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Organoid Cultures Derived from Patients with Advanced Prostate Cancer
Open accessAbstract
The lack of in vitro prostate cancer models that recapitulate the diversity of human prostate cancer has hampered progress in understanding disease pathogenesis and therapy response. Using a 3D organoid system, we report success in long-term culture of prostate cancer from biopsy specimens and circulating tumor cells. The first seven fully characterized organoid lines recapitulate the molecular diversity of prostate cancer subtypes, including TMPRSS2-ERG fusion, SPOP mutation, SPINK1 overexpression, and CHD1 loss. Whole-exome sequencing shows a low mutational burden, consistent with genomics studies, but with mutations in FOXA1 and PIK3R1, as well as in DNA repair and chromatin modifier pathways that have been reported in advanced disease. Loss of p53 and RB tumor suppressor pathway function are the most common feature shared across the organoid lines. The methodology described here should enable the generation of a large repertoire of patient-derived prostate cancer lines amenable to genetic and pharmacologic studies.
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“Tumor tissue, derived from either biopsies or surgical resections, is also typically processed akin to normal tissue to isolate tumour cells to grow as organoids16,49–51.”
From Organoids (2022) · cites this paper as [51]
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Cites
Fast and accurate short read alignment with Burrows-Wheeler transform
Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709
The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data
McKenna, A., Hanna, M., Banks, E., Sivachenko, A., Cibulskis, K., Kernytsky, A., Garimella, K., Altshuler, D., Gabriel, S., Daly, M., et al. (2010) · Genome Research · doi:10.1101/gr.107524.110 · Cited by 27,895
Cerami, E., Gao, J., Dogrusoz, U., Gross, B. E., Sumer, S. O., Aksoy, B. A., Jacobsen, A., Byrne, C. J., Heuer, M. L., Larsson, E., et al. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0095 · Cited by 17,455
Fast and accurate long-read alignment with Burrows-Wheeler transform.
Li, H., & Durbin, R. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp698 · Cited by 12,063
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
Barretina, J., Caponigro, G., Stransky, N., Venkatesan, K., Margolin, A. A., Kim, S., Wilson, C. J., Lehár, J., Kryukov, G. V., Sonkin, D., et al. (2012) · Nature · doi:10.1038/nature11003 · Cited by 7,950
Integrated genomic analyses of ovarian carcinoma
Perou, C. M. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/hvp3-wg08 · Cited by 7,927
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
Sato, T., Vries, R. G., Snippert, H. J., van de Wetering, M., Barker, N., Stange, D. E., van Es, J. H., Abo, A., Kujala, P., Peters, P. J., et al. (2009) · Nature · doi:10.1038/nature07935 · Cited by 7,204
Self-citationIncreased Survival with Enzalutamide in Prostate Cancer after Chemotherapy
Scher, H. I., Fizazi, K., Saad, F., Taplin, M.-E., Sternberg, C. N., Miller, K., de Wit, R., Mulders, P., Chi, K. N., Shore, N. D., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1207506 · Cited by 4,586
Self-citationAbiraterone and Increased Survival in Metastatic Prostate Cancer
de Bono, J. S., Logothetis, C. J., Molina, A., Fizazi, K., North, S., Chu, L., Chi, K. N., Jones, R. J., Goodman, O. B., Saad, F., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1014618 · Cited by 4,407 · cited 1×
“These include the next-generation antiandrogen enzalutamide and the androgen synthesis inhibitor abiraterone acetate, both of which have been shown to significantly prolong life (de Bono et al., 2011; Ryan et al., 2012; Scher et al., 2012).”
