DeBerardinis, Ralph J.

Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation

Cell death mechanisms and regulationAutophagy in Disease and Therapy

Cited by 6,680

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G., & Thompson, C. B. (2008) · Cell Metabolism

Cancer, Hypoxia, and MetabolismCancer, Lipids, and Metabolism

Cited by 4,088

Fundamentals of Cancer Metabolism

DeBerardinis, R. J., & Chandel, N. S. (2016) · Science Advances

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 3,013

Metabolic reprogramming and cancer progression

Faubert, B., Solmonson, A., & DeBerardinis, R. J. (2020) · Science

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 2,740

Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

DeBerardinis, R. J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., & Thompson, C. B. (2007) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and Metabolism

Cited by 2,622

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

Wise, D. R., DeBerardinis, R. J., Mancuso, A., Sayed, N., Zhang, X.-Y., Pfeiffer, H. K., Nissim, I., Daikhin, E., Yudkoff, M., McMahon, S. B., et al. (2008) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and Metabolism

Cited by 2,001

Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer

DeBerardinis, R. J., & Cheng, T. (2010) · Oncogene

Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and Metabolism

Cited by 1,365

Lactate Metabolism in Human Lung Tumors

Faubert, B., Li, K. Y., Cai, L., Hensley, C. T., Kim, J., Zacharias, L. G., Yang, C., Do, Q. N., Doucette, S., Burguete, D., et al. (2017) · Cell

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 1,343

Reductive carboxylation supports growth in tumour cells with defective mitochondria

Mullen, A. R., Wheaton, W. W., Jin, E. S., Chen, P.-H., Sullivan, L. B., Cheng, T., Yang, Y., Linehan, W. M., Chandel, N. S., & DeBerardinis, R. J. (2012) · Nature

Cancer, Hypoxia, and MetabolismCancer, Lipids, and Metabolism

Cited by 1,328

Oxidative stress inhibits distant metastasis by human melanoma cells

Piskounova, E., Agathocleous, M., Murphy, M. M., Hu, Z., Huddlestun, S. E., Zhao, Z., Leitch, A. M., Johnson, T. M., DeBerardinis, R. J., & Morrison, S. J. (2015) · Nature

Cancer Cells and MetastasisRedox biology and oxidative stress

Cited by 1,269

Glutamine and cancer: cell biology, physiology, and clinical opportunities

Hensley, C. T., Wasti, A. T., & DeBerardinis, R. J. (2013) · Journal of Clinical Investigation

Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and Metabolism

Cited by 1,262

Toll-like receptor–induced changes in glycolytic metabolism regulate dendritic cell activation

Krawczyk, C. M., Holowka, T., Sun, J., Blagih, J., Amiel, E., DeBerardinis, R. J., Cross, J. R., Jung, E., Thompson, C. B., Jones, R. G., et al. (2010) · Blood

Immune Response and InflammationImmunotherapy and Immune Responses

Cited by 1,246

Metabolic heterogeneity in human lung tumors

Hensley, C. T., Faubert, B., Yuan, Q., Lev-Cohain, N., Jin, E., Kim, J., Jiang, L., Ko, B., Skelton, R., Loudat, L., et al. (2016) · Cell

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 1,138

The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche

Simsek, T., Kocabas, F., Zheng, J., DeBerardinis, R. J., Mahmoud, A. I., Olson, E. N., Schneider, J. W., Zhang, C. C., & Sadek, H. A. (2010) · Cell Stem Cell

Hematopoietic Stem Cell TransplantationCancer, Hypoxia, and Metabolism

Cited by 1,101

High frequency retrotransposition in cultured mammalian cells

Moran, J. V., Holmes, S. E., Naas, T. P., DeBerardinis, R. J., Boeke, J. D., & Kazazian, H. H. (1996) · Cell

Chromosomal and Genetic VariationsGenomic variations and chromosomal abnormalities

Cited by 1,022

Brick by brick: metabolism and tumor cell growth

DeBerardinis, R. J., Sayed, N., Ditsworth, D., & Thompson, C. B. (2008) · Current Opinion in Genetics & Development

Cancer, Hypoxia, and MetabolismCancer, Lipids, and Metabolism

Cited by 1,018

Cellular Metabolism and Disease: What Do Metabolic Outliers Teach Us?

DeBerardinis, R. J., & Thompson, C. B. (2012) · Cell

Cancer, Hypoxia, and MetabolismCancer and biochemical research

Cited by 858

2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas

Choi, C., Ganji, S. K., DeBerardinis, R. J., Hatanpaa, K. J., Rakheja, D., Kovacs, Z., Yang, X.-L., Mashimo, T., Raisanen, J. M., Marin-Valencia, I., et al. (2012) · Nature Medicine

Glioma Diagnosis and TreatmentAdvanced MRI Techniques and Applications

Cited by 839

Acetate is a bioenergetic substrate for human glioblastoma and brain metastases

Mashimo, T., Pichumani, K., Vemireddy, V., Hatanpaa, K. J., Singh, D. K., Sirasanagandla, S., Nannepaga, S., Piccirillo, S. G., Kovacs, Z., Foong, C., et al. (2014) · Cell

Cancer, Hypoxia, and MetabolismCancer, Lipids, and Metabolism

Cited by 760

Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research

Kurhanewicz, J., Vigneron, D. B., Brindle, K., Chekmenev, E. Y., Comment, A., Cunningham, C. H., DeBerardinis, R. J., Green, G. G., Leach, M. O., Rajan, S. S., et al. (2011) · Neoplasia

Advanced NMR Techniques and ApplicationsAtomic and Subatomic Physics Research

Cited by 681

Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport

Yang, C., Ko, B., Hensley, C. T., Jiang, L., Wasti, A. T., Kim, J., Sudderth, J., Calvaruso, M. A., Lumata, L., Mitsche, M., et al. (2014) · Molecular Cell

Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and Metabolism

Cited by 679

Mechanisms and Implications of Metabolic Heterogeneity in Cancer

Kim, J., & DeBerardinis, R. J. (2019) · Cell Metabolism

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 606

Reductive carboxylation supports redox homeostasis during anchorage-independent growth

Jiang, L., Shestov, A. A., Swain, P., Yang, C., Parker, S. J., Wang, Q. A., Terada, L. S., Adams, N. D., McCabe, M. T., Pietrak, B., et al. (2016) · Nature

Cancer, Hypoxia, and MetabolismRedox biology and oxidative stress

Cited by 582

Ascorbate regulates haematopoietic stem cell function and leukaemogenesis

Agathocleous, M., Meacham, C. E., Burgess, R. J., Piskounova, E., Zhao, Z., Crane, G. M., Cowin, B. L., Bruner, E., Murphy, M. M., Chen, W., et al. (2017) · Nature

Hematopoietic Stem Cell TransplantationVitamin C and Antioxidants Research

Cited by 545