Understanding Angiotensin II Type 1 Receptor Signaling in Vascular Pathophysiology

Eguchi, Satoru; Kawai, Tatsuo; Scalia, Rosario; Rizzo, Victor

doi:10.1161/hypertensionaha.118.10266

Cited by 189Renin-Angiotensin System StudiesEicosanoids and Hypertension PharmacologyCardiovascular, Neuropeptides, and Oxidative Stress Research

Understanding Angiotensin II Type 1 Receptor Signaling in Vascular Pathophysiology

Open access

Eguchi, Satoru, Kawai, Tatsuo, Scalia, Rosario, Rizzo, Victor·2018·Hypertension

DOI 10.1161/hypertensionaha.118.10266PMC PMC5897153

Open this paper in CoChat — free account Open PDF

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1161/hypertensionaha.118.10266

Cites

83 of 83 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Ang II binds the ATR1 receptor leading to release of TNFα and IL-6, which is associated with hypertension, diabetes, and heart disease-major comorbidities in severe COVID-19.
“Ang II binds the ATR1 (Ang II receptor 1) receptor leading to release of TNF α and IL-6, 55 which is associated with hypertension, diabetes, and heart disease 52,56,57 -major comorbidities in severe COVID-19.”
From COVID-19, Myocarditis and Pericarditis (2023) · cites this paper as [55]
The paper’s introductory discussion says Ang II acts through the AT1 receptor and that this signaling contributes to inflammation and hypertension. The ADAM17 section discusses possible TNFα generation, but the passages do not establish that Ang II binding to AT1 releases both TNFα and IL-6; the paper does not address severe COVID-19 comorbidities. (LLM, conf=0.86)
Experimental — accuracy not yet measured
The AngII-AT1R axis activates ADAM17, which generates the mature form of EGFR ligand and TNFα, two NF-κB stimulators.
“This axis activates ADAM17, which generates the mature form of EGFR ligand and TNFα, two NF-κB stimulators (346).”
From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [346]
The ADAM17 section states that AT1R activates ADAM17, which generates a mature EGFR ligand, and identifies TNFα as another ADAM17 substrate. It does not identify those two products as NF-κB stimulators; the ER Stress section instead links NF-κB activation to sustained ER stress. Page numbers are unavailable in our copy. (LLM, conf=0.88)
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.
Griendling, K. K., Minieri, C. A., Ollerenshaw, J. D., & Alexander, R. W. (1994) · Circulation Research · doi:10.1161/01.res.74.6.1141 · Cited by 2,735 · see citing works
International Union of Pharmacology. XXIII. The Angiotensin II Receptors
Marc De Gasparo, B., Catt, K. J., Inagami, T., Wright, J. W., & Unger, T. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01458-3 · Cited by 2,131 · see citing works
Molecular characterization of angiotensin II--induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype.
Sadoshima, J., & Izumo, S. (1993) · Circulation Research · doi:10.1161/01.res.73.3.413 · Cited by 1,425 · see citing works
Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro
Sadoshima, J.-I., Xu, Y., Slayter, H. S., & Izumo, S. (1993) · Cell · doi:10.1016/0092-8674(93)90541-w · Cited by 1,348 · see citing works
Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor
Murphy, T. J., Alexander, R. W., Griendling, K. K., Runge, M. S., & Bernstein, K. E. (1991) · Nature · doi:10.1038/351233a0 · Cited by 1,250 · see citing works
Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology
Forrester, S. J., Booz, G. W., Sigmund, C. D., Coffman, T. M., Kawai, T., Rizzo, V., Scalia, R. G., & Eguchi, S. (2018) · Physiological Reviews · doi:10.1152/physrev.00038.2017 · Cited by 1,106 · see citing works
Self-citation
