The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Pathological Axonal Death through a MAPK Cascade that Triggers a Local Energy Deficit
Open accessAbstract
Summary Axonal death disrupts functional connectivity of neural circuits and is a critical feature of many neurodegenerative disorders. Pathological axon degeneration often occurs independently of known programmed death pathways, but the underlying molecular mechanisms remain largely unknown. Using traumatic injury as a model, we systematically investigate mitogen-activated protein kinase (MAPK) families, and delineate a MAPK cascade that represents the early degenerative response to axonal injury. The adaptor protein Sarm1 is required for activation of this MAPK cascade, and this Sarm1-MAPK pathway disrupts axonal energy homeostasis, leading to ATP depletion before physical breakdown of damaged axons. The protective cytoNmnat1/Wlds protein inhibits activation of this MAPK cascade. Further, MKK4, a key component in the Sarm1-MAPK pathway, is antagonized by AKT signaling, which modulates the degenerative response by limiting activation of downstream JNK signaling. Our results reveal a regulatory mechanism that integrates distinct signals to instruct pathological axon degeneration.
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Cites
The JNK signal transduction pathway
Weston, C. (2002) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(01)00258-1 · Cited by 1,528
The JNK signal transduction pathway
Weston, C. R., & Davis, R. J. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.02.001 · Cited by 1,021
Self-citationRegulation of MAP Kinase Signaling Modules by Scaffold Proteins in Mammals
Morrison, D. K., & Davis, R. J. (2003) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.19.111401.091942 · Cited by 786
Self-citationdSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway
Osterloh, J. M., Yang, J., Rooney, T. M., Fox, A. N., Adalbert, R., Powell, E. H., Sheehan, A. E., Avery, M. A., Hackett, R., Logan, M. A., et al. (2012) · Science · doi:10.1126/science.1223899 · Cited by 687
Self-citationWallerian degeneration: an emerging axon death pathway linking injury and disease
Conforti, L., Gilley, J., & Coleman, M. P. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3680 · Cited by 611
Couillault, C., Pujol, N., Reboul, J., Sabatier, L., Guichou, J.-F., Kohara, Y., & Ewbank, J. J. (2004) · Nature Immunology · doi:10.1038/ni1060 · Cited by 478
Axon degeneration: Molecular mechanisms of a self-destruction pathway
Wang, J. T., Medress, Z. A., & Barres, B. A. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201108111 · Cited by 442
A critical role of neural-specific JNK3 for ischemic apoptosis
Kuan, C.-Y., Whitmarsh, A. J., Yang, D. D., Liao, G., Schloemer, A. J., Dong, C., Bao, J., Banasiak, K. J., Haddad, G. G., Flavell, R. A., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2336254100 · Cited by 409
Self-citationSarm1-Mediated Axon Degeneration Requires Both SAM and TIR Interactions
Gerdts, J., Summers, D. W., Sasaki, Y., DiAntonio, A., & Milbrandt, J. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1197-13.2013 · Cited by 375
A local mechanism mediates NAD-dependent protection of axon degeneration
Wang, J., Zhai, Q., Chen, Y., Lin, E., Gu, W., McBurney, M. W., & He, Z. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200504028 · Cited by 352
Cited by
Essuman, K., Summers, D. W., Sasaki, Y., Mao, X., DiAntonio, A., & Milbrandt, J. (2017) · Neuron · doi:10.1016/j.neuron.2017.02.022 · Cited by 619
Tao, S.-C., Yuan, T., Rui, B.-Y., Zhu, Z.-Z., Guo, S.-C., & Zhang, C.-Q. (2017) · Theranostics · doi:10.7150/thno.17450 · Cited by 346
Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism
Gerdts, J., Summers, D. W., Milbrandt, J., & DiAntonio, A. (2016) · Neuron · doi:10.1016/j.neuron.2015.12.023 · Cited by 320
Retrograde Axonal Degeneration in Parkinson Disease
Tagliaferro, P., & Burke, R. E. (2016) · Journal of Parkinson’s Disease · doi:10.3233/jpd-150769 · Cited by 272
The Axon-Myelin Unit in Development and Degenerative Disease
Stassart, R. M., Möbius, W., Nave, K.-A., & Edgar, J. M. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00467 · Cited by 246
Metadata
- Authors
- Yang, J., Wu, Z., Renier, N., Simon, D. J., Uryu, K., Park, D. S., Greer, P. A., Tournier, C., Davis, R. J., & Tessier-Lavigne, M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 160
- Issue
- 1-2
- Pages
- 161-176
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2075925391
- Cited by
- 294
- References
- 31
- FWCI
- 13.19
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Yang, J., Wu, Z., Renier, N., Simon, D. J., Uryu, K., Park, D. S., Greer, P. A., Tournier, C., Davis, R. J., & Tessier-Lavigne, M. (2015). Pathological Axonal Death through a MAPK Cascade that Triggers a Local Energy Deficit. Cell. https://doi.org/10.1016/j.cell.2014.11.053
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