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Items 501–600 of 1,000
Patient-Derived In Vitro Models for Drug Discovery in Colorectal Carcinoma
Ramzy, G. M., Koessler, T., Ducrey, E., McKee, T., Ris, F., Buchs, N. C., Rubbia‐Brandt, L., Dietrich, P., & Nowak-Sliwinska, P. M. (2020) · Cancers · doi:10.3390/cancers12061423 · Cited by 45
Recent Discoveries in the Androgen Receptor Pathway in Castration-Resistant Prostate Cancer
Obinata, D., Lawrence, M. G., Takayama, K., Choo, N., Risbridger, G. P., Takahashi, S., & Inoue, S. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.581515 · Cited by 44
Prostate organoids: emerging experimental tools for translational research
Beshiri, M. L., Agarwal, S., Yin, J. J., & Kelly, K. (2023) · Journal of Clinical Investigation · doi:10.1172/jci169616 · Cited by 40
Breast cancer organoids derived from patients: A platform for tailored drug screening
Tzeng, Y. T., Hsiao, J., Tseng, L., Hou, M., & Li, C. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115803 · Cited by 45
van Loo, B., ten Den, S. A., Araújo‐Gomes, N., de Jong, V., Snabel, R. R., Schot, M., Rivera‐Arbeláez, J. M., Veenstra, G. J. C., Passier, R. C., Kamperman, T., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42297-0 · Cited by 44
Lawrence, M. G., Pook, D. W., Wang, H., Porter, L. H., Frydenberg, M., Kourambas, J., Appu, S., Poole, C., Beardsley, E. K., Ryan, A., et al. (2015) · The Prostate · doi:10.1002/pros.23039 · Cited by 41
OncoLoop: A Network-Based Precision Cancer Medicine Framework
Vasciaveo, A., Arriaga, J. M., de Almeida, F. N., Zou, M., Douglass, E. F., Picech, F., Shibata, M., Rodríguez-Calero, A., de Brot, S., Mitrofanova, A., et al. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-22-0342 · Cited by 38
Self-citationKe, X., Yan, R., Sun, Z., Cheng, Y., Meltzer, A., Lü, N., Shu, X., Wang, Z., Huang, B., Liu, X., et al. (2017) · Neoplasia · doi:10.1016/j.neo.2017.06.007 · Cited by 42
Translational potential of human brain organoids
Sun, A. X., Ng, H., & Tan, E. (2018) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.505 · Cited by 45
Vivarelli, S., Candido, S., Caruso, G., Falzone, L., & Libra, M. (2020) · Cancers · doi:10.3390/cancers12123636 · Cited by 41
Patient-Derived Cancer Organoids for Precision Oncology Treatment
Pernik, M. N., Bird, C. E., Traylor, J. I., Shi, D. D., Richardson, T. E., McBrayer, S. K., & Abdullah, K. G. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11050423 · Cited by 46
Genome engineering of stem cell organoids for disease modeling
Sun, Y., & Ding, Q. (2017) · Protein & Cell · doi:10.1007/s13238-016-0368-0 · Cited by 39
Somarelli, J. A., Roghani, R. S., Moghaddam, A. S., Thomas, B. C., Rupprecht, G., Ware, K. E., Altunel, E., Mantyh, J. B., Kim, S. Y., McCall, S. J., et al. (2020) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-20-0454 · Cited by 39
Three-dimensional culture models to study glioblastoma — current trends and future perspectives
Joseph, J. V., Blaavand, M. S., Daubon, T., Kruyt, F. A. E., & Thomsen, M. K. (2021) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2021.08.019 · Cited by 42
Lung cancer organoids, a promising model still with long way to go
Ma, H., Zhu, Y.-J., Zhou, R., Yu, Y., Xiao, Z., & Zhang, H.-B. (2022) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2022.103610 · Cited by 41
Human organoid systems in modeling reproductive tissue development, function, and disease
Haider, S., & Beristain, A. G. (2023) · Human Reproduction · doi:10.1093/humrep/dead085 · Cited by 39
Organoids: opportunities and challenges of cancer therapy
Jiang, X., Oyang, L., Qiu, P., Liu, Q., Xu, X., Wu, N., Tan, S., Yang, W., Han, Y., Lin, J., et al. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1232528 · Cited by 41
Hu, B., Wang, R., Wu, D., Long, R., Fan, J., Hu, Z., Hu, X., Ma, D., Li, F., Sun, C., et al. (2024) · Advanced Science · doi:10.1002/advs.202302340 · Cited by 38