Signal Transduction Mechanisms Mediating the Physiological and Pathophysiological Actions of Angiotensin II in Vascular Smooth Muscle Cells
Touyz, R. M., & Schiffrin, E. L. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01471-6 · Cited by 933 · see citing works
Cloning and expression of a complementary DNA encoding a bovine adrenal angiotensin II type-1 receptor
Sasaki, K., Yamano, Y., Bardhan, S., et al. (1991) · Nature · doi:10.1038/351230a0 · Cited by 814 · see citing works
Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors.
Mukoyama, M., Nakajima, M., Horiuchi, M., Sasamura, H., Pratt, R. E., & Dzau, V. J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74498-6 · Cited by 768 · see citing works
Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition.
Kambayashi, Y., Bardhan, S., Takahashi, K., Tsuzuki, S., Inui, H., Hamakubo, T., & Inagami, T. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74499-8 · Cited by 714 · see citing works
Inflammation, Immunity, and Hypertensive End-Organ Damage
McMaster, W. G., Kirabo, A., Madhur, M. S., & Harrison, D. G. (2015) · Circulation Research · doi:10.1161/circresaha.116.303697 · Cited by 708 · see citing works
Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II
Zou, Y., Akazawa, H., Qin, Y., Sano, M., Takano, H., Minamino, T., Makita, N., Iwanaga, K., Zhu, W., Kudoh, S., et al. (2004) · Nature Cell Biology · doi:10.1038/ncb1137 · Cited by 685 · see citing works
Vascular smooth muscle cell hypertrophy vs. hyperplasia. Autocrine transforming growth factor-beta 1 expression determines growth response to angiotensin II.
Gibbons, G. H., Pratt, R. E., & Dzau, V. J. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115881 · Cited by 645 · see citing works
The Putative Drp1 Inhibitor mdivi-1 Is a Reversible Mitochondrial Complex I Inhibitor that Modulates Reactive Oxygen Species
Bordt, E. A., Clerc, P., Roelofs, B. A., Saladino, A. J., Tretter, L., Ádám‐Vizi, V., Cherok, E., Khalil, A., Yadava, N., Ge, S. X., et al. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.02.020 · Cited by 598 · see citing works
Vascular inflammation and the renin-angiotensin system
Brasier, A. R., Recinos, A., & Eledrisi, M. S. (2002) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000021412.56621.a2 · Cited by 586 · see citing works
Calcium-dependent Epidermal Growth Factor Receptor Transactivation Mediates the Angiotensin II-induced Mitogen-activated Protein Kinase Activation in Vascular Smooth Muscle Cells
Eguchi, S., Numaguchi, K., Iwasaki, H., Matsumoto, T., Yamakawa, T., Utsunomiya, H., Motley, E. D., Kawakatsu, H., Owada, K. M., Hirata, Y., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.15.8890 · Cited by 566 · see citing works
Self-citation
Mitochondrial Oxidative Stress Mediates Angiotensin II–Induced Cardiac Hypertrophy and Gαq Overexpression–Induced Heart Failure
Dai, D.-F., Johnson, S. C., Villarin, J. J., Chin, M. T., Nieves-Cintrón, M., Chen, T., Marcinek, D. J., Dorn, G. W., Kang, Y. J., Prolla, T. A., et al. (2011) · Circulation Research · doi:10.1161/circresaha.110.232306 · Cited by 527 · see citing works
Role of Endoplasmic Reticulum Stress in Metabolic Disease and Other Disorders
Özcan, L., & Tabas, I. A. (2011) · Annual Review of Medicine · doi:10.1146/annurev-med-043010-144749 · Cited by 458 · see citing works
The “A Disintegrin And Metalloprotease” (ADAM) family of sheddases: Physiological and cellular functions
Reiß, K., & Säftig, P. (2008) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2008.11.002 · Cited by 424 · see citing works
ADAM-17: the enzyme that does it all
Gooz, M. B. (2010) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409231003628015 · Cited by 413 · see citing works
