Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity

Merkwirth, Carsten, Jovaisaite, Virginija, Durieux, Jenni, Matilainen, Olli, Jordan, Sabine D., Quiros, Pedro M., Steffen, Kristan K., Williams, Evan G., Mouchiroud, Laurent, Tronnes, Sarah U., Murillo, Virginia, Wolff, Suzanne C., Shaw, Reuben J., Auwerx, Johan, Dillin, Andrew·2016·Cell
DOI 10.1016/j.cell.2016.04.012

Cited by (374)

Items 301–374 of 374

  1. The epigenetics of aging
    Athanasios Metaxakis, Ilias Gkikas, Nektarios Tavernarakis · 2022 · Elsevier eBooks
  2. Oxidative Stress and Cardiovascular Disease: Implication of Gender and Age
    Mia Karam, Maha M. Itani, Marwa Faraj, Aneese A. Jaffa, Joseph Jelwan, Kawthar Sharaf Aldeen, Ayad A. Jaffa · 2024 · Oxidative stress in applied basic research and clinical practice
  3. Organellar insights in ageing and longevity
    Philip Mannino, Mooncheol Park, Meng Carla Wang · 2026 · Nature Cell Biology
  4. Mitochondrial unfolded protein response as a central stress-integration hub: mechanisms and implications in disease contexts
    Yanmin Xin, Yiting He, Xingguo Liu · 2026 · Burns & Trauma
  5. Perturbation of mitochondrial Ca2+ homeostasis activates cross-compartmental proteostatic response in Arabidopsis
    Xiaoyan Zhang, Chongyang Ma, Xinyue Bao, Shenyu Zhang, Omar Zayed, Zhengjing Zhang, Kai Tang, Shaojun Xie, Yunsheng Wang, Dayong Zhang et al. · 2026 · Stress Biology
  6. Medium chain fatty acid sensing receptor GPR84 limits antitumor immunity mediated by CD4 T cells in mice
    Anamaria Morales Alvarez, Timothy A. Gilbertson, Hung Dang Nguyen · 2026 · ImmunoHorizons
  7. Stressed-out chromatin promotes longevity
    Siu Sylvia Lee, Jessica K. Tyler · 2016 · Nature
  8. Epigenetic Regulation of Toxicity of Environmental Toxicants or Stresses
    Dayong Wang · 2019 · Springer eBooks
  9. Role of epigenetic molecular mechanisms in insect evolutionary innovations
    Cristián Villagra · 2024 · Elsevier eBooks
  10. Early-Life Adjustment of Epigenetic Aging Clock
    Alexander M. Vaiserman, Oleh V. Lushchak · 2019 · Healthy ageing and longevity
  11. Stem Cell Quiescence versus Senescence: The Key for Healthy Aging
    Anna Meiliana, Nurrani Mustika Dewi, Andi Wijaya · 2021 · The Indonesian Biomedical Journal
  12. Twinkle is not the mitochondrial DNA replicative helicase in C. elegans , but may have alternate mitochondrial functions
    Hope R. Henderson, Liliya Euro, Anu Suomalainen, Andrew G. Dillin · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  13. Coenzyme Q regulates UCP1 expression and thermogenesis through the integrated stress responses
    Ching-Fang Chang, Amanda L. Gunawan, Peter‐James H. Zushin, Greg A. Timblin, Ambre M. Bertholet, Biao Wang, Kaoru Sajio, Yuriy Kirichok, Andreas Stahl · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  14. Glial-derived mitochondrial signals impact neuronal proteostasis and aging