Mpindi, J.-P., Potdar, S., Bychkov, D., Saarela, J., Saeed, K., Wennerberg, K., Aittokallio, T. A., Östling, P., & Kallioniemi, O. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btv455 · Cited by 39
Cultured circulating tumor cells and their derived xenografts for personalized oncology
Wang, R., Chu, G. C., Mrđenović, S., Annamalai, A., Hendifar, A. E., Nissen, N. N., Tomlinson, J. S., Lewis, M. S., Palanisamy, N., Tseng, H., et al. (2016) · Asian journal of urology · doi:10.1016/j.ajur.2016.08.005 · Cited by 39
Saito, Y., Nakaoka, T., Muramatsu, T., Ojima, H., Sukeda, A., Sugiyama, Y., Uchida, R., Furukawa, R., Kitahara, A., Sato, T., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-21121-6 · Cited by 40
Uchida, R., Saito, Y., Nogami, K., Kajiyama, Y., Suzuki, Y., Kawase, Y., Nakaoka, T., Muramatsu, T., Kimura, M., & Saito, H. (2018) · npj Aging and Mechanisms of Disease · doi:10.1038/s41514-018-0031-5 · Cited by 41
Breast cancer organoids from a patient with giant papillary carcinoma as a high-fidelity model
Li, X., Pan, B., Song, X., Li, N., Zhao, D., Li, M., & Zhao, Z. (2020) · Cancer Cell International · doi:10.1186/s12935-020-01171-5 · Cited by 39
3D organoids derived from the small intestine: An emerging tool for drug transport research
Zhang, Y., Huang, S., Zhong, W., Chen, W., Yao, B., & Wang, X. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.12.002 · Cited by 40
Patient-derived Tumour Organoids: A Bridge between Cancer Biology and Personalised Therapy
Wu, W., Li, X., & Yu, S. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.04.050 · Cited by 40
Enzalutamide Sensitizes Castration‐Resistant Prostate Cancer to Copper‐Mediated Cell Death
Gao, X., Zhao, H., Liu, J., Wang, M., Dai, Z., Hao, W., Wang, Y., Wang, X., Zhang, M., Liu, P., et al. (2024) · Advanced Science · doi:10.1002/advs.202401396 · Cited by 39
Wang, Y., Takeishi, K., Li, Z., Cervantes‐Alvarez, E., de l’Hortet, A. C., Guzman‐Lepe, J., Cui, X., & Zhu, J. (2017) · Organogenesis · doi:10.1080/15476278.2017.1322243 · Cited by 38
Microfluidic device for primary tumor spheroid isolation
Zhou, J., Su, J. L.-S., Fu, X., Zheng, L., & Yin, Z. (2017) · Experimental Hematology and Oncology · doi:10.1186/s40164-017-0084-3 · Cited by 38
Translation of combination nanodrugs into nanomedicines: lessons learned and future outlook
Mu, Q., Yu, J., McConnachie, L. A., Kraft, J. C., Gao, Y., Gulati, G. K., & Ho, R. J. Y. (2017) · Journal of drug targeting · doi:10.1080/1061186x.2017.1419363 · Cited by 39
Importance of Organoids for Personalized Medicine
Perkhofer, L., Frappart, P., Müller, M., & Kleger, A. (2018) · Personalized Medicine · doi:10.2217/pme-2018-0071 · Cited by 40
Zhang, X., Ju, S., Wang, X., & Cong, H. (2019) · Clinical and Experimental Medicine · doi:10.1007/s10238-019-00563-w · Cited by 38
Zhang, B., Ci, X., Tao, R., Ni, J. J., Xuan, X., King, J. L., Xia, S., Li, Y., Frierson, H. F., Lee, D.-K., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14737-8 · Cited by 41
Organoid models in gynaecological oncology research
Semertzidou, A., Brosens, J. J., McNeish, I. A., & Kyrgiou, M. (2020) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2020.102103 · Cited by 38
Lee, T. W., Lai, A., Harms, J. K., Singleton, D. C., Dickson, B. D., Macann, A., Hay, M. P., & Jamieson, S. M. F. (2020) · Cancers · doi:10.3390/cancers12123743 · Cited by 38
Smit, D. J., Pantel, K., & Jücker, M. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114589 · Cited by 38
Wang, Z., Li, Y., Zhao, W., Jiang, S., Huang, Y., Hou, J. W., Zhang, X., Zhai, Z., Chen, Y., Wang, J., et al. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01393-9 · Cited by 39
Self-citationA Versatile Microarray Platform for Capturing Rare Cells
Brinkmann, F., Hirtz, M., Haller, A., Gorges, T. M., Vellekoop, M., Riethdorf, S., Müller, V., Pantel, K., & Fuchs, H. (2015) · Scientific Reports · doi:10.1038/srep15342 · Cited by 37