Angiotensin II Signaling in Vascular Smooth Muscle
Griendling, K. K., Ushio‐Fukai, M., Lassegue, B. P., & Alexander, R. W. (1997) · Hypertension · doi:10.1161/01.hyp.29.1.366 · Cited by 406 · see citing works
Nomenclature for angiotensin receptors. A report of the Nomenclature Committee of the Council for High Blood Pressure Research.
Bumpus, F. M., Catt, K. J., Chiu, A. T., deGasparo, M., Goodfriend, T. L., Husain, A., Peach, M. J., Taylor, D. G., & Timmermans, P. B. M. W. M. (1991) · Hypertension · doi:10.1161/01.hyp.17.5.720 · Cited by 386 · see citing works
Structure of the Angiotensin Receptor Revealed by Serial Femtosecond Crystallography
Zhang, H., Ünal, H., Gati, C., Han, G. W., Liu, W., Zatsepin, N. A., James, D., Wang, D., Nelson, G., Weierstall, U., et al. (2015) · Cell · doi:10.1016/j.cell.2015.04.011 · Cited by 384 · see citing works
Gq‐coupled receptors as mechanosensors mediating myogenic vasoconstriction
y Schnitzler, M. M., Storch, U., Meibers, S., Nurwakagari, P., Breit, A., Essin, K., Gollasch, M., & Gudermann, T. W. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.233 · Cited by 379 · see citing works
Mitochondrial Targeted Antioxidant Peptide Ameliorates Hypertensive Cardiomyopathy
Dai, D., Chen, T., Szeto, H. H., Nieves‐Cintrón, M., Kutyavin, V. I., Santana, L. F., & Rabinovitch, P. S. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.12.044 · Cited by 363 · see citing works
Angiotensin II-Induced Production of Mitochondrial Reactive Oxygen Species: Potential Mechanisms and Relevance for Cardiovascular Disease
Dikalov, S. I., & Nazarewicz, R. R. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4604 · Cited by 356 · see citing works
Sirt3 Impairment and SOD2 Hyperacetylation in Vascular Oxidative Stress and Hypertension
Dikalova, A., Itani, H. A., Nazarewicz, R. R., McMaster, W. G., Flynn, C. R., Uzhachenko, R. V., Fessel, J. P., Gamboa, J. L., Harrison, D. G., & Dikalov, S. (2017) · Circulation Research · doi:10.1161/circresaha.117.310933 · Cited by 317 · see citing works
Nox2-Induced Production of Mitochondrial Superoxide in Angiotensin II-Mediated Endothelial Oxidative Stress and Hypertension
Dikalov, S., Nazarewicz, R. R., Bikineyeva, A. T., Hilenski, L. L., Lassegue, B. P., Griendling, K. K., Harrison, D. G., & Dikalova, A. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4918 · Cited by 312 · see citing works
Caveolae, caveolins, and cavins: complex control of cellular signalling and inflammation
Chidlow, J. H., & Sessa, W. C. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq075 · Cited by 310 · see citing works
Involvement of Tumor Necrosis Factor-α in Angiotensin II–Mediated Effects on Salt Appetite, Hypertension, and Cardiac Hypertrophy
Sriramula, S., Haque, M., Majid, D. S. A., & Francis, J. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.102152 · Cited by 279 · see citing works
Aberrant mitochondrial fission in neurons induced by protein kinase Cδ under oxidative stress conditions in vivo
Qi, X., Disatnik, M., Shen, N., Sobel, R. A., & Mochly‐Rosen, D. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-06-0551 · Cited by 259 · see citing works
Structural basis for selectivity and diversity in angiotensin II receptors
Zhang, H., Han, G. W., Batyuk, A., Ishchenko, A., White, K. L., Patel, N., Sadybekov, A., Zamlynny, B., Rudd, M. T., Hollenstein, K., et al. (2017) · Nature · doi:10.1038/nature22035 · Cited by 221 · see citing works
AT1 receptor signaling pathways in the cardiovascular system
Kawai, T., Forrester, S. J., O’Brien, S. L., Baggett, A., Rizzo, V., & Eguchi, S. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.05.008 · Cited by 218 · see citing works
Self-citation
