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Acetate Is a Bioenergetic Substrate for Human Glioblastoma and Brain Metastases
Open accessAbstract
Glioblastomas and brain metastases are highly proliferative brain tumors with short survival times. Previously, using (13)C-NMR analysis of brain tumors resected from patients during infusion of (13)C-glucose, we demonstrated that there is robust oxidation of glucose in the citric acid cycle, yet glucose contributes less than 50% of the carbons to the acetyl-CoA pool. Here, we show that primary and metastatic mouse orthotopic brain tumors have the capacity to oxidize [1,2-(13)C]acetate and can do so while simultaneously oxidizing [1,6-(13)C]glucose. The tumors do not oxidize [U-(13)C]glutamine. In vivo oxidation of [1,2-(13)C]acetate was validated in brain tumor patients and was correlated with expression of acetyl-CoA synthetase enzyme 2, ACSS2. Together, the data demonstrate a strikingly common metabolic phenotype in diverse brain tumors that includes the ability to oxidize acetate in the citric acid cycle. This adaptation may be important for meeting the high biosynthetic and bioenergetic demands of malignant growth.
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“The relevance of acetate as a potential fuel source has also been observed in vivo: in glioblastoma tumors resected from patients, up to half of the intramitochondrial acetyl-CoA pool is derived from circulating acetate (70).”
From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [70]
In the citing paper
“Some cancer types, including liver and glioblastomas, readily take up acetate, which can be converted to acetyl-CoA by ACSS and undergo oxidation in the TCA cycle (70, 195).”
From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [70]
In the citing paper
“Finally, extracellular acetate has recently been shown to be utilized by some cancers as a source of acetyl-CoA for biosynthesis.”
From The emerging hallmarks of cancer metabolism (2016) · cites this paper as Mashimo et al., 2014
In the citing paper
“Specifically, a variety of tumor types localized to the brain, including primary glioblastomas as well as brain metastases that originated from other tissues, have been shown to assimilate exogenous acetate and incorporate acetate-derived carbons into de novo synthesized fatty acids (Comerford et al., 2014; Mashimo et al., 2014; Schug et al., 2015).”
From The emerging hallmarks of cancer metabolism (2016) · cites this paper as Mashimo et al., 2014
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The Somatic Genomic Landscape of Glioblastoma
Brennan, C. W., Verhaak, R. G. W., McKenna, A., Campos, B., Noushmehr, H., Salama, S. R., Zheng, S., Chakravarty, D., Sanborn, J. Z., Berman, S. H., et al. (2013) · Cell · doi:10.1016/j.cell.2013.09.034 · Cited by 5,016
The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism
Frost, G., Sleeth, M. L., Sahuri-Arisoylu, M., Lizarbe, B., Cerdan, S., Brody, L., Anastasovska, J., Ghourab, S., Hankir, M., Zhang, S., et al. (2014) · Nature Communications · doi:10.1038/ncomms4611 · Cited by 1,771
Serpins Promote Cancer Cell Survival and Vascular Co-Option in Brain Metastasis
Valiente, M., Obenauf, A. C., Jin, X., Chen, Q., Zhang, X. H.-F., Lee, D. J., Chaft, J. E., Kris, M. G., Huse, J. T., Brogi, E., et al. (2014) · Cell · doi:10.1016/j.cell.2014.01.040 · Cited by 895
Comerford, S. A., Huang, Z., Du, X., Wang, Y., Cai, L., Witkiewicz, A. K., Walters, H., Tantawy, M. N., Fu, A., Manning, H. C., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.020 · Cited by 681 · cited 5×
“The current work and that of Comerford et al. (2014) underscores the value of in vivo studies in cancermetabolism.”
InfluentialSelf-citationEpidermal growth factor receptor and Ink4a/Arf
Bachoo, R. M., Maher, E. A., Ligon, K. L., Sharpless, N. E., Chan, S., You, M. J., Tang, Y., DeFrances, J., Stover, E. H., Weissleder, R., et al. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00046-6 · Cited by 659
Self-citationGlioblastoma: From Molecular Pathology to Targeted Treatment
Cloughesy, T. F., Cavenee, W. K., & Mischel, P. S. (2011) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-011110-130324 · Cited by 531
Marin-Valencia, I., Yang, C., Mashimo, T., Cho, S., Baek, H., Yang, X.-L., Rajagopalan, K. N., Maddie, M., Vemireddy, V., Zhao, Z., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.05.001 · Cited by 529
Self-citationImp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cellsPreprint
Janiszewska, M., Suvà, M. L., Riggi, N., Houtkooper, R. H., Auwerx, J. H., Clément‐Schatlo, V., Radovanovic, I., Rheinbay, E., Provero, P., & Stamenkovic, I. (2012) · Genes & Development · doi:10.1101/gad.188292.112 · Cited by 454
Ebert, D., Haller, R. G., & Walton, M. E. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05928.2003 · Cited by 427
11C-acetate PET imaging in hepatocellular carcinoma and other liver masses.
