Mechanoreciprocity in cell migration
Open accessAbstract
Cell migration is an adaptive process that depends on and responds to physical and molecular triggers. Moving cells sense and respond to tissue mechanics and induce transient or permanent tissue modifications, including extracellular matrix stiffening, compression and deformation, protein unfolding, proteolytic remodelling and jamming transitions. Here we discuss how the bi-directional relationship of cell-tissue interactions (mechanoreciprocity) allows cells to change position and contributes to single-cell and collective movement, structural and molecular tissue organization, and cell fate decisions.
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Interstitial compartments are organized into various 3D architectures, including fibrillar porous networks or aligned bundles, heterogeneous in density, topology, and stiffness.
“Interstitial compartments are organized into various 3D architectures, including fibrillar porous networks or aligned bundles, heterogeneous in density, topology, and stiffness [11,12].”
From Cancer-on-chip models for metastasis: importance of the tumor microenvironment (2024) · cites this paper as [11]
Engineered approaches account for controlled ECM architecture for studies of tumor growth and invasion.
“Engineered approaches account for controlled ECM architecture for studies of tumor growth and invasion [11].”
From Cancer-on-chip models for metastasis: importance of the tumor microenvironment (2024) · cites this paper as [11]
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Self-citationChen, Y., Liu, Z., Gong, P., Zhang, H., Chen, Y., Yao, S., Li, W., Zhang, Y., & Yu, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169041 · Cited by 25 · see citing works
- Authors
- van Helvert, S., Storm, C., & Friedl, P.
- Affiliations
- Eindhoven University of Technology (NL)
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Friedl, Peter
- Venue
- Nature Cell Biology
- Published
- 2017-12-21
- Volume
- 20
- Issue
- 1
- Pages
- 8-20
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- PMC
- PMC5943039
- OpenAlex
- W2775339123
- Cited by
- 587
- References
- 188
- Citations by year
- 2026: 31 · 2025: 69 · 2024: 61 · 2023: 77 · 2022: 83 · 2021: 85 · 2020: 88 · 2019: 62 · 2018: 29 · 2017: 1 · 2012: 1
- FWCI
- 5.74
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- TU/e Research Portal (submittedVersion)
- Funders
- Technische Universiteit Eindhoven
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (918.11.626)
- National Institutes of Health (CA210184)
- University of Texas MD Anderson Cancer Center
- National Cancer Institute (U54CA210184, P30CA016672)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Physical Sciences › Physics and Astronomy › Atomic and Molecular Physics, and Optics › Force Microscopy Techniques and Applications
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- cell migration, cell-tissue interactions, tissue mechanics, extracellular matrix stiffening, cell compression, protein unfolding, jamming transition, collective cell migration, single-cell migration, tissue organization, cell fate determination
- MeSH terms
- Animals, Biomechanical Phenomena, Bone and Bones, Brain, Cell Communication, Cell Differentiation, Cell Movement, Eukaryotic Cells, Extracellular Matrix, Humans, Organ Specificity, Tendons, Muscle, Skeletal, Mechanotransduction, Cellular, Proteolysis
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