Endoplasmic Reticulum Stress Is Involved in Cardiac Damage and Vascular Endothelial Dysfunction in Hypertensive Mice
Kassan, M., Galán, M., Partyka, M., Saifudeen, Z. R., Henrion, D., Trebak, M., & Matrougui, K. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.249318 · Cited by 216 · see citing works
Evidence for direct local effect of angiotensin in vascular hypertrophy. In vivo gene transfer of angiotensin converting enzyme.
Morishita, R., Gibbons, G. H., Ellison, K., Lee, W., Zhang, L., Yu, H., Kaneda, Y., Ogihara, T., & Dzau, V. J. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117464 · Cited by 204 · see citing works
Brain Angiotensin-Converting Enzyme Type 2 Shedding Contributes to the Development of Neurogenic Hypertension
Xia, H., Sriramula, S., Chhabra, K. H., & Lazartigues, E. D. (2013) · Circulation Research · doi:10.1161/circresaha.113.301811 · Cited by 173 · see citing works
Clinical Relevance and Role of Neuronal AT 1 Receptors in ADAM17-Mediated ACE2 Shedding in Neurogenic Hypertension
Xu, J., Sriramula, S., Xia, H., Moreno-Walton, L. A., Culicchia, F., Domenig, O., Poglitsch, M., & Lazartigues, E. D. (2017) · Circulation Research · doi:10.1161/circresaha.116.310509 · Cited by 171 · see citing works
Epidermal Growth Factor Receptor Transactivation: Mechanisms, Pathophysiology, and Potential Therapies in the Cardiovascular System
Forrester, S. J., Kawai, T., O’Brien, S. L., Thomas, W. G., Harris, R. C., & Eguchi, S. (2015) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-070115-095427 · Cited by 170 · see citing works
Self-citation
Lack of Specificity of Commercial Antibodies Leads to Misidentification of Angiotensin Type 1 Receptor Protein
Herrera, M., Sparks, M. A., Alfonso-Pecchio, A. R., Harrison‐Bernard, L. M., & Coffman, T. M. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.203679 · Cited by 168 · see citing works
ER stress in the brain subfornical organ mediates angiotensin-dependent hypertension
Young, C. N., Cao, X., Guruju, M. R., Pierce, J. P., Morgan, D. A., Wang, G., Iadecola, C., Mark, A. L., & Davisson, R. L. (2012) · Journal of Clinical Investigation · doi:10.1172/jci64583 · Cited by 152 · see citing works
Tumor Necrosis Factor-α Produced in the Kidney Contributes to Angiotensin II–dependent Hypertension
Zhang, J., Patel, M. B., Griffiths, R., Mao, A., Song, Y.-S., Karlovich, N. S., Sparks, M. A., Jin, H., Wu, M., Lin, E. E., et al. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.03863 · Cited by 149 · see citing works
ADAM17 Mediates Epidermal Growth Factor Receptor Transactivation and Vascular Smooth Muscle Cell Hypertrophy Induced by Angiotensin II
Ohtsu, H., Dempsey, P. J., Frank, G. D., et al. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000236203.90331.d0 · Cited by 140 · see citing works
Attenuation of Angiotensin II–Induced Vascular Dysfunction and Hypertension by Overexpression of Thioredoxin 2
Widder, J. D., Fraccarollo, D., Galuppo, P., Hansen, J. M., Jones, D. P., Ertl, G., & Bauersachs, J. K. (2009) · Hypertension · doi:10.1161/hypertensionaha.108.127928 · Cited by 136 · see citing works
Angiotensin II blockade: a strategy to slow ageing by protecting mitochondria?
de Cavanagh, E. M. V., Inserra, F., & Ferder, L. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq285 · Cited by 136 · see citing works
Stretch–Activation of Angiotensin II Type 1aReceptors Contributes to the Myogenic Response of Mouse Mesenteric and Renal Arteries
Schleifenbaum, J., Kaßmann, M., Szijártó, I. A., Hercule, H. C., Tano, J., Weinert, S., Heidenreich, M., Pathan, A. R., Anistan, Y., Alenina, N. V., et al. (2014) · Circulation Research · doi:10.1161/circresaha.115.302882 · Cited by 134 · see citing works
