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The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Structure of the Angiotensin Receptor Revealed by Serial Femtosecond Crystallography

Open access
Zhang, Haitao, Unal, Hamiyet, Gati, Cornelius, Han, Gye Won, Liu, Wei, Zatsepin, Nadia A., James, Daniel, Wang, Dingjie, Nelson, Garrett, Weierstall, Uwe, Sawaya, Michael R., Xu, Qingping, Messerschmidt, Marc, Williams, Garth J., Boutet, Sébastien, Yefanov, Oleksandr M., White, Thomas A., Wang, Chong, Ishchenko, Andrii, Tirupula, Kalyan C., Desnoyer, Russell, Coe, Jesse, Conrad, Chelsie E., Fromme, Petra, Stevens, Raymond C., Katritch, Vsevolod, Karnik, Sadashiva S., Cherezov, Vadim·2015·Cell
DOI 10.1016/j.cell.2015.04.011
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Abstract

SUMMARY Angiotensin II type 1 receptor (AT1R) is a G protein-coupled receptor that serves as a primary regulator for blood pressure maintenance. Although several anti-hypertensive drugs have been developed as AT1R blockers (ARBs), the structural basis for AT1R ligand-binding and regulation has remained elusive, mostly due to the difficulties of growing high quality crystals for structure determination using synchrotron radiation. By applying the recently developed method of serial femtosecond crystallography at an X-ray free-electron laser, we successfully determined the room-temperature crystal structure of the human AT1R in complex with its selective antagonist ZD7155 at 2.9 Å resolution. The AT1R-ZD7155 complex structure revealed key structural features of AT1R and critical interactions for ZD7155 binding. Docking simulations of the clinically used ARBs into the AT1R structure further elucidated both the common and distinct binding modes for these anti-hypertensive drugs. Our results thereby provide fundamental insights into AT1R structure-function relationship and structure-based drug design.

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Metadata

Authors
Zhang, H., Unal, H., Gati, C., Han, G. W., Liu, W., Zatsepin, N. A., James, D., Wang, D., Nelson, G., Weierstall, U., Sawaya, M. R., Xu, Q., Messerschmidt, M., Williams, G. J., Boutet, S., Yefanov, O. M., White, T. A., Wang, C., Ishchenko, A., Tirupula, K. C., Desnoyer, R., Coe, J., Conrad, C. E., Fromme, P., Stevens, R. C., Katritch, V., Karnik, S. S., & Cherezov, V.
Venue
Cell
Publisher
Elsevier BV
Published
2015-05
Volume
161
Issue
4
Pages
833-844
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2015.04.011
OpenAlex
W2110177837
Cited by
382
References
4
FWCI
21.10
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Structure of the Angiotensin Receptor Revealed by Serial Femtosecond Crystallography. https://app.cochat.ai/papers/10.1016/j.cell.2015.04.011
The paper
Zhang, H., Unal, H., Gati, C., Han, G. W., Liu, W., Zatsepin, N. A., James, D., Wang, D., Nelson, G., Weierstall, U., Sawaya, M. R., Xu, Q., Messerschmidt, M., Williams, G. J., Boutet, S., Yefanov, O. M., White, T. A., Wang, C., Ishchenko, A., . . . Cherezov, V. (2015). Structure of the Angiotensin Receptor Revealed by Serial Femtosecond Crystallography. Cell. https://doi.org/10.1016/j.cell.2015.04.011

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.