The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Cortical Contractility Triggers a Stochastic Switch to Fast Amoeboid Cell Motility
Open accessAbstract
3D amoeboid cell migration is central to many developmental and disease-related processes such as cancer metastasis. Here, we identify a unique prototypic amoeboid cell migration mode in early zebrafish embryos, termed stable-bleb migration. Stable-bleb cells display an invariant polarized balloon-like shape with exceptional migration speed and persistence. Progenitor cells can be reversibly transformed into stable-bleb cells irrespective of their primary fate and motile characteristics by increasing myosin II activity through biochemical or mechanical stimuli. Using a combination of theory and experiments, we show that, in stable-bleb cells, cortical contractility fluctuations trigger a stochastic switch into amoeboid motility, and a positive feedback between cortical flows and gradients in contractility maintains stable-bleb cell polarization. We further show that rearward cortical flows drive stable-bleb cell migration in various adhesive and non-adhesive environments, unraveling a highly versatile amoeboid migration phenotype.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Stages of embryonic development of the zebrafish
Kimmel, C. B., Ballard, W. W., Kimmel, S. R., Ullmann, B., & Schilling, T. F. (1995) · Developmental Dynamics · doi:10.1002/aja.1002030302 · Cited by 12,037
The zebrafish book : a guide for the laboratory use of zebrafish (Danio rerio)
Westerfield, M. (1995) · Medical Entomology and Zoology · Cited by 6,813
Cellular Motility Driven by Assembly and Disassembly of Actin Filaments
Pollard, T. D., & Borisy, G. G. (2003) · Cell · doi:10.1016/s0092-8674(03)00120-x · Cited by 4,195
Cancer Invasion and the Microenvironment: Plasticity and Reciprocity
Friedl, P., & Alexander, S. (2011) · Cell · doi:10.1016/j.cell.2011.11.016 · Cited by 1,940
The emerging role of lysophosphatidic acid in cancer
Mills, G. B., & Moolenaar, W. H. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1143 · Cited by 1,094
Confinement and Low Adhesion Induce Fast Amoeboid Migration of Slow Mesenchymal Cells
Liu, Y.-J., Le Berre, M., Lautenschlaeger, F., Maiuri, P., Callan-Jones, A., Heuzé, M., Takaki, T., Voituriez, R., & Piel, M. (2015) · Cell · doi:10.1016/j.cell.2015.01.007 · Cited by 861
Self-citationPaxillin and focal adhesion signalling
Turner, C. E. (2000) · Nature Cell Biology · doi:10.1038/35046659 · Cited by 839
Mechanical modes of ‘amoeboid’ cell migration
Lämmermann, T., & Sixt, M. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.05.003 · Cited by 669
Self-citationRole of cortical tension in bleb growth
Tinevez, J.-Y., Schulze, U., Salbreux, G., Roensch, J., Joanny, J.-F., & Paluch, E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903353106 · Cited by 542
Anisotropies in cortical tension reveal the physical basis of polarizing cortical flows
Mayer, M., Depken, M., Bois, J. S., Jülicher, F., & Grill, S. W. (2010) · Nature · doi:10.1038/nature09376 · Cited by 495
Cited by
The actin cytoskeleton and actin-based motility
Svitkina, T. (2018) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018267 · Cited by 761
Active matter at the interface between materials science and cell biology
Needleman, D., & Dogic, Z. (2017) · Nature Reviews Materials · doi:10.1038/natrevmats.2017.48 · Cited by 649
Cancer cell motility: lessons from migration in confined spaces
Paul, C. D., Mistriotis, P., & Konstantopoulos, K. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2016.123 · Cited by 648
Case, L. B., & Waterman, C. M. (2015) · Nature Cell Biology · doi:10.1038/ncb3191 · Cited by 520
Cytoskeletal Crosstalk in Cell Migration
Seetharaman, S., & Etienne-Manneville, S. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.06.004 · Cited by 470
Metadata
- Authors
- Ruprecht, V., Wieser, S., Callan-Jones, A., Smutny, M., Morita, H., Sako, K., Barone, V., Ritsch-Marte, M., Sixt, M., Voituriez, R., & Heisenberg, C.-P.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 160
- Issue
- 4
- Pages
- 673-685
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1984474513
- Cited by
- 437
- References
- 30
- FWCI
- 20.04
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Cortical Contractility Triggers a Stochastic Switch to Fast Amoeboid Cell Motility. https://app.cochat.ai/papers/10.1016/j.cell.2015.01.008
- The paper
- Ruprecht, V., Wieser, S., Callan-Jones, A., Smutny, M., Morita, H., Sako, K., Barone, V., Ritsch-Marte, M., Sixt, M., Voituriez, R., & Heisenberg, C.-P. (2015). Cortical Contractility Triggers a Stochastic Switch to Fast Amoeboid Cell Motility. Cell. https://doi.org/10.1016/j.cell.2015.01.008
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
