Clevers, Hans

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

Sato, T., Vries, R. G., Snippert, H. J., van de Wetering, M., Barker, N., Stange, D. E., van Es, J. H., Abo, A., Kujala, P., Peters, P. J., et al. (2009) · Nature

Cancer Cells and MetastasisWnt/β-catenin signaling in development and cancer

Cited by 7,204

Identification of stem cells in small intestine and colon by marker gene Lgr5

Barker, N., van Es, J. H., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Haegebarth, A., Korving, J., Begthel, H., Peters, P. J., et al. (2007) · Nature

Wnt/β-catenin signaling in development and cancerCancer Cells and Metastasis

Cited by 5,687

Wnt/β-Catenin Signaling in Development and Disease

Clevers, H. (2006) · Cell

Wnt/β-catenin signaling in development and cancerDevelopmental Biology and Gene Regulation

Cited by 5,568

Wnt/β-catenin signaling and disease

Clevers, H., & Nusse, R. (2012) · Cell

Wnt/β-catenin signaling in development and cancerSignaling Pathways in Disease

Cited by 5,554

Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities

Nusse, R., & Clevers, H. (2017) · Cell

Wnt/β-catenin signaling in development and cancerHedgehog Signaling Pathway Studies

Cited by 4,342

Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett’s epithelium

Sato, T., Stange, D. E., Ferrante, M., Vries, R. G. J., van Es, J. H., van den Brink, S., van Houdt, W. J., Pronk, A., van Gorp, J., Siersema, P. D., et al. (2011) · Gastroenterology

Cancer Cells and MetastasisWnt/β-catenin signaling in development and cancer

Cited by 3,753

Wnt signalling in stem cells and cancer

Reya, T., & Clevers, H. (2005) · Nature

Wnt/β-catenin signaling in development and cancerCancer Cells and Metastasis

Cited by 3,666

Modeling Development and Disease with Organoids

Clevers, H. (2016) · Cell

Pluripotent Stem Cells Research3D Printing in Biomedical Research

Cited by 3,196

Cancer stem cells revisited

Batlle, E., & Clevers, H. (2017) · Nature Medicine

Cancer Cells and MetastasisMesenchymal stem cell research

Cited by 2,769

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

Öhlund, D., Handly-Santana, A., Biffi, G., Elyada, E., Almeida, A. S., Ponz-Sarvise, M., Corbo, V., Oni, T. E., Hearn, S. A., Lee, E. J., et al. (2017) · Journal of Experimental Medicine

Pancreatic and Hepatic Oncology ResearchPancreatitis Pathology and Treatment

Cited by 2,590

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

Sato, T., van Es, J. H., Snippert, H. J., Stange, D. E., Vries, R. G., van den Born, M., Barker, N., Shroyer, N. F., van de Wetering, M., & Clevers, H. (2011) · Nature

Wnt/β-catenin signaling in development and cancerDigestive system and related health

Cited by 2,510

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

van de Wetering, M., Francies, H. E., Francis, J. M., Bounova, G., Iorio, F., Pronk, A., van Houdt, W., van Gorp, J., Taylor-Weiner, A., Kester, L., et al. (2015) · Cell

Cancer Cells and MetastasisColorectal Cancer Treatments and Studies

Cited by 2,408

The human cell atlas

Regev, A., Teichmann, S. A., Lander, E. S., Amit, I., Benoist, C., Birney, E., Bodenmiller, B., Campbell, P., Carninci, P., Clatworthy, M., et al. (2017) · eLife

Single-cell and spatial transcriptomicsGene Regulatory Network Analysis

Cited by 2,232

Organoid models of human and mouse ductal pancreatic cancer

Boj, S. F., Hwang, C.-I., Baker, L. A., Chio, I. I. C., Engle, D. D., Corbo, V., Jager, M., Ponz-Sarvise, M., Tiriac, H., Spector, M. S., et al. (2015) · Cell

Pancreatic and Hepatic Oncology ResearchCancer Cells and Metastasis

Cited by 2,150

The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells

van de Wetering, M., Sancho, E., Verweij, C., de Lau, W., Oving, I., Hurlstone, A., van der Horn, K., Batlle, E., Coudreuse, D., Haramis, A.-P., et al. (2002) · Cell

Wnt/β-catenin signaling in development and cancerGenetic factors in colorectal cancer

Cited by 2,030

A living biobank of breast cancer organoids captures disease heterogeneity

Sachs, N., de Ligt, J., Kopper, O., Gogola, E., Bounova, G., Weeber, F., Balgobind, A. V., Wind, K., Gracanin, A., Begthel, H., et al. (2018) · Cell

Cancer Cells and MetastasisBreast Cancer Treatment Studies

Cited by 1,973

Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells

Snippert, H. J., van der Flier, L. G., Sato, T., van Es, J. H., van den Born, M., Kroon-Veenboer, C., Barker, N., Klein, A. M., van Rheenen, J., Simons, B. D., et al. (2010) · Cell

Developmental Biology and Gene RegulationCancer Cells and Metastasis

Cited by 1,951

XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos

Molenaar, M., van de Wetering, M., Oosterwegel, M., Peterson-Maduro, J., Godsave, S., Korinek, V., Roose, J., Destrée, O., & Clevers, H. (1996) · Cell

Wnt/β-catenin signaling in development and cancerDevelopmental Biology and Gene Regulation

Cited by 1,824

Organoids in cancer research

Drost, J., & Clevers, H. (2018) · Nature Reviews Cancer

Cancer Cells and Metastasis3D Printing in Biomedical Research

Cited by 1,790

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

Huch, M., Gehart, H., van Boxtel, R., Hamer, K., Blokzijl, F., Verstegen, M. M. A., Ellis, E., van Wenum, M., Fuchs, S. A., de Ligt, J., et al. (2015) · Cell

Liver physiology and pathologyTissue Engineering and Regenerative Medicine

Cited by 1,619

SARS-CoV-2 productively infects human gut enterocytes

Lamers, M. M., Beumer, J., van der Vaart, J., Knoops, K., Puschhof, J., Breugem, T. I., Ravelli, R. B. G., Paul van Schayck, J., Mykytyn, A. Z., Duimel, H. Q., et al. (2020) · Science

SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studies

Cited by 1,573

Organoid Cultures Derived from Patients with Advanced Prostate Cancer

Gao, D., Vela, I., Sboner, A., Iaquinta, P. J., Karthaus, W. R., Gopalan, A., Dowling, C., Wanjala, J. N., Undvall, E. A., Arora, V. K., et al. (2014) · Cell

Prostate Cancer Treatment and ResearchCancer Genomics and Diagnostics

Cited by 1,559

Canonical wnt signaling in differentiated osteoblasts controls osteoclast differentiation.

Glass, D. A., Bialek, P., Ahn, J. D., Starbuck, M., Patel, M. S., Clevers, H., Taketo, M. M., Long, F., McMahon, A. P., Lang, R. A., et al. (2005) · Developmental Cell

Bone Metabolism and DiseasesWnt/β-catenin signaling in development and cancer

Cited by 1,558

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

Huch, M., Dorrell, C., Boj, S. F., van Es, J. H., Li, V. S. W., van de Wetering, M., Sato, T., Hamer, K., Sasaki, N., Finegold, M. J., et al. (2013) · Nature

Liver physiology and pathologyWnt/β-catenin signaling in development and cancer

Cited by 1,555