Jurado P. Kodama E. Tanizawa Y. Mori I., 2010 Distinct thermal migration behaviors in response to different thermal gradients in Caenorhabditis elegans. Genes Brain Behav. 9: 120– 127. 10.1111/j.1601-183X.2009.00549.x 20002199 · DOI
  95. Kang L. Gao J. Schafer W. R. Xie Z. Xu X. Z., 2010 C. elegans TRP family protein TRP-4 is a pore-forming subunit of a native mechanotransduction channel. Neuron 67: 381– 391. 10.1016/j.neuron.2010.06.032 20696377 PMC2928144 · DOI
  96. Kaplan J. M. Horvitz H. R., 1993 A dual mechanosensory and chemosensory neuron in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 90: 2227– 2231. 10.1073/pnas.90.6.2227 8460126 PMC46059 · DOI
  97. Katta S. Krieg M. Goodman M. B., 2015 Feeling force: physical and physiological principles enabling sensory mechanotransduction. Annu. Rev. Cell Dev. Biol. 31: 347– 371. 10.1146/annurev-cellbio-100913-013426 26566115 · DOI
  98. Kellenberger S. Schild L., 2015 International Union of basic and clinical pharmacology. XCI. structure, function, and pharmacology of acid-sensing ion channels and the epithelial Na+ channel. Pharmacol. Rev. 67: 1– 35. 10.1124/pr.114.009225 25287517 · DOI
  99. Kerr R. Lev-Ram V. Baird G. Vincent P. Tsien R. Y., 2000 Optical imaging of calcium transients in neurons and pharyngeal muscle of C. elegans. Neuron 26: 583– 594. 10.1016/S0896-6273(00)81196-4 10896155 · DOI
  100. Kim A. A. Nekimken A. L. Fechner S. O’Brien L. E. Pruitt B. L., 2018 Microfluidics for mechanobiology of model organisms. Methods Cell Biol. 146: 217– 259. 10.1016/bs.mcb.2018.05.010 30037463 PMC6418080 · DOI
  101. Kimura K. D. Miyawaki A. Matsumoto K. Mori I., 2004 The C. elegans thermosensory neuron AFD responds to warming. Curr. Biol. 14: 1291– 1295. 10.1016/j.cub.2004.06.060 15268861 · DOI
  102. Kindt K. S. Tam T. Whiteman S. Schafer W. R., 2002 Serotonin promotes G(o)-dependent neuronal migration in Caenorhabditis elegans. Curr. Biol. 12: 1738– 1747. 10.1016/S0960-9822(02)01199-5 12401168 · DOI
  103. Kindt K. S. Quast K. B. Giles A. C. De S. Hendrey D., 2007a Dopamine mediates context-dependent modulation of sensory plasticity in C. elegans. Neuron 55: 662– 676. 10.1016/j.neuron.2007.07.023 17698017 · DOI
  104. Kindt K. S. Viswanath V. Macpherson L. Quast K. Hu H., 2007b Caenorhabditis elegans TRPA-1 functions in mechanosensation. Nat. Neurosci. 10: 568– 577. 10.1038/nn1886 17450139 · DOI
  105. Kobayashi K. Nakano S. Amano M. Tsuboi D. Nishioka T., 2016 Single-cell memory regulates a neural circuit for sensory behavior. Cell Rep. 14: 11– 21. 10.1016/j.celrep.2015.11.064 26725111 · DOI
  106. Kotera I. Tran N. A. Fu D. Kim J. H. Byrne Rodgers J., 2016 Pan-neuronal screening in Caenorhabditis elegans reveals asymmetric dynamics of AWC neurons is critical for thermal avoidance behavior. eLife 5: e19021 10.7554/eLife.19021 27849153 PMC5142811 · DOI
  107. Krieg M. Stuhmer J. Cueva J. G. Fetter R. Spilker K., 2017 Genetic defects in β-spectrin and tau sensitize C. elegans axons to movement-induced damage via torque-tension coupling. eLife 6: e20172 10.7554/eLife.20172 28098556 PMC5298879 · DOI
