Neuronal CRTC-1 Governs Systemic Mitochondrial Metabolism and Lifespan via a Catecholamine Signal

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Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

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AMPK: a nutrient and energy sensor that maintains energy homeostasis

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Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

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Metformin improves healthspan and lifespan in mice

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GABA receptors differentially regulate life span and health span in C. elegans through distinct downstream mechanisms

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Overexpression of Activated AMPK in the Anopheles stephensi Midgut Impacts Mosquito Metabolism, Reproduction and Plasmodium Resistance

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Neuronal Mechanisms that Drive Organismal Aging Through the Lens of Perception

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SMRT sequencing of the full-length transcriptome of Odontotermes formosanus (Shiraki) under Serratia marcescens treatment

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Calcineurin inhibition enhances Caenorhabditis elegans lifespan by defecation defects-mediated calorie restriction and nuclear hormone signalingPreprint

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The serotonin receptor 5-HT2A modulates lifespan and protein feeding in Drosophila melanogaster

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D-arabinose acts as antidepressant by activating the ACSS2-PPARγ/TFEB axis and CRTC1 transcription

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Fasting metabolism modulates the interleukin-12/interleukin-10 cytokine axis

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New Insights Into the Pivotal Role of CREB-Regulated Transcription Coactivator 1 in Depression and Comorbid Obesity

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The CRTC-1 transcriptional domain is required for COMPASS complex-mediated longevity in C. elegans

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Germline stem cell integrity and quiescence are controlled by an AMPK-dependent neuronal trafficking pathway

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Mechanistic role of the CREB-regulated transcription coactivator 1 in cardiac hypertrophy

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Animal Models to Study AMPK

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The nuclear pore complex connects energy sensing to transcriptional plasticity in longevity

Zhou, Y., Ahsan, F. M., Emans, S. W., & Soukas, A. A. (2025) · Molecular Cell · doi:10.1016/j.molcel.2025.08.035 · Cited by 11

Devo-Aging: Intersections Between Development and Aging

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Synthetic Ligands of Cannabinoid Receptors Affect Dauer Formation in the NematodeCaenorhabditis elegans

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Non‐canonical activation of CREB mediates neuroprotection in a Caenorhabditis elegans model of excitotoxic necrosis

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Prioritization and functional analysis of GWAS risk loci for Barrett’s esophagus and esophageal adenocarcinoma

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Nuclear hormone receptors as mediators of metabolic adaptability following reproductive perturbations

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Novel imaging tools to study mitochondrial morphology in Caenorhabditis elegans

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Octopamine enhances oxidative stress resistance through the fasting‐responsive transcription factor DAF ‐16/ FOXO in C. elegans

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Bone morphogenetic protein signaling regulation of AMPK and PI3K in lung cancer cells and C. elegans

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High-dimensional Ageome Representations of Biological Aging across Functional ModulesPreprint

Ying, K., Tyshkovskiy, A., Chen, Q., Crespo, E. L., Zhang, B., Liu, H., Matei-Dediu, B., Poganik, J. R., Moqri, M., Kirschne, K., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.17.613599 · Cited by 10

WNT regulates programmed muscle remodeling through PLC-β and calcineurin in C. elegans males

LeBoeuf, B., Chen, X., & Garcia, L. R. (2020) · Development · doi:10.1242/dev.181305 · Cited by 9

Membrane ion Channels and Receptors in Animal lifespan Modulation

Sheng, Y., Tang, L., Kang, L., & Xiao, R. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25824 · Cited by 9

AMPK Regulates Developmental Plasticity through an Endogenous Small RNA Pathway in Caenorhabditis elegans

Wong, C., & Roy, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21062238 · Cited by 8

Longevity control by the nervous system: Sensory perception, stress response and beyond

Lin, C.-T., He, C.-W., Huang, T., & Pan, C. (2017) · Translational Medicine of Aging · doi:10.1016/j.tma.2017.07.001 · Cited by 9

The discovery and consequences of the central role of the nervous system in the control of protein homeostasis

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5′-AMP-Activated Protein Kinase Signaling in Caenorhabditis elegans

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Surviving Starvation: AMPK Protects Germ Cell Integrity by Targeting Multiple Epigenetic Effectors

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Intracellular protons accelerate aging and switch on aging hallmarks in mice

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Influences of Germline Cells on Organismal Lifespan and Healthspan

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AXIN-AMPK signaling: Implications for healthy aging

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Cabin1 domain-containing gene picd-1 interacts with pry-1/Axin to regulate multiple processes in Caenorhabditis elegans

