The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
ANGPTL8/Betatrophin Does Not Control Pancreatic Beta Cell Expansion
Open accessAbstract
Recently, it was reported that angiopoietin-like protein 8 (ANGPTL8) was the long-sought "betatrophin" that could control pancreatic beta cell proliferation. However, studies of Angptl8(?/?) mice revealed profound reduction of triglyceride levels, but no abnormalities in glucose homeostasis. We now report that Angptl8(?/?) mice undergo entirely normal beta cell expansion in response to insulin resistance resulting from either a high-fat diet or from the administration of the insulin receptor antagonist S961. Furthermore, overexpression of ANGPTL8 in livers of mice doubles plasma triglyceride levels, but does not alter beta cell expansion nor glucose metabolism. These data indicate that ANGPTL8 does not play a role in controlling beta cell growth, nor can it be given to induce such expansion. The findings that plasma triglyceride levels are reduced by Angptl8 deletion and increased following ANGPTL8 overexpression support the possibility that inhibition of ANGPTL8 represents a therapeutic strategy for hypertriglyceridemia.
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“Subsequent studies, however, did not reveal impairments in glucose homeostasis179 or β-cell expansion in Angptl8 knockout mice.180”
From Pancreatic regulation of glucose homeostasis. (2016) · cites this paper as [180]
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1 retracted
RETRACTED: Betatrophin: A Hormone that Controls Pancreatic β Cell Proliferation
Yi, P., Park, J.-S., & Melton, D. A. (2013) · Cell · doi:10.1016/j.cell.2013.04.008 · Cited by 449
Retractedβ-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes
Butler, A. E., Janson, J., Bonner-Weir, S., Ritzel, R., Rizza, R. A., & Butler, P. C. (2003) · Diabetes · doi:10.2337/diabetes.52.1.102 · Cited by 4,011
Self-citationAdult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
Dor, Y., Brown, J., Martinez, O. I., & Melton, D. A. (2004) · Nature · doi:10.1038/nature02520 · Cited by 2,219
U.K. Prospective Diabetes Study Group (1995) · Diabetes · doi:10.2337/diab.44.11.1249 · Cited by 1,923
Michael, M. D., Kulkarni, R. N., Postic, C., Previs, S. F., Shulman, G. I., Magnuson, M. A., & Kahn, C. R. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00015-8 · Cited by 1,296
Selective β-Cell Loss and α-Cell Expansion in Patients with Type 2 Diabetes Mellitus in Korea
Yoon, K., Ko, S., Cho, J., Lee, J. M., Ahn, Y., Song, K. H., Yoo, S. J., Kang, M. I., Cha, B. Y., Lee, K. W., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020735 · Cited by 651
Self-citationCompensatory Growth of Pancreatic β-Cells in Adult Rats After Short-Term Glucose Infusion
Bonner‐Weir, S., Deery, D. J., Leahy, J. L., & Weir, G. C. (1989) · Diabetes · doi:10.2337/diab.38.1.49 · Cited by 444
Self-citationAtypical angiopoietin-like protein that regulates ANGPTL3
Quagliarini, F., Wang, Y., Kozlitina, J., Grishin, N. V., Hyde, R., Boerwinkle, E., Valenzuela, D. M., Murphy, A. J., Cohen, J. C., & Hobbs, H. H. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217552109 · Cited by 409
Self-citationTerauchi, Y., Takamoto, I., Kubota, N., Matsui, J., Suzuki, R., Komeda, K., Hara, A., Toyoda, Y., Miwa, I., Aizawa, S., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci17645 · Cited by 327
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Items 201–202 of 202
Isoastragaloside I improves hyperglycaemia and increases β‐cell mass in mice
Pan, A. G., Wu, H., Wang, Q., Zhang, S., Chen, Y., Zhang, T., Liu, M., & Teng, C. (2025) · Diabetic Medicine · doi:10.1111/dme.70162
Metadata
- Authors
- Gusarova, V., Alexa, C. A., Na, E., Stevis, P. E., Xin, Y., Bonner-Weir, S., Cohen, J. C., Hobbs, H. H., Murphy, A. J., Yancopoulos, G. D., & Gromada, J.
- Affiliations
- Regeneron (United States) (US)
- The University of Texas Southwestern Medical Center (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Gusarova, Viktoria
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-10
- Volume
- 159
- Issue
- 3
- Pages
- 691-696
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC4243040
- OpenAlex
- W1971926341
- Cited by
- 202
- References
- 23
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 6 · 2023: 4 · 2022: 15 · 2021: 16 · 2020: 12 · 2019: 18 · 2018: 25 · 2017: 27 · 2016: 40 · 2015: 30 · 2014: 4
- FWCI
- 33.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (P01 HL-20948, P01HL020948)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- ANGPTL8, betatrophin, beta-cell proliferation, insulin resistance, hypertriglyceridemia, plasma triglycerides, glucose homeostasis, high-fat diet, insulin receptor antagonist
- MeSH terms
- Angiopoietin-like Proteins, Angiopoietin-Like Protein 8, Animals, Insulin Resistance, Male, Mice, Inbred C57BL, Triglycerides, Angiopoietins, Insulin-Secreting Cells, Mice, Diet, High-Fat
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