    Raz Bar‐Ziv, Naibedya Dutta, Adam J. Hruby, Edward Sukarto, Maxim Averbukh, Athena Alcala, Hope R. Henderson, Jenni Durieux, Sarah U. Tronnes, Qazi Ahmad et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  15. Global Functions of PRC2 Complexes
    V. Pirrotta · 2017 · Elsevier eBooks
  16. GPS2 regulates mitochondria biogenesis via mitochondrial retrograde signaling and chromatin remodeling of nuclear-encoded mitochondrial genes
    Maria Dafne Cardamone, Bogdan Tanasă, Carly Cederquist, Jiawen Huang, Kiana Mahdaviani, Wembo Li, Michael G. Rosenfeld, Marc Liesa, Valentina Perissi · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
  17. FSHR-1/GPCR activates the mitochondrial unfolded protein response in Caenorhabditis elegans
    Sung‐Jin Kim, Derek Sieburth · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  18. PARTIAL INHIBITION OF MITOCHONDRIAL COMPLEX I ACTIVATES STRESS RESPONSE PATHWAYS INDUCING A PROTECTION AGAINST OXIDATIVE STRESS
    Utkarsh Tripathi · 2017 · OakTrust (Texas A&M University Libraries)
  19. Tissue repair and stress responses of aged skin epidermis
    Wesley Wong · 2020 · Digital Repository Service (Northeastern University)
  20. Epigenetic codes of mitochondrial homeostasis
    Ying Liu · 2021 · Nature Aging
  21. A tRNA processing enzyme is a central regulator of the mitochondrial unfolded protein response
    James P. Held, Benjamin R. Saunders, Claudia V. Pereira, Maulik R. Patel · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  22. Multi-Omics Analysis Identifies Essential Regulators of Mitochondrial Stress Response in Two Wild-Type C. Elegans Strains
    Arwen W. Gao, Gaby El Alam, Amélia Lalou, Terytty Yang Li, Marte Molenaars, Yunyun Zhu, Katherine A. Overmyer, Evgenia Shishkova, Kevin Hof, Maroun S. Bou Sleiman et al. · 2021 · SSRN Electronic Journal
  23. An omics analysis of genetic sleep loss in C. elegans
    Anastasios Koutsoumparis · 2020 · eDiss (Georg-August-Universität Göttingen)
  24. Faculty Opinions recommendation of HSB-1/HSF-1 pathway modulates histone H4 in mitochondria to control mtDNA transcription and longevity.
    Seung‐Jae Lee, Yoonji Jung · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  25. Femtosecond laser microdissection isolating regenerating C. elegans neurons for single cell RNA sequencing
    Peisen Zhao, Chris Martin, Ke-Yue Ma, Ning Jenny Jiang, Adela Ben‐Yakar · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  26. A conserved role of CBP/p300 in mitochondrial stress response and longevity
    Terytty Yang Li, Maroun S. Bou Sleiman, Hao Li, Arwen W. Gao, Adrienne Mottis, Alexis Bachmann, Gaby El Alam, Ludger J.E. Goeminne, Xiaoxu Li, Kristina Schoonjans et al. · 2020
  27. Model of Chaperones in Aging
    Jan Olof Nehlin, Jens Krøll · 2018 · Elsevier eBooks
  28. Healthy Mitochondria: The Brake of Cell Proliferation of Malignant Melanoma
    Zhenyao Yu, Zizhen Zhao, Chen Fu, Wei Zhou, Junchen Wang, Ailing Fu · 2020 · Research Square
