Cited by 2,531Cancer-related molecular mechanisms researchGenomics and Chromatin DynamicsRNA Research and Splicing

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Long Noncoding RNAs: Cellular Address Codes in Development and Disease

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Batista, Pedro J., Chang, Howard Y.·2013·Cell

DOI 10.1016/j.cell.2013.02.012PMC PMC3651923

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Abstract

In biology as in real estate, location is a cardinal organizational principle that dictates the accessibility and flow of informational traffic. An essential question in nuclear organization is the nature of the address code--how objects are placed and later searched for and retrieved. Long noncoding RNAs (lncRNAs) have emerged as key components of the address code, allowing protein complexes, genes, and chromosomes to be trafficked to appropriate locations and subject to proper activation and deactivation. lncRNA-based mechanisms control cell fates during development, and their dysregulation underlies some human disorders caused by chromosomal deletions and translocations.

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Self-citation
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Authors: Batista, P. J., & Chang, H. Y.
Affiliations: Howard Hughes Medical Institute (US)
Corresponding author: Chang, Howard Y.
ORCID: Batista, Pedro J.
Chang, Howard Y.
Venue: Cell
Publisher: Elsevier BV
Published: 2013-03
Volume: 152
Issue: 6
Pages: 1298-1307
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2013.02.012
PMC: PMC3651923
OpenAlex: W1970741980
Cited by: 2,531
References: 106
Citations by year: 2026: 26 · 2025: 63 · 2024: 124 · 2023: 181 · 2022: 232 · 2021: 304 · 2020: 365 · 2019: 296 · 2018: 266 · 2017: 194 · 2016: 161 · 2015: 153 · 2014: 107 · 2013: 51
FWCI: 13.05
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 378 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Howard Hughes Medical Institute
California Institute for Regenerative Medicine
Damon Runyon Cancer Research Foundation
California Institute of Regenerative Medicine
National Institutes of Health
National Human Genome Research Institute (R01HG004361)
National Cancer Institute (R01CA118750)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Keywords: long non-coding RNA, nuclear organization, chromatin accessibility, gene expression regulation, cell fate specification, development (biology), chromosomal deletion, chromosomal translocation
MeSH terms: Animals, Cell Nucleus, Disease, Gene Expression Regulation, Humans, RNA, Long Noncoding

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