  108. Kuhara A. Okumura M. Kimata T. Tanizawa Y. Takano R., 2008 Temperature sensing by an olfactory neuron in a circuit controlling behavior of C. elegans. Science 320: 803– 807. 10.1126/science.1148922 18403676 · DOI
  109. Kuhara A. Ohnishi N. Shimowada T. Mori I., 2011 Neural coding in a single sensory neuron controlling opposite seeking behaviours in Caenorhabditis elegans. Nat. Commun. 2: 355 10.1038/ncomms1352 21673676 PMC3156818 · DOI
  110. Kuhn M., 2016 Molecular physiology of membrane guanylyl cyclase receptors. Physiol. Rev. 96: 751– 804. 10.1152/physrev.00022.2015 27030537 · DOI
  111. Land M. Rubin C. S., 2017 A calcium- and diacylglycerol-stimulated protein kinase C (PKC), Caenorhabditis elegans PKC-2, links thermal signals to learned behavior by acting in sensory neurons and intestinal cells. Mol. Cell. Biol. 37: e00192-17 10.1128/MCB.00192-17 28716951 PMC5599713 · DOI
  112. Landler L. Nimpf S. Hochstoeger T. Nordmann G. C. Papadaki-Anastasopoulou A., 2018 Comment on “Magnetosensitive neurons mediate geomagnetic orientation in Caenorhabditis elegans”. eLife 7: e30187 10.7554/eLife.30187 29651983 PMC5898909 · DOI
  113. Larsch J. Ventimiglia D. Bargmann C. I. Albrecht D. R., 2013 High-throughput imaging of neuronal activity in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 110: E4266– E4273. 10.1073/pnas.1318325110 24145415 PMC3831453 · DOI
  114. Lee S. J. Kenyon C., 2009 Regulation of the longevity response to temperature by thermosensory neurons in Caenorhabditis elegans. Curr. Biol. 19: 715– 722. 10.1016/j.cub.2009.03.041 19375320 PMC2868911 · DOI
  115. Lefevre C. T. Bazylinski D. A., 2013 Ecology, diversity, and evolution of magnetotactic bacteria. Microbiol. Mol. Biol. Rev. 77: 497– 526. 10.1128/MMBR.00021-13 24006473 PMC3811606 · DOI
  116. Leifer A. M. Fang-Yen C. Gershow M. Alkema M. J. Samuel A. D., 2011 Optogenetic manipulation of neural activity in freely moving Caenorhabditis elegans. Nat. Methods 8: 147– 152. 10.1038/nmeth.1554 21240279 PMC3032981 · DOI
  117. Li K. Gong Z., 2017 Feeling hot and cold: thermal sensation in Drosophila. Neurosci. Bull. 33: 317– 322. 10.1007/s12264-016-0087-9 27995563 PMC5567507 · DOI
  118. Li W. Feng Z. Sternberg P. W. Xu X. Z., 2006 A C. elegans stretch receptor neuron revealed by a mechanosensitive TRP channel homologue. Nature 440: 684– 687. 10.1038/nature04538 16572173 PMC2865900 · DOI
  119. Li W. Kang L. Piggott B. J. Feng Z. Xu X. Z., 2011 The neural circuits and sensory channels mediating harsh touch sensation in Caenorhabditis elegans. Nat. Commun. 2: 315 10.1038/ncomms1308 21587232 PMC3098610 · DOI
  120. Liu K. S. Sternberg P. W., 1995 Sensory regulation of male mating behavior in Caenorhabditis elegans. Neuron 14: 79– 89. 10.1016/0896-6273(95)90242-2 7826644 · DOI
  121. Liu J. Ward A. Gao J. Dong Y. Nishio N., 2010 C. elegans phototransduction requires a G protein-dependent cGMP pathway and a taste receptor homolog. Nat. Neurosci. 13: 715– 722. 10.1038/nn.2540 20436480 PMC2882063 · DOI
  122. Liu S. Schulze E. Baumeister R., 2012 Temperature- and touch-sensitive neurons couple CNG and TRPV channel activities to control heat avoidance in Caenorhabditis elegans. PLoS One 7: e32360 10.1371/journal.pone.0032360 22448218 PMC3308950 · DOI