  29. Faculty Opinions recommendation of Mitonuclear genomics and aging.
    Heinz Dieter Osiewacz · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  30. O papel do exercício físico no desequilíbrio mitonuclear e UPRmt na musculatura esquelética de camundongos idosos
    André V. Cordeiro · 2019
  31. The new epigenetic driver role of PPARα and mitochondria in metabolic dysfunction associated liver disease (MASLD), paving the way towards new therapeutics and diagnostic biomarkers
    Claudia Theys · 2024
  32. Molecular Toxicology in Caenorhabditis elegans
    Dayong Wang · 2022 · CABI eBooks
  33. The Cellular and Molecular Biology of Aging
    E. Mo · 2024 · BIO Web of Conferences
  34. Mild activation of the endoplasmic reticulum unfolded protein response conferred cadmium resistance in the nematode Caenorhabditis elegans
    Shunchang Wang, Dan Zhu, Jingjing Wu, Yin Ma, Wenhui Wang, Zhaoxia Chu, Mei He · 2025 · Ecotoxicology and Environmental Safety
  35. Longevity-promoting mitochondrial unfolded protein response activation requires elements of the PeBoW complex
    Adebanjo Adedoja, Niclole Stuhr, Yifei Zhou, Yuyao Zhang, Armen I. Yerevanian, Alexander A. Soukas · 2025 · Genes & Development
  36. COMPASS-mediated epigenetic regulation of transcription accelerates forgetting with age
    Titas Sengupta, Rachel L. Kaletsky, Katherine S. Morillo, Shiyi Zhou, Alan Brown, K. Novak, Ying-Ti Weng, Patrick Dougherty, Amayel Ka, Coleen T. Murphy · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  37. Additional file 10 of Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics
    Liu, Yunpeng, Lu, Shuaiyao, Jing Yang, Yang, Yun, Jiao, Li, Hu, Jingwen, Li, Yanyan, Fengmei Yang, Pang, Yunli, Zhao, Yuan et al. · 2024 · Figshare
  38. Additional file 9 of Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics
    Liu, Yunpeng, Lu, Shuaiyao, Jing Yang, Yang, Yun, Jiao, Li, Hu, Jingwen, Li, Yanyan, Fengmei Yang, Pang, Yunli, Zhao, Yuan et al. · 2024 · Figshare
  39. Additional file 17 of Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics
    Liu, Yunpeng, Lu, Shuaiyao, Jing Yang, Yang, Yun, Jiao, Li, Hu, Jingwen, Li, Yanyan, Fengmei Yang, Pang, Yunli, Zhao, Yuan et al. · 2024 · Figshare
  40. Additional file 3 of Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics
    Liu, Yunpeng, Lu, Shuaiyao, Jing Yang, Yang, Yun, Jiao, Li, Hu, Jingwen, Li, Yanyan, Fengmei Yang, Pang, Yunli, Zhao, Yuan et al. · 2024 · Figshare
  41. Additional file 7 of Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics
    Liu, Yunpeng, Lu, Shuaiyao, Jing Yang, Yang, Yun, Jiao, Li, Hu, Jingwen, Li, Yanyan, Fengmei Yang, Pang, Yunli, Yuan Zhao et al. · 2024 · Figshare
  42. Additional file 14 of Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics
    Liu, Yunpeng, Lu, Shuaiyao, Jing Yang, Yang, Yun, Jiao, Li, Hu, Jingwen, Li, Yanyan, Fengmei Yang, Pang, Yunli, Zhao, Yuan et al. · 2024 · Figshare
  43. Additional file 2 of Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics
    Liu, Yunpeng, Lu, Shuaiyao, Jing Yang, Yang, Yun, Jiao, Li, Hu, Jingwen, Li, Yanyan, Fengmei Yang, Pang, Yunli, Zhao, Yuan et al. · 2024 · Figshare
  44. Additional file 4 of Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics
    Liu, Yunpeng, Lu, Shuaiyao, Jing Yang, Yun Yang, Jiao, Li, Hu, Jingwen, Li, Yanyan, Fengmei Yang, Pang, Yunli, Zhao, Yuan et al. · 2024 · Figshare
  45. Additional file 8 of Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics
    Liu, Yunpeng, Lu, Shuaiyao, Jing Yang, Yang, Yun, Jiao, Li, Hu, Jingwen, Li, Yanyan, Fengmei Yang, Pang, Yunli, Zhao, Yuan et al. · 2024 · Figshare
