Non-Cell-Autonomous Tumor Suppression by p53

Lujambio, Amaia, Akkari, Leila, Simon, Janelle, Grace, Danielle, Tschaharganeh, Darjus F., Bolden, Jessica E., Zhao, Zhen, Thapar, Vishal, Joyce, Johanna A., Krizhanovsky, Valery, Lowe, Scott W.·2013·Cell

DOI 10.1016/j.cell.2013.03.020

Cited by (766)

Items 501–600 of 766

The Role of p53-Mediated Signaling in the Therapeutic Response of Colorectal Cancer to 9F, a Spermine-Modified Naphthalene Diimide Derivative
Lei Gao, Chaochao Ge, Senzhen Wang, Xiaojuan Xu, Yongli Feng, Xinna Li, Chaojie Wang, Yuxia Wang, Fujun Dai, Songqiang Xie · 2020 · Cancers
Tumor cell malignancy: A complex trait built through reciprocal interactions between tumors and tissue-body system
Jean Feunteun, Pauline Ostyn, Suzette Delaloge · 2022 · iScience
Maspin inhibits macrophage phagocytosis and enhances inflammatory cytokine production via activation of NF-κB signaling
Yimeng Wang, Luguo Sun, Zhenbo Song, Danfeng Wang, Yongli Bao, Yuxin Li · 2017 · Molecular Immunology
Cellular Senescence in Glial Cells: Implications for Multiple Sclerosis
Maupin, Elizabeth A., Adams, Katrina L. · 2025 · Journal of Neurochemistry
Co-dependencies in the tumor immune microenvironment
Peiwen Chen, Prasenjit Dey · 2022 · Oncogene
Targeting senescent cells in atherosclerosis: Pathways to novel therapies
Yuhan Tian, Sihang Shao, Haibo Feng, Rui Zeng, Shanshan Li, Qixiong Zhang · 2024 · Ageing Research Reviews
The Role of p53 Mutations in Early and Late Response to Mitotic Aberrations
Anna Hertel, Zuzana Štorchová · 2025 · Biomolecules
p16INK4A enhances the transcriptional and the apoptotic functions of p53 through DNA‐dependent interaction
Huda H. Al‐Khalaf, Shreeram C. Nallar, Dhananjaya V. Kalvakolanu, Abdelilah Aboussekhra · 2017 · Molecular Carcinogenesis
PEA15 Regulates the DNA Damage-Induced Cell Cycle Checkpoint and Oncogene-Directed Transformation
Arvindhan Govindasamy Nagarajan, Shaillay Kumar Dogra, Alex Y. Liu, Michael R. Green, Narendra Wajapeyee · 2014 · Molecular and Cellular Biology
Aging and metabolic dysfunction-associated steatotic liver disease: a bidirectional relationship
Chen Chen, Lin Wang · 2025 · Frontiers of Medicine
Stromal p53 Regulates Breast Cancer Development, the Immune Landscape, and Survival in an Oncogene-Specific Manner
Jinghai Wu, Xin Liu, Julie W. Reeser, Anthony J. Trimboli, Thierry Pécot, Gina M. Sizemore, Shan K. Naidu, Soledad Fernández, Lianbo Yu, Michael T. Hallett et al. · 2022 · Molecular Cancer Research
The chameleonic behavior of p53 in health and disease: the transition from a client to an aberrant condensate scaffold in cancer
Mayra A. Marques, Guilherme A. P. de Oliveira, Jerson Lima Silva · 2022 · Essays in Biochemistry
The Potent and Paradoxical Biology of Cellular Senescence in Cancer
Paul Bernard Romesser, Scott W. Lowe · 2023 · Annual Review of Cancer Biology
Novel insights into the impact of liver inflammatory responses on primary liver cancer development
Yeni Ait Ahmed, Fouad Lafdil · 2023 · Liver Research
Quantitative Proteomics Reveals That the Inhibition of Na+/K+-ATPase Activity Affects S-Phase Progression Leading to a Chromosome Segregation Disorder by Attenuating the Aurora A Function in Hepatocellular Carcinoma Cells
Zhongwei Xu, Fengmei Wang, Fengxu Fan, Yanjun Gu, Nana Shan, Xiangyan Meng, Shixiang Cheng, Ying-fu Liu, Chengyan Wang, Yueying Song et al. · 2015 · Journal of Proteome Research
HSC-specific knockdown of GGPPS alleviated CCl4-induced chronic liver fibrosis through mediating RhoA/Rock pathway.