G Protein Coupling and Second Messenger Generation Are Indispensable for Metalloprotease-dependent, Heparin-binding Epidermal Growth Factor Shedding through Angiotensin II Type-1 Receptor
Mifune, M., Ohtsu, H., Suzuki, H., NAKASHIMA, H., Brailoiu, E., Dun, N. J., Frank, G. D., Inagami, T., Higashiyama, S., Thomas, W. G., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502906200 · Cited by 123 · see citing works
Self-citation
A Novel Role for Type 1 Angiotensin Receptors on T Lymphocytes to Limit Target Organ Damage in Hypertension
Zhang, J.-D., Patel, M. B., Song, Y.-S., Griffiths, R., Burchette, J. L., Ruiz, P., Sparks, M. A., Yan, M., Howell, D. N., Gómez, J. A., et al. (2012) · Circulation Research · doi:10.1161/circresaha.111.261768 · Cited by 116 · see citing works
Role of Epidermal Growth Factor Receptor and Endoplasmic Reticulum Stress in Vascular Remodeling Induced by Angiotensin II
Takayanagi, T., Kawai, T., Forrester, S. J., Obama, T., Tsuji, T., Fukuda, Y., Elliott, K. J., Tilley, D. G., Davisson, R. L., Park, J., et al. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.05344 · Cited by 100 · see citing works
Self-citation
Type 1 angiotensin receptors on macrophages ameliorate IL-1 receptor–mediated kidney fibrosis
Zhang, J.-D., Patel, M. B., Griffiths, R., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci61368 · Cited by 97 · see citing works
Atg5 deficiency-mediated mitophagy aggravates cardiac inflammation and injury in response to angiotensin II
Zhao, W., Li, Y., Jia, L., Pan, L., Li, H., & Du, J. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.01.002 · Cited by 87 · see citing works
A Role for Angiotensin II Type 1 Receptors on Bone Marrow-Derived Cells in the Pathogenesis of Angiotensin II–Dependent Hypertension
Crowley, S. D., Song, Y.-S., Sprung, G. M., Griffiths, R., Sparks, M. A., Yan, M., Burchette, J. L., Howell, D. N., Lin, E. E., Okeiyi, B., et al. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.144964 · Cited by 85 · see citing works
Age- and Hypertension-Associated Protein Aggregates in Mouse Heart Have Similar Proteomic Profiles
Ayyadevara, S., Mercanti, F., Wang, X., Mackintosh, S. G., Tackett, A. J., Prayaga, S., Romeo, F., Reis, R. J. S., & Mehta, J. L. (2016) · Hypertension · doi:10.1161/hypertensionaha.115.06849 · Cited by 84 · see citing works
Vascular ADAM17 as a Novel Therapeutic Target in Mediating Cardiovascular Hypertrophy and Perivascular Fibrosis Induced by Angiotensin II
Takayanagi, T., Forrester, S. J., Kawai, T., et al. (2016) · Hypertension · doi:10.1161/hypertensionaha.116.07620 · Cited by 83 · see citing works
Self-citation
Regulation of Mitochondrial Morphology by Positive Feedback Interaction Between PKCδ and Drp1 in Vascular Smooth Muscle Cell
Lim, S., Lee, S., Seo, H., Ham, O., Lee, C., Park, J., Lee, J., Seung, M., Yun, I., Han, S. M., et al. (2014) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25016 · Cited by 74 · see citing works
Importance of Tyrosine Phosphorylation in Angiotensin II Type 1 Receptor Signaling
Schieffer, B., Paxton, W. G., Marrero, M. B., et al. (1996) · Hypertension · doi:10.1161/01.hyp.27.3.476 · Cited by 70 · see citing works
Vascular Type 1A Angiotensin II Receptors Control BP by Regulating Renal Blood Flow and Urinary Sodium Excretion
Sparks, M. A., Stegbauer, J., Chen, D., Gomez, J. A., Griffiths, R. C., Azad, H., Herrera, M., Gurley, S. B., & Coffman, T. M. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014080816 · Cited by 69 · see citing works
Valsartan Regulates Myocardial Autophagy and Mitochondrial Turnover in Experimental Hypertension
Zhang, X., Li, Z.-L., Crane, J. A., Jordan, K. L., Pawar, A. S., Textor, S. C., Lerman, A., & Lerman, L. O. (2014) · Hypertension · doi:10.1161/hypertensionaha.113.02151 · Cited by 68 · see citing works