Ecotropic viral integration site 1, a novel oncogene in prostate cancer
Queisser, A., Hagedorn, S., Wang, H., Schaefer, T., Konantz, M., Alavi, S., Deng, M., Vogel, W., von Mäßenhausen, A., Kristiansen, G., et al. (2016) · Oncogene · doi:10.1038/onc.2016.325 · Cited by 37
Mohan, S., Chemi, F., & Brady, G. (2017) · Translational Lung Cancer Research · doi:10.21037/tlcr.2017.06.04 · Cited by 36
A synopsis of prostate organoid methodologies, applications, and limitations
Gleave, A., Ci, X., Lin, D., & Wang, Y. Z. (2020) · The Prostate · doi:10.1002/pros.23966 · Cited by 37
Propagation of human prostate tissue from induced pluripotent stem cells
Hepburn, A. C., Curry, E. L., Moad, M., Steele, R. E., Franco, O. E., Wilson, L., Singh, P., Buskin, A., Crawford, S. E., Gaughan, L., et al. (2020) · Stem Cells Translational Medicine · doi:10.1002/sctm.19-0286 · Cited by 36
Dong, H., Han, L., Wu, Z.-S., Zhang, T., Xie, J., Ma, J., Wang, J., Li, T., Gao, Y., Shao, J., et al. (2017) · Chemistry of Materials · doi:10.1021/acs.chemmater.7b03044 · Cited by 36
Decoding the basis of histological variation in human cancer
Fujii, M., Sekine, S., & Sato, T. (2023) · Nature reviews. Cancer · doi:10.1038/s41568-023-00648-5 · Cited by 35
Organoid‐Guided Precision Medicine: From Bench to Bedside
Tao, B., Li, X., Hao, M., Tian, T., Li, Y., Li, X., Yang, C., Li, Q., Feng, Q., Zhou, H., et al. (2025) · MedComm · doi:10.1002/mco2.70195 · Cited by 38
Alberter, B., Klein, C. A., & Polzer, B. (2015) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.2016.1121099 · Cited by 36
Development and Application of Liquid Biopsies in Metastatic Prostate Cancer
Morrison, G. J., & Goldkorn, A. (2018) · Current Oncology Reports · doi:10.1007/s11912-018-0683-0 · Cited by 36
Organoids Provide an Important Window on Inflammation in Cancer
Baker, K. (2018) · Cancers · doi:10.3390/cancers10050151 · Cited by 37
Linxweiler, J., Hammer, M., Muhs, S., Kohn, M., Pryalukhin, A. E., Veith, C., Bohle, R. M., Stöckle, M., Junker, K., & Saar, M. (2018) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-018-2803-5 · Cited by 36
Dzobo, K., Rowe, A., Senthebane, D. A., AlMazyadi, M., Patten, V. A., & Parker, M. I. (2018) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2018.0172 · Cited by 37
UBTD1 is a mechano‐regulator controlling cancer aggressiveness
Torrino, S., Roustan, F., Kaminski, L., Bertero, T., Pisano, S., Ambrosetti, D., Dufies, M., Uhler, J. P., Lemichez, E., Mettouchi, A., et al. (2019) · EMBO Reports · doi:10.15252/embr.201846570 · Cited by 37
Organoids: Past Learning and Future Directions
O’Connell, L., & Winter, D. C. (2019) · Stem Cells and Development · doi:10.1089/scd.2019.0227 · Cited by 39
Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer
Che, M., Chaturvedi, A. P., Munro, S. A., Pitzen, S. P., Ling, A. L., Zhang, W., Mentzer, J., Ku, S., Puca, L., Zhu, Y., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26612-1 · Cited by 37
Self-citationDecellularized normal and cancer tissues as tools for cancer research
Gentilin, E., D’Angelo, E., Agostini, M., & Astolfi, L. (2021) · Cancer Gene Therapy · doi:10.1038/s41417-021-00398-2 · Cited by 37
Mutant p53 elicits context-dependent pro-tumorigenic phenotypes
McCann, J. J., Vasilevskaya, I. A., McNair, C. M., Gallagher, P., Neupane, N. P., de Leeuw, R., Shafi, A. A., Dylgjeri, E., Mandigo, A. C., Schiewer, M. J., et al. (2021) · Oncogene · doi:10.1038/s41388-021-01903-5 · Cited by 40
Patient-derived cancer models: Valuable platforms for anticancer drug testing
Genta, S., Coburn, B. A., Cescon, D. W., & Spreafico, A. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.976065 · Cited by 39
Application of three-dimensional (3D) bioprinting in anti-cancer therapy
Wu, B., Wu, Z. Q., Hou, Y.-Y., Fang, Z.-X., Deng, Y., Wu, H.-T., & Liu, J. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e20475 · Cited by 38
Notch signaling in prostate cancer: refining a therapeutic opportunity.