Shanshan Lai, Xiao Fu, Qi Cheng, Zihan Yu, Enze Jiang, Dandan Zhao, Decai Yu, Yudong Qiu, Xiang Gao, Huangxian Ju et al. · 2019 · PubMed Central
Dysregulation of lysophospholipid signaling by p53 in malignant cells and the tumor microenvironment
Sue Çhin Lee, Kuan‐Hung Lin, Andrea Balogh, Derek D. Norman, Mitul N. Bavaria, Bryan Kuo, Junming Yue, Louisa Balázs, Zoltán Benyó, Gábor Tigyi · 2020 · Cellular Signalling
Using comparative biology to understand how aging affects mitochondrial metabolism
Rashpal S. Dhillon, John M. Denu · 2016 · Molecular and Cellular Endocrinology
Gallid Herpesvirus 1 Initiates Apoptosis in Uninfected Cells through Paracrine Repression of p53
Hai Li, Qi Gao, Yuhao Shao, Bangyao Sun, Fengjie Wang, Yangyang Qiao, Nana Wang, Shengwang Liu · 2018 · Journal of Virology
Detection of somatic TP53 mutation in surgically resected small-cell lung cancer by targeted exome sequencing: association with longer relapse-free survival
Hiroshi Yokouchi, Hiroshi Nishihara, Toshiyuki Harada, Shigeo Yamazaki, Hajime Kikuchi, Satoshi Oizumi, Hidetaka Uramoto, Fumihiro Tanaka, Masao Harada, Kenji Akie et al. · 2020 · Heliyon
Role of ADAM17 in the non-cell autonomous effects of oncogene-induced senescence.
Morancho, Beatriz, Martínez-Barriocanal, Águeda, Villanueva, Josep, Arribas, Joaquín · 2015 · Breast Cancer Research
MTFR2‐Mediated Fission Drives Fatty Acid and Mitochondrial Co‐Transfer from Hepatic Stellate Cells to Tumor Cells Fueling Oncogenesis
Zhang La, Baoyong Zhou, Jun Yang, Cong Ren, Jing Luo, Zhenghang Li, Qiang Liu, Zuotian Huang, Zhongjun Wu, Ning Jiang · 2025 · Advanced Science
Targeting Cellular Senescence: Pathophysiology in Multisystem Age-Related Diseases
Jinxue Liu, Hongliang Yu, Yuanyuan Xu · 2025 · Biomedicines
Stromal senescence contributes to age-related increases in cancer
Jiayu Ye, Anupama Melam, Sheila A. Stewart · 2025 · Nature reviews. Cancer
Unlocking the potential of Mesenchymal stem cells in liver Fibrosis: Insights into the impact of autophagy and aging
Hongxia Tao, Qianglin Liu, Anqi Zeng, Linjiang Song · 2023 · International Immunopharmacology
Flip a coin: cell senescence at the maternal–fetal interface
Guang-Shun Gong, Kahindo P. Muyayalo, Yujing Zhang, Xinxiu Lin, Aihua Liao · 2023 · Biology of Reproduction
Therapy‐induced senescent cancer cells exhibit complement activation and increased complement regulatory protein expression
Anas H. A. Abu-Humaidan, Mohammad A. Ismail, Fatima M. Ahmad, Sofian Al Shboul, Raghad Barham, Joud S Tadros, Ahmad Alhesa, Mohammed El‐Sadoni, Moureq Rashed Alotaibi, Nidaa A. Ababneh et al. · 2024 · Immunology and Cell Biology
New Insights into the Role of Cellular Senescence and Its Therapeutic Implications in Ocular Diseases
Junying Wu, Xiuxing Liu, Yidan Liu, Wenru Su, Yehong Zhuo · 2025 · Bioengineering
A gradient tree boosting and network propagation derived pan-cancer survival network of the tumor microenvironment
Kristina Thedinga, Ralf Herwig · 2021 · iScience
Silencing of RND3/RHOE inhibits the growth of human hepatocellular carcinoma and is associated with reversible senescence
Sara Basbous, Lisa Paysan, Sandra Sena, Nathalie Allain, Jean‐Baptiste Hiriart, Nathalie Dugot‐Senant, Benoît Rousseau, Edith Chevret, Valérie Lagrée, Violaine Moreau · 2022 · Cancer Gene Therapy
