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Expansion of Biological Pathways Based on Evolutionary Inference
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CCC shows close co-evolution with the WASH complex.
“the CCC complex shows close co-evolution with the WASH complex20,36”
From Endosomal PI(3)P regulation by the COMMD/CCDC22/CCDC93 (CCC) complex controls membrane protein recycling (2019) · cites this paper as [36]
In Results, under “Exploring the evolutionary modularity of 1025 canonical pathways and complexes” (page not provided), two genes, CCDC93 and CCDC22, score highly in the expansion of a WASH evolutionary module. That supports shared evolutionary history for those genes and WASH components, but the passage does not identify them as the CCC complex or establish close co-evolution of the complexes as wholes. (LLM, conf=0.84)
Experimental — accuracy not yet measuredCCC subunits co-evolved with the WASH complex.
“CCC subunits co-evolved with the WASH complex20,36”
From Endosomal PI(3)P regulation by the COMMD/CCDC22/CCDC93 (CCC) complex controls membrane protein recycling (2019) · cites this paper as [36]
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Metadata
- Authors
- Li, Y., Calvo, S. E., Gutman, R., Liu, J. S., & Mootha, V. K.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-07
- Volume
- 158
- Issue
- 1
- Pages
- 213-225
- ISSN
- 0092-8674
- PMC
- PMC4171950
- Cited by
- 122
- References
- 0
- Language
- en
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