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Cited by 761Cellular Mechanics and InteractionsMicrotubule and mitosis dynamicsProtein Kinase Regulation and GTPase Signaling

The actin cytoskeleton and actin-based motility

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Svitkina, Tatyana·2018·Cold Spring Harbor Perspectives in Biology
DOI 10.1101/cshperspect.a018267PMC PMC5749151
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Abstract

The actin cytoskeleton-a collection of actin filaments with their accessory and regulatory proteins-is the primary force-generating machinery in the cell. It can produce pushing (protrusive) forces through coordinated polymerization of multiple actin filaments or pulling (contractile) forces through sliding actin filaments along bipolar filaments of myosin II. Both force types are particularly important for whole-cell migration, but they also define and change the cell shape and mechanical properties of the cell surface, drive the intracellular motility and morphogenesis of membrane organelles, and allow cells to form adhesions with each other and with the extracellular matrix.

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  • The osteoclast cytoskeleton is made of four categories of filamentous structures and fulfills essential functions including cell adhesion, migration, contractility, division, vesicular transport, and bone resorption.

    “The osteoclast cytoskeleton is made of filamentous structures that belong to one of four categories: polarized actin filaments; polarized microtubules; non-polarized intermediate filaments; or non-polarized septin filaments. The cytoskeleton fulfills essential functions including cell adhesion, migration, contractility, division, vesicular transport, and bone resorption [2,3,4,5,6].”

    From Osteoclasts and Microgravity (2020) · cites this paper as [3]

    The Introduction (page unavailable) describes actin filaments as polar, and the Abstract and section 5.2 (page unavailable) describe roles in adhesion, migration, contraction, intracellular organelle movement, and cell division. The paper does not establish the four-category classification for osteoclasts or address bone resorption. (LLM, conf=0.88)

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Authors
Svitkina, T.
Affiliations
University of Pennsylvania (US)
Corresponding author
Svitkina, Tatyana
ORCID
Svitkina, Tatyana
Venue
Cold Spring Harbor Perspectives in Biology
Publisher
Cold Spring Harbor Laboratory
Published
2018-01
Volume
10
Issue
1
Pages
a018267
ISSN
1943-0264 (ISSN-L)
DOI
10.1101/cshperspect.a018267
PMC
PMC5749151
OpenAlex
W2782095023
Cited by
761
References
5
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Type
posted content
Language
en
Open access
Locations
  • Cold Spring Harbor Perspectives in Biology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute of General Medical Sciences (R01GM095977)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords
actin cytoskeleton, actin-based motility, F-actin, myosin II, force generation, cell migration, contractile force, cell shape, cell mechanics, intracellular motility, cell adhesion, extracellular matrix
MeSH terms
Actins, Animals, Biological Transport, Cell Movement, Humans, Actin Cytoskeleton, Morphogenesis, Muscle Contraction, Phagocytosis, Myosin Type II

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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