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A moderate static magnetic field promotes C. elegans longevity through cytochrome P450s

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Regulator of Lipid Metabolism NHR-49 Mediates Pathogen Avoidance through Precise Control of Neuronal Activity

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Aging‐Induced Episodic‐Like Memory Impairment Could be Alleviated by Melatonin Treatment via Preserving Blood–Brain Barrier Integrity and Upregulating CRTC1

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An emerging role for cysteine-mediated redox signaling in aging

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Calcineurin inhibition enhances Caenorhabditis elegans lifespan by defecation defects-mediated calorie restriction and nuclear hormone signaling

Das, P., Aballay, A., & Singh, J. (2023) · eLife · doi:10.7554/elife.89572.3 · Cited by 15

Intestine-specific disruption of mitochondrial superoxide dismutase extends longevity

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Dietary Restriction in C. elegans

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Exercise-Induced Differential Transcriptional Output of AMPK Signaling Improves Axon Regeneration and Functional Recovery

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CRTC1 in Mc4r-Expressing Cells Is Required for Peripheral Metabolism and Systemic Energy Homeostasis

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For Longevity, Perception is Everything

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Aging in the Nematode Caenorhabditis elegans

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Neuronal mTORC1 inhibition promotes longevity without suppressing anabolic growth and reproduction in C. elegansPreprint

Smith, H. J., Lanjuin, A., Sharma, A., Prabhakar, A., Tabakovic, E., Sehgal, R., & Mair, W. B. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.12.456148 · Cited by 3

Confirming the Pro-longevity Effects of H3K4me3-deficient set-2 Mutants in Extending Lifespan in C. elegansPreprint

Silva-García, C. G., & Mair, W. B. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.08.02.502497 · Cited by 2

Dissecting the Neuronal Contributions of the Lipid Regulator NHR-49 Function in Lifespan and Behavior in C. elegans

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Novel role of AMPK in cocaine reinforcement via regulating CRTC1

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An insulin, AMPK, and steroid hormone-mediated metabolic switch regulates the transition between growth and diapause in C. elegansPreprint

Penkov, S., Raghuraman, B. K., Erkut, C., Oertel, J., Galli, R., Ackerman, E. J. M., Vorkel, D., Verbavatz, J., Koch, E., Fahmy, K., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/323956 · Cited by 2

Calcineurin inhibition enhances Caenorhabditis elegans lifespan by defecation defects-mediated calorie restriction and nuclear hormone signalingPreprint

Das, P., Aballay, A., & Singh, J. (2023) · eLife · doi:10.7554/elife.89572.1 · Cited by 2

Novel Imaging Tools to Study Mitochondrial Dynamics in Caenorhabditis elegansPreprint

Valera‐Alberni, M., Yao, P., Romero-Sanz, S., Lanjuin, A., & Mair, W. B. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.16.603730 · Cited by 2

Role of AMPK in aging and age-related loss of behavioral plasticity in C. elegans

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RevAMPing Mitochondrial Shape to Live Longer

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Sensory integration via glutamatergic signaling in Caenorhabditis elegans

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AMPK opens the door to organelle memory and longevity

Sharma, A. (2025) · Trends in Cell Biology · doi:10.1016/j.tcb.2025.10.005 · Cited by 2

Ribonuclease DIS3 delays aging and senescence by generating tRNA halves

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Reductive death is averted by a conserved de novo lipogenic switch

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Chapter Six - Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases

Giorgi, C., Marchi, S., Simoes, I., Ren, Z., Morciano, G., Perrone, M., Patalas‐Krawczyk, P., Borchard, S., Jędrak, P., Pierzynowska, K., et al. (2018) · UCL Discovery (University College London) · Cited by 1

Role of the central nervous system in cell non-autonomous signaling mechanisms of aging and longevity in mammals

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Longevity, enhanced memory, and altered density of dendritic spines in hippocampal CA3 and dentate gyrus after hemizygous deletion of Pde2a in mice

Baumgärtel, K., Broadbent, N., Su, H., Masatsugu, B., Maruyama, K. P., Johnson, R. W., Green, A. L., Hornberger, D. K., Petroski, R. E., Scott, R. H., et al. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-02031-w · Cited by 1

CRTC2 regulates plasma cell metabolism and survivalPreprint

Hong, J. S., Ahsan, F. M., Montecino‐Rodriguez, E., Pioli, P. D., Lee, M.-S., Nguyen, T. L., Brooks, D. G., Golovato, J., Niazi, K., Dorshkind, K. A., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.04.14.439620 · Cited by 1

