Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer

Ciriello, Giovanni; Gatza, Michael L.; Beck, Andrew H.; Wilkerson, Matthew D.; Rhie, Suhn K.; Pastore, Alessandro; Zhang, Hailei; McLellan, Michael; Yau, Christina; Kandoth, Cyriac; Bowlby, Reanne; Shen, Hui; Hayat, Sikander; Fieldhouse, Robert; Lester, Susan C.; Tse, Gary M.K.; Factor, Rachel E.; Collins, Laura C.; Allison, Kimberly H.; Chen, Yunn-Yi; Jensen, Kristin; Johnson, Nicole B.; Oesterreich, Steffi; Mills, Gordon B.; Cherniack, Andrew D.; Robertson, Gordon; Benz, Christopher; Sander, Chris; Laird, Peter W.; Hoadley, Katherine A.; King, Tari A.; Perou, Charles M.; Akbani, Rehan; Auman, J. Todd; Balasundaram, Miruna; Balu, Saianand; Barr, Thomas; Beck, Andrew; Benz, Christopher; Benz, Stephen; Berrios, Mario; Beroukhim, Rameen; Bodenheimer, Tom; Boice, Lori; Bootwalla, Moiz S.; Bowen, Jay; Bowlby, Reanne; Brooks, Denise; Cherniack, Andrew D.; Chin, Lynda

doi:10.1016/j.cell.2015.09.033

Cited by 1,858

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer

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Ciriello, Giovanni, Gatza, Michael L., Beck, Andrew H., Wilkerson, Matthew D., Rhie, Suhn K., Pastore, Alessandro, Zhang, Hailei, McLellan, Michael, Yau, Christina, Kandoth, Cyriac, Bowlby, Reanne, Shen, Hui, Hayat, Sikander, Fieldhouse, Robert, Lester, Susan C., Tse, Gary M.K., Factor, Rachel E., Collins, Laura C., Allison, Kimberly H., Chen, Yunn-Yi, Jensen, Kristin, Johnson, Nicole B., Oesterreich, Steffi, Mills, Gordon B., Cherniack, Andrew D., Robertson, Gordon, Benz, Christopher, Sander, Chris, Laird, Peter W., Hoadley, Katherine A., King, Tari A., Perou, Charles M., Akbani, Rehan, Auman, J. Todd, Balasundaram, Miruna, Balu, Saianand, Barr, Thomas, Beck, Andrew, Benz, Christopher, Benz, Stephen, Berrios, Mario, Beroukhim, Rameen, Bodenheimer, Tom, Boice, Lori, Bootwalla, Moiz S., Bowen, Jay, Bowlby, Reanne, Brooks, Denise, Cherniack, Andrew D., Chin, Lynda, Cho, Juok, Chudamani, Sudha, Ciriello, Giovanni, Davidsen, Tanja, Demchok, John A., Dennison, Jennifer B., Ding, Li, Felau, Ina, Ferguson, Martin L., Frazer, Scott, Gabriel, Stacey B., Gao, JianJiong, Gastier-Foster, Julie M., Gatza, Michael L., Gehlenborg, Nils, Gerken, Mark, Getz, Gad, Gibson, William J., Hayes, D. Neil, Heiman, David I., Hoadley, Katherine A., Holbrook, Andrea, Holt, Robert A., Hoyle, Alan P., Hu, Hai, Huang, Mei, Hutter, Carolyn M., Hwang, E. Shelley, Jefferys, Stuart R., Jones, Steven J.M., Ju, Zhenlin, Kim, Jaegil, Lai, Phillip H., Laird, Peter W., Lawrence, Michael S., Leraas, Kristen M., Lichtenberg, Tara M., Lin, Pei, Ling, Shiyun, Liu, Jia, Liu, Wenbin, Lolla, Laxmi, Lu, Yiling, Ma, Yussanne, Maglinte, Dennis T., Mardis, Elaine, Marks, Jeffrey, Marra, Marco A., McAllister, Cynthia, McLellan, Michael, Meng, Shaowu, Meyerson, Matthew, Mills, Gordon B., Moore, Richard A., Mose, Lisle E., Mungall, Andrew J., Murray, Bradley A., Naresh, Rashi, Noble, Michael S., Oesterreich, Steffi, Olopade, Olufunmilayo, Parker, Joel S., Perou, Charles M., Pihl, Todd, Saksena, Gordon, Schumacher, Steven E., Shaw, Kenna R. Mills, Ramirez, Nilsa C., Rathmell, W. Kimryn, Rhie, Suhn K., Roach, Jeffrey, Robertson, A. Gordon, Saksena, Gordon, Sander, Chris, Schein, Jacqueline E., Schultz, Nikolaus, Shen, Hui, Sheth, Margi, Shi, Yan, Shih, Juliann, Shelley, Carl Simon, Shriver, Craig, Simons, Janae V., Sofia, Heidi J., Soloway, Matthew G., Sougnez, Carrie, Sun, Charlie, Tarnuzzer, Roy, Tiezzi, Daniel G., Van Den Berg, David J., Voet, Doug, Wan, Yunhu, Wang, Zhining, Weinstein, John N., Weisenberger, Daniel J., Wilkerson, Matthew D., Wilson, Richard, Wise, Lisa, Wiznerowicz, Maciej, Wu, Junyuan, Wu, Ye, Yang, Liming, Yau, Christina, Zack, Travis I., Zenklusen, Jean C., Zhang, Hailei, Zhang, Jiashan, Zmuda, Erik·2015·Cell

