The DOI matches its Crossref record; 64 of the 65 references it cites were found in a registry or an index.
Hippo Signaling Regulates Microprocessor and Links Cell-Density-Dependent miRNA Biogenesis to Cancer
Open accessAbstract
Global downregulation of microRNAs (miRNAs) is commonly observed in human cancers and can have a causative role in tumorigenesis. The mechanisms responsible for this phenomenon remain poorly understood. Here, we show that YAP, the downstream target of the tumor-suppressive Hippo-signaling pathway regulates miRNA biogenesis in a cell-density-dependent manner. At low cell density, nuclear YAP binds and sequesters p72 (DDX17), a regulatory component of the miRNA-processing machinery. At high cell density, Hippo-mediated cytoplasmic retention of YAP facilitates p72 association with Microprocessor and binding to a specific sequence motif in pri-miRNAs. Inactivation of the Hippo pathway or expression of constitutively active YAP causes widespread miRNA suppression in cells and tumors and a corresponding posttranscriptional induction of MYC expression. Thus, the Hippo pathway links contact-inhibition regulation to miRNA biogenesis and may be responsible for the widespread miRNA repression observed in cancer.
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“has been functionally linked with the Hippo pathway (21, 104).”
From The Hippo signal transduction network for exercise physiologists (2016) · cites this paper as [104]
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2 retracted
Fukuda, T., Yamagata, K., Fujiyama, S., Μatsumoto, T., Koshida, I., Yoshimura, K., Mihara, M., Naitou, M., Endoh, H., Nakamura, T., et al. (2007) · Nature Cell Biology · doi:10.1038/ncb1577 · Cited by 452
RetractedA TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function
Melo, S. A., Ropero, S., Moutinho, C., Aaltonen, L. A., Yamamoto, H., Calin, G. A., Rossi, S., Fernández, A. F., Carneiro, F., Oliveíra, C., et al. (2009) · Nature Genetics · doi:10.1038/ng.317 · Cited by 375
RetractedMicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068
WebLogo: A Sequence Logo Generator: Figure 1Preprint
Crooks, G. E., Hon, G. C., Chandonia, J., & Brenner, S. E. (2004) · Genome Research · doi:10.1101/gr.849004 · Cited by 12,418
MicroRNA expression profiles classify human cancers
Lü, J., Getz, G. A., Miska, E. A., Alvarez-Saavedra, E., Lamb, J., Peck, D., Sweet-Cordero, A., Ebert, B. L., Mak, R. H., Ferrando, A. A., et al. (2005) · Nature · doi:10.1038/nature03702 · Cited by 9,637
Role of YAP/TAZ in mechanotransduction
Dupont, S., Morsut, L., Aragona, M., Enzo, E., Giulitti, S., Cordenonsi, M., Zanconato, F., Le Digabel, J., Forcato, M., Bicciato, S., et al. (2011) · Nature · doi:10.1038/nature10137 · Cited by 5,979
Zhao, B., Wei, X., Li, W., Udan, R. S., Yang, Q., Kim, J., Xie, J., Ikenoue, T., Yu, J., Li, L., et al. (2007) · Genes & Development · doi:10.1101/gad.1602907 · Cited by 3,092
The Microprocessor complex mediates the genesis of microRNAs
Gregory, R. I., Yan, K.-P., Amuthan, G., Chendrimada, T. P., Doratotaj, B., Cooch, N. S., & Shiekhattar, R. (2004) · Nature · doi:10.1038/nature03120 · Cited by 2,851
Self-citationProcessing of primary microRNAs by the Microprocessor complex
Denli, A. M., Tops, B. B. J., Plasterk, R. H. A., Ketting, R. F., & Hannon, G. J. (2004) · Nature · doi:10.1038/nature03049 · Cited by 2,784
