Melton, Douglas A.

Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

Melton, D. A., Krieg, P. A., Rebagliati, M. R., Maniatis, T., Zinn, K., & Green, M. R. (1984) · Nucleic Acids Research

Molecular Biology Techniques and ApplicationsRNA and protein synthesis mechanisms

Cited by 6,324

Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells

Boyer, L. A., Lee, T. I., Cole, M. F., Johnstone, S. E., Levine, S. S., Zucker, J. P., Guenther, M. G., Kumar, R. M., Murray, H. L., Jenner, R. G., et al. (2005) · Cell

Pluripotent Stem Cells ResearchDevelopmental Biology and Gene Regulation

Cited by 4,505

Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation

Dor, Y., Brown, J., Martinez, O. I., & Melton, D. A. (2004) · Nature

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 2,219

Generation of Functional Human Pancreatic β Cells In Vitro

Pagliuca, F. W., Millman, J. R., Gürtler, M., Segel, M., Van Dervort, A., Ryu, J. H., Peterson, Q. P., Greiner, D., & Melton, D. A. (2014) · Cell

Pancreatic function and diabetesPluripotent Stem Cells Research

Cited by 2,025

In vivo reprogramming of adult pancreatic exocrine cells to β-cells

Zhou, Q., Brown, J., Kanarek, A., Rajagopal, J., & Melton, D. A. (2008) · Nature

Pancreatic function and diabetesPluripotent Stem Cells Research

Cited by 2,010

Functional messenger RNAs are produced by SP6 in vitro transcription of cloned cDNAs

Krieg, P. A., & Melton, D. A. (1984) · Nucleic Acids Research

RNA and protein synthesis mechanismsRNA Research and Splicing

Cited by 1,533

A Single-Cell Transcriptomic Map of the Human and Mouse Pancreas Reveals Inter- and Intra-cell Population Structure

Baron, M., Veres, A., Wolock, S. L., Faust, A. L., Gaujoux, R., Vetere, A., Ryu, J. H., Wagner, B. K., Shen-Orr, S. S., Klein, A. M., et al. (2016) · Cell Systems

Single-cell and spatial transcriptomicsPancreatic function and diabetes

Cited by 1,508

Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice

Vegas, A. J., Veiseh, O., Gürtler, M., Millman, J. R., Pagliuca, F. W., Bader, A. R., Doloff, J. C., Li, J., Chen, M., Olejnik, K., et al. (2016) · Nature Medicine

Pancreatic function and diabetesTissue Engineering and Regenerative Medicine

Cited by 710

Notochord repression of endodermal Sonic hedgehog permits pancreas development

Hebrok, M., Kim, S. K., & Melton, D. A. (1998) · Genes & Development

Hedgehog Signaling Pathway StudiesDevelopmental Biology and Gene Regulation

Cited by 628

Recovery from diabetes in mice by β cell regeneration

Nir, T., Melton, D. A., & Dor, Y. (2007) · Journal of Clinical Investigation

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 595

Identifying gene expression programs of cell-type identity and cellular activity with single-cell RNA-Seq

Kotliar, D., Veres, A., Nagy, M. A., Tabrizi, S., Hodis, E., Melton, D. A., & Sabeti, P. C. (2019) · eLife

Single-cell and spatial transcriptomicsGene expression and cancer classification

Cited by 563

Charting cellular identity during human in vitro β-cell differentiation

Veres, A., Faust, A. L., Bushnell, H. L., Engquist, E. N., Kenty, J. H.-R., Harb, G., Poh, Y.-C., Sintov, E., Gürtler, M., Pagliuca, F. W., et al. (2019) · Nature

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 552

RETRACTED: Betatrophin: A Hormone that Controls Pancreatic β Cell Proliferation

Yi, P., Park, J.-S., & Melton, D. A. (2013) · Cell

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 449

Regulation of pancreas development by hedgehog signaling

Hebrok, M., Kim, S. K., St-Jacques, B., McMahon, A. P., & Melton, D. A. (2000) · Development

Hedgehog Signaling Pathway StudiesPancreatic function and diabetes

Cited by 412

Notochord to endoderm signaling is required for pancreas development

Kim, S. K., Hebrok, M., & Melton, D. A. (1997) · Development

Developmental Biology and Gene RegulationPancreatic function and diabetes

Cited by 405

Early mouse endoderm is patterned by soluble factors from adjacent germ layers

Wells, J. M., & Melton, D. A. (2000) · Development

Developmental Biology and Gene RegulationPluripotent Stem Cells Research

Cited by 366

Generation of hypoimmunogenic human pluripotent stem cells

Han, X., Wang, M., Duan, S., Franco, P. J., Kenty, J. H.-R., Hedrick, P., Xia, Y., Allen, A., Ferreira, L. M. R., Strominger, J. L., et al. (2019) · Proceedings of the National Academy of Sciences

Pluripotent Stem Cells ResearchCRISPR and Genetic Engineering

Cited by 363

Differentiated human stem cells resemble fetal, not adult, β cells

Hrvatin, S., O’Donnell, C. W., Deng, F., Millman, J. R., Pagliuca, F. W., DiIorio, P., Rezania, A., Gifford, D. K., & Melton, D. A. (2014) · Proceedings of the National Academy of Sciences

Pancreatic function and diabetesPluripotent Stem Cells Research

Cited by 302

Global expression analysis of gene regulatory pathways during endocrine pancreatic development

Gu, G., Wells, J. M., Dombkowski, D., Preffer, F., Aronow, B., & Melton, D. A. (2004) · Development

Pancreatic function and diabetesDevelopmental Biology and Gene Regulation

Cited by 229

Artifactual Insulin Release From Differentiated Embryonic Stem Cells

Hansson, M., Tonning, A., Frandsen, U., Petri, A., Rajagopal, J., Englund, M. C. O., Heller, R. S., Håkansson, J., Fleckner, J., Sköld, H. N., et al. (2004) · Diabetes

Pancreatic function and diabetesPluripotent Stem Cells Research

Cited by 225

Activin receptor patterning of foregut organogenesis

Kim, S. K., Hebrok, M., Li, E., Oh, S. P., Schrewe, H., Harmon, E. B., Lee, J. S., & Melton, D. A. (2000) · Genes & Development

Developmental Biology and Gene RegulationPancreatic function and diabetes

Cited by 212

Transcriptional dynamics of endodermal organ formation

Sherwood, R. I., Chen, T. A., & Melton, D. A. (2009) · Developmental Dynamics

Developmental Biology and Gene RegulationPluripotent Stem Cells Research

Cited by 191

Circadian Entrainment Triggers Maturation of Human In Vitro Islets

Alvarez-Dominguez, J. R., Donaghey, J., Rasouli, N., Kenty, J. H. R., Helman, A., Charlton, J., Straubhaar, J. R., Meissner, A., & Melton, D. A. (2020) · Cell Stem Cell

Pancreatic function and diabetesPluripotent Stem Cells Research

Cited by 189

Alginate-microencapsulation of human stem cell–derived β cells with CXCL12 prolongs their survival and function in immunocompetent mice without systemic immunosuppression

Alagpulinsa, D. A., Cao, J. J. L., Driscoll, R. K., Sîrbulescu, R. F., Penson, M. F. E., Sremac, M., Engquist, E. N., Brauns, T. A., Markmann, J. F., Melton, D. A., et al. (2019) · American Journal of Transplantation

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 130