Interactions Between the Immune and the Renin–Angiotensin Systems in Hypertension
Rudemiller, N. P., & Crowley, S. D. (2016) · Hypertension · doi:10.1161/hypertensionaha.116.06591 · Cited by 67 · see citing works
Essential Role of Smooth Muscle STIM1 in Hypertension and Cardiovascular Dysfunction
Kassan, M., Ait‐Aissa, K., Radwan, E., et al. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.307869 · Cited by 65 · see citing works
Caveolin-Dependent Angiotensin II Type 1 Receptor Signaling in Vascular Smooth Muscle
Ushio‐Fukai, M., & Alexander, R. W. (2006) · Hypertension · doi:10.1161/01.hyp.0000242907.70697.5d · Cited by 62 · see citing works
Endoplasmic Reticulum Stress Contributes to Aortic Stiffening via Proapoptotic and Fibrotic Signaling Mechanisms
Spitler, K. M., & Webb, R. C. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.02558 · Cited by 62 · see citing works
Angiotensin II Type 1A Receptors in Vascular Smooth Muscle Cells Do Not Influence Aortic Remodeling in Hypertension
Sparks, M. A., Parsons, K. K., Stegbauer, J., Gurley, S. B., Vivekanandan‐Giri, A., Fortner, C. N., Snouwaert, J., Raasch, E. W., Griffiths, R. C., Haystead, T., et al. (2011) · Hypertension · doi:10.1161/hypertensionaha.110.165274 · Cited by 62 · see citing works
Caveolin-1 Deletion Prevents Hypertensive Vascular Remodeling Induced by Angiotensin II
Forrester, S. J., Elliott, K. J., Kawai, T., Obama, T., Boyer, M. J., Preston, K. J., Yan, Z., Eguchi, S., & Rizzo, V. (2016) · Hypertension · doi:10.1161/hypertensionaha.116.08278 · Cited by 61 · see citing works
Self-citation
Moderate Caveolin-1 Downregulation Prevents NADPH Oxidase–Dependent Endothelial Nitric Oxide Synthase Uncoupling by Angiotensin II in Endothelial Cells
Lobysheva, I. I., Rath, G., Sekkali, B., Bouzin, C., Féron, O., Gallez, B., Dessy, C., & Balligand, J. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.230623 · Cited by 56 · see citing works
Constitutive smooth muscle tumour necrosis factor regulates microvascular myogenic responsiveness and systemic blood pressure
Kroetsch, J. T., Levy, A. S., Zhang, H., Aschar‐Sobbi, R., Lidington, D., Offermanns, S., Nedospasov, S. A., Backx, P. H., Heximer, S. P., & Bolz, S. (2017) · Nature Communications · doi:10.1038/ncomms14805 · Cited by 55 · see citing works
Vascular ADAM17 (a Disintegrin and Metalloproteinase Domain 17) Is Required for Angiotensin II/β-Aminopropionitrile–Induced Abdominal Aortic Aneurysm
Kawai, T., Takayanagi, T., Forrester, S. J., Preston, K. J., Obama, T., Tsuji, T., Kobayashi, T., Boyer, M. J., Cooper, H. A., Kwok, H. F., et al. (2017) · Hypertension · doi:10.1161/hypertensionaha.117.09822 · Cited by 52 · see citing works
Self-citation
Mitochondrial Fission: Regulation and ER Connection
Lee, H., & Yoon, Y. (2014) · Molecules and Cells · doi:10.14348/molcells.2014.2329 · Cited by 51 · see citing works
Caveolin 1 is critical for abdominal aortic aneurysm formation induced by angiotensin II and inhibition of lysyl oxidase
Takayanagi, T., Crawford, K., Kobayashi, T., Obama, T., Tsuji, T., Elliott, K. J., Hashimoto, T. N., Rizzo, V., & Eguchi, S. (2013) · Clinical Science · doi:10.1042/cs20130660 · Cited by 51 · see citing works
Self-citation
Fibroblast Angiotensin II Type 1a Receptors Contribute to Angiotensin II–Induced Medial Hyperplasia in the Ascending Aorta
Poduri, A., Rateri, D. L., Howatt, D. A., et al. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.305995 · Cited by 51 · see citing works
Metalloprotease-dependent ErbB ligand shedding in mediating EGFR transactivation and vascular remodelling