  46. Additional file 13 of Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics
    Liu, Yunpeng, Lu, Shuaiyao, Jing Yang, Yang, Yun, Jiao, Li, Hu, Jingwen, Li, Yanyan, Fengmei Yang, Pang, Yunli, Zhao, Yuan et al. · 2024 · Figshare
  47. Additional file 15 of Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics
    Liu, Yunpeng, Lu, Shuaiyao, Jing Yang, Yang, Yun, Jiao, Li, Hu, Jingwen, Li, Yanyan, Fengmei Yang, Pang, Yunli, Zhao, Yuan et al. · 2024 · Figshare
  48. Additional file 6 of Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics
    Liu, Yunpeng, Lu, Shuaiyao, Yang, Jing, Yang, Yun, Jiao, Li, Hu, Jingwen, Li, Yanyan, Fengmei Yang, Pang, Yunli, Yuan Zhao et al. · 2024 · Figshare
  49. Additional file 5 of Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics
    Liu, Yunpeng, Lu, Shuaiyao, Yang, Jing, Yun Yang, Jiao, Li, Hu, Jingwen, Li, Yanyan, Fengmei Yang, Pang, Yunli, Zhao, Yuan et al. · 2024 · Figshare
  50. Additional file 16 of Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics
    Liu, Yunpeng, Lu, Shuaiyao, Jing Yang, Yang, Yun, Jiao, Li, Hu, Jingwen, Li, Yanyan, Fengmei Yang, Pang, Yunli, Zhao, Yuan et al. · 2024 · Figshare
  51. Additional file 18 of Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics
    Liu, Yunpeng, Lu, Shuaiyao, Jing Yang, Yun Yang, Jiao, Li, Hu, Jingwen, Li, Yanyan, Fengmei Yang, Pang, Yunli, Zhao, Yuan et al. · 2024 · Figshare
  52. Additional file 20 of Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics
    Liu, Yunpeng, Lu, Shuaiyao, Jing Yang, Yang, Yun, Jiao, Li, Hu, Jingwen, Li, Yanyan, Fengmei Yang, Pang, Yunli, Zhao, Yuan et al. · 2024 · Figshare
  53. Additional file 19 of Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics
    Liu, Yunpeng, Lu, Shuaiyao, Jing Yang, Yang, Yun, Jiao, Li, Hu, Jingwen, Li, Yanyan, Fengmei Yang, Pang, Yunli, Zhao, Yuan et al. · 2024 · Figshare
  54. Additional file 11 of Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics
    Liu, Yunpeng, Lu, Shuaiyao, Jing Yang, Yang, Yun, Jiao, Li, Hu, Jingwen, Li, Yanyan, Fengmei Yang, Pang, Yunli, Zhao, Yuan et al. · 2024 · Figshare
  55. Additional file 12 of Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics
    Liu, Yunpeng, Lu, Shuaiyao, Jing Yang, Yang, Yun, Jiao, Li, Hu, Jingwen, Li, Yanyan, Fengmei Yang, Pang, Yunli, Zhao, Yuan et al. · 2024 · Figshare
  56. Additional file 1 of Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics
    Liu, Yunpeng, Lu, Shuaiyao, Jing Yang, Yang, Yun, Jiao, Li, Hu, Jingwen, Li, Yanyan, Fengmei Yang, Pang, Yunli, Zhao, Yuan et al. · 2024 · Figshare
  57. Methionine synthase reductase regulates heterochromatin independently of methionine synthesis through mitochondrial homeostasis
    Fernanda Rezende Pabst, Andrey Tvardovskiy, Iratxe Estibariz, Veronica Finazzi, Pauline Couacault, Anna Artati, Michael A. Witting, Antonio Scialdone, Till Bartke, Robert Schneider et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  58. Histone methyltransferase SET-18/SMYD2-mediated activation of NADase TIR-1d/SARM1 increases mtROS to promote aging
    Dongxue Xue, Xin Su, Aaron Pambu Lelo, Yongjun Zhang, Xueqing Ba, Cheng‐Gang Zou, Aohe Ma, Yao Liu, Xiaoxue Li · 2026 · iScience
  59. Age-dependent H3K9 trimethylation by dSetdb1 impairs mitochondrial UPR leading to degeneration of olfactory neurons and loss of olfactory function in Drosophila
    Francisco Muñoz-Carvajal, Nicole Sanhueza, Mario Sanhueza, Felipe A. Court · 2026 · eLife
  60. Transcriptional regulation in cardiovascular aging