TEAD mediates YAP-dependent gene induction and growth control
Zhao, B., Ye, X., Yu, J., Li, L., Li, W., Li, S., Yu, J., Lin, J. D., Wang, C.-Y., Chinnaiyan, A. M., et al. (2008) · Genes & Development · doi:10.1101/gad.1664408 · Cited by 2,498
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Items 301–335 of 335
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Zhang, Z., Xu, Z., Qian, X., Chen, Y., Li, D., Qin, Z., Chen, L., Zhang, Y., Jin, Y., & Ji, H. (2024) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2024.09.001 · Cited by 1
Niu, K., Qu, S., Zhang, X., Dai, J., Wang, J., Nie, Y., Zhang, H., Tao, K., & Song, W. (2020) · doi:10.21203/rs.3.rs-100940/v1 · Cited by 1
Niu, K., Qu, S., Zhang, X., Dai, J., Wang, J., Nie, Y., Zhang, H., Tao, K., & Song, W. (2021) · Research Square · doi:10.21203/rs.3.rs-335058/v1 · Cited by 1
Deregulation of microRNA Processing in Idiopathic Pulmonary Fibrosis
Guenther, K. L. (2015) · University of Minnesota Digital Conservancy (University of Minnesota)
Characterization of CDK5RAP2 as a novel regulator in the Hippo signaling pathway
Sukumaran, S. K. (2014) · Kölner Universitäts PublikationsServer (Universität zu Köln)
Herrera, J. (2015) · University of Minnesota Digital Conservancy (University of Minnesota)
Orchestrated Role of microRNAs in Skin Development and Regeneration
Botchkareva, N. V., & Yi, R. (2018) · Contributions to management science · doi:10.1007/978-3-319-16769-5_7
Diaconu, B. (2019) · UWSpace (University of Waterloo)
Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems
Kohl, J. V. (2014) · Figshare · doi:10.6084/m9.figshare.994281.v1
The roles of RNA helicases and other ribosome biogenesis factors during small subunit maturation
Gallesio, J. D. (2020) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-8004
The Hippo Pathway Effector TAZ Regulates Ferroptosis in NSCLCPreprint
Zhang, Y., Li, J., Guo, R., & Zhu, L. (2022) · Research Square · doi:10.21203/rs.3.rs-2018160/v1
Ikuno, Y., Watanabe, K., Kakeya, Y., Ikeno, S., Nakabo, T., Narumoto, A., Kande, Y., Hayashi, T., Minami, K., Nobuhiro, K., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-2204556/v1
Ikuno, Y., Watanabe, K., Kakeya, Y., Ikeno, S., Nakabo, T., Narumoto, A., Kande, Y., Hayashi, T., Minami, K., Nobuhiro, K., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-2204556/v2
Ikuno, Y., Watanabe, K., Kakeya, Y., Ikeno, S., Nakabo, T., Narumoto, A., Kande, Y., Hayashi, T., Minami, K., Nobuhiro, K., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-2204556/v3
Clockwork Orangutan: microRNAs, thermoregulatory tradeoffs, and models of brain size evolutionPreprint
Sorger, T., & Fromm, B. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.21.595052
Fujii, W., Tomimaru, Y., Kobayashi, S., Torigata, K., Hasegawa, K., Harada, A., Sasaki, K., Hasegawa, S., Yamada, D., Akita, H., et al. (2025) · Hepatology Research · doi:10.1111/hepr.14228
Additional file 3 of YAP1 is essential for malignant mesothelioma tumor maintenance
Calvet, L., Dos-Santos, O., Spanakis, E., Jean‐Baptiste, V., Bail, J.-C. L., Buzy, A., Paul, P., Henry, C., Valence, S., Dib, C., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20056233
Wan, W., Miao, Y., Niu, Y., Zhu, K., Ma, Y., Pan, M., Ma, B., & Wei, Q. (2023) · Figshare · doi:10.6084/m9.figshare.22619555
