Generation of Functional Human Pancreatic β Cells In Vitro

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Items 501–600 of 1,004

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6. Macroencapsulated Human iPSC-Derived Pancreatic Progenitors Protect against STZ-Induced Hyperglycemia in Mice
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9. Role of microRNA-21 in the formation of insulin-producing cells from pancreatic progenitor cells
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10. Current status and future of clinical islet xenotransplantation
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11. Redefining definitive endoderm subtypes by robust induction of human induced pluripotent stem cells
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12. Mesenchymal stem cells and differentiated insulin producing cells are new horizons for pancreatic regeneration in type I diabetes mellitus
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13. Stem cells as a potential therapy for diabetes mellitus: a call-to-action in Latin America
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14. Modeling different types of diabetes using human pluripotent stem cells
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15. Determinants and dynamics of pancreatic islet architecture
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16. Pancreas transplant alone
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17. Size effect of engineered islets prepared using microfabricated wells on islet cell function and arrangement
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18. Differentiation of human pluripotent stem cells into two distinct NKX6.1 populations of pancreatic progenitors
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19. Single-cell transcriptomics reveal that PD-1 mediates immune tolerance by regulating proliferation of regulatory T cells
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20. Pancreatic Stellate Cells: A Rising Translational Physiology Star as a Potential Stem Cell Type for Beta Cell Neogenesis
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21. Rapid Irreversible Transcriptional Reprogramming in Human Stem Cells Accompanied by Discordance between Replication Timing and Chromatin Compartment
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22. Mimicking nature-made beta cells: recent advances towards stem cell-derived islets
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23. New trends in cellular therapy
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24. Analysis of the behavior of 2D monolayers and 3D spheroid human pancreatic beta cells derived from induced pluripotent stem cells in a microfluidic environment
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25. Development of a scalable method to isolate subsets of stem cell-derived pancreatic islet cells
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26. Recent Advances in Cell Replacement Therapies for the Treatment of Type 1 Diabetes
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27. Enzymatically degradable poly(ethylene glycol) hydrogels for the 3D culture and release of human embryonic stem cell derived pancreatic precursor cell aggregates
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28. Concise Review: The Potential Use of Intestinal Stem Cells to Treat Patients with Intestinal Failure
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29. Steroid Hormones and the Physiological Regulation of Tissue-Resident Stem Cells: Lessons from the Drosophila Ovary
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30. An engineered macroencapsulation membrane releasing FTY720 to precondition pancreatic islet transplantation
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31. MicroRNAs can effectively induce formation of insulin-producing cells from mesenchymal stem cells
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32. A high-content small molecule screen identifies novel inducers of definitive endoderm
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33. Small molecule-induced cellular conversion
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34. Cellular models for beta‐cell function and diabetes gene therapy
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35. Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling
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36. Diabetes through a 3D lens: organoid models
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37. Recent advances in the design of implantable insulin secreting heterocellular islet organoids.
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38. Using single-nucleus RNA-sequencing to interrogate transcriptomic profiles of archived human pancreatic islets
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39. Restoring normal islet mass and function in type 1 diabetes through regenerative medicine and tissue engineering
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40. A Century-long Journey From the Discovery of Insulin to the Implantation of Stem Cell–derived Islets
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41. Three‐dimensional pancreas organogenesis models
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42. Pancreatic β-Cell Development and Regeneration
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43. The Current Status of Allogenic Islet Cell Transplantation
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44. Current issues in allogeneic islet transplantation
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45. Localized Immunosuppression With Tannic Acid Encapsulation Delays Islet Allograft and Autoimmune-Mediated Rejection
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46. SUR1-mutant iPS cell-derived islets recapitulate the pathophysiology of congenital hyperinsulinism
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47. Regenerative Engineering: Current Applications and Future Perspectives
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48. First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes—Chapter 6: patient selection for pilot clinical trials of islet xenotransplantation
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49. Reprogramming of Pancreatic Exocrine Cells AR42J Into Insulin-producing Cells Using mRNAs for Pdx1, Ngn3, and MafA Transcription Factors
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50. Genetic Engineering of Immune Evasive Stem Cell-Derived Islets