Ho, C.-L., Yu, S. C. H., & Yeung, D. W. C. (2003) · PubMed · Cited by 380
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Items 201–300 of 763
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RetractedMsn2/4 regulate expression of glycolytic enzymes and control transition from quiescence to growth
Kuang, Z., Pinglay, S., Ji, H., & Boeke, J. D. (2017) · eLife · doi:10.7554/elife.29938 · Cited by 73
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Pascual, G., Domínguez, D., & Benitah, S. A. (2018) · Disease Models & Mechanisms · doi:10.1242/dmm.032920 · Cited by 74
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Minh, G. L., Esquea, E. M., Young, R. G., Huang, J., & Reginato, M. J. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105344 · Cited by 71
Attacking the supply wagons to starve cancer cells to death
Selwan, E. M., Finicle, B. T., Kim, S. M., & Edinger, A. L. (2016) · FEBS Letters · doi:10.1002/1873-3468.12121 · Cited by 73
NF-Y activates genes of metabolic pathways altered in cancer cells
Benatti, P., Chiaramonte, M. L., Lorenzo, M., Hartley, J. A., Hochhauser, D., Gnesutta, N., Mantovani, R., Imbriano, C., & Dolfini, D. (2015) · Oncotarget · doi:10.18632/oncotarget.6453 · Cited by 72
Flura-seq identifies organ-specific metabolic adaptations during early metastatic colonization
Basnet, H., Tian, L. H., Ganesh, K., Huang, Y.-H., Macalinao, D. G., Brogi, E., Finley, L. W. S., & Massagué, J. (2019) · eLife · doi:10.7554/elife.43627 · Cited by 69
Brindle, K. M., Izquierdo-García, J. L., Lewis, D. Y., Mair, R. J., & Wright, A. J. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2017.72.7636 · Cited by 70
Functional and regulatory profiling of energy metabolism in fission yeast
Małecki, M., Bitton, D. A., Rodríguez‐López, M., Rallis, C., Calavia, N. G., Smith, G. C., & Bähler, J. (2016) · Genome biology · doi:10.1186/s13059-016-1101-2 · Cited by 61
Dong, W., Keibler, M. A., & Stephanopoulos, G. N. (2017) · Metabolic Engineering · doi:10.1016/j.ymben.2017.02.002 · Cited by 69
The pyruvate dehydrogenase complex: Life’s essential, vulnerable and druggable energy homeostat
Stacpoole, P. W., & McCall, C. E. (2023) · Mitochondrion · doi:10.1016/j.mito.2023.02.007 · Cited by 70
T cell metabolic reprogramming and plasticity
Slack, M. A., Wang, T., & Wang, R. (2015) · Molecular Immunology · doi:10.1016/j.molimm.2015.07.036 · Cited by 70
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Allen, E. L., Ulanet, D., Pirman, D. A., Mahoney, C. E., Coco, J., Si, Y., Chen, Y., Huang, L., Ren, J., Choe, S. E., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.09.052 · Cited by 69
Khurshed, M., Molenaar, R. J., Lenting, K., Leenders, W. P. J., & Noorden, C. J. F. V. (2017) · Oncotarget · doi:10.18632/oncotarget.17106 · Cited by 72
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Li, Y., Gruber, J. J., Litzenburger, U. M., Zhou, Y., Miao, Y. R., LaGory, E. L., Li, A. M., Hu, Z., Yip, M., Hart, L. S., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2303-9 · Cited by 65
Pachnis, P., Wu, Z., Faubert, B., Tasdogan, A., Gu, W., Shelton, S. D., Solmonson, A., Rao, A. D., Kaushik, A., Rogers, T. J., et al. (2022) · Science Advances · doi:10.1126/sciadv.abn9550 · Cited by 65
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Corbet, C., & Féron, O. (2015) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000178 · Cited by 61
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Ramalho, R., Rao, M., Zhang, C., Agrati, C., Ippolito, G., Wang, F., Zumla, A. I., & Maeurer, M. J. (2020) · Seminars in Immunopathology · doi:10.1007/s00281-020-00798-w · Cited by 63
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Zhang, T., Zhang, Y., Liu, J., Ma, Y., Ye, Q., Yan, X., & Ding, L. (2022) · Cancer & Metabolism · doi:10.1186/s40170-021-00276-3 · Cited by 56
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Gemeinhardt, M. E., Limbach, M. N., Gebhardt, T. R., Eriksson, C. W., Eriksson, S. L., Lindale, J. R., Goodson, E. A., Warren, W. S., Chekmenev, E. Y., & Goodson, B. M. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201910506 · Cited by 55
