Inhibition of dihydroorotate dehydrogenase overcomes differentiation blockade in acute myeloid leukemia

Sykes, David B., Kfoury, Youmna S., Mercier, François E., Wawer, Mathias J., Law, Jason M., Haynes, Mark K., Lewis, Timothy A., Schajnovitz, Amir +22 more·2016·Cell

DOI 10.1016/j.cell.2016.08.057

Cited by (516)

Items 201–300 of 516

Loss of MBD2 attenuates MLL-AF9-driven leukemogenesis by suppressing the leukemic cell cycle via CDKN1C
Kuangguo Zhou, Mi Zhou, Ling Cheng, Xing Chen, Xiaomin Wang, Yajing Chu, Qilin Yu, Shu Zhang, Na Wang, Lei Zhao et al. · 2021 · Oncogenesis
Metabolic drug survey highlights cancer cell dependencies and vulnerabilities
Tea Pemovska, Johannes W. Bigenzahn, Ismet Srndic, Alexander Lercher, Andreas Bergthaler, Adrián César‐Razquin, Felix Kartnig, Christoph Kornauth, Peter Valent, Philipp Bernhard Staber et al. · 2021 · Nature Communications
Therapeutic targeting of leukemia stem cells in acute myeloid leukemia
Karina Barbosa, A. Deshpande · 2023 · Frontiers in Oncology
Phytophthora infestans Dihydroorotate Dehydrogenase Is a Potential Target for Chemical Control – A Comparison With the Enzyme From Solanum tuberosum
Manuel F. Garavito, Heidy Y. Narvaez‐Ortiz, Dania Camila Pulido, Monika Löffler, Howard S. Judelson, Silvia Restrepo, Bárbara H. Zimmermann · 2019 · Frontiers in Microbiology
Acute myeloid leukemia maturation lineage influences residual disease and relapse following differentiation therapy
Steven D. Ngo, Ethan P. Oxley, Margherita Ghisi, Maximilian M. Garwood, Mark D. McKenzie, Helen L. Mitchell, Peter Kanellakis, Olivia Susanto, Michael J. Hickey, Andrew Charles Perkins et al. · 2021 · Nature Communications
Prediction of prognosis and immunotherapy response of amino acid metabolism genes in acute myeloid leukemia
Hui Zhou, Fengjuan Wang, Ting Niu · 2022 · Frontiers in Nutrition
Wogonoside induces depalmitoylation and translocation of PLSCR 1 and N‐ RAS in primary acute myeloid leukaemia cells
Hui Li, Xiaoxuan Yu, Xiao Liu, Po Hu, Le Shen, Yuxin Zhou, Yu Zhu, Zhiyu Li, Hui Hui, Qinglong Guo et al. · 2018 · Journal of Cellular and Molecular Medicine
Hydroxyazoles as acid isosteres and their drug design applications—Part 1: Monocyclic systems
Stefano Sainas, Agnese Chiara Pippione, Donatella Boschi, Marco L. Lolli · 2021 · Advances in heterocyclic chemistry
Targeting dihydroorotate dehydrogenase in acute myeloid leukemia
Zhihong Zeng, Marina Y Konopleva · 2018 · Haematologica
DHODH Alleviates Heart Failure via the Modulation of CoQ-Related Ferroptotic Inhibition
Chen Wang, Chuchu Chen, Jiabin Zhou, Jiayu Shi, Hanrui Sun, Jingyu Li, Pengyang Gu, Xinglin Wang, Qi Lu, Shuai Wang · 2024 · Frontiers in Bioscience-Landmark
De novo pyrimidine biosynthesis inhibition synergizes with BCL-XL targeting in pancreatic cancer
Huan Zhang, Naiara Santana-Codina, Qijia Yu, Clara L. Poupault, Claudia Campos, Xingping Qin, Nicole Sindoni, Marina Ciscar, Aparna Padhye, Miljan Kuljanin et al. · 2025 · Nature Communications
Amino acid metabolism: challenges and opportunities for the therapeutic treatment of leukemia and lymphoma
Peiyun Liao, Ning Chang, Binyan Xu, Yingqi Qiu, Sheng Wang, Lijuan Zhou, Yanjie He, Xiaoling Xie, Yuhua Li · 2022 · Immunology and Cell Biology