Su, Q., & Xin, L. (2016) · PubMed · doi:10.14670/hh-11-685 · Cited by 36
Circulating tumor stem like cells in oral squamous cell carcinoma: An unresolved paradox
Patel, S., Shah, K., Mirza, S., Shah, K., & Rawal, R. (2016) · Oral Oncology · doi:10.1016/j.oraloncology.2016.10.019 · Cited by 36
Wang, Z., Hu, L., Salari, K., Bechis, S. K., Ge, R., Wu, S., Rassoulian, C., Pham, J., Wu, C., Tabatabaei, S., et al. (2017) · The Journal of Pathology · doi:10.1002/path.4985 · Cited by 37
Saeed, K., Ojamies, P., Pellinen, T. S., Eldfors, S., Turkki, R., Lundin, J. E., Järvinen, P., Nísen, H., Taari, K., af Hällström, T. M., et al. (2018) · International Journal of Cancer · doi:10.1002/ijc.31815 · Cited by 41
Tao, M., & Wu, X. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-02139-7 · Cited by 35
Croglio, M. P., Haake, J. M., Ryan, C. P., Wang, V. S., Lapier, J., Schlarbaum, J. P., Dayani, Y., Artuso, E., Prandi, C., Koltai, H., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.7414 · Cited by 35
Self-citationMosaad, E. M. O., Chambers, K., Futrega, K., Clements, J. A., & Doran, M. R. (2018) · BMC Cancer · doi:10.1186/s12885-018-4473-8 · Cited by 35
Multi-Cell Type Glioblastoma Tumor Spheroids for Evaluating Sub-Population-Specific Drug Response
Sivakumar, H., Devarasetty, M., Kram, D. E., Strowd, R. E., III, & Skardal, A. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.538663 · Cited by 35
Patient-derived tumour models for personalized therapeutics in urological cancers
van de Merbel, A. F., van der Horst, G., & van der Pluijm, G. (2020) · Nature Reviews Urology · doi:10.1038/s41585-020-00389-2 · Cited by 35
Circulating Tumor Cells: Technologies and Their Clinical Potential in Cancer Metastasis
Xiao, J., Pohlmann, P. R., Isaacs, C. J., Weinberg, B. A., He, A. R., Schlegel, R., & Agarwal, S. (2021) · Biomedicines · doi:10.3390/biomedicines9091111 · Cited by 36
Regenerative Engineering: Current Applications and Future Perspectives
Goldenberg, D., McLaughlin, C., Koduru, S. V., & Ravnic, D. J. (2021) · Frontiers in Surgery · doi:10.3389/fsurg.2021.731031 · Cited by 37
ETS factors in prostate cancer
Qian, C., Li, D., & Chen, Y. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.01.009 · Cited by 39
Self-citationProstate luminal progenitor cells: from mouse to human, from health to disease
Baurès, M., Dariane, C., Tika, E., Lombardi, E. P., Delongchamps, N. B., Blanpain, C., Guidotti, J., & Goffin, V. (2022) · Nature Reviews Urology · doi:10.1038/s41585-021-00561-2 · Cited by 38
High-grade serous ovarian carcinoma organoids as models of chromosomal instability
Vias, M., Gavarró, L. M., Sauer, C. M., Sanders, D. A., Piskorz, A., Couturier, D., Ballereau, S. J., Hernando, B., Schneider, M. P., Hall, J. A. M., et al. (2023) · eLife · doi:10.7554/elife.83867 · Cited by 35
Circulating tumor cell-derived preclinical models: current status and future perspectives
Kahounová, Z., Pícková, M., Drápela, S., Bouchal, J., Szczyrbová, E., Navrátil, J., & Souček, K. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06059-6 · Cited by 37
Prostate cancer organoids: a potential new tool for testing drug sensitivity
Vela, I., & Chen, Y. (2015) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.2015.1003046 · Cited by 35
