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Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease
Open accessAbstract
Decreases in the diversity of enteric bacterial populations are observed in patients with Crohn's disease (CD) and ulcerative colitis (UC). Less is known about the virome in these diseases. We show that the enteric virome is abnormal in CD and UC patients. In-depth analysis of preparations enriched for free virions in the intestine revealed that CD and UC were associated with a significant expansion of Caudovirales bacteriophages. The viromes of CD and UC patients were disease and cohort specific. Importantly, it did not appear that expansion and diversification of the enteric virome was secondary to changes in bacterial populations. These data support a model in which changes in the virome may contribute to intestinal inflammation and bacterial dysbiosis. We conclude that the virome is a candidate for contributing to, or being a biomarker for, human inflammatory bowel disease and speculate that the enteric virome may play a role in other diseases.
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“recent work suggests a role for viruses in IBD, with a significant expansion of Caudovirales bacteriophage in patients.71”
From The gut microbiota and host health: a new clinical frontier (2016) · cites this paper as [71]
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Vig, T., Das, P., Sakhuja, P., Gaur, K., Majumdar, K., & Pulimood, A. B. (2022) · Springer eBooks · doi:10.1007/978-981-16-6395-6_12 · Cited by 2
Ishizaka, A., Tamura, A., Koga, M., Mizutani, T., Yamayoshi, S., Iwatsuki‐Horimoto, K., Yasuhara, A., Yamamoto, S., Nagai, H., Adachi, E., et al. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.00998-24 · Cited by 3
Optimizing Therapeutic Potential of Fecal Transplant in Inflammatory Bowel Disease
Magier, S., Morley, T. S., & Kelly, C. R. (2025) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2024.12.002 · Cited by 2
Viewing Psychiatric Disorders Through Viruses: Simple Architecture, Burgeoning Implications
Kong, L., Zhu, B., Zhuang, Y., Lai, J., & Hu, S. (2025) · Neuroscience Bulletin · doi:10.1007/s12264-025-01443-y · Cited by 2
Human gut strains of Desulfovibrio piger exhibit spontaneous induction of multiple prophages
Mayer, M. J., Sayavedra, L., Gotts, K., Wong, N., Whiley, H., Barham, M., & Narbad, A. (2025) · Applied and Environmental Microbiology · doi:10.1128/aem.01917-25 · Cited by 2
Vásquez, J.-N., Doncel, P., Camacho, J., Ruiz, E., Recio, V., & Tarragó, D. (2025) · PLoS ONE · doi:10.1371/journal.pone.0337322 · Cited by 2
Bile Derivative T3K Ameliorates Colitis by Regulating the Intestinal Microbiota-Bile Acid Axis
Zhou, Y., Zhang, Y., Li, Y., Chen, Y., Chi, X., 尤忠毓, Zhang, H., Li, Y., & 吴练秋 (2025) · Pharmaceutics · doi:10.3390/pharmaceutics18010020 · Cited by 2
A prophage-encoded sRNA limits phage infection of adherent-invasive E. coli
Pershing, N. L., Brzozowski, R. S., Schmidt, A. K., Faith, D. R., Joyce, A. C., de Ora, L. O., Kominsky, J., Dankwardt, A., Maciver, A., Bell, R. S., et al. (2026) · PLoS Pathogens · doi:10.1371/journal.ppat.1013836 · Cited by 2
Harnessing engineered bacteria for revolutionizing cancer immunotherapy
Zhou, K., Cao, L., Luo, H.-Y., Wang, K.-N., Song, Z., & Bu, L. (2026) · Advanced Composites and Hybrid Materials · doi:10.1007/s42114-026-01664-3 · Cited by 2
Virome and Microbiome Interaction and Their Implication in the Human Gut Health
AboNahas, H. H., El‐Maradny, Y. A., Gezaf, S. A., Nouh, F. A. A., AboNahas, Y. H., Landa‐Acuña, D., Gil-Polo, A., Saied, E. M., & Abdel-Azeem, A. M. (2022) · Springer eBooks · doi:10.1007/978-981-16-1626-6_4 · Cited by 2
Don’t forget the bacteriophages
de Agüero, M. G., & Rahimi-Midani, A. (2022) · Lab Animal · doi:10.1038/s41684-022-00986-1 · Cited by 2
Crohn’s Disease - The Current State of the Art
Pal, P. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.104329 · Cited by 1
Metadata
- Authors
- Norman, J. M., Handley, S. A., Baldridge, M. T., Droit, L., Liu, C. Y., Keller, B. C., Kambal, A., Monaco, C. L., Zhao, G., Fleshner, P., Stappenbeck, T. S., McGovern, D. P. B., Keshavarzian, A., Mutlu, E. A., Sauk, J., Gevers, D., Xavier, R. J., Wang, D., Parkes, M., & Virgin, H. W.
- Affiliations
- Washington University in St. Louis (US)
- Cedars-Sinai Medical Center (US)
- Rush University Medical Center (US)
- Harvard University (US)
- Broad Institute (US)
- University of Cambridge (GB)
- Corresponding author
- Virgin, Herbert W.
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 160
- Issue
- 3
- Pages
- 447-460
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC4312520
- OpenAlex
- W2081319466
- Cited by
- 1,285
- References
- 81
- Citations by year
- 2026: 67 · 2025: 101 · 2024: 116 · 2023: 116 · 2022: 159 · 2021: 171 · 2020: 112 · 2019: 121 · 2018: 107 · 2017: 93 · 2016: 78 · 2015: 40
- FWCI
- 96.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute for Health and Care Research
- National Institutes of Health (UL1TR000448, R01OD011170)
- Agency for Healthcare Research and Quality (R01HS021747, HS021747)
- National Heart, Lung, and Blood Institute (T32HL007317)
- National Cancer Institute (P30 CA 91842, T32CA009547, P30CA091842)
- National Institute of Allergy and Infectious Diseases (AI067068, U01AI067068, R01AI084887, U54AI057160, T32AI007172, T32AI007163)
- National Institute of Diabetes and Digestive and Kidney Diseases (P01DK046763, DK062413, R01DK092405, R21DK071838, DK046763-19, DK071838, U01DK062413, P30DK043351)
- National Institute of Dental and Craniofacial Research (U54DE023789, U54DE023798)
- National Center for Advancing Translational Sciences
- National Center for Complementary and Integrative Health (AT001628, R21AT001628, R01AT007143)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › Bacteriophages and microbial interactions
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- enteric virome, inflammatory bowel disease, Crohn's disease, ulcerative colitis, bacteriophages, Caudovirales, viral diversity, bacterial dysbiosis, intestinal inflammation, biomarkers, gut microbiota
- MeSH terms
- Bacteria, Colitis, Ulcerative, Crohn Disease, Feces, Humans, Cohort Studies, Case-Control Studies, Caudovirales, Microviridae, Metagenome, Dysbiosis
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