DHODH: a promising target in the treatment of T-cell acute lymphoblastic leukemia
Amy N. Sexauer, Gabriela Alexe, Karin U. Gustafsson, Elizabeth Zanetakos, Jelena Milosevic, Mary Ayres, Varsha V. Gandhi, Yana Pikman, Kimberly Stegmaier, David B. Sykes · 2023 · Blood Advances
α-Ketoglutarate dehydrogenase is a therapeutic vulnerability in acute myeloid leukemia
Scott E. Millman, Almudena Chaves Perez, Sudha Janaki‐Raman, Yu-Jui Ho, John P. Morris, Varun K. Narendra, Chi-Chao Chen, Benjamin T. Jackson, Jossie J. Yashinskie, Riccardo Mezzadra et al. · 2025 · Blood
Checkpoint kinase 1 inhibition sensitises transformed cells to dihydroorotate dehydrogenase inhibition
Stéphanie Arnould, Geneviève Rodier, Gisèle Matar, Charles Vincent, Nelly Pirot, Yoann Delorme, Charlène Berthet, Yoan Buscail, Jean Noel, Simon Lachambre et al. · 2017 · Oncotarget
Inhibition of mitochondrial complex III induces differentiation in acute myeloid leukemia
Youping Zhang, Ting L. Luo, Xinyu Ding, Yung‐Ting Chang, Chuanxu Liu, Yongqiang Zhang, Siguo Hao, Qianqian Yin, Biao Jiang · 2021 · Biochemical and Biophysical Research Communications
Dihydroorotate Dehydrogenase Inhibitors Promote Cell Cycle Arrest and Disrupt Mitochondria Bioenergetics in Ramos Cells
Mohamad Fairus Abdul Kadir, Shatrah Othman, Kavitha Nellore · 2020 · Current Pharmaceutical Biotechnology
Characterization of uridine-cytidine kinase like-1 nucleoside kinase activity and its role in tumor growth
Emily C. Matchett, Elise C. Ambrose, Jacki Kornbluth · 2022 · Biochemical Journal
Inhibition of O-GlcNAcase Inhibits Hematopoietic and Leukemic Stem Cell Self-Renewal and Drives Dendritic Cell Differentiation via STAT3/5 Signaling
Sudjit Luanpitpong, Napachai Rodboon, Parinya Samart, Montira Janan, Phatchanat Klaihmon, Chanchao Lorthongpanich, Yaowalak U‐pratya, Surapol Issaragrisil · 2022 · Stem Cells
High-Throughput Quantitative Glycomics Enabled by 12-plex Isobaric Multiplex Labeling Reagents for Carbonyl-Containing Compound (SUGAR) Tags
Miyang Li, Feng Yu, Mengyao Ma, Arvinder Kapur, Manish S. Patankar, Lingjun Li · 2023 · Journal of Proteome Research
PSTK inhibition activates cGAS-STING, precipitating ferroptotic cell death in leukemic stem cells
Lingli He, Ting Zhao, Wei Zhong Leong, Azeem Sharda, Christina Mayerhofer, Shenglin Mei, Gracia M. Bonilla, Juan Bautista Menendez-Gonzalez, Karin M. Gustafsson, Tsuyoshi Fukushima et al. · 2025 · Blood
Cross-Cancer Pleiotropic Associations with Lung Cancer Risk in African Americans
Carissa C. Jones, Yuki Bradford, Christopher Ian Amos, William J. Blot, Stephen Jacob Chanock, Curtis C. Harris, Ann G. Schwartz, Margaret R. Spitz, John K. Wiencke, Margaret Wrensch et al. · 2019 · Cancer Epidemiology Biomarkers & Prevention
Potent human dihydroorotate dehydrogenase inhibitory activity of new quinoline-4-carboxylic acids derived from phenolic aldehydes: Synthesis, cytotoxicity, lipophilicity and molecular docking studies
Milena M. Petrović, Cornelia Roschger, Sidrah Chaudary, Andreas F. Zierer, Milan P. Mladenović, Katarina Jakovljević, Violeta R. Marković, Bruno Botta, Milan D. Joksović · 2020 · Bioorganic Chemistry
Acute myeloid leukemia: therapeutic targeting of stem cells
