The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism
Open accessAbstract
Wallerian axon degeneration is a form of programmed subcellular death that promotes axon breakdown in disease and injury. Active degeneration requires SARM1 and MAP kinases including DLK, while the NAD+ synthetic enzyme NMNAT2 prevents degeneration. New studies reveal that these pathways cooperate in a locally-mediated axon destruction program with NAD+ metabolism playing a central role. Here, we review the biology of Wallerian type axon degeneration and discuss the most recent findings with special emphasis on critical signaling events and their potential as therapeutic targets for axonopathy.
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1 retracted
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Cited by
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Self-citationThe etiology of Bell’s palsy: a review
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The Axon-Myelin Unit in Development and Degenerative Disease
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NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion
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Metadata
- Authors
- Gerdts, J., Summers, D. W., Milbrandt, J., & DiAntonio, A.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 89
- Issue
- 3
- Pages
- 449-460
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2257942016
- Cited by
- 320
- References
- 22
- FWCI
- 20.04
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Gerdts, J., Summers, D. W., Milbrandt, J., & DiAntonio, A. (2016). Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism. Neuron. https://doi.org/10.1016/j.neuron.2015.12.023
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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