Self-citationApplication status and optimization suggestions of tumor organoids and CAR-T cell co-culture models
Ning, R.-X., Liu, C.-Y., Wang, S., Li, W.-K., Kong, X., & He, Z. (2024) · Cancer Cell International · doi:10.1186/s12935-024-03272-x · Cited by 35
Human-cell-derived organoids as a new ex vivo model for drug assays in oncology
Mebarki, M., Griscelli, A. B., & Bonhomme‐Faivre, L. (2018) · Drug Discovery Today · doi:10.1016/j.drudis.2018.02.003 · Cited by 34
Three-dimensional tumor cell cultures employed in virotherapy research
Kloker, L. D., Yurttas, C., & Lauer, U. M. (2018) · Oncolytic Virotherapy · doi:10.2147/ov.s165479 · Cited by 34
Galectins in prostate and bladder cancer: tumorigenic roles and clinical opportunities
Martínez‐Bosch, N., Rodríguez‐Vida, A., Juanpere-Rodero, N., Lloreta, J., Rovira, A., Albanell, J., Joaquim Bellmunt, B., & Navarro, P. (2019) · Nature Reviews Urology · doi:10.1038/s41585-019-0183-5 · Cited by 34
Linden, C. V., & Corbet, C. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.05.016 · Cited by 34
Knowing what’s growing: Why ductal and intraductal prostate cancer matter
Lawrence, M. G., Porter, L. H., Clouston, D. R., Murphy, D. G., Frydenberg, M., Taylor, R. A., & Risbridger, G. P. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aaz0152 · Cited by 34
The Organoid Era Permits the Development of New Applications to Study Glioblastoma
Andreatta, F., Beccaceci, G., Fortuna, N., Celotti, M., Felice, D. D., Lorenzoni, M., Foletto, V., Genovesi, S., Rubert, J., & Alaimo, A. (2020) · Cancers · doi:10.3390/cancers12113303 · Cited by 36
G3BP1 inhibits Cul3SPOP to amplify AR signaling and promote prostate cancer
Mukhopadhyay, C., Yang, C., Xu, L., Liu, D., Wang, Y., Huang, D., Deonarine, L. D., Cyrta, J., Davicioni, E., Sboner, A., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-27024-x · Cited by 35
Self-citationPrecision or Personalized Medicine for Cancer Chemotherapy: Is there a Role for Herbal Medicine
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Self-citationRodenhizer, D., Dean, T., Xu, B., Cojocari, D., & McGuigan, A. P. (2018) · Nature Protocols · doi:10.1038/s41596-018-0022-9 · Cited by 35
Parker, R. N., Cairns, D. M., Wu, W. A., Jordan, K. E., Guo, C., Huang, W., Martín‐Moldes, Z., & Kaplan, D. L. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.202000266 · Cited by 33
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Chowdhury, T., Cressiot, B., Parisi, C., Smolyakov, G., Thiébot, B., Trichet, L., Fernandes, F. M., Pelta, J., & Manivet, P. (2023) · ACS Sensors · doi:10.1021/acssensors.2c02308 · Cited by 34
Rhee, H., Ng, K. L., Tse, B. W.-C., Yeh, M.-C., Russell, P. J., Nelson, C. C., Thomas, P. A., Samaratunga, H., Vela, I., Gobe, G. C., et al. (2016) · Pathology · doi:10.1016/j.pathol.2016.05.011 · Cited by 33
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Anselmino, N., Labanca, E., Shepherd, P. D. A., Dong, J., Yang, J., Song, X., Nandakumar, S., Kundra, R., Lee, C. J., Schultz, N. D., et al. (2024) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-2438 · Cited by 33
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Dong, H., Han, L., Wang, J., Xie, J., Gao, Y., Xie, F., & Jia, L. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.05.004 · Cited by 32