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51. Chromatin Regulators in Pancreas Development and Diabetes
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52. Wnt signaling in stem cells during development and cell lineage specification
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53. Pancreatic β-cell heterogeneity in adult human islets and stem cell-derived islets
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54. Implication of epigenetics in pancreas development and disease
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55. Pluripotent stem cells as a model for embryonic patterning: From signaling dynamics to spatial organization in a dish
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56. Closed-channel culture system for efficient and reproducible differentiation of human pluripotent stem cells into islet cells
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57. Thyroid Hormone Coordinates Pancreatic Islet Maturation During the Zebrafish Larval-to-Juvenile Transition to Maintain Glucose Homeostasis
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58. Generation of iPSC-derived insulin-producing cells from patients with type 1 and type 2 diabetes compared with healthy control
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59. Inducible Pluripotent Stem Cells as a Potential Cure for Diabetes
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60. Using hESCs to Probe the Interaction of the Diabetes-Associated Genes CDKAL1 and MT1E
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61. Wnt Pathway in Pancreatic Development and Pathophysiology
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62. Long-term in vitro expansion of a human fetal pancreas stem cell that generates all three pancreatic cell lineages
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66. Identification of a small molecule that facilitates the differentiation of human iPSCs/ESCs and mouse embryonic pancreatic explants into pancreatic endocrine cells
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67. Harnessing CXCL12 signaling to protect and preserve functional β-cell mass and for cell replacement in type 1 diabetes
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68. Stem Cells, Self-Renewal, and Lineage Commitment in the Endocrine System
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69. The Role of Epigenetics in Type 1 Diabetes
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70. From Disease and Patient Heterogeneity to Precision Medicine in Type 1 Diabetes
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71. Cell-Penetrating Peptide as a Means of Directing the Differentiation of Induced-Pluripotent Stem Cells
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72. Insulin‐producing cells derived from ‘induced pluripotent stem cells’ of patients with fulminant type 1 diabetes: Vulnerability to cytokine insults and increased expression of apoptosis‐related genes
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75. Development of the endocrine pancreas and novel strategies for β-cell mass restoration and diabetes therapy
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77. The Human Endocrine Pancreas: New Insights on Replacement and Regeneration
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78. An arduous journey from human pluripotent stem cells to functional pancreatic β cells
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79. Prioritising Causal Genes at Type 2 Diabetes Risk Loci
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80. Single‐cell transcriptomic analyses reveal distinct dorsal/ventral pancreatic programs
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81. Pluripotent stem cell replacement approaches to treat type 1 diabetes
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82. Retinoic acid signaling within pancreatic endocrine progenitors regulates mouse and human β cell specification
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83. A Novel Subcutaneous Site of Islet Transplantation Superior to the Liver
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84. Hyperpolarized Multi-Metal 13C-Sensors for Magnetic Resonance Imaging
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85. Advances and challenges of the cell-based therapies among diabetic patients
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86. Embryonic macrophages support endocrine commitment during human pancreatic differentiation
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88. Diabetes and Stem Cell Function
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89. Mass production of functional human pancreatic β‐cells: why and how?
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90. An Integrated Miniature Bioprocessing for Personalized Human Induced Pluripotent Stem Cell Expansion and Differentiation into Neural Stem Cells
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91. Concise Review: Translating Regenerative Biology into Clinically Relevant Therapies: Are We on the Right Path?
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92. Postnatal Ontogenesis of the Islet Circadian Clock Plays a Contributory Role in β-Cell Maturation Process
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93. Human urine-derived stem cells play a novel role in the treatment of STZ-induced diabetic mice
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94. Microporous Polymer Scaffolds for the Transplantation of Embryonic Stem Cell Derived Pancreatic Progenitors to a Clinically Translatable Site for the Treatment of Type I Diabetes
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95. Cluster-assembled zirconia substrates promote long-term differentiation and functioning of human islets of Langerhans
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96. Engineering Strategies to Improve Islet Transplantation for Type 1 Diabetes Therapy
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98. Generation of Pancreatic Progenitors from Human Pluripotent Stem Cells by Small Molecules
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99. PTPN2 Regulates the Interferon Signaling and Endoplasmic Reticulum Stress Response in Pancreatic β-Cells in Autoimmune Diabetes
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100. Immune-Protective Formulations and Process Strategies for Improved Survival and Function of Transplanted Islets
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