  123. Lockhead D. Schwarz E. M. O’Hagan R. Bellotti S. Krieg M., 2016 The tubulin repertoire of C. elegans sensory neurons and its context-dependent role in process outgrowth. Mol. Biol. Cell. 27: 3717– 3728. 10.1091/mbc.e16-06-0473 PMC5170555 27654945 · DOI
  124. Loewenstein W. R. Mendelson M., 1965 Components of receptor adaptation in a Pacinian corpuscle. J. Physiol. 177: 377– 397. 10.1113/jphysiol.1965.sp007598 14321486 PMC1357253 · DOI
  125. Luo L. Clark D. A. Biron D. Mahadevan L. Samuel A. D., 2006 Sensorimotor control during isothermal tracking in Caenorhabditis elegans. J. Exp. Biol. 209: 4652– 4662. 10.1242/jeb.02590 17114399 · DOI
  126. Luo L. Cook N. Venkatachalam V. Martinez-Velazquez L. A. Zhang X., 2014a Bidirectional thermotaxis in Caenorhabditis elegans is mediated by distinct sensorimotor strategies driven by the AFD thermosensory neurons. Proc. Natl. Acad. Sci. USA 111: 2776– 2781. 10.1073/pnas.1315205111 24550307 PMC3932917 · DOI
  127. Luo L. Wen Q. Ren J. Hendricks M. Gershow M., 2014b Dynamic encoding of perception, memory, and movement in a C. elegans chemotaxis circuit. Neuron 82: 1115– 1128. 10.1016/j.neuron.2014.05.010 24908490 PMC4082684 · DOI
  128. Maguire S. M. Clark C. M. Nunnari J. Pirri J. K. Alkema M. J., 2011 The C. elegans touch response facilitates escape from predacious fungi. Curr. Biol. 21: 1326– 1330. 10.1016/j.cub.2011.06.063 21802299 PMC3266163 · DOI
  129. Mazzochette E. A. Nekimken A. L. Loizeau F. Whitworth J. Huynh B., 2018 The tactile receptive fields of freely moving Caenorhabditis elegans nematodes. Integr. Biol. 10: 450– 463. 10.1039/c8ib00045j PMC6168290 30027970 · DOI
  130. McClanahan P. D. Xu J. H. Fang-Yen C., 2017 Comparing Caenorhabditis elegans gentle and harsh touch response behavior using a multiplexed hydraulic microfluidic device. Integr. Biol. (Camb). 9: 800– 809. 10.1039/c7ib00120g 28914311 PMC5645015 · DOI
  131. McCormick K. E. Gaertner B. E. Sottile M. Phillips P. C. Lockery S. R., 2011 Microfluidic devices for analysis of spatial orientation behaviors in semi-restrained Caenorhabditis elegans. PLoS One 6: e25710 10.1371/journal.pone.0025710 22022437 PMC3192130 · DOI
  132. Miyawaki A. Llopis J. Heim R. McCaffery J. M. Adams J. A., 1997 Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulin. Nature 388: 882– 887. 10.1038/42264 9278050 · DOI
  133. Mohammadi A. Byrne Rodgers J. Kotera I. Ryu W. S., 2013 Behavioral response of Caenorhabditis elegans to localized thermal stimuli. BMC Neurosci. 14: 66 10.1186/1471-2202-14-66 23822173 PMC3703451 · DOI
  134. Mohri A. Kodama E. Kimura K. D. Koike M. Mizuno T., 2005 Genetic control of temperature preference in the nematode Caenorhabditis elegans. Genetics 169: 1437– 1450. 10.1534/genetics.104.036111 15654086 PMC1449549 · DOI
  135. Mori I. Ohshima Y., 1995 Neural regulation of thermotaxis in Caenorhabditis elegans. Nature 376: 344– 348. 10.1038/376344a0 7630402 · DOI
  136. Mouritsen H., 2018 Long-distance navigation and magnetoreception in migratory animals. Nature 558: 50– 59. 10.1038/s41586-018-0176-1 29875486 · DOI
