Molecular organization of vomeronasal chemoreception
Open accessAbstract
The vomeronasal organ (VNO) has a key role in mediating the social and defensive responses of many terrestrial vertebrates to species- and sex-specific chemosignals. More than 250 putative pheromone receptors have been identified in the mouse VNO, but the nature of the signals detected by individual VNO receptors has not yet been elucidated. To gain insight into the molecular logic of VNO detection leading to mating, aggression or defensive responses, we sought to uncover the response profiles of individual vomeronasal receptors to a wide range of animal cues. Here we describe the repertoire of behaviourally and physiologically relevant stimuli detected by a large number of individual vomeronasal receptors in mice, and define a global map of vomeronasal signal detection. We demonstrate that the two classes (V1R and V2R) of vomeronasal receptors use fundamentally different strategies to encode chemosensory information, and that distinct receptor subfamilies have evolved towards the specific recognition of certain animal groups or chemical structures. The association of large subsets of vomeronasal receptors with cognate, ethologically and physiologically relevant stimuli establishes the molecular foundation of vomeronasal information coding, and opens new avenues for further investigating the neural mechanisms underlying behaviour specificity.
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Vomeronasal receptors detect pheromonal cues emitted during social encounters, leading to activation of distinct neural ensembles in the vomeronasal organ.
“Vomeronasal receptors (VRs) detect pheromonal cues emitted during social encounters, leading to the activation of distinct neural ensembles in the vomeronasal organ (VNO) (Dulac and Torello, 2003; Holy et al., 2000; Isogai et al., 2011).”
From Neuronal Representation of Social Information in the Medial Amygdala of Awake Behaving Mice (2017) · cites this paper as Isogai et al., 2011
There is significant signal integration at this level of the VNO pathway compared to the initial narrow tuning demonstrated in most VRs.
“In virgin mice, 58% ± 6% (mean ± SD) of the recorded MeApd neurons responded to more than one social stimulus, suggesting the existence of significant signal integration at this level of the VNO pathway compared to the initial narrow tuning demonstrated in most VRs (Isogai et al., 2011) (Figure 4C).”
From Neuronal Representation of Social Information in the Medial Amygdala of Awake Behaving Mice (2017) · cites this paper as Isogai et al., 2011
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- Authors
- Isogai, Y., Si, S., Pont-Lezica, L., Tan, T., Kapoor, V., Murthy, V. N., & Dulac, C.
- Affiliations
- Harvard University (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Dulac, Catherine
- Venue
- Nature
- Published
- 2011-09-21
- Volume
- 478
- Issue
- 7368
- Pages
- 241-245
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3192931
- OpenAlex
- W2152243497
- Cited by
- 317
- References
- 34
- Citations by year
- 2026: 10 · 2025: 8 · 2024: 22 · 2023: 21 · 2022: 15 · 2021: 25 · 2020: 24 · 2019: 19 · 2018: 27 · 2017: 16 · 2016: 27 · 2015: 21 · 2014: 31 · 2013: 25 · 2012: 21
- FWCI
- 13.80
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- RePEc: Research Papers in Economics (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute on Deafness and Other Communication Disorders (R01DC003903, R01DC009019)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
- Keywords
- vomeronasal organ, vomeronasal receptors, pheromone receptors, V1R, V2 receptor, kairomones, pheromones, innate behavior, social behavior, aggression, mating behavior, mice
- MeSH terms
- Animals, Birds, Chemoreceptor Cells, Cues, Female, Gene Expression Regulation, Male, Mammals, Pheromones, Predatory Behavior, Sex Characteristics, Species Specificity, Receptors, Odorant, Vomeronasal Organ, Mice, Early Growth Response Protein 1
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