Mechanisms of p53 Functional De-Regulation: Role of the IκB-α/p53 Complex
Giovanna Carrà, Sabrina Crivellaro, Riccardo Taulli, Angelo Guerrasio, Giuseppe Nicola Saglio, Alessandro Morotti · 2016 · International Journal of Molecular Sciences
BRD7 inhibits tumor progression by positively regulating the p53 pathway in hepatocellular carcinoma
Changlong Chen, Huaqian Mo, Yanhui Jiang, Xiaohui Zhao, Shuang Ma, Kaiyun You, Yue Pan, Yimin Liu · 2021 · Journal of Cancer
Multi-omics and single cell characterization of cancer immunosenescence landscape
Qiuxia Wei, Ruizhi Chen, Xuedan He, Yanan Qu, Changjian Yan, Xiaoni Liu, Jing Liu, Jiahao Luo, Zining Yu, Wenping Hu et al. · 2024 · Scientific Data
The Discovery of Cryptic Pockets Increases the Druggability of “Undruggable” Proteins
Mingyue Mou, Wei‐Cheng Yang, Guangyi Huang, Xiaoyan Yang, Xiao Li Zhang, Wishwajith Kandegama, Charles R. Ashby, Ge‐Fei Hao, Yangyang Gao · 2025 · Medicinal Research Reviews
The Role of Senescence, its Therapeutic Relevance and Clinical Implications in the Tumor Microenvironment
Hanzhe Shi, Mingming Xiao, Yangyi Li, Xiyu Liu, Jintong Na, Chen Liang, Jie Hua, Qingcai Meng, Miaoyan Wei, Wei Wang et al. · 2025 · Theranostics
Natural products with anti-tumorigenesis potential targeting macrophage
Hao Liu, Manru Huang, Dandan Xin, Hong Wang, Haiyang Yu, Weiling Pu · 2024 · Phytomedicine
Non cell autonomous upregulation of CDKN2 transcription linked to progression of chronic hepatitis C disease
Mark W. Robinson, Dagmara McGuinness, Rachael E. Swann, Stephen T. Barclay, Peter R. Mills, Arvind H. Patel, John McLauchlan, Paul G. Shiels · 2013 · Aging Cell
Non-autonomous cell proliferation in the mammary gland and cancer
Robert J. Weber, Tejal Ashwin Desai, Zev J. Gartner · 2017 · Current Opinion in Cell Biology
Focus
Scott L. Friedman · 2013 · Journal of Hepatology
Mitochondria‐Targeting Plasmonic Spiky Nanorods Increase the Elimination of Aging Cells in Vivo
Meiru Lu, Aihua Qu, Si Li, Maozhong Sun, Liguang Xu, Hua Kuang, Chuanlai Xu · 2020 · Angewandte Chemie
Hepatic Stellate Cells Functional Heterogeneity in Liver Cancer
Laura Sererols-Viñas, Gemma Garcia‐Vicién, Paloma Ruiz-Blázquez, Ting‐Fang Lee, Youngmin A. Lee, Ester Gonzalez‐Sanchez, Javier Vaquero, Anna Moles, Aveline A. Filliol, Silvia Affò · 2025 · Seminars in Liver Disease
Therapy-Induced Senescence (TIS) and SASP: The p53-Mediated Interplay in Cancer Progression and Treatment
Chang Hoon Lee, Tuan Minh Nguyen, Yongook Lee, Seoung Gyu Choi, Phương Ngân Nguyễn, Jung Ho Park, Mi Kyung Park · 2025 · International Journal of Molecular Sciences
Novel insights into the impact of the SUMOylation pathway in hematological malignancies (Review)
Ling Wang, Jinjun Qian, Ye Yang, Chunyan Gu · 2021 · International Journal of Oncology
Bioactive coumarin-derivative esculetin decreases hepatic stellate cell activation via induction of cellular senescence via the PI3K-Akt-GSK3β pathway
Mengfan Zhang, Turtushikh Damba, Zongmei Wu, Sandra Serna Salas, Manon Buist‐Homan, Klaas Nico Faber, Han J. Moshage · 2022 · Food Bioscience
