The DOI matches its Crossref record; 199 of the 199 references it cites were found in a registry or an index.
Interplay between the Cancer Genome and Epigenome
Open accessAbstract
Cancer arises as a consequence of cumulative disruptions to cellular growth control, with Darwinian selection for those heritable changes which provide the greatest clonal advantage. These traits can be acquired and stably maintained by either genetic or epigenetic means. Here we explore the ways in which alterations in the genome and epigenome influence each other and cooperate to promote oncogenic transformation. Disruption of epigenomic control is pervasive in malignancy, and can be classified as an enabling characteristic of cancer cells, akin to genome instability and mutation.
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Citations
Cites
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Cited by
Epigenetic plasticity and the hallmarks of cancer
Flavahan, W. A., Gaskell, E., & Bernstein, B. E. (2017) · Science · doi:10.1126/science.aal2380 · Cited by 1,340
“A major, unanticipated outcome of large-scale cancer genome sequencing projects is the finding that roughly 50% of human cancers harbor mutations in chromatin proteins (7, 8).”
BackgroundComprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma
The Cancer Genome Atlas Research Network (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1505917 · Cited by 1,336
Epigenetic Determinants of Cancer
Baylin, S. B., & Jones, P. A. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a019505 · Cited by 1,226
Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials
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“Some of the alterations determine cell function and are involved in oncogenic transformation.(4) However, by reversing these mutations by drugs or gene therapy, the phenotype of cancer can revert to normal.”
BackgroundCancer Epigenetics: Tumor Heterogeneity, Plasticity of Stem-like States, and Drug Resistance
Easwaran, H., Tsai, H.-C., & Baylin, S. B. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.05.015 · Cited by 915
Metadata
- Authors
- Shen, H., & Laird, P. W.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 153
- Issue
- 1
- Pages
- 38-55
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1978154786
- Cited by
- 910
- References
- 199
- FWCI
- 35.37
- Type
- journal article
- Language
- en
- Open access
- bronze
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