Degrading intestinal DAF-2 nearly doubles Caenorhabditis elegans lifespan without affecting development or reproductionPreprint

Zhang, Y., Zhang, W., Zhang, P., Li, Q., Sun, Y., Wang, J., Zhang, S. O., Cai, T., Zhan, C., & Dong, M. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.07.31.454567 · Cited by 1

picd-1 , a gene that encodes CABIN1 domain-containing protein, interacts with pry-1/Axin to regulate multiple processes in Caenorhabditis elegansPreprint

Mallick, A., Taylor, S. K. B., Mehta, S., & Gupta, B. P. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.27.462077 · Cited by 1

Efficacy of longevity interventions in C. elegans is determined by early life activity of RNA splicing factorsPreprint

Dutta, S., Heintz, C., Pérez-Matos, M. C., Mutlu, A. S., Piper, M. E., Mistry, M., Sharma, A., Smith, H. J., Howell, P. R., Sehgal, R., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.11.01.466772 · Cited by 1

Neuronal HLH-30/TFEB modulates muscle mitochondrial fragmentation to improve thermoresistance in C. elegansPreprint

Wong, S. Q., Ryan, C. J., & Lapierre, L. R. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.04.07.487519 · Cited by 1

Calcineurin inhibition enhances Caenorhabditis elegans lifespan by defecation defects-mediated calorie restriction and nuclear hormone signalingPreprint

Das, P., Aballay, A., & Singh, J. (2024) · eLife · doi:10.7554/elife.89572.2 · Cited by 1

AMPK Modulates Associative Learning via Neuronal Mitochondrial Fusion in C. elegansPreprint

Escoubas, C. C., Laversenne, V., Tabakovic, E., Weir, H. J. M., Clark, N., & Mair, W. B. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.11.05.370031

The discovery and consequences of the central role of the nervous system in the control of protein homeostasis

Prahlad, V. (2022) · CRC Press eBooks · doi:10.1201/9781003239758-36

Faculty Opinions recommendation of Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy.

Crawford, J. M., & Goddard, T. N. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.736512366.793566892

Faculty Opinions recommendation of Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy.

Chao, N. J. A. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.736512366.793568917

Faculty Opinions recommendation of Dietary restriction and AMPK increase lifespan via mitochondrial network and peroxisome remodeling.

Fontana, L. (2017) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.732061632.793538504

Faculty Opinions recommendation of Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy.

Han, J. J. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.736512366.793573403

Faculty Opinions recommendation of Neuronal TORC1 modulates longevity via AMPK and cell nonautonomous regulation of mitochondrial dynamics in C. elegans.

Lee, S., Kim, E. J. E., & Park, S. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.736422675.793569072

Lysosome Lipid Signaling from the Periphery to Neurons Regulates LongevityPreprint

Savini, M., Duffy, J. D., Folick, A., Lee, Y.-T., Hu, P.-W., Neve, I. A. A., Jin, F., Zhang, Q., Tillman, M. C., Ye, Y., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.06.10.447794

Exercise preserves fitness capacity during aging through AMPK and mitochondrial dynamicsPreprint

Campos, J. C., Bozi, L. H. M., Traa, A., van der Bliek, A. M., Raamsdonk, J. M. V., Blackwell, T. K., & Ferreira, J. C. B. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.20.496837

CRTC-1 balances histone trimethylation and acetylation to promote longevityPreprint

Silva-García, C. G., Láscarez-Lagunas, L. I., Papsdorf, K., Heintz, C., Prabhakar, A., Morrow, C. S., Torres, L. P., Sharma, A., Liu, J., Colaiácovo, M. P., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.08.31.506037

Methionine cycle in a pair of serotonergic neurons regulates diet-dependent behavior and longevity through a neuron-gut signalingPreprint

Rahman, S. S., Bhattacharjee, S., Prakash, G., Motwani, S., Nair, T., Keerthana, R. S., & Mukhopadhyay, A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.01.582891

Temporally controlled nervous system-to-gut signaling bidirectionally regulates longevity in C. elegansPreprint

Xu, L., Han, C., Chun, L., Xu, X. Z. S., & Liu, J. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.12.589179

Temporally controlled nervous system-to-gut signaling bidirectionally regulates longevity in C. elegansPreprint

Xu, L., Han, C., Chun, L., Xu, X. Z. S., & Liu, J. (2024) · eLife · doi:10.7554/elife.97829

Temporally controlled nervous system-to-gut signaling bidirectionally regulates longevity in C. elegansPreprint

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