Genetics of human aggressive behaviour

Craig, Ian W.; Halton, Kelly E.

doi:10.1007/s00439-009-0695-9

Cited by 213Neurotransmitter Receptor Influence on BehaviorPsychopathy, Forensic Psychiatry, Sexual OffendingGenetic Associations and Epidemiology

Genetics of human aggressive behaviour

Craig, Ian W., Halton, Kelly E.·2009·Human Genetics

DOI 10.1007/s00439-009-0695-9

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Abstract

A consideration of the evolutionary, physiological and anthropological aspects of aggression suggests that individual differences in such behaviour will have important genetic as well as environmental underpinning. Surveys of the likely pathways controlling the physiological and neuronal processes involved highlight, as obvious targets to investigate, genes implicated in sexual differentiation, anxiety, stress response and the serotonin neurotransmitter pathway. To date, however, association studies on single candidates have provided little evidence for any such loci with a major effect size. This may be because genes do not operate independently, but function against a background in which other genetic and environmental factors are crucial. Indeed, a series of recent studies, particularly concentrating on the serotonin and norepinephrine metabolising enzyme, monoamine oxidase A, has emphasised the necessity of examining gene by environmental interactions if the contributions of individual loci are to be understood. These findings will have major significance for the interpretation and analysis of data from detailed whole genome association studies. Functional imaging studies of genetic variants affecting serotonin pathways have also provided valuable insights into potential links between genes, brain and aggressive behaviour.

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MAOA is an important locus widely associated with pathological forms of aggression, manifesting in humans in psychiatric conditions such as manic and bipolar disorders and schizophrenia.
“This includes a polymorphism in the promoter of the monoamine oxidase A (MAOA) gene, an important locus widely associated with pathological forms of aggression which, in humans, manifests in a broad spectrum of psychiatric conditions, such as manic and bipolar disorders and schizophrenia, among others [17, 18].”
From Gene expression profiles underlying aggressive behavior in the prefrontal cortex of cattle (2021) · cites this paper as [17]
PFC lesions result in offensive aggression in rodents.
“The PFC role in aggression has been studied in different species, e.g. PFC lesions result in impulsive and antisocial behaviors in humans [23] and offensive aggression in rodents [17].”
From Gene expression profiles underlying aggressive behavior in the prefrontal cortex of cattle (2021) · cites this paper as [17]