Cindy M. Pabon, H. Abbas, M. Konopleva · 2022 · Expert opinion on therapeutic targets
Targeting cellular metabolism in head and neck cancer precision medicine era: A promising strategy to overcome therapy resistance
Xiaohu Lin, Wenkai Zhou, Zheqi Liu, Wei Cao, Chengzhong Lin · 2022 · Oral Diseases
Nucleic acid metabolism: the key therapeutic target for myeloid tumors
Tomohiro Yabushita, Susumu Goyama · 2024 · Experimental Hematology
Discovery of Orally Available Retinoic Acid Receptor-Related Orphan Receptor γ-t/Dihydroorotate Dehydrogenase Dual Inhibitors for the Treatment of Refractory Inflammatory Bowel Disease
Jian Chen, Hui Ma, Zehui Liu, Jinlong Tian, Sisi Lu, Wenqing Fang, Shuyin Ze, Weiqiang Lü, Qiong Xie, Jin Yan Huang et al. · 2021 · Journal of Medicinal Chemistry
Surviving the hunger games: Metabolic reprogramming in medulloblastoma
Lorenzo Manfreda, Elena Rampazzo, Luca Persano, Giampietro Viola, Roberta Bortolozzi · 2023 · Biochemical Pharmacology
Proteinase 3 depletion attenuates leukemia by promoting myeloid differentiation
Huan Liu, Lu Sun, Hongfei Zhao, Zihan Zhao, Shiyue Zhang, Shan Jiang, Tianran Cheng, Xiaohan Wang, Tong Wang, Ya Shao et al. · 2024 · Cell Death and Differentiation
Off-Target Inhibition of Human Dihydroorotate Dehydrogenase (hDHODH) Highlights Challenges in the Development of Fat Mass and Obesity-Associated Protein (FTO) Inhibitors
Marco Tarullo, Guillermo Fernandez Rodriguez, Alessia Iaiza, Sara Venezia, Alberto Macone, Alessio Incocciati, Silvia Masciarelli, Marcella Marchioni, Marta Giorgis, Marco L. Lolli et al. · 2024 · ACS Pharmacology & Translational Science
Pretreatment of umbilical cord derived MSCs with IFN-γ and TNF-α enhances the tumor-suppressive effect on acute myeloid leukemia
Luchen Sun, Jingyue Wang, Qiuping Wang, Zhonglei He, Tingzhe Sun, Yongfang Yao, Wenxin Wang, Pingping Shen · 2022 · Biochemical Pharmacology
Control in dormancy or eradication of cancer stem cells: Mathematical modeling and stability issues
Walid Djema, Catherine Bonnet, Frédéric Mazenc, Jean Clairambault, Emilia Fridman, Pierre Hirsch, François Delhommeau · 2018 · Journal of Theoretical Biology
A network-based approach to integrate nutrient microenvironment in the prediction of synthetic lethality in cancer metabolism
Iñigo Apaolaza, Edurne San José‐Eneriz, Luis V. Valcárcel, Xabier Agirre, Felipe Prósper, Francisco J. Planes · 2022 · PLoS Computational Biology
Chasing leukemia differentiation through induction therapy, relapse and transplantation
Jennifer N. Saultz, Jeffrey W Tyner · 2022 · Blood Reviews
Inhibition of nucleotide biosynthesis disrupts lipid accumulation and adipogenesis
Abhijit Babaji Shinde, Elizabeth R. Nunn, Genesis A. Wilson, Mathew T. Chvasta, Julia A. Pinette, Jacob W. Myers, Sun H. Peck, Jessica B. Spinelli, Elma Zaganjor · 2023 · Journal of Biological Chemistry
Cell of origin epigenetic priming determines susceptibility to Tet2 mutation
Giulia Schiroli, Vinay K. Kartha, Fabiana M. Duarte, Trine Ahn Kristiansen, Christina Mayerhofer, Rojesh Shrestha, Andrew Earl, Yan Hu, Tristan Tay, Catherine Rhee et al. · 2024 · Nature Communications
Discovery of JNJ-74856665: A Novel Isoquinolinone DHODH Inhibitor for the Treatment of AML
