The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Tachykinin-Expressing Neurons Control Male-Specific Aggressive Arousal in Drosophila
Open accessAbstract
Males of most species are more aggressive than females, but the neural mechanisms underlying this dimorphism are not clear. Here, we identify a neuron and a gene that control the higher level of aggression characteristic of Drosophila melanogaster males. Males, but not females, contain a small cluster of FruM(+) neurons that express the neuropeptide tachykinin (Tk). Activation and silencing of these neurons increased and decreased, respectively, intermale aggression without affecting male-female courtship behavior. Mutations in both Tk and a candidate receptor, Takr86C, suppressed the effect of neuronal activation, whereas overexpression of Tk potentiated it. Tk neuron activation overcame reduced aggressiveness caused by eliminating a variety of sensory or contextual cues, suggesting that it promotes aggressive arousal or motivation. Tachykinin/Substance P has been implicated in aggression in mammals, including humans. Thus, the higher aggressiveness of Drosophila males reflects the sexually dimorphic expression of a neuropeptide that controls agonistic behaviors across phylogeny.
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Cites
A GAL4-Driver Line Resource for Drosophila Neurobiology
Jenett, A., Rubin, G. M., Ngo, T.-T. B., Shepherd, D., Murphy, C., Dionne, H., Pfeiffer, B. D., Cavallaro, A., Hall, D., Jeter, J., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.09.011 · Cited by 1,449
Functional identification of an aggression locus in the mouse hypothalamus
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“Studies in mice have localized aggression-promoting neurons to the ventrolateral subdivision of the ventromedial hypothalamus (VMHvl) (Lin et al., 2011).”
Self-citationAutomated monitoring and analysis of social behavior in Drosophila
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Self-citationCellular Organization of the Neural Circuit that Drives Drosophila Courtship Behavior
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A dimorphic pheromone circuit in Drosophila from sensory input to descending output
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Sexual Dimorphism in the Fly Brain
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Genetics of human aggressive behaviour
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“In humans, violent aggression constitutes a major public health problem (Filley et al., 2001) and its incidence is overwhelmingly higher among males than females (Craig and Halton, 2009).”
A neuropeptide circuit that coordinates sperm transfer and copulation duration in Drosophila
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Cited by
A framework for studying emotions across species
Anderson, D. J., & Adolphs, R. (2014) · Cell · doi:10.1016/j.cell.2014.03.003 · Cited by 691
Self-citationComputational Neuroethology: A Call to Action
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Self-citationRecent advances in neuropeptide signaling in Drosophila, from genes to physiology and behavior
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Multimodal Chemosensory Circuits Controlling Male Courtship in Drosophila
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Cell types and neuronal circuitry underlying female aggression in Drosophila
Schretter, C. E., Aso, Y., Robie, A. A., Dreher, M., Dolan, M.-J., Chen, N., Ito, M., Yang, T., Parekh, R., Branson, K. M., et al. (2020) · eLife · doi:10.7554/elife.58942 · Cited by 125
Metadata
- Authors
- Asahina, K., Watanabe, K., Duistermars, B. J., Hoopfer, E., González, C. R., Eyjólfsdóttir, E. A., Perona, P., & Anderson, D. J.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 156
- Issue
- 1-2
- Pages
- 221-235
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1987692590
- Cited by
- 351
- References
- 9
- FWCI
- 10.87
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Asahina, K., Watanabe, K., Duistermars, B. J., Hoopfer, E., González, C. R., Eyjólfsdóttir, E. A., Perona, P., & Anderson, D. J. (2014). Tachykinin-Expressing Neurons Control Male-Specific Aggressive Arousal in Drosophila. Cell. https://doi.org/10.1016/j.cell.2013.11.045
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