The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Myelin Membrane Wrapping of CNS Axons by PI(3,4,5)P3-Dependent Polarized Growth at the Inner Tongue
Open accessAbstract
Summary Central nervous system myelin is a multilayered membrane sheath generated by oligodendrocytes for rapid impulse propagation. However, the underlying mechanisms of myelin wrapping have remained unclear. Using an integrative approach of live imaging, electron microscopy and genetics, we show that new myelin membranes are incorporated adjacent to the axon at the innermost tongue. Simultaneously, newly formed layers extend laterally ultimately leading to the formation of a set of closely apposed paranodal loops. An elaborated system of cytoplasmic channels within the growing myelin sheath enables membrane trafficking to the leading edge. Most of these channels are closing with ongoing development, but can be re-opened in adult by experimentally raising phosphatidylinositol-(3,4,5)-triphosphate levels, which reinitiates myelin growth. Our model can explain assembly of myelin as a multilayered structure, abnormal myelin outfoldings in neurological disease, and plasticity of myelin biogenesis observed in adult life.
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Cites
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Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity
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Self-citationThe origin and development of glial cells in peripheral nerves
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Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination
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“Does the leading edge resemble a glial growth cone-like extension related to the one that drives axonal outgrowth in developing neurons? It has also become apparent that myelin is a dynamically active structure (Young et al., 2013) that can provide metabolic support to associated axons (Fünfschilling et al.”
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Cited by
Myelination of the Nervous System: Mechanisms and Functions
Nave, K.-A., & Werner, H. B. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100913-013101 · Cited by 983
Self-citationCell type- and brain region-resolved mouse brain proteome
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Self-citationOligodendrocytes in development, myelin generation and beyond
Kuhn, S., Gritti, L., Crooks, D., & Dombrowski, Y. (2019) · Cells · doi:10.3390/cells8111424 · Cited by 625
Age-related myelin degradation burdens the clearance function of microglia during aging
Safaiyan, S., Kannaiyan, N., Snaidero, N., Brioschi, S., Biber, K., Yona, S., Edinger, A. L., Jung, S., Rossner, M. J., & Simons, M. (2016) · Nature Neuroscience · doi:10.1038/nn.4325 · Cited by 604
Self-citationOligodendroglial NMDA receptors regulate glucose import and axonal energy metabolism
Saab, A. S., Tzvetavona, I. D., Trevisiol, A., Baltan, S., Dibaj, P., Kusch, K., Möbius, W., Goetze, B., Jahn, H. M., Huang, W., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.05.016 · Cited by 590
“Myelin is assembled as a spiral extension of oligo- dendroglial cell membrane, which requires vesicular transport of membrane material through non-compacted cytosolic chan- nels to the growing tip (Snaidero et al., 2014).”
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Metadata
- Authors
- Snaidero, N., Möbius, W., Czopka, T., Hekking, L. H. P., Mathisen, C., Verkleij, D., Goebbels, S., Edgar, J., Merkler, D., Lyons, D. A., Nave, K.-A., & Simons, M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 156
- Issue
- 1-2
- Pages
- 277-290
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2041083111
- Cited by
- 451
- References
- 48
- FWCI
- 15.69
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Snaidero, N., Möbius, W., Czopka, T., Hekking, L. H. P., Mathisen, C., Verkleij, D., Goebbels, S., Edgar, J., Merkler, D., Lyons, D. A., Nave, K.-A., & Simons, M. (2014). Myelin Membrane Wrapping of CNS Axons by PI(3,4,5)P3-Dependent Polarized Growth at the Inner Tongue. Cell. https://doi.org/10.1016/j.cell.2013.11.044
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
