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Cited by 164Neurobiology and Insect Physiology ResearchInsect Pheromone Research and ControlOlfactory and Sensory Function Studies

Genetic and Neural Mechanisms that Inhibit Drosophila from Mating with Other Species

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Fan, Pu, Manoli, Devanand S., Ahmed, Osama M., Chen, Yi, Agarwal, Neha, Kwong, Sara, Cai, Allen G., Neitz, Jeffrey +3 more·2013·Cell
DOI 10.1016/j.cell.2013.06.008PMC PMC3823234
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Abstract

Genetically hard-wired neural mechanisms must enforce behavioral reproductive isolation because interspecies courtship is rare even in sexually naïve animals of most species. We find that the chemoreceptor Gr32a inhibits male D. melanogaster from courting diverse fruit fly species. Gr32a recognizes nonvolatile aversive cues present on these reproductively dead-end targets, and activity of Gr32a neurons is necessary and sufficient to inhibit interspecies courtship. Male-specific Fruitless (Fru(M)), a master regulator of courtship, also inhibits interspecies courtship. Gr32a and Fru(M) are not coexpressed, but Fru(M) neurons contact Gr32a neurons, suggesting that these genes influence a shared neural circuit that inhibits interspecies courtship. Gr32a and Fru(M) also suppress within-species intermale courtship, but we show that distinct mechanisms preclude sexual displays toward conspecific males and other species. Although this chemosensory pathway does not inhibit interspecies mating in D. melanogaster females, similar mechanisms appear to inhibit this behavior in many other male drosophilids.

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  • These LC neurons may act partially as distractors to prevent relentless pursuit of the female.

    “suggesting that these LC neurons may act partially as distractors to prevent relentless pursuit of the female43,44”

    From Mapping model units to visual neurons reveals population code for social behaviour (2024) · cites this paper as [43]

    The Results section on Gr32a neurons reports inhibition of courtship toward females of other species, but it does not address LC neurons acting as distractors or preventing relentless pursuit. Searches for LC or lobula columnar neurons, distraction, and pursuit found no passage supporting that proposed role. The indexed passages provide no page numbers. (LLM, conf=0.74)

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Authors
Fan, P., Manoli, D. S., Ahmed, O. M., Chen, Y., Agarwal, N., Kwong, S., Cai, A. G., Neitz, J., Renslo, A., Baker, B. S., & Shah, N. M.
Affiliations
  • University of California, San Francisco (US)
  • Howard Hughes Medical Institute (US)
Corresponding author
Shah, Nirao M.
ORCID
Venue
Cell
Publisher
Elsevier BV
Published
2013-07
Volume
154
Issue
1
Pages
89-102
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2013.06.008
PMC
PMC3823234
OpenAlex
W2016802710
Cited by
164
References
5
Citations by year
2026: 7 · 2025: 9 · 2024: 9 · 2023: 16 · 2022: 9 · 2021: 11 · 2020: 12 · 2019: 22 · 2018: 10 · 2017: 12 · 2016: 13 · 2015: 15 · 2014: 14 · 2013: 4
FWCI
7.53
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • Howard Hughes Medical Institute
  • National Institute of Mental Health (R25MH060482)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
  • Life Sciences › Agricultural and Biological Sciences › Insect Science › Insect Pheromone Research and Control
  • Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
Keywords
reproductive isolation, chemoreceptors, fruitless, Drosophila melanogaster, neural circuits, male courtship behavior, Drosophilidae
MeSH terms
Animals, Courtship, Drosophila, Drosophila melanogaster, Female, Male, Nerve Tissue Proteins, Neurons, Receptors, Cell Surface, Transcription Factors, Drosophila Proteins, Genetic Speciation, Mating Preference, Animal

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