The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Inflammasome Complexes: Emerging Mechanisms and Effector Functions
Open accessAbstract
Canonical activation of the inflammasome is critical to promote caspase-1-dependent maturation of the proinflammatory cytokines IL-1β and IL-18, as well as to induce pyroptotic cell death in response to pathogens and endogenous danger signals. Recent discoveries, however, are beginning to unveil new components of the inflammasome machinery, and the full spectrum of inflammasome functions, extending their influence beyond canonical functions, to regulation of eicosanoid storm, autophagy and metabolism. In addition, the receptor components of the inflammasome can also regulate diverse biological processes, such as cellular proliferation, gene transcription and tumorigenesis, all of which are independent of their inflammasome complex-forming capabilities. Here, we review these recent advances that are shaping our understanding of the complex biology of the inflammasome and its constituents.
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Cites
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Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
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Self-citationActivation and regulation of the inflammasomes
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AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
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Self-citationNon-canonical inflammasome activation targets caspase-11
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Cited by
Pyroptosis: Mechanisms and Diseases
Yu, P., Zhang, X., Liu, N., Tang, L., Peng, C., & Chen, X. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00507-5 · Cited by 2,353
Pyroptosis: A new frontier in cancer
Fang, Y., Tian, S., Pan, Y., Li, W., Wang, Q., Tang, Y., Yu, T., Wu, X., Shi, Y., Ma, P., et al. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109595 · Cited by 1,049
Fundamental Mechanisms of Regulated Cell Death and Implications for Heart Disease
Del Re, D. P., Amgalan, D., Linkermann, A., Liu, Q., & Kitsis, R. N. (2019) · Physiological Reviews · doi:10.1152/physrev.00022.2018 · Cited by 961
Adeno-associated virus as a delivery vector for gene therapy of human diseases
Wang, J.-H., Gessler, D. J., Zhan, W., Gallagher, T. L., & Gao, G. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01780-w · Cited by 904
Autophagy-Independent Functions of the Autophagy Machinery
Galluzzi, L., & Green, D. R. (2019) · Cell · doi:10.1016/j.cell.2019.05.026 · Cited by 863
“One of the substrates of non-conventional secretion is mature interleukin 1 beta (IL1B, best known as IL-1b), which is produced in the cytosol of cells with pro-inflammatory activity (like macrophages) upon proteolytic maturation of the IL-1b precursor by the NLRP3 inflammasome (Rathinam and Fitzgerald, 2016).”
Background
Metadata
- Authors
- Rathinam, V. A. K., & Fitzgerald, K. A.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 165
- Issue
- 4
- Pages
- 792-800
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2346799309
- Cited by
- 1,101
- References
- 20
- FWCI
- 27.84
- Type
- journal article
- Language
- en
- Open access
- bronze
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