Wan, W., Miao, Y., Niu, Y., Zhu, K., Ma, Y., Pan, M., Ma, B., & Wei, Q. (2023) · Figshare · doi:10.6084/m9.figshare.22619558
The Biogenesis, Regulation, and Canonical and Noncanonical Functional Machinery of miRNAs
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Cui, J., Li, M., Wang, L., Li, F., Ruan, K. Q., Lv, M., & Shi, Y. (2026) · Structure · doi:10.1016/j.str.2026.02.009
Rapid endothelialization induced by VEGF-mimetic peptide in small-diameter vascular scaffold
Wang, H., Gong, F., Zhou, C., Huang, Y., Wang, J., & Gao, X. (2026) · Biomedical Materials · doi:10.1088/1748-605x/ae5582
Ha, T. W., Kim, H. K., No, D., Lee, J. B., Kim, A., Kim, B., Song, Y., Munkhzul, C., Choi, Y., Lee, M., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27073000
Rôle des miARN dans la régulation des fonctions plaquettaires
Dréano, E. (2016) · theses.fr (ABES) · doi:10.70675/7f34ffbbz8891z466bzacaez75b277e21002
Thibord, F. (2019) · theses.fr (ABES) · doi:10.70675/01efeca0z30c7z4e8bza07cz61f3b56ea5cc
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Yeter-Alat, H. (2021) · theses.fr (ABES) · doi:10.70675/1d81d70ezc649z4e03zadcez4bb3a725ada5
A nanobody based approach to capture interactomes of dimeric protein complexes in living cells
Sleiman, N. H. (2024) · theses.fr (ABES) · doi:10.70675/633151e1z9a1cz42b0zbcbaz776177601937
Kingsley, C., Nair-Menon, J. U., McKee, P. R., Daulagala, A. C., Yoon, A. J., Pandruvada, S. N. M., Engevik, A. C., Engevik, M. A., & Kourtidis, A. (2026) · American Journal Of Pathology · doi:10.1016/j.ajpath.2026.04.007
WBP2/YAP1 complex governs miR-133b maturation and ovarian development in teleostsPreprint
Zhou, J., Min, Q., Yi, X., Huang, B., Lv, M., Li, R., Zhao, N., & Zhang, B. (2026) · Research Square · doi:10.21203/rs.3.rs-11080484/v1
Akbari‐Ardabili, S. (2026) · Veterinary and Animal Science · doi:10.1016/j.vas.2026.100916
Baker, T. M. (2014) · ProQuest Demo Repository
Metadata
- Authors
- Mori, M., Triboulet, R., Mohseni, M., Schlegelmilch, K., Shrestha, K., Camargo, F. D., & Gregory, R. I.
- Affiliations
- Boston Children's Hospital (US)
- Corresponding author
- Camargo, Fernando D.
- Gregory, Richard I.
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-02
- Volume
- 156
- Issue
- 5
- Pages
- 893-906
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC3982296
- OpenAlex
- W2166840595
- Cited by
- 335
- References
- 65
- Citations by year
- 2026: 9 · 2025: 5 · 2024: 16 · 2023: 11 · 2022: 30 · 2021: 35 · 2020: 30 · 2019: 34 · 2018: 35 · 2017: 24 · 2016: 37 · 2015: 41 · 2014: 28
- FWCI
- 21.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Japan Heart Foundation
- Stand Up To Cancer
- Bayer Yakuhin
- National Cancer Institute (R01CA131426)
- National Institute of General Medical Sciences (R01GM086386)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK034854)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR064036)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- Hippo signaling pathway, YAP, microRNA biogenesis, microprocessors, DDX17, cell density, contact inhibition, pri-miRNA processing, MYC expression
- MeSH terms
- Hippo Signaling Pathway, Cell Count, Cell Line, Humans, Neoplasms, Nuclear Proteins, Transcription Factors, Signal Transduction, Proto-Oncogene Proteins c-myc, Protein Serine-Threonine Kinases, Cell Cycle Proteins, MicroRNAs, DEAD-box RNA Helicases, Transcriptome
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