  137. Mouritsen H. Heyers D. Gunturkun O., 2016 The neural basis of long-distance navigation in birds. Annu. Rev. Physiol. 78: 133– 154. 10.1146/annurev-physiol-021115-105054 26527184 · DOI
  138. Narayan A. Laurent G. Sternberg P. W., 2011 Transfer characteristics of a thermosensory synapse in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 108: 9667– 9672. 10.1073/pnas.1106617108 21606366 PMC3111291 · DOI
  139. Nekimken A. L. Fehlauer H. Kim A. A. Manosalvas-Kjono S. N. Ladpli P., 2017a Pneumatic stimulation of C. elegans mechanoreceptor neurons in a microfluidic trap. Lab Chip 17: 1116– 1127. 10.1039/C6LC01165A 28207921 PMC5360562 · DOI
  140. Nekimken A. L. Mazzochette E. A. Goodman M. B. Pruitt B. L., 2017b Forces applied during classical touch assays for Caenorhabditis elegans. PLoS One 12: e0178080 10.1371/journal.pone.0178080 28542494 PMC5438190 · DOI
  141. Nguyen P. A. Liou W. Hall D. H. Leroux M. R., 2014 Ciliopathy proteins establish a bipartite signaling compartment in a C. elegans thermosensory neuron. J. Cell Sci. 127: 5317– 5330. 10.1242/jcs.157610 25335890 PMC4265742 · DOI
  142. Nishida Y. Sugi T. Nonomura M. Mori I., 2011 Identification of the AFD neuron as the site of action of the CREB protein in Caenorhabditis elegans thermotaxis. EMBO Rep. 12: 855– 862. 10.1038/embor.2011.120 21738224 PMC3147260 · DOI
  143. O’Hagan R., 2005 Components of a mechanotransduction complex in C. elegans touch receptor neuorns: an in vivo electrophysiological study, pp. 135 in Biological Sciences. Columbia University, New York.
  144. O’Hagan R. Chalfie M. Goodman M. B., 2005 The MEC-4 DEG/ENaC channel of Caenorhabditis elegans touch receptor neurons transduces mechanical signals. Nat. Neurosci. 8: 43– 50. 10.1038/nn1362 15580270 · DOI
  145. Ohnishi N. Kuhara A. Nakamura F. Okochi Y. Mori I., 2011 Bidirectional regulation of thermotaxis by glutamate transmissions in Caenorhabditis elegans. EMBO J. 30: 1376– 1388. 10.1038/emboj.2011.13 21304490 PMC3094115 · DOI
  146. Ohta A. Ujisawa T. Sonoda S. Kuhara A., 2014 Light and pheromone-sensing neurons regulates cold habituation through insulin signalling in Caenorhabditis elegans. Nat. Commun. 5: 4412 10.1038/ncomms5412 25048458 PMC4109018 · DOI
  147. Okochi Y. Kimura K. D. Ohta A. Mori I., 2005 Diverse regulation of sensory signaling by C. elegans nPKC-epsilon/eta TTX-4. EMBO J. 24: 2127– 2137. 10.1038/sj.emboj.7600697 15920475 PMC1150891 · DOI
  148. Oren-Suissa M. Hall D. H. Treinin M. Shemer G. Podbilewicz B., 2010 The fusogen EFF-1 controls sculpting of mechanosensory dendrites. Science 328: 1285– 1288. 10.1126/science.1189095 20448153 PMC3057141 · DOI
  149. Ortiz C. O. Etchberger J. F. Posy S. L. Frokjaer-Jensen C. Lockery S., 2006 Searching for neuronal left/right asymmetry: genomewide analysis of nematode receptor-type guanylyl cyclases. Genetics 173: 131– 149. 10.1534/genetics.106.055749 16547101 PMC1461427 · DOI
  150. Park S. J. Goodman M. B. Pruitt B. L., 2007 Analysis of nematode mechanics by piezoresistive displacement clamp. Proc. Natl. Acad. Sci. USA 104: 17376– 17381. 10.1073/pnas.0702138104 17962419 PMC2077264 · DOI
