The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Selection of Bone Metastasis Seeds by Mesenchymal Signals in the Primary Tumor Stroma
Open accessAbstract
Summary How organ-specific metastatic traits arise in primary tumors remains unknown. Here we show a role of the breast tumor stroma in selecting cancer cells that are primed for metastasis in bone. Cancer-associated fibroblasts (CAFs) in triple-negative (TN) breast tumors skew heterogeneous cancer cell populations towards a predominance of clones that thrive on the CAF-derived factors CXCL12 and IGF1. Limiting concentrations of these factors select for cancer cells with high Src activity, a known clinical predictor of bone relapse and an enhancer of PI3K-Akt pathway activation by CXCL12 and IGF1. Carcinoma clones selected in this manner are primed for metastasis in the CXCL12-rich microenvironment of the bone marrow. The evidence suggests that stromal signals resembling those of a distant organ select for cancer cells that are primed for metastasis in that organ, thus illuminating the evolution of metastatic traits in a primary tumor and its distant metastases.
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Self-citationTurning foes to friends: targeting cancer-associated fibroblasts
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Targeting metastasis-initiating cells through the fatty acid receptor CD36
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Metadata
- Authors
- Zhang, X. H.-F., Jin, X., Malladi, S., Zou, Y., Wen, Y. H., Brogi, E., Smid, M., Foekens, J. A., & Massagué, J.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 154
- Issue
- 5
- Pages
- 1060-1073
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2116910749
- Cited by
- 425
- References
- 47
- FWCI
- 18.81
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zhang, X. H.-F., Jin, X., Malladi, S., Zou, Y., Wen, Y. H., Brogi, E., Smid, M., Foekens, J. A., & Massagué, J. (2013). Selection of Bone Metastasis Seeds by Mesenchymal Signals in the Primary Tumor Stroma. Cell. https://doi.org/10.1016/j.cell.2013.07.036
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