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Mao, N., Zhang, Z., Lee, Y. S., Choi, D., Rivera, A. C. A., Li, D., Lee, C., Haywood, S., Chen, X., Chang, Q., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25341-9 · Cited by 33
Self-citation
Metadata
- Authors
- Gao, D., Vela, I., Sboner, A., Iaquinta, P. J., Karthaus, W. R., Gopalan, A., Dowling, C., Wanjala, J. N., Undvall, E. A., Arora, V. K., Wongvipat, J., Kossai, M., Ramazanoglu, S., Barboza, L. P., Di, W., Cao, Z., Zhang, Q. F., Sirota, I., Ran, L., MacDonald, T. Y., Beltran, H., Mosquera, J.-M., Touijer, K. A., Scardino, P. T., Laudone, V. P., Curtis, K. R., Rathkopf, D. E., Morris, M. J., Danila, D. C., Slovin, S. F., Solomon, S. B., Eastham, J. A., Chi, P., Carver, B., Rubin, M. A., Scher, H. I., Clevers, H., Sawyers, C. L., & Chen, Y.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- NewYork–Presbyterian Hospital (US)
- Royal Netherlands Academy of Arts and Sciences (NL)
- Corresponding author
- Sawyers, Charles L.
- Chen, Yu
- ORCID
- Gao, Dong
- Vela, Ian
- Sboner, Andrea
- Karthaus, Wouter R.
- Gopalan, Anuradha
- Dowling, Catherine
- Arora, Vivek K.
- Di, Wei
- Cao, Zhen
- Sirota, Inna
- Ran, Leili
- Beltran, Himisha
- Scardino, Peter T.
- Laudone, Vincent P.
- Rathkopf, Dana E.
- Morris, Michael J.
- Danila, Daniel C.
- Slovin, Susan F.
- Solomon, Stephen B.
- Chi, Ping
- Carver, Brett
- Rubin, Mark A.
- Scher, Howard I.
- Clevers, Hans
- Sawyers, Charles L.
- Chen, Yu
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 159
- Issue
- 1
- Pages
- 176-187
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC4237931
- OpenAlex
- W2059586354
- Cited by
- 1,559
- References
- 50
- Citations by year
- 2026: 110 · 2025: 117 · 2024: 138 · 2023: 145 · 2022: 155 · 2021: 172 · 2020: 180 · 2019: 131 · 2018: 131 · 2017: 120 · 2016: 87 · 2015: 67 · 2014: 5
- FWCI
- 73.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- KNAW research portal (Royal Academy of Art and Sciences (KNAW)) (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- QUT ePrints (Queensland University of Technology) (submittedVersion)
- NSUWorks (Nova Southeastern University) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion)
- Funders
- U.S. Department of Defense (W81XWH, W81XWH1010197)
- American Association for Cancer Research (SU2C-AACR-DT0712)
- Prostate Cancer Foundation (SU2C-AACR-DT0712)
- Memorial Sloan-Kettering Cancer Center (P50CA092629)
- Movember Foundation
- National Institutes of Health (W81XWH, UL1TR000457)
- Stand Up To Cancer (SU2C-AACR-DT0712)
- National Cancer Institute (R01CA182503, K08CA151660, R01CA116337, CA155169-01A1, K08CA140946, R01CA155169, P30CA008748, P50CA092629, R01CA193837)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- prostate cancer, organoids, circulating tumor cells, 3D organoid culture, TMPRSS2-ERG fusion, SPOP mutations, FOXA1, PIK3R1, DNA repair mutations, p53 deficiency, mutational burden, advanced prostate cancer
- MeSH terms
- Humans, Male, Neoplasm Metastasis, Organoids, Pharmacology, Prostatic Neoplasms, Tumor Suppressor Proteins, Culture Techniques, Heterografts
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