Lindsey G. DeRatt, Zhuming Zhang, Christine Pietsch, Justin S. Cisar, Xiaochun Zhang, Weixue Wang, Alexandra Tanner, Rosalie Matico, Paul L. Shaffer, Edgar Jacoby et al. · 2024 · Journal of Medicinal Chemistry
Hsp90 inhibitor induces KG-1a cell differentiation and apoptosis via Akt/NF-κB signaling
Jinhong Qin, Kun Wang, Xinlu Fu, Pengjun Zhou, Zhong Liu, Dandan Xu, Yifei Wang, Depo Yang, Qiuling Xie, Qiuying Liu · 2017 · Oncology Reports
Epithelial-mesenchymal transition in haematopoietic stem cell development and homeostasis
Sofiane Hamidi, Guojun Sheng · 2018 · The Journal of Biochemistry
An expert overview of emerging therapies for acute myeloid leukemia: novel small molecules targeting apoptosis, p53, transcriptional regulation and metabolism
Kapil Saxena, Marina Y Konopleva · 2020 · Expert Opinion on Investigational Drugs
Epigenetic therapy with chidamide alone or combined with 5‑azacitidine exerts antitumour effects on acute myeloid leukaemia cells in vitro
Zheng Li, Jian Zhang, Min Zhou, Jinli Li, Qiao‐Cheng Qiu, Jianhong Fu, Shengli Xue, Hui-Ying Qiu · 2022 · Oncology Reports
Targeting mitochondrial metabolism in acute myeloid leukemia
Madison Rex, Robert Williams, Kıvanç Birsoy, Martin S. Ta llman, Maximillian Stahl · 2021 · Leukemia & lymphoma/Leukemia and lymphoma
Recent Advances in Cancer Drug Discovery Through the Use of Phenotypic Reporter Systems, Connectivity Mapping, and Pooled CRISPR Screening
Natasha Salame, Katharine Fooks, Nehmé El-Hachem, Jean‐Pierre Bikorimana, François Mercier, Moutih Rafei · 2022 · Frontiers in Pharmacology
Targeting metabolic vulnerabilities to overcome resistance to therapy in acute myeloid leukemia
Priyanka Sharma, Gautam M. Borthakur · 2023 · Cancer Drug Resistance
Stability analysis and robustness results for a nonlinear system with distributed delays describing hematopoiesis
Walid Djema, Frédéric Mazenc, Catherine Bonnet · 2017 · Systems & Control Letters
Cabozantinib promotes erythroid differentiation in K562 erythroleukemia cells through global changes in gene expression and JNK activation
Yu-Hsuan Fu, Da‐Liang Ou, Yi-Ru Yang, Kuan-Wei Su, Chien‐Yuan Chen, Hwei‐Fang Tien, Zheng-Sheng Lai, Che-Kun James Shen, Hsiung‐Fei Chien, Liang‐In Lin · 2021 · Cancer Gene Therapy
Emvododstat, a Potent Dihydroorotate Dehydrogenase Inhibitor, Is Effective in Preclinical Models of Acute Myeloid Leukemia
Arthur A. Branstrom, Liangxian Cao, Bansri Furia, Christopher R. Trotta, Marianne A Santaguida, Jason D. Graci, Joseph M. Colacino, Balmiki Ray, Wencheng Li, Josephine Sheedy et al. · 2022 · Frontiers in Oncology
Novel endogenous endoplasmic reticulum transmembrane protein SURF4 suppresses cell death by negatively regulating the STING‐STAT6 axis in myeloid leukemia
Jayoung Kim, Hansong Lee, Chae Mi Hong, Ji Ho Nam, Hye Ju Yeo, Woo Hyun Cho, Hyung‐Sik Kim, Changwan Hong, Yun Hak Kim, Dongjun Lee · 2022 · 癌症：英文版
SHP1 and SHP2 inhibition enhances the pro-differentiative effect of phorbol esters: an alternative approach against acute myeloid leukemia
Alejandro Pérez‐Fernández, Guillermo López-Ruano, Rodrigo Prieto-Bermejo, Carla Ijurko, María Díez‐Campelo, Fermin M. Sanchez-Guijo, Ángel Hernández‐Hernández · 2019 · Journal of Experimental & Clinical Cancer Research