  151. Perkins L. A. Hedgecock E. M. Thomson J. N. Culotti J. G., 1986 Mutant sensory cilia in the nematode Caenorhabditis elegans. Dev. Biol. 117: 456– 487. 10.1016/0012-1606(86)90314-3 2428682 · DOI · Paper page
  152. Petzold B. C. Park S. J. Mazzochette E. A. Goodman M. B. Pruitt B. L., 2013 MEMS-based force-clamp analysis of the role of body stiffness in C. elegans touch sensation. Integr. Biol. 5: 853– 864. 10.1039/c3ib20293c PMC3701114 23598612 · DOI
  153. Potter L. R., 2011 Guanylyl cyclase structure, function and regulation. Cell. Signal. 23: 1921– 1926. 10.1016/j.cellsig.2011.09.001 21914472 PMC4856045 · DOI
  154. Prahlad V. Cornelius T. Morimoto R. I., 2008 Regulation of the cellular heat shock response in Caenorhabditis elegans by thermosensory neurons. Science 320: 811– 814. 10.1126/science.1156093 18467592 PMC3429343 · DOI
  155. Procko C. Lu Y. Shaham S., 2011 Glia delimit shape changes of sensory neuron receptive endings in C. elegans. Development 138: 1371– 1381. 10.1242/dev.058305 21350017 PMC3050665 · DOI
  156. Rabinowitch I. Chatzigeorgiou M. Schafer W. R., 2013 A gap junction circuit enhances processing of coincident mechanosensory inputs. Curr. Biol. 23: 963– 967. 10.1016/j.cub.2013.04.030 23707432 PMC3675673 · DOI
  157. Ramot D. MacInnis B. L. Goodman M. B., 2008a Bidirectional temperature-sensing by a single thermosensory neuron in C. elegans. Nat. Neurosci. 11: 908– 915. 10.1038/nn.2157 18660808 PMC2587641 · DOI
  158. Ramot D. MacInnis B. L. Lee H. C. Goodman M. B., 2008b Thermotaxis is a robust mechanism for thermoregulation in Caenorhabditis elegans nematodes. J. Neurosci. 28: 12546– 12557. 10.1523/JNEUROSCI.2857-08.2008 19020047 PMC3899394 · DOI
  159. Rankin C. H. Broster B. S., 1992 Factors affecting habituation and recovery from habituation in the nematode Caenorhabditis elegans. Behav. Neurosci. 106: 239– 249. 10.1037/0735-7044.106.2.239 1590951 · DOI
  160. Russell J. Pierce-Shimomura J. T., 2014 Apparatus for investigating the reactions of soft-bodied invertebrates to controlled humidity gradients. J. Neurosci. Methods 237: 54– 59. 10.1016/j.jneumeth.2014.08.021 25176025 PMC4440416 · DOI
  161. Russell J. Vidal-Gadea A. G. Makay A. Lanam C. Pierce-Shimomura J. T., 2014 Humidity sensation requires both mechanosensory and thermosensory pathways in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 111: 8269– 8274. 10.1073/pnas.1322512111 24843133 PMC4050571 · DOI · Paper page
  162. Ryu W. S. Samuel A. D., 2002 Thermotaxis in Caenorhabditis elegans analyzed by measuring responses to defined Thermal stimuli. J. Neurosci. 22: 5727– 5733. 10.1523/JNEUROSCI.22-13-05727.2002 12097525 PMC6758190 · DOI
  163. Sanders J. Nagy S. Fetterman G. Wright C. Treinin M., 2013 The Caenorhabditis elegans interneuron ALA is (also) a high-threshold mechanosensor. BMC Neurosci. 14: 156 10.1186/1471-2202-14-156 24341457 PMC3878553 · DOI
  164. Sato M., 1961 Response of Pacinian corpuscles to sinusoidal vibration. J. Physiol. 159: 391– 409. 10.1113/jphysiol.1961.sp006817 14497425 PMC1359541 · DOI
  165. Savage C. Hamelin M. Culotti J. G. Coulson A. Albertson D. G., 1989 mec-7 is a beta-tubulin gene required for the production of 15-protofilament microtubules in Caenorhabditis elegans. Genes Dev. 3: 870– 881. 10.1101/gad.3.6.870 2744465 · DOI