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PREVALENCE OF ALCOHOL PROBLEMS AMONG ADULT SOMATIC IN-PATIENTS OF A COPENHAGEN HOSPITAL
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Serotonin transporter polymorphisms affect human blood glucose control
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Hypogilycemia and Aggression: A Review
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The MAO-A genotype does not modulate resting brain metabolism in adults
Nelly Alia-klein, A., Kriplani, A., Pradhan, K., Yeming, J., Logan, J., Williams, B. S., Craig, I., Telang, F., Tomasi, D. G., Goldstein, R. Z., et al. (2008) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2007.12.010 · Cited by 15 · see citing works
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Effects of LY379268, A Selective Agonist of mGLu2/3 Receptors, on Isolation-Induced Aggression in Male Mice
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P.1.d.006 Effects of LY379268, a selective agonist of mGlu2/3 receptors, on isolation-induced aggression in male mice
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Biosocial construction of sex differences and similarities in behavior
Wood, W., & Eagly, A. H. (2012) · Advances in experimental social psychology · doi:10.1016/b978-0-12-394281-4.00002-7 · Cited by 770 · see citing works
Vitamin D and the omega‐3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior
Patrick, R. P., & Ames, B. N. (2015) · The FASEB Journal · doi:10.1096/fj.14-268342 · Cited by 505 · see citing works
Two types of aggression in human evolution.
Wrangham, R. W. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1713611115 · Cited by 410 · see citing works
Tachykinin-Expressing Neurons Control Male-Specific Aggressive Arousal in Drosophila
Asahina, K., Watanabe, K., Duistermars, B. J., Hoopfer, E. D., González, C. R., Eyjólfsdóttir, E., Perona, P., & Anderson, D. J. (2014) · Cell · doi:10.1016/j.cell.2013.11.045 · Cited by 358 · see citing works
Genetics of Human Social Behavior
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Evolutionary Shift from Fighting to Foraging in Blind Cavefish through Changes in the Serotonin Network
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Exaggerated aggression and decreased anxiety in mice deficient in brain serotonin
Mosienko, V., Bert, B., Beis, D. M., Matthes, S., Fink, H., Bäder, M., & Alenina, N. V. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.44 · Cited by 264 · see citing works
Functional and clinical neuroanatomy of morality.
Fumagalli, M., & Priori, A. (2012) · Brain : a journal of neurology · doi:10.1093/brain/awr334 · Cited by 232 · see citing works
Systematic meta-analyses and field synopsis of genetic association studies of violence and aggression
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Genes, hormones, and circuits: An integrative approach to study the evolution of social behavior
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The reciprocal interaction between serotonin and social behaviour
Kiser, D., SteemerS, B., Branchi, I., & Homberg, J. R. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.12.009 · Cited by 214 · see citing works
Peripheral SLC6A4 DNA Methylation Is Associated with In Vivo Measures of Human Brain Serotonin Synthesis and Childhood Physical Aggression
Wang, D., Szyf, M., Benkelfat, C., Provençal, N., Turecki, G., Caramaschi, D., Côté, S. M., Vitaro, F., Tremblay, R. E., & Booij, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039501 · Cited by 208 · see citing works
Genetics of borderline personality disorder: Systematic review and proposal of an integrative model
Amad, A., Ramoz, N., Thomas, P., Jardri, R., & Gorwood, P. A. P. M. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.01.003 · Cited by 190 · see citing works
Environmental risk, Oxytocin Receptor Gene (OXTR) methylation and youth callous-unemotional traits: a 13-year longitudinal study
Cecil, C. A. M., Lysenko, L., Jaffee, S. R., Pingault, J., Smith, R. G., Relton, C. L., Woodward, G., McArdle, W. L., Mill, J. S., & Barker, E. D. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.95 · Cited by 187 · see citing works
The neurobiological basis of human aggression: A review on genetic and epigenetic mechanisms
Waltes, R., Chiocchetti, A. G., & Freitag, C. M. (2016) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32388 · Cited by 182 · see citing works
A genome‐wide approach to children's aggressive behavior: The EAGLE consortium
