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Sequencing the Mouse Y Chromosome Reveals Convergent Gene Acquisition and Amplification on Both Sex Chromosomes
Open accessAbstract
Summary We sequenced the MSY (Male-Specific region of the Y chromosome) of the C57BL/6J strain of the laboratory mouse Mus musculus. In contrast to theories that Y chromosomes are heterochromatic and gene poor, the mouse MSY is 99.9% euchromatic and contains about 700 protein-coding genes. Only two percent of the MSY derives from the ancestral autosomes that gave rise to the mammalian sex chromosomes. Instead, all but 50 of the MSY's genes belong to three acquired, massively amplified gene families that have no homologs on primate MSYs, but do have acquired, amplified homologs on the mouse X chromosome. The complete mouse MSY sequence brings to light dramatic forces in sex chromosome evolution: lineage-specific convergent acquisition and amplification of X-Y gene families, possibly fueled by antagonism between acquired X-Y homologs. The mouse MSY sequence presents opportunities for experimental studies of a sex-specific chromosome in its entirety, in a genetically tractable model organism.
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An integrated encyclopedia of DNA elements in the human genome
The ENCODE Project Consortium (2012) · Nature · doi:10.1038/nature11247 · Cited by 18,072
Wang, H., Yang, H., Shivalila, C. S., Dawlaty, M. M., Cheng, A. W., Zhang, F., & Jaenisch, R. (2013) · Cell · doi:10.1016/j.cell.2013.04.025 · Cited by 3,495
Evolutionary Dynamics of Gene and Isoform Regulation in Mammalian Tissues
Merkin, J., Russell, C., Chen, P., & Burge, C. B. (2012) · Science · doi:10.1126/science.1228186 · Cited by 972
Cited by
Wright, A. E., Dean, R., Zimmer, F., & Mank, J. E. (2016) · Nature Communications · doi:10.1038/ncomms12087 · Cited by 285
Burgoyne, P. S., & Arnold, A. P. (2016) · Biology of Sex Differences · doi:10.1186/s13293-016-0115-5 · Cited by 154
Chang, C.-H., & Larracuente, A. M. (2019) · Genetics · doi:10.1534/genetics.118.301765 · Cited by 141
Metadata
- Authors
- Soh, Y. Q. S., Alföldi, J., Pyntikova, T., Brown, L. G., Graves, T., Minx, P. J., Fulton, R. S., Kremitzki, C., Koutseva, N., Mueller, J. L., Rozen, S., Hughes, J. F., Owens, E., Womack, J. E., Murphy, W. J., Cao, Q., de Jong, P., Warren, W. C., Wilson, R. K., Skaletsky, H., & Page, D. C.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 159
- Issue
- 4
- Pages
- 800-813
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2102283657
- Cited by
- 325
- References
- 3
- FWCI
- 15.26
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Soh, Y. Q. S., Alföldi, J., Pyntikova, T., Brown, L. G., Graves, T., Minx, P. J., Fulton, R. S., Kremitzki, C., Koutseva, N., Mueller, J. L., Rozen, S., Hughes, J. F., Owens, E., Womack, J. E., Murphy, W. J., Cao, Q., de Jong, P., Warren, W. C., Wilson, R. K., . . . Page, D. C. (2014). Sequencing the Mouse Y Chromosome Reveals Convergent Gene Acquisition and Amplification on Both Sex Chromosomes. Cell. https://doi.org/10.1016/j.cell.2014.09.052
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