Rothman, D. L., de Graaf, R. A., Hyder, F., Mason, G. F., Behar, K. L., & De Feyter, H. M. (2019) · NMR in Biomedicine · doi:10.1002/nbm.4172 · Cited by 53
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Ruan, X., Yan, W., Cao, M., Daza, R. A. M., Fong, M., Yang, K., Wu, J., Liu, X., Palomares, M. R., Wu, X., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48740-0 · Cited by 55
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Li, W., Ren, L., Zheng, X., Liu, J., Wang, J., Ji, T., & Du, G. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.12.012 · Cited by 52
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Zhou, Z., Ren, Y., Yang, J., Liu, M., Shi, X., Luo, W., Fung, K.-M. A., Xu, C., Bronze, M. S., Zhang, Y., et al. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.06.058 · Cited by 57
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Sun, P., Li, J., Zhang, X., Guan, Z., Xiao, Q., Zhao, C., Song, M., Zhou, Y., Mou, L., Ke, M., et al. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.003876 · Cited by 47
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Nguyen, T. T. T., Zhang, Y., Shang, E., Shu, C., Quinzii, C. M., Westhoff, M., Karpel‐Massler, G., & Siegelin, M. D. (2020) · Cells · doi:10.3390/cells9071661 · Cited by 47
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Sun, L., Kong, Y., Cao, M., Zhou, H., Li, H., Cui, Y., Fang, F., Zhang, W., Li, J., Zhu, X., et al. (2017) · Cancer Science · doi:10.1111/cas.13252 · Cited by 47
Chapp, A. D., Schum, S., Behnke, J. E., Hahka, T. M., Huber, M. J., Jiang, E., Larson, R. A., Shan, Z. J., & Chen, Q. (2018) · Physiological Reports · doi:10.14814/phy2.13666 · Cited by 48
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Zhao, Y., Li, J., Li, D., Wang, Z., Zhao, J., Wu, X., Sun, Q., Lin, P. P., Plum, P. S., Damanakis, A. I., et al. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.08.026 · Cited by 47
Jiang, Y., Hu, T., Wang, T., Shi, X. E., Kitano, A., Eagle, K., Hoegenauer, K. A., Konopleva, M. Y., Lin, C. Y., Young, N. L., et al. (2019) · Blood · doi:10.1182/blood.2019001076 · Cited by 47
Research into cancer metabolomics: Towards a clinical metamorphosis
Olivares, O., Däbritz, J. H. M., King, A., Gottlieb, E., & Halsey, C. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.09.008 · Cited by 45
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Metadata
- Authors
- Mashimo, T., Pichumani, K., Vemireddy, V., Hatanpaa, K. J., Singh, D. K., Sirasanagandla, S., Nannepaga, S., Piccirillo, S. G., Kovacs, Z., Foong, C., Huang, Z., Barnett, S., Mickey, B. E., DeBerardinis, R. J., Tu, B. P., Maher, E. A., & Bachoo, R. M.
- Affiliations
- Harold C. Simmons Comprehensive Cancer Center (US)
- The University of Texas Southwestern Medical Center (US)
- Children's Medical Center (US)
- Corresponding author
- Maher, Elizabeth A.
- Bachoo, Robert M.
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-12
- Volume
- 159
- Issue
- 7
- Pages
- 1603-1614
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC4374602
- OpenAlex
- W1992524428
- Cited by
- 760
- References
- 41
- Citations by year
- 2026: 32 · 2025: 69 · 2024: 64 · 2023: 64 · 2022: 88 · 2021: 77 · 2020: 66 · 2019: 64 · 2018: 53 · 2017: 69 · 2016: 71 · 2015: 41 · 2014: 2
- FWCI
- 19.48
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA154843, R01CA157996, P30CA142543)
- National Institute of Neurological Disorders and Stroke (R01NS065195)
- National Institute of Biomedical Imaging and Bioengineering (P41EB015908, EB 015908)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Health Sciences › Medicine › Oncology › Glioma Diagnosis and Treatment
- Keywords
- acetate oxidation, glioblastoma, brain metastases, TCA cycle, acetyl-CoA, ACSS2, acetyl-CoA synthetase 2, glucose oxidation, cancer metabolism, 13C NMR, glutamine metabolism, tumor bioenergetics
- MeSH terms
- Acetates, Acetate-CoA Ligase, Animals, Brain Neoplasms, Citric Acid Cycle, Disease Models, Animal, Glioblastoma, Humans, Neoplasm Metastasis, Glutamic Acid, Mice
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