Pappa, I., St Pourcain, B., Benke, K., Cavadino, A., Hakulinen, C., Nivard, M. G., Nolte, I. M., Tiesler, C. M. T., Bakermans‐Kranenburg, M. J., Davies, G. E., et al. (2016) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32333 · Cited by 195 · see citing works
Testosterone and aggressive behavior in man
Batrinos, M. L. (2012) · Intern J Endocrinol Metab · doi:10.5812/ijem.3661 · Cited by 172 · see citing works
Genetic mapping of canine fear and aggression
Zapata, I., Serpell, J. A., & Alvarez, C. E. (2016) · BMC Genomics · doi:10.1186/s12864-016-2936-3 · Cited by 168 · see citing works
Candidate gene polymorphisms for behavioural adaptations during urbanization in blackbirds
Mueller, J. C., Partecke, J., Hatchwell, B. J., Gaston, K. J., & Evans, K. L. (2013) · Molecular Ecology · doi:10.1111/mec.12288 · Cited by 152 · see citing works
Candidate Genes for Aggression and Antisocial Behavior: A Meta-analysis of Association Studies of the 5HTTLPR and MAOA-uVNTR
Ficks, C. A., & Waldman, I. D. (2014) · Behavior Genetics · doi:10.1007/s10519-014-9661-y · Cited by 182 · see citing works
The role of monoamine oxidase A in the neurobiology of aggressive, antisocial, and violent behavior: A tale of mice and men
Kolla, N. J., & Bortolato, M. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101875 · Cited by 138 · see citing works
Childhood trauma and adult interpersonal relationship problems in patients with depression and anxiety disorders
Huh, H., Kim, S.-Y., Yu, J. J., & Chae, J. (2014) · Annals of General Psychiatry · doi:10.1186/s12991-014-0026-y · Cited by 122 · see citing works
Aggression in borderline personality disorder: A multidimensional model.
Mancke, F., Herpertz, S. C., & Bertsch, K. (2015) · Personality Disorders Theory Research and Treatment · doi:10.1037/per0000098 · Cited by 110 · see citing works
Behavioural, hormonal and neurobiological mechanisms of aggressive behaviour in human and nonhuman primates
de Almeida, R. M. M., Cabral, J. C. C., & Narvaes, R. F. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.02.053 · Cited by 108 · see citing works
Right Anterior Cingulate Cortical Thickness and Bilateral Striatal Volume Correlate with Child Behavior Checklist Aggressive Behavior Scores in Healthy Children
Ducharme, S., Hudziak, J. J., Botteron, K. N., Ganjavi, H., Lepage, C., Collins, D. L., Albaugh, M. D., Evans, A. C., & Karama, S. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.03.015 · Cited by 103 · see citing works
The Role of the Catechol-o-Methyltransferase (COMT) GeneVal158Met in Aggressive Behavior, a Review of Genetic Studies
Qayyum, A., C. Zai, C., Hirata, Y., K. Tiwari, A., Cheema, S., Nowrouzi, B., Beitchman, J., & Kennedy, L. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666150612225836 · Cited by 95 · see citing works
Variation at the DRD4 locus is associated with wariness and local site selection in urban black swans
van Dongen, W. F. D., Robinson, R. W., Weston, M. A., Mulder, R. A., & Guay, P. (2015) · BMC Evolutionary Biology · doi:10.1186/s12862-015-0533-8 · Cited by 90 · see citing works
Human brain evolution writ large and small
Sherwood, C. C., Bauernfeind, A. L., Bianchi, S., Raghanti, M. A., & Hof, P. R. (2012) · Progress in Brain Research · doi:10.1016/b978-0-444-53860-4.00011-8 · Cited by 113 · see citing works
Aggressive behavior in humans: Genes and pathways identified through association studies
Fernàndez‐Castillo, N., & Cormand, B. (2016) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32419 · Cited by 87 · see citing works
Behavioral genetics in antisocial spectrum disorders and psychopathy: A review of the recent literature
Gunter, T. D., Vaughn, M. G., & Philibert, R. A. (2010) · Behavioral Sciences & the Law · doi:10.1002/bsl.923 · Cited by 86 · see citing works
Genetics and neurobiology of aggression in Drosophila
Zwarts, L., Versteven, M., & Callaerts, P. (2012) · Fly · doi:10.4161/fly.19249 · Cited by 83 · see citing works
Genetic variation in dopaminergic activity is associated with the risk for psychiatric side effects of levetiracetam
Helmstaedter, C., Mihov, Y., Toliat, M. R., Thiele, H., Nüernberg, P., Schoch, S., Surges, R., Elger, C. E., Kunz, W. S., & Hurlemann, R. (2012) · Epilepsia · doi:10.1111/j.1528-1167.2012.03603.x · Cited by 81 · see citing works
Complex genetic architecture of Drosophila aggressive behavior
Zwarts, L., Magwire, M. M., Carbone, M. A., Versteven, M., Herteleer, L., Anholt, R. R. H., Callaerts, P., & Mackay, T. F. C. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113877108 · Cited by 72 · see citing works
Wolbachia Influences the Production of Octopamine and Affects Drosophila Male Aggression
