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Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans
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“LPS toxicity varies depending on lipid A composition, and this depends on bacterial species, strain and environmental conditions [3–5].”
From The endotoxin hypothesis of neurodegeneration (2019) · cites this paper as [5]
In the citing paper
“E. coli LPS induces a strong inflammatory response via MD2/TLR4, whereas B. dorei LPS does not [5]. Moreover, because B. dorei LPS binds but does not activate the MD2/TLR4 receptor complex, it can inhibit the inflammatory response to E. coli LPS [5].”
From The endotoxin hypothesis of neurodegeneration (2019) · cites this paper as [5]
In the citing paper
“Thus, some LPS species are MD2/TLR4 antagonists, and hence anti-inflammatory, as a result of binding but not activating MD2 and/or TLR4 [5].”
From The endotoxin hypothesis of neurodegeneration (2019) · cites this paper as [5]
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Metadata
- Authors
- Vatanen, T., Kostic, A. D., d’Hennezel, E., Siljander, H., Franzosa, E. A., Yassour, M., Kolde, R., Vlamakis, H., Arthur, T. D., Hämäläinen, A.-M., Peet, A., Tillmann, V., Uibo, R., Mokurov, S., Dorshakova, N., Ilonen, J., Virtanen, S. M., Szabo, S. J., Porter, J. A., Lähdesmäki, H., Huttenhower, C., Gevers, D., Cullen, T. W., Knip, M., & Xavier, R. J.
- Corresponding author
- Xavier, Ramnik J.
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 165
- Issue
- 6
- Pages
- 1551
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W4239130026
- Cited by
- 298
- References
- 0
- Citations by year
- 2026: 11 · 2025: 18 · 2024: 22 · 2023: 35 · 2022: 45 · 2021: 41 · 2020: 29 · 2019: 42 · 2018: 20 · 2017: 30 · 2016: 5
- FWCI
- 13.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- Funders
- Novo Nordisk Fonden (NNF11OC1014751)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- gut microbiota, lipopolysaccharide, immunogenicity, autoimmunity, type 1 diabetes, Bacteroides, immune tolerance, children
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