DOI 10.1016/j.cell.2015.09.033

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Abstract

Summary Invasive lobular carcinoma (ILC) is the second most prevalent histologic subtype of invasive breast cancer. Here, we comprehensively profiled 817 breast tumors, including 127 ILC, 490 ductal (IDC), and 88 mixed IDC/ILC. Besides E-cadherin loss, the best known ILC genetic hallmark, we identified mutations targeting PTEN, TBX3 and FOXA1 as ILC enriched features. PTEN loss associated with increased AKT phosphorylation, which was highest in ILC among all breast cancer subtypes. Spatially clustered FOXA1 mutations correlated with increased FOXA1 expression and activity. Conversely, GATA3 mutations and high expression characterized Luminal A IDC, suggesting differential modulation of ER activity in ILC and IDC. Proliferation and immune-related signatures determined three ILC transcriptional subtypes associated with survival differences. Mixed IDC/ILC cases were molecularly classified as ILC-like and IDC-like revealing no true hybrid features. This multidimensional molecular atlas sheds new light on the genetic bases of ILC and provides potential clinical options.

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Authors: Ciriello, G., Gatza, M. L., Beck, A. H., Wilkerson, M. D., Rhie, S. K., Pastore, A., Zhang, H., McLellan, M., Yau, C., Kandoth, C., Bowlby, R., Shen, H., Hayat, S., Fieldhouse, R., Lester, S. C., Tse, G. M. K., Factor, R. E., Collins, L. C., Allison, K. H., Chen, Y.-Y., Jensen, K., Johnson, N. B., Oesterreich, S., Mills, G. B., Cherniack, A. D., Robertson, G., Benz, C., Sander, C., Laird, P. W., Hoadley, K. A., King, T. A., Perou, C. M., Akbani, R., Auman, J. T., Balasundaram, M., Balu, S., Barr, T., Beck, A., Benz, C., Benz, S., Berrios, M., Beroukhim, R., Bodenheimer, T., Boice, L., Bootwalla, M. S., Bowen, J., Bowlby, R., Brooks, D., Cherniack, A. D., Chin, L., Cho, J., Chudamani, S., Ciriello, G., Davidsen, T., Demchok, J. A., Dennison, J. B., Ding, L., Felau, I., Ferguson, M. L., Frazer, S., Gabriel, S. B., Gao, J., Gastier-Foster, J. M., Gatza, M. L., Gehlenborg, N., Gerken, M., Getz, G., Gibson, W. J., Hayes, D. N., Heiman, D. I., Hoadley, K. A., Holbrook, A., Holt, R. A., Hoyle, A. P., Hu, H., Huang, M., Hutter, C. M., Hwang, E. S., Jefferys, S. R., Jones, S. J. M., Ju, Z., Kim, J., Lai, P. H., Laird, P. W., Lawrence, M. S., Leraas, K. M., Lichtenberg, T. M., Lin, P., Ling, S., Liu, J., Liu, W., Lolla, L., Lu, Y., Ma, Y., Maglinte, D. T., Mardis, E., Marks, J., Marra, M. A., McAllister, C., McLellan, M., Meng, S., Meyerson, M., Mills, G. B., Moore, R. A., Mose, L. E., Mungall, A. J., Murray, B. A., Naresh, R., Noble, M. S., Oesterreich, S., Olopade, O., Parker, J. S., Perou, C. M., Pihl, T., Saksena, G., Schumacher, S. E., Shaw, K. R. M., Ramirez, N. C., Rathmell, W. K., Rhie, S. K., Roach, J., Robertson, A. G., Saksena, G., Sander, C., Schein, J. E., Schultz, N., Shen, H., Sheth, M., Shi, Y., Shih, J., Shelley, C. S., Shriver, C., Simons, J. V., Sofia, H. J., Soloway, M. G., Sougnez, C., Sun, C., Tarnuzzer, R., Tiezzi, D. G., Van Den Berg, D. J., Voet, D., Wan, Y., Wang, Z., Weinstein, J. N., Weisenberger, D. J., Wilkerson, M. D., Wilson, R., Wise, L., Wiznerowicz, M., Wu, J., Wu, Y., Yang, L., Yau, C., Zack, T. I., Zenklusen, J. C., Zhang, H., Zhang, J., & Zmuda, E.
Venue: Cell
Publisher: Elsevier BV
Published: 2015-10
Volume: 163
Issue: 2
Pages: 506-519
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2015.09.033
OpenAlex: W1908864745
Cited by: 1,858
References: 8
FWCI: 49.26
Type: journal article
Language: en
Open access: bronze

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This page: CoChat. (2026). Citation check: Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer. https://app.cochat.ai/papers/10.1016/j.cell.2015.09.033
The paper: Ciriello, G., Gatza, M. L., Beck, A. H., Wilkerson, M. D., Rhie, S. K., Pastore, A., Zhang, H., McLellan, M., Yau, C., Kandoth, C., Bowlby, R., Shen, H., Hayat, S., Fieldhouse, R., Lester, S. C., Tse, G. M. K., Factor, R. E., Collins, L. C., Allison, K. H., . . . Zmuda, E. (2015). Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer. Cell. https://doi.org/10.1016/j.cell.2015.09.033

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Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer

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