Rohrscheib, C. E., Bondy, E. C., Josh, P. F., Riegler, M., Eyles, D. W., van Swinderen, B., Weible, M. W., & Jeremy, B. (2015) · Applied and Environmental Microbiology · doi:10.1128/aem.00573-15 · Cited by 65 · see citing works
Study of the Catechol‐O‐Methyltransferase (COMT) Gene with High Aggression in Children
Hirata, Y., Zai, C. C., Nowrouzi, B., Beitchman, J. H., & Kennedy, J. L. (2013) · Aggressive Behavior · doi:10.1002/ab.21448 · Cited by 65 · see citing works
Aggression, Digit Ratio, and Variation in the Androgen Receptor, Serotonin Transporter, and Dopamine D4 Receptor Genes in African Foragers: The Hadza
Butovskaya, M., Vasilyev, V. A., Lazebny, O. E., Burkova, V. N., Куликов, А. М., Mabulla, A. Z. P., Shibalev, D. V., & Рысков, А. П. (2012) · Behavior Genetics · doi:10.1007/s10519-012-9533-2 · Cited by 65 · see citing works
Genetic Risk for Violent Behavior and Environmental Exposure to Disadvantage and Violent Crime
Barnes, J. C., & Jacobs, B. A. (2012) · Journal of Interpersonal Violence · doi:10.1177/0886260512448847 · Cited by 63 · see citing works
Sociability and brain development in BALB/cJ and C57BL/6J mice
Fairless, A. H., Dow, H. C., Kreibich, A. S., Torre, M., Kuruvilla, M., Gordon, E., Morton, E. A., Tan, J., Berrettini, W. H., Li, H., et al. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.12.001 · Cited by 60 · see citing works
Octopamine neuron dependent aggression requires dVGLUT from dual-transmitting neurons
Sherer, L. M., Catudio-Garrett, E. L., Morgan, H. R., Brewer, E. D., Sirrs, L. A., Shearin, H. K., Williams, J. L., McCabe, B. D., Stowers, R. S., & Certel, S. J. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1008609 · Cited by 56 · see citing works
Polymorphism in the Serotonin Receptor 2a (HTR2A) Gene as Possible Predisposal Factor for Aggressive Traits
Bánlaki, Z., Elek, Z., Nánási, T., Székely, A., Nemoda, Z., Sasvári‐Székely, M., & Rónai, Z. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117792 · Cited by 55 · see citing works
Prefrontal neuromodulation by nicotinic receptors for cognitive processes
Coura, R., & Granon, S. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2596-6 · Cited by 51 · see citing works
Androgen Receptor Gene Polymorphism, Aggression, and Reproduction in Tanzanian Foragers and Pastoralists
Butovskaya, M., Lazebny, O. E., Vasilyev, V. A., Dronova, D. A., Карелин, Д. В., Mabulla, A. Z. P., Shibalev, D. V., Shackelford, T. K., Fink, B., & Рысков, А. П. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136208 · Cited by 48 · see citing works
Treating Traumatized Offenders and Veterans by Means of Narrative Exposure Therapy
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The Genetics of Human Aggressive Behaviour
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Self-citation
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Recent advances in genetics of aggressive behavior
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Genetic architecture for human aggression: A study of gene–phenotype relationship in OMIM
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Authors: Craig, I. W., & Halton, K. E.
Affiliations: King's College London (GB)
Corresponding author: Craig, Ian W.
Halton, Kelly E.
ORCID: Craig, Ian W.
Venue: Human Genetics
Publisher: Springer Science and Business Media LLC
Published: 2009-06-09
Volume: 126
Issue: 1
Pages: 101-113
ISSN: 0018-7348 (ISSN-L)
0340-6717
1432-1203
DOI: 10.1007/s00439-009-0695-9
OpenAlex: W2158647822
Cited by: 213
References: 127
Citations by year: 2026: 1 · 2025: 4 · 2024: 3 · 2023: 5 · 2022: 5 · 2021: 14 · 2020: 29 · 2019: 8 · 2018: 16 · 2017: 9 · 2016: 8 · 2015: 25 · 2014: 17 · 2013: 14 · 2012: 31
FWCI: 1.58
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Human Genetics (publishedVersion)
PubMed (publishedVersion)
Research Portal (King's College London) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords: aggression, sexual differentiation, anxiety, stress response, serotonin pathway, monoamine oxidase A, norepinephrine, gene-environment interaction, individual differences, whole-genome association studies
MeSH terms: Adolescent, Aggression, Alleles, Catechol O-Methyltransferase, Child, Dopamine beta-Hydroxylase, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Male, Monoamine Oxidase, Pituitary-Adrenal System, Polymorphism, Genetic, Receptors, Androgen, Serotonin, Sex Factors, Stress, Psychological, Testosterone, Genetic Variation, Meta-Analysis as Topic, Tandem Repeat Sequences, Chromosomes, Human, Y, Epigenesis, Genetic, Serotonin Plasma Membrane Transport Proteins, Nitric Oxide Synthase Type I, Genome-Wide Association Study, Young Adult

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