  166. Sawin E. R. Ranganathan R. Horvitz H. R., 2000 C. elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway. Neuron 26: 619– 631. 10.1016/S0896-6273(00)81199-X 10896158 · DOI · Paper page
  167. Schaad N. C. De Castro E. Nef S. Hegi S. Hinrichsen R., 1996 Direct modulation of calmodulin targets by the neuronal calcium sensor NCS-1. Proc. Natl. Acad. Sci. USA 93: 9253– 9258. 10.1073/pnas.93.17.9253 8799187 PMC38628 · DOI
  168. Schafer W. R., 2015 Mechanosensory molecules and circuits in C. elegans. Pflugers Arch. 467: 39– 48. 10.1007/s00424-014-1574-3 25053538 PMC4281349 · DOI
  169. Schild L. C. Glauser D. A., 2013 Dynamic switching between escape and avoidance regimes reduces Caenorhabditis elegans exposure to noxious heat. Nat. Commun. 4: 2198 10.1038/ncomms3198 23887613 · DOI
  170. Schild L. C. Zbinden L. Bell H. W. Yu Y. V. Sengupta P., 2014 The balance between cytoplasmic and nuclear CaM kinase-1 signaling controls the operating range of noxious heat avoidance. Neuron 84: 983– 996. 10.1016/j.neuron.2014.10.039 25467982 PMC4318703 · DOI
  171. Schulenburg H. Felix M. A., 2017 The natural biotic environment of Caenorhabditis elegans. Genetics 206: 55– 86. 10.1534/genetics.116.195511 28476862 PMC5419493 · DOI
  172. Sengupta P. Garrity P., 2013 Sensing temperature. Curr. Biol. 23: R304– R307. 10.1016/j.cub.2013.03.009 23618661 PMC3685181 · DOI
  173. Shaw M. Elmi M. Pawar V. Srinivasan M. A., 2016 Investigation of mechanosensation in C. elegans using light field calcium imaging. Biomed. Opt. Express 7: 2877– 2887. 10.1364/BOE.7.002877 27446713 PMC4948637 · DOI
  174. Shida T. Cueva J. G. Xu Z. Goodman M. B. Nachury M. V., 2010 The major alpha-tubulin K40 acetyltransferase alphaTAT1 promotes rapid ciliogenesis and efficient mechanosensation. Proc. Natl. Acad. Sci. USA 107: 21517– 21522. 10.1073/pnas.1013728107 21068373 PMC3003046 · DOI
  175. Singhvi A. Liu B. Friedman C. J. Fong J. Lu Y., 2016 A glial K/Cl transporter controls neuronal receptive ending shape by chloride inhibition of an rGC. Cell 165: 936– 948. 10.1016/j.cell.2016.03.026 27062922 PMC4860081 · DOI
  176. Smith C. J. Watson J. D. Spencer W. C. O’Brien T. Cha B., 2010 Time-lapse imaging and cell-specific expression profiling reveal dynamic branching and molecular determinants of a multi-dendritic nociceptor in C. elegans. Dev. Biol. 345: 18– 33. 10.1016/j.ydbio.2010.05.502 20537990 PMC2919608 · DOI
  177. Stirman J. N. Crane M. M. Husson S. J. Wabnig S. Schultheis C., 2011 Real-time multimodal optical control of neurons and muscles in freely behaving Caenorhabditis elegans. Nat. Methods 8: 153– 158. 10.1038/nmeth.1555 21240278 PMC3189501 · DOI
  178. Sugi T. Okumura E. Kiso K. Igarashi R., 2016 Nanoscale mechanical stimulation method for quantifying C. elegans mechanosensory behavior and memory. Anal. Sci. 32: 1159– 1164. 10.2116/analsci.32.1159 27829619 · DOI
  179. Sukul N. C. Croll N. A., 1978 Influence of potential difference and current on the electrotaxis of Caenorhaditis elegans. J. Nematol. 10: 314– 317. 19305860 PMC2617915
  180. Sulston J. Dew M. Brenner S., 1975 Dopaminergic neurons in the nematode Caenorhabditis elegans. J. Comp. Neurol. 163: 215– 226. 10.1002/cne.901630207 240872 · DOI