Cellular senescence-related gene signature as a valuable predictor of prognosis in hepatocellular carcinoma
Shuqiao Zhang, Yilu Zheng, Xinyu Li, Shijun Zhang, Hao Hu, Weihong Kuang · 2023 · Aging
Mechanisms of Senescence in Cancer: Positive and Negative Aspects of Cancer Cells Senescence
Agnieszka Zaczek, Sebastian Kalenik, Aleksandra Rodacka · 2023 · Cellular Physiology and Biochemistry
Immune regulation of therapy-resistant niches: emerging targets for improving anticancer drug responses
Masahisa Jinushi · 2014 · Cancer and Metastasis Reviews
Various stress stimuli rewire the profile of liver secretome in a p53-dependent manner
Meital Charni‐Natan, Hilla Solomon, Alina Molchadsky, Adi Jacob-Berger, Naomi Goldfinger, Varda Rotter · 2018 · Cell Death and Disease
Tribbles homolog 2 promotes hepatic fibrosis and hepatocarcinogenesis through phosphatase 1A‐Mediated stabilization of yes‐associated protein
Dejuan Xiang, Xiaoyun Zhu, Yanqiu Zhang, Jie Zou, Jie Li, Ling‐Yi Kong, Hao Zhang · 2021 · Liver International
Cellular senescence: Silent operator and therapeutic target in cancer
Deepika Ramu, Wei Shan Teoh, Jayshree L. Hirpara, Shazib Pervaiz · 2021 · IUBMB Life
The potential of targeting Sin3B and its associated complexes for cancer therapy
David John Cantor, Gregory David · 2017 · Expert Opinion on Therapeutic Targets
Restoring guardianship of the genome: Anticancer drug strategies to reverse oncogenic mutant p53 misfolding
Husam A. Babikir, Rayhaneh Afjei, Ramasamy Paulmurugan, Tarik F. Massoud · 2018 · Cancer Treatment Reviews
Targeting immunosenesence promotes clearance of senescent cells
Anteneh Mehari Tizazu, Eyerusalem Amossa Tessema, Olivier Cexus · 2025 · Immunity & Ageing
Association between endometrial senescent cells and immune cells in women with repeated implantation failure
Dimitar Angelov Parvanov, Rumiana Ganeva, Katarina Arsov, Ivon Decheva, Maria Handzhiyska, Margarita Ruseva, Nina Vidolova, Fabio Scarpellini, Dimitar Metodiev, Georgi Stamenov · 2023 · Journal of Assisted Reproduction and Genetics
Hepatic stellate cell-intrinsic role of SOCS1 in controlling hepatic fibrogenic response and the pro-inflammatory macrophage compartment during liver fibrosis
Rajani Kandhi, Mehdi Yeganeh, Akihiko Yoshimura, Alfredo Menéndez, Sheela Ramanathan, Subburaj Ilangumaran · 2023 · Frontiers in Immunology
The C-type lectin COLEC10 is predominantly produced by hepatic stellate cells and involved in the pathogenesis of liver fibrosis
Mengfan Zhang, Yang Jing, Wenze Xu, Xiaojing Shi, Wenguang Zhang, Pengfei Chen, Xiaocang Cao, Xinwei Han, Xuhua Duan, Jianzhuang Ren · 2023 · Cell Death and Disease
Therapeutic implications of signaling pathways and tumor microenvironment interactions in esophageal cancer
Inamu Rashid Khan, Hana Q. Sadida, Sheema Hashem, Mayank Kumar Singh, Muzafar Ahmad Macha, Ammira S. Al-Shabeeb Akil, Ibraq Khurshid, Ajaz Ahmad Bhat · 2024 · Biomedicine & Pharmacotherapy
Genetic variants in ERBB4 is associated with chronic hepatitis B virus infection
Yao Liu, Qun Y. Zhou, Xiao‐Shun He, Li-Ming Song, Lin Chen, Weijuan Jiao, Tong Shen, Su Yao, Hua Wu, Zhi-Bin Hu et al. · 2015 · Oncotarget
DNMT3B Oncogenic Activity in Human Intestinal Cancer Is Not Linked to CIMP or BRAFV600E Mutation
