The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Water Permeation Drives Tumor Cell Migration in Confined Microenvironments
Open accessAbstract
SUMMARY Cell migration is a critical process for diverse (patho) physiological phenomena. Intriguingly, cell migration through physically confined spaces can persist even when typical hallmarks of 2D planar migration, such as actin polymerization and myosin II-mediated contractility, are inhibited. Here, we present an integrated experimental and theoretical approach (“Osmotic Engine Model”) and demonstrate that directed water permeation is a major mechanism of cell migration in confined microenvironments. Using microfluidic and imaging techniques along with mathematical modeling, we show that tumor cells confined in a narrow channel establish a polarized distribution of Na+/H+ pumps and aquaporins in the cell membrane, which creates a net inflow of water and ions at the cell leading edge and a net outflow of water and ions at the trailing edge, leading to net cell displacement. Collectively, this study presents an alternate mechanism of cell migration in confinement that depends on cell-volume regulation via water permeation.
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Cites
Functional significance of cell volume regulatory mechanisms
LANG, F., BUSCH, G. L., RITTER, M., VÖLKL, H., WALDEGGER, S., GULBINS, E., & HÄUSSINGER, D. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.1.247 · Cited by 1,891
Cited by
Mechanoreciprocity in cell migration
van Helvert, S., Storm, C., & Friedl, P. (2018) · Nature Cell Biology · doi:10.1038/s41556-017-0012-0 · Cited by 587
Case, L. B., & Waterman, C. M. (2015) · Nature Cell Biology · doi:10.1038/ncb3191 · Cited by 520
Scarcelli, G., Polacheck, W. J., Nia, H. T., Patel, K., Grodzinsky, A. J., Kamm, R. D., & Yun, S. H. (2015) · Nature Methods · doi:10.1038/nmeth.3616 · Cited by 432
Matrix mechanical plasticity regulates cancer cell migration through confining microenvironments
Wisdom, K. M., Adebowale, K., Chang, J., Lee, J. Y., Nam, S., Desai, R., Rossen, N. S., Rafat, M., West, R. B., Hodgson, L., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06641-z · Cited by 426
Extracellular fluid viscosity enhances cell migration and cancer dissemination
Bera, K., Kiepas, A., Godet, I., Li, Y., Mehta, P., Ifemembi, B., Paul, C. D., Sen, A., Serra, S. A., Stoletov, K., et al. (2022) · Nature · doi:10.1038/s41586-022-05394-6 · Cited by 412
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Metadata
- Authors
- Stroka, K. M., Jiang, H., Chen, S.-H., Tong, Z., Wirtz, D., Sun, S. X., & Konstantopoulos, K.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-04
- Volume
- 157
- Issue
- 3
- Pages
- 611-623
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2102554836
- Cited by
- 537
- References
- 1
- FWCI
- 17.27
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Stroka, K. M., Jiang, H., Chen, S.-H., Tong, Z., Wirtz, D., Sun, S. X., & Konstantopoulos, K. (2014). Water Permeation Drives Tumor Cell Migration in Confined Microenvironments. Cell. https://doi.org/10.1016/j.cell.2014.02.052
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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