  181. Suzuki H. Kerr R. Bianchi L. Frokjaer-Jensen C. Slone D., 2003 In vivo imaging of C. elegans mechanosensory neurons demonstrates a specific role for the MEC-4 channel in the process of gentle touch sensation. Neuron 39: 1005– 1017. 10.1016/j.neuron.2003.08.015 12971899 · DOI
  182. Syeda R. Florendo M. N. Cox C. D. Kefauver J. M. Santos J. S., 2016 Piezo1 channels are inherently mechanosensitive. Cell Rep. 17: 1739– 1746. 10.1016/j.celrep.2016.10.033 27829145 PMC5129625 · DOI
  183. Takeishi A. Yu Y. V. Hapiak V. M. Bell H. W. O’Leary T., 2016 Receptor-type guanylyl cyclases confer thermosensory responses in C. elegans. Neuron 90: 235– 244. 10.1016/j.neuron.2016.03.002 27041501 PMC4840083 · DOI
  184. Tatum M. C. Ooi F. K. Chikka M. R. Chauve L. Martinez-Velazquez L. A., 2015 Neuronal serotonin release triggers the heat shock response in C. elegans in the absence of temperature increase. Curr. Biol. 25: 163– 174. 10.1016/j.cub.2014.11.040 25557666 PMC4840938 · DOI
  185. Timbers T. A. Giles A. C. Ardiel E. L. Kerr R. A. Rankin C. H., 2013 Intensity discrimination deficits cause habituation changes in middle-aged Caenorhabditis elegans. Neurobiol. Aging 34: 621– 631. 10.1016/j.neurobiolaging.2012.03.016 22575357 · DOI
  186. Topalidou I. Keller C. Kalebic N. Nguyen K. C. Somhegyi H., 2012 Genetically separable functions of the MEC-17 tubulin acetyltransferase affect microtubule organization. Curr. Biol. 22: 1057– 1065. 10.1016/j.cub.2012.03.066 22658602 PMC3382010 · DOI
  187. Troemel E. R. Sagasti A. Bargmann C. I., 1999 Lateral signaling mediated by axon contact and calcium entry regulates asymmetric odorant receptor expression in C. elegans. Cell 99: 387– 398. 10.1016/S0092-8674(00)81525-1 10571181 · DOI
  188. Tsalik E. L. Hobert O., 2003 Functional mapping of neurons that control locomotory behavior in Caenorhabditis elegans. J. Neurobiol. 56: 178– 197. 10.1002/neu.10245 12838583 · DOI
  189. Tsukada Y. Yamao M. Naoki H. Shimowada T. Ohnishi N., 2016 Reconstruction of spatial thermal gradient encoded in thermosensory neuron AFD in Caenorhabditis elegans. J. Neurosci. 36: 2571– 2581. 10.1523/JNEUROSCI.2837-15.2016 26936999 PMC4879206 · DOI
  190. Ujisawa T. Ohta A. Uda-Yagi M. Kuhara A., 2016 Diverse regulation of temperature sensation by trimeric G-protein signaling in Caenorhabditis elegans. PLoS One 11: e0165518 10.1371/journal.pone.0165518 27788246 PMC5082853 · DOI
  191. Vásquez V. Scherrer G. Goodman M. B., 2014 Sensory biology: it takes Piezo2 to tango. Curr. Biol. 24: R566– R569. 10.1016/j.cub.2014.05.011 24937283 PMC7341064 · DOI
  192. Venkatachalam V. Ji N. Wang X. Clark C. Mitchell J. K., 2016 Pan-neuronal imaging in roaming Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 113: E1082– E1088. 10.1073/pnas.1507109113 26711989 PMC4776525 · DOI
  193. Vidal-Gadea A. Ward K. Beron C. Ghorashian N. Gokce S., 2015 Magnetosensitive neurons mediate geomagnetic orientation in Caenorhabditis elegans. eLife 4 10.7554/eLife.07493 PMC4525075 26083711 · DOI