Douglas J. MacKenzie, Neil Robertson, Iqbal Rather, Claire Reid, Gintarė Sendžikaitė, Hazel A. Cruickshanks, Tony McBryan, Andrew P. Hodges, Catrin A. Pritchard, Karen Blyth et al. · 2020 · iScience
Targets and Potential Mechanism of Scutellaria baicalensis in Treatment of Primary Hepatocellular Carcinoma Based on Bioinformatics Analysis
Defu Liu, Zhengjun Wang, Li Zhong, Caoyu Xie, Xiaonan Huang, Yaofeng Zhi, Yuzhuo Zhang, Jiaying Liang, Zhenni Shi, Jin Huang et al. · 2022 · Journal of Oncology
Tumors arise from the excessive repair of damaged stem cells
Jùnwén Lǐ, Dong Yuan Yang, Danfeng Yang, Zhaoli Chen, Jing Zhi Miao, Weili Liu, Xinxing Wang, Zhigang Qiu, Min Jin, Zhiqiang Shen · 2017 · Medical Hypotheses
Do cell-autonomous and non-cell-autonomous effects drive the structure of tumor ecosystems?
Tazzio Tissot, Beáta Újvári, Éric Solary, Patrice Lassus, Benjamín Roche, Frédéric Thomas A · 2016 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
PTEN in the Stroma
Katie Thies, Julia E. Lefler, Gustavo W. Leone, Michael C. Ostrowski · 2019 · Cold Spring Harbor Perspectives in Medicine
Suppression of AGTR1 Induces Cellular Senescence in Hepatocellular Carcinoma Through Inactivating ERK Signaling
Houhong Wang, Yayun Cui, Huihui Gong, Jianguo Xu, Shuqin Huang, Amao Tang · 2022 · Frontiers in Bioengineering and Biotechnology
SRBD1 Regulates the Cell Cycle, Apoptosis, and M2 Macrophage Polarization via the RPL11‐MDM2‐p53 Pathway in Glioma
Hongfu Chen, Shuping Gao, Peng Wang, Manyi Xie, Hui Zhang, Yue-chao Fan, Er Nie, Qing Lan · 2024 · Environmental Toxicology
The crosstalk between senescence, tumor, and immunity: molecular mechanism and therapeutic opportunities
Zehua Wang, Chen Chen, Jiaoyu Ai, Yaping Gao, Lei Wang, Shurui Xia, Yongxu Jia, Yanru Qin · 2025 · MedComm
Tp53 determines the spatial dynamics of M1/M2 tumor-associated macrophages and M1-driven tumoricidal effects
Yi‐Jing Hsiao, Min‐Shu Hsieh, Gee‐Chen Chang, Yin-Chen Hsu, Chia-Yu Wang, Yan-Ming Chen, Yi-Ling Chen, Pan‐Chyr Yang, Sung‐Liang Yu · 2025 · Cell Death and Disease
Unveiling the complexity of cellular senescence in cancers: From mechanism to therapeutic opportunities
Qiuming Pan, Zhu Ye, Zhi Ye, Huayang Zhang, Junxi Wang, Guozhong Yi, Zhiyong Li, Rongyang Xu, Luyao Wang, Zhenzhen Wu et al. · 2025 · BMEMat
Single-cell RNA sequencing advances in revealing the development and progression of MASH: the identifications and interactions of non-parenchymal cells
Meng Ning, Donghui Lu, Dong Liang, Pei‐Gen Ren · 2025 · Frontiers in Molecular Biosciences
Myeloid cell path to malignancy: insights into liver cancer
Christel F. A. Ramirez, Leila Akkari · 2025 · Trends in cancer
Inflammatory level under different p53 mutation status and the regulation role of curcumin in tumor microenvironment
Liping Xu, Xiaoli Xie, Xinbo Li, Wenfang Duan, Lei Qiu, Huan Liu, Ying Luo · 2022 · Immunobiology
The role of ubiquitin pathway‐mediated regulation of immune checkpoints in cancer immunotherapy
Xiaoming Zhou, Chengxiao Fu, Xisha Chen · 2023 · Cancer
Comparative analysis of post-transplant lymphoproliferative disorders after solid organ and hematopoietic stem cell transplantation reveals differences in the tumor microenvironment