Eguchi, S., Frank, G. D., Mifune, M., et al. (2003) · Biochemical Society Transactions · doi:10.1042/bst0311198 · Cited by 50 · see citing works
Self-citation
Angiotensin II, From Vasoconstrictor to Growth Factor
Vukelic, S., & Griendling, K. K. (2014) · Circulation Research · doi:10.1161/circresaha.114.303045 · Cited by 49 · see citing works
The micro RNA miR‐124 inhibits vascular smooth muscle cell proliferation by targeting S100 calcium‐binding protein A4 (S100A4)
Choe, N., Kwon, D., Shin, S., Kim, Y. S., Kim, Y. K., Kim, J., Ahn, Y., Eom, G. H., & Kook, H. (2017) · FEBS Letters · doi:10.1002/1873-3468.12606 · Cited by 46 · see citing works
Epidermal growth factor receptor inhibitor protects against abdominal aortic aneurysm in a mouse model
Obama, T., Tsuji, T., Kobayashi, T., et al. (2014) · Clinical Science · doi:10.1042/cs20140696 · Cited by 45 · see citing works
Novel role of mechanosensitive AT1B receptors in myogenic vasoconstriction
Blodow, S., Schneider, H., Storch, U., Wizemann, R., Forst, A. W., Gudermann, T. W., & y Schnitzler, M. M. (2013) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-013-1372-3 · Cited by 44 · see citing works
Epidermal growth factor receptor is indispensable for c-Fos expression and protein synthesis by angiotensin II
Eguchi, S., Iwasaki, H., Hirata, Y., Frank, G. D., Motley, E. D., Yamakawa, T., Numaguchi, K., & Inagami, T. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00357-x · Cited by 44 · see citing works
Self-citation
A Disintegrin and Metalloprotease-17 Regulates Pressure Overload–Induced Myocardial Hypertrophy and Dysfunction Through Proteolytic Processing of Integrin β1
Dong, F., Takawale, A. R., Shen, M., Samokhvalov, V., Basu, R., Patel, V. B., Wang, X., Fernández-Patrón, C., Seubert, J. M., Oudit, G. Y., et al. (2016) · Hypertension · doi:10.1161/hypertensionaha.116.07566 · Cited by 44 · see citing works
ADAM17 silencing by adenovirus encoding miRNA-embedded siRNA revealed essential signal transduction by angiotensin II in vascular smooth muscle cells
Elliott, K. J., Bourne, A., Takayanagi, T., et al. (2013) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2013.05.005 · Cited by 38 · see citing works
Epidermal Growth Factor Receptor Is Critical For Angiotensin II–Mediated Hypertrophy in Cerebral Arterioles
Chan, S., Umesalma, S., & Baumbach, G. L. (2015) · Hypertension · doi:10.1161/hypertensionaha.114.04794 · Cited by 36 · see citing works
Deletion of the EGF receptor in vascular smooth muscle cells prevents chronic angiotensin II ‐induced arterial wall stiffening and media thickening
Schreier, B., Hünerberg, M., Mildenberger, S., et al. (2017) · Acta Physiologica · doi:10.1111/apha.12996 · Cited by 32 · see citing works
Src mediates the mechanical activation of myogenesis by activating TNFα-converting enzyme
Niu, A., Wen, Y., Liu, H., Zhan, M., Jin, B., & Li, Y.-P. (2013) · Journal of Cell Science · doi:10.1242/jcs.125328 · Cited by 31 · see citing works
Lack of Specificity of Commercial Antibodies Leads to Misidentification of Angiotensin Type-1 Receptor Protein
Elliott, K. J., Kimura, K., & Eguchi, S. (2013) · Hypertension · doi:10.1161/hypertensionaha.111.00943 · Cited by 31 · see citing works
Self-citation
Essential Role of Angiotensin II Type 1a Receptors in the Host Vascular Wall, but Not the Bone Marrow, in the Pathogenesis of Angiotensin II−Induced Atherosclerosis
Koga, J., Egashira, K., Matoba, T., Kubo, M., Ihara, Y., Iwai, M., Horiuchi, M., & Sunagawa, K. (2008) · Hypertension Research · doi:10.1291/hypres.31.1791 · Cited by 27 · see citing works
Organelles in health and diseases
Eguchi, S., & Rizzo, V. (2016) · Clinical Science · doi:10.1042/cs20160610 · Cited by 14 · see citing works
Self-citation