    Yiguang Fan, Chao Song, Fangnan Feng, Qing Xun, Yuhao Lu, Chunquan Li · 2026 · Frontiers in Cardiovascular Medicine
  61. Immunotherapy for senescent cell clearance: Hallmarks, strategies and translational challenges
    Wenjie Zhang, Shihong Chen, Xianghua Zhuang · 2026 · Ageing Research Reviews
  62. Mitochondrial Signaling and Stress Responses, Key Regulators of Aging and Longevity
    Y SHENG, Zachary Markovich, Sung Min Han, Rui Xiao · 2026 · BioEssays
  63. A Stress-Responsive Nuclear Factor, GLDI-8, Mediates Mitochondrial Stress Responses to ETC Dysfunction
    Yung Wu, Hongyun Tang · 2026 · International Journal of Molecular Sciences
  64. JMJD3 modulates benign prostatic hyperplasia through epigenetic regulation of TGF-β1
    Bo Chen, Jinze Li (612091), Yin Huang, Xinyang Liao, Mingjing He, Zeyu Chen, Jia You, Jie Chen, Qiyou Wu, Jinbao Wang et al. · 2026 · Cell Death and Disease
  65. A Forward Genetic Screen in Caenorhabditis elegans for Genes that Modulate α-synuclein-Induced Neurodegeneration through the Mitochondrial UPR
    Karolina Willicott, Joy D. Iroegbu, Madeline R. Greene, Aidan C. Meyers, Rachel Martin, Rose Davidson-Tullis, Laura E. Berkowitz, Guy A. Caldwell, Kim A. Caldwell · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  66. HTZ-1/H2A.Z expression sustains transcriptional programs that regulate Caenorhabditis elegans lifespan
    Beijia Xie, Enzo Scifo, Ioanna-Maria Menegatou, Rossella Erminia Ciliberti, Mrityunjoy Mondal, Yiru Wang, Antonia Piazzesi, J B Hu, Elena De Domenico, Stefan Paulusch et al. · 2026 · Mechanisms of Ageing and Development
  67. FUBL-3/FUBP1 mediates mitochondrial stress–induced chromatin remodeling and longevity
    Qian Zhang, Hangyu Dong, Y Jiang, Z. Y. Wang, Jiasheng Li, Ye Tian · 2026 · Science Advances
  68. Developmental priming of adult proteostasis and longevity by NuA4 complex activity in early life
    Yihan Wang, Xiong Xiong, Runshuai Zhang, Long Xiao, Xinyu Ruan, Tianyi Ni, Zicheng Liu, J Chen, Shenlu Qin, Zhuo Du et al. · 2026 · The EMBO Journal
  69. Kdm2a histone demethylase ablation restores anti-tumor immunogenicity in liver cancer
    Laura Gragnani, Matteo Lulli, Patrizio Caini, Pinuccia Faviana, Rossella Del Frate, Enrico Desideri, Katia De Ieso, Francesco Bartoli, Andrew Rennie Hall, Tu Vinh Luong et al. · 2026 · British Journal of Cancer
  70. Protein Homeostasis and Mitochondrial Quality Control in Neurodegeneration
    Rosa Di Lorenzo, Rola S Zeidan, Riccardo Calvani, Vito Pesce, Emanuele Marzetti, Anna Picca · 2026 · WIREs Mechanisms of Disease
  71. Mitochondrial superoxide–induced mitohormesis is mediated by citrate and cardioprotective
    Matthew P. Donnelly, Kailash Chandra Mangalhara, Yuening Liu, Kathryn Lande, Gladys R. Rojas, Kym J. Grae, Mack B. Reynolds, Sagnika Ghosh, Neva Olliffe, Pau B. Esparza‐Moltó et al. · 2026 · Science Advances
  72. An atfs-1 loss-of-function screen identifies novel regulators of α-synuclein toxicity in Caenorhabditis elegans dopaminergic neurons
    Karolina Willicott, Joy D. Iroegbu, Madeline R. Greene, Aidan C. Meyers, Pia Francesca Scarpino, Titus O Oyetade, Rachel Martin, Rose Davidson-Tullis, Laura A. Berkowitz, Guy A. Caldwell et al. · 2026 · G3 Genes Genomes Genetics
  73. Mitochondrial Unfolded Protein Response Under Hypoxic Conditions
    Gamze Bilgili, Fevzi Sökmen, Yunus Emre Cavlak, Hasan Hüseyin Kazan, Ahmet Caglar Ozketen · 2026 · Cureus
  74. Chromatin signaling in aging and cellular senescence
    Laurence M. Gagné, Florence Couteau, Frédérick A. Mallette · 2026 · Elsevier eBooks