Mathis Overkamp, Massimo Granai, Irina Bonzheim, Julia Steinhilber, Jens Schittenhelm, Wolfgang Andreas Bethge, Leticia Quintanilla‐Martínez, Falko Fend, Birgit Federmann · 2020 · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin
Cellular Stress and Senescence Induction during Trypanosoma cruzi Infection
Kamila Guimarães Pinto, Jesuino Rafael Machado Ferreira, André Luiz Amorim da Costa, Alexandre Morrot, Leonardo Freire‐de‐Lima, Débora Decotè-Ricardo, Célio Geraldo Freire-de-Lima, Alessandra A. Filardy · 2022 · Tropical Medicine and Infectious Disease
Non‐Cell Autonomous or Secretory Tumor Suppression
Christelle En Lin Chua, Shu Ning Chan, Bor Luen Tang · 2014 · Journal of Cellular Physiology
Repurposing Clemastine to Target Glioblastoma Cell Stemness
Michael A. Sun, Rui Ryan Yang, Heng Liu, Wenzhe Wang, Xiao Song, Bo Hu, Nathan Reynolds, Kristen Roso, Lee H. Chen, Paula K. Greer et al. · 2023 · Cancers
Loss of myosin light chain kinase induces the cellular senescence associated secretory phenotype to promote breast epithelial cell migration
Dayoung Kim, Jonathan A. Cooper, David M. Helfman · 2024 · Scientific Reports
Targeting Senescence in Oncology: An Emerging Therapeutic Avenue for Cancer
Satoru Meguro, Syunta Makabe, Kei Yaginuma, Akifumi Onagi, Ryo Tanji, Kanako Matsuoka, Seiji Hoshi, Tomoyuki Koguchi, Emina Kayama, Junya Hata et al. · 2025 · Current Oncology
Human innate immune cell crosstalk induces melanoma cell senescence
Felix Funck, Jens H. W. Pahl, Lenka Kyjacová, Lukas Freund, Stephanie Oehrl, Galina Gräbe, Silvia Pezer, Jessica C. Hassel, Jonathan Paul Sleeman, Adelheid Cerwenka et al. · 2020 · OncoImmunology
Could senescence phenotypes strike the balance to promote tumor dormancy?
Fang-Yen Chiu, Raegan M. Kvadas, Zeinab Mheidly, Ashkan Shahbandi, James G. Jackson · 2023 · Cancer and Metastasis Reviews
Stellate Cells, Portal Myofibroblasts, and Epithelial-to-Mesenchymal Transition
Yukinori Koyama, Ping Wang, David A. Brenner, Tatiana Kisseleva · 2015 · Elsevier eBooks
Pharmacological rescue of mutant p53 triggers spontaneous tumor regression via immune responses
Jiabing Li, Shuang Zhang, Baohui Wang, Yuting Dai, Jiale Wu, Dianjia Liu, Ying Liang, Shujun Xiao, Zhengyuan Wang, Jiaqi Wu et al. · 2025 · Cell Reports Medicine
Reprogramming and targeting of cholesterol metabolism in tumor-associated macrophages
Qiaoluo Ma, Ying Zhu, Dongya Zhang, Xiaohan Su, Can Jiang, Yuzhu Zhang, Xingting Zhang, Na Han, Guang Shu, Gang Yin et al. · 2025 · Journal of Materials Chemistry B
α-Lipoic acid alleviate myocardial infarction by suppressing age-independent macrophage senescence
Yuchao Wang, Yue Zheng, Xiaoyu Liang, Yun Chang, Yanwu Liu, Xian Wu Cheng, Meng Zhang, Wenqing Gao, Tong Li · 2025 · Scientific Reports
NFATc1 facilitates hepatocellular carcinoma progression by regulating the senescence-associated secretory phenotype
Zhaobin Chen, Liyuan Huang, Leping Ding, Congrui Zhang, Yanpeng Li, Bingyuan Wang, Junping Shi, Jing Zhang · 2025 · Scientific Reports
Hepatic Stellate Cell Senescence in Liver Tumorigenesis
Nadine Martin, Dorian V. Ziegler, Romain Parent, David Bernard · 2020 · Hepatology