  194. Vidal-Gadea A. Bainbridge C. Clites B. Palacios B. E. Bakhtiari L., 2018 Response to comment on “Magnetosensitive neurons mediate geomagnetic orientation in Caenorhabditis elegans”. eLife 7: e31414 10.7554/eLife.31414 29651982 PMC5898907 · DOI
  195. Vogel B. E. Hedgecock E. M., 2001 Hemicentin, a conserved extracellular member of the immunoglobulin superfamily, organizes epithelial and other cell attachments into oriented line-shaped junctions. Development 128: 883– 894. 11222143
  196. Vyklický L. Vlachova V. Vitaskova Z. Dittert I. Kabat M., 1999 Temperature coefficient of membrane currents induced by noxious heat in sensory neurones in the rat. J. Physiol. 517: 181– 192. 10.1111/j.1469-7793.1999.0181z.x 10226158 PMC2269336 · DOI
  197. Walker D. S. Vazquez-Manrique R. P. Gower N. J. Gregory E. Schafer W. R., 2009 Inositol 1,4,5-trisphosphate signalling regulates the avoidance response to nose touch in Caenorhabditis elegans. PLoS Genet. 5: e1000636 10.1371/journal.pgen.1000636 19730689 PMC2729924 · DOI
  198. Wang D. O’Halloran D. Goodman M. B., 2013 GCY-8, PDE-2, and NCS-1 are critical elements of the cGMP-dependent thermotransduction cascade in the AFD neurons responsible for C. elegans thermotaxis. J. Gen. Physiol. 142: 437– 449. 10.1085/jgp.201310959 24081984 PMC3787776 · DOI
  199. Wang X. Hu R. Ge A. Hu L. Wang S., 2015 Highly efficient microfluidic sorting device for synchronizing developmental stages of C. elegans based on deflecting electrotaxis. Lab Chip 15: 2513– 2521. 10.1039/C5LC00354G 25963054 · DOI
  200. Ward S. Thomson N. White J. G. Brenner S., 1975 Electron microscopical reconstruction of the anterior sensory anatomy of the nematode Caenorhabditis elegans.?2UU. J. Comp. Neurol. 160: 313– 337. 10.1002/cne.901600305 1112927 · DOI

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Cited by

Sorted by citations

Authors
Goodman, M. B., & Sengupta, P.
Affiliations
  • Stanford University (US)
  • Brandeis University (US)
Corresponding author
  • Goodman, Miriam B
  • Sengupta, Piali
ORCID
Venue
Genetics
Publisher
Oxford University Press (OUP)
Published
2019-03-11
Volume
212
Issue
1
Pages
25-51
ISSN
  • 0016-6731 (ISSN-L)
  • 1943-2631
DOI
10.1534/genetics.118.300241
PMC
PMC6499529
OpenAlex
W2943264169
Cited by
131
References
4
Citations by year
2026: 15 · 2025: 21 · 2024: 26 · 2023: 20 · 2022: 18 · 2021: 14 · 2020: 14 · 2019: 3
FWCI
2.14
Type
journal article
Language
en
Open access
Licence
Locations
  • Genetics (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • National Institute of General Medical Sciences (P01GM103770, R35GM122463)
  • National Institute of Neurological Disorders and Stroke (R35NS105092)
Topics
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords
Caenorhabditis elegans, mechanosensing, thermosensation, sensory neurons, mechanotransduction channels, ion channels, temperature sensing, magnetic field sensing, optical sensing, humidity sensing, sensory transduction, signaling pathways, calcium imaging
MeSH terms
Animals, Sensory Receptor Cells, Sensation, Stress, Physiological, Temperature, Thermosensing, Signal Transduction, Caenorhabditis elegans, Mechanotransduction, Cellular, Mechanical Phenomena

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