Flagged first, then by citations

Research works printed but not linked: 4

[1]Karnik SS Unal H Kemp JR Tirupula KC Eguchi S Vanderheyden PM Thomas WG International Union of Basic and Clinical Pharmacology XCIX. Angiotensin Receptors: Interpreters of Pathophysiological Angiotensinergic Stimuli [corrected] Pharmacol Rev 2015 67 754 819 26315714 PMC4630565
[27]Eguchi S Iwasaki H Ueno H Frank GD Motley ED Eguchi K Marumo F Hirata Y Inagami T Intracellular signaling of angiotensin II-induced p70 S6 kinase phosphorylation at Ser(411) in vascular smooth muscle cells. Possible requirement of epidermal growth factor receptor, Ras, extracellular signal-regulated kinase, and Akt J Biol Chem 1999 274 36843 51 10601235
[28]Eguchi S Dempsey PJ Frank GD Motley ED Inagami T Activation of MAPKs by angiotensin II in vascular smooth muscle cells. Metalloprotease-dependent EGF receptor activation is required for activation of ERK and p38 MAPK but not for JNK J Biol Chem 2001 276 7957 62 11116149
[65]Mori J Basu R McLean BA Das SK Zhang L Patel VB Wagg CS Kassiri Z Lopaschuk GD Oudit GY Agonist-induced hypertrophy and diastolic dysfunction are associated with selective reduction in glucose oxidation: a metabolic contribution to heart failure with normal ejection fraction Circ Heart Fail 2012 5 493 503 22705769

Sorted by citations

Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
Ferrucci, L., & Fabbri, E. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0064-2 · Cited by 3,690 · see citing works
IL-6 in inflammation, autoimmunity and cancer
Hirano, T. (2021) · International Immunology · doi:10.1093/intimm/dxaa078 · Cited by 1,453 · see citing works
“Since SARS-CoV-2 uses angiotensin-converting enzyme (ACE) 2 as a receptor (342, 343), it is speculated that SARS-CoV-2 induces pro-inflammatory cytokines through angiotensin II (AngII)/angiotensin type 1 receptor (AT1R) (15) as SARS-CoV-1 does (344–346).”
Background
How COVID-19 induces cytokine storm with high mortality
Hojyo, S., Uchida, M., Tanaka, K., Hasebe, R., Tanaka, Y., Murakami, M., & Hirano, T. (2020) · Inflammation and Regeneration · doi:10.1186/s41232-020-00146-3 · Cited by 663 · see citing works
COVID-19, Myocarditis and Pericarditis
Fairweather, D., Beetler, D. J., Di Florio, D. N., Musigk, N., Heidecker, B., & Cooper, L. T. (2023) · Circulation Research · doi:10.1161/circresaha.123.321878 · Cited by 181 · see citing works

Authors: Eguchi, S., Kawai, T., Scalia, R., & Rizzo, V.
Affiliations: Temple University (US)
ORCID: Eguchi, Satoru
Kawai, Tatsuo
Scalia, Rosario
Rizzo, Victor
Venue: Hypertension
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2018-05
Volume: 71
Issue: 5
Pages: 804-810
ISSN: 0194-911X (ISSN-L)
1524-4563
DOI: 10.1161/hypertensionaha.118.10266
PMC: PMC5897153
OpenAlex: W2790198199
Cited by: 189
References: 83
Citations by year: 2026: 7 · 2025: 21 · 2024: 16 · 2023: 25 · 2022: 39 · 2021: 42 · 2020: 28 · 2019: 5 · 2018: 6
FWCI: 3.78
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Hypertension (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: American Heart Association (16GRNT30410007, 16GRNT30130013, 16POST3051004)
National Institutes of Health
National Heart, Lung, and Blood Institute (R01HL133248, R01HL128324)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK111042, R01DK096521)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
Keywords: angiotensin II type 1 receptor, receptor signaling, vascular pathophysiology, renin-angiotensin system
MeSH terms: Animals, Cardiovascular Diseases, Female, Humans, Hypertension, Male, Muscle, Smooth, Vascular, Renin-Angiotensin System, Sensitivity and Specificity, Vascular Diseases, Signal Transduction, Mice, Knockout, Models, Animal, Receptor, Angiotensin, Type 1, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Understanding Angiotensin II Type 1 Receptor Signaling in Vascular Pathophysiology

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Record

About these checks