Targeting the stress support network regulated by autophagy and senescence for cancer treatment
Jae‐Jin Kim, Yeonghyeon Lee, Kyeonghwan Roh, Mi-Sung Kim, Chanhee Kang · 2021 · Advances in cancer research
Construction of a tumor immune infiltration macrophage signature for predicting prognosis and immunotherapy response in liver cancer
Anmin Huang, Bei Lv, Yunjie Zhang, Junhui Yang, Jie Li, Chengjun Li, Zhijie Yu, Jinglin Xia · 2022 · Frontiers in Molecular Biosciences
Hepatic ribosomal protein S6 (Rps6) insufficiency results in failed bile duct development and loss of hepatocyte viability; a ribosomopathy-like phenotype that is partially p53-dependent
Sarah A. Comerford, Elizabeth A. Hinnant, Yidong Chen, Robert E. Hammer · 2023 · PLoS Genetics
Aging Mouse Models Reveal Complex Tumor-Microenvironment Interactions in Cancer Progression
Hidetoshi Mori, Robert D. Cardiff, Alexander D. Borowsky · 2018 · Frontiers in Cell and Developmental Biology
Infiltration of Apoptotic M2 Macrophage Subpopulation Is Negatively Correlated with the Immunotherapy Response in Colorectal Cancer
Rui Liu, Chongyin Han, Jiaqi Hu, Baowen Zhang, Wei Luo, Fei Ling · 2022 · International Journal of Molecular Sciences
To clear, or not to clear (senescent cells)? That is the question
Amaia Lujambio · 2016 · Inside the Cell
Restoration of angiogenic capacity in senescent endothelial cells by a pharmacological reprogramming approach
Katrin Kalies, Kai Knöpp, Susanne Koch, Claudia Pilowski, Leonie Wurmbrand, Daniel Sedding · 2025 · PLoS ONE
Inducible FAK loss but not FAK inhibition in endothelial cells of PYK2-null mice activates p53 tumor suppressor to prevent tumor growth
Xiao Lei Chen, Marjaana Ojalill, Christine Jean, Isabelle Tancioni, Shulin Jiang, Antonia D. Boyer, Duygu Ozmadenci, Sean A. Uryu, David Tarin, Joseph Schlessinger et al. · 2025 · Molecular Biology of the Cell
A Primer on the Role of TP53 Mutation and Targeted Therapy in Endometrial Cancer
Bohao Zhang, Haozhe Zhang, Yanru Qin · 2025 · Frontiers in Bioscience-Landmark
ATR suppresses the pro-tumorigenic functions of breast stromal fibroblasts
Mysoon M. Al‐Ansari, Abdelilah Aboussekhra · 2018 · Oncotarget
Senescent Secretome of Blind Mole Rat Spalax Inhibits Malignant Behavior of Human Breast Cancer Cells Triggering Bystander Senescence and Targeting Inflammatory Response
Amani Odeh, Hossam Eddini, Lujain Shawasha, Anastasia Chaban, Aaron Avivi, Imad Shams, Irena Manov · 2023 · International Journal of Molecular Sciences
Tumor-derived microparticles-based nanomaterial as platform for delivery of tumor antigens to enhance immunogenicity
Qi Tan, Zimo Yang, Shichen Bu, Jiangbin Chen, Wenjuan Chen, Wei Geng, Qi Huang, Limin Duan, Mengfei Guo, Yali Wu et al. · 2023 · Chemical Engineering Journal
The African-centric P47S Variant of TP53 Confers Immune Dysregulation and Impaired Response to Immune Checkpoint Inhibition
David C. Stieg, Joshua L.D. Parris, Tyler Hong Loong Yang, Gauri Mirji, Sarah Kim Reiser, Nivitha Murali, Madison Werts, Thibaut Barnoud, David Y. Lu, Rahul Suresh Shinde et al. · 2023 · Cancer Research Communications
SIN3B, the SASP, and pancreatic cancer
David John Cantor, Gregory David · 2014 · Molecular & Cellular Oncology