Dihydroorotate dehydrogenase inhibition reveals metabolic vulnerability in chronic myeloid leukemia
Mohammad Houshmand, Nicoletta Vitale, Francesca Orso, Alessandro Cignetti, Ivan Molineris, Valentina Gaidano, Stefano Sainas, Marta Giorgis, Donatella Boschi, Carmen Fava et al. · 2022 · Cell Death and Disease
Chemotherapy Dose Shapes the Expression of Immune-Interacting Markers on Cancer Cells
Alexander J. Najibi, Kerry A. Larkin, Zhaoqianqi Feng, Nicholas C. Jeffreys, Mason T. Dacus, Yashika Rustagi, Frank Stephen Hodi, David J. Mooney · 2022 · Cellular and Molecular Bioengineering
Targeting both the enzymatic and non-enzymatic functions of DHODH as a therapeutic vulnerability in c-Myc-driven cancer
Qiang Zhang, Kaisa Cui, Yue Kong, Jing Yu, Zhanhao Luo, Xiaoya Yang, Liang Gong, Yanchun Xie, Jiuxiu Lin, Chen Liu et al. · 2025 · Cell Reports
Limited plasticity of monocyte fate and function associated with epigenetic scripting at the level of progenitors
Catherine Rhee, Elizabeth W. Scadden, Lai Ping Wong, Giulia Schiroli, Michael C. Mazzola, Phillip L. Chea, Hiroki Kato, Friedrich Felix Hoyer, Meeta Mistry, Bum‐Kyu Lee et al. · 2023 · Blood
Hydroxyazoles as acid isosteres and their drug design applications—Part 2: Bicyclic systems
Agnese Chiara Pippione, Stefano Sainas, Donatella Boschi, Marco L. Lolli · 2021 · Advances in heterocyclic chemistry
The curious case of IDH mutant acute myeloid leukaemia: biochemistry and therapeutic approaches
Emily Gruber, Lev M. Kats · 2023 · Biochemical Society Transactions
C/EBPβ-induced lymphoid-to-myeloid transdifferentiation emulates granulocyte-monocyte progenitor biology
Linh Thuy Nguyen, Karin Zimmermann, Elisabeth Kowenz‐Leutz, Ramonique Lim, Maria Hofstätter, Alexander Mildner, Achim Leutz · 2023 · Stem Cell Reports
Unveiling the Antiviral Capabilities of Targeting Human Dihydroorotate Dehydrogenase against SARS-CoV-2
Aline Dias da Purificação, Sabrina Silva Mendonça, Luiza V. Cruz, Carolina Q. Sacramento, Jairo Ramos Temerozo, Natalia Fintelman Rodrigues, Caroline Souza de Freitas, Bruna Fleck Godoi, Miguel de Menezes Vaidergorn, Juliana Almeida Leite et al. · 2024 · ACS Omega
Identifying regulators of aberrant stem cell and differentiation activity in colorectal cancer using a dual endogenous reporter system
Sándor Spisák, David J. Chen, Pornlada Likasitwatanakul, Khoa Tat Doan, Zhixin Li, Pratyusha Bala, Laura Vízkeleti, Viktória Tisza, Pushpamali De Silva, Marios Giannakis et al. · 2024 · Nature Communications
A carboxylic acid isostere screen of the DHODH inhibitor Brequinar
Lindsey G. DeRatt, E. Christine Pietsch, Alexandra Tanner, Paul L. Shaffer, Edgar Jacoby, Weixue Wang, Faraz Kazmi, Xiaochun Zhang, Ricardo M. Attar, James P. Edwards et al. · 2020 · Bioorganic & Medicinal Chemistry Letters
Identification of Human Dihydroorotate Dehydrogenase Inhibitor by a Pharmacophore-Based Virtual Screening Study
Salvatore Galati, Stefano Sainas, Marta Giorgis, Donatella Boschi, Marco L. Lolli, Gabriella Ortore, Giulio Poli, Tiziano Tuccinardi · 2022 · Molecules
Reading oscillatory instructions: How cells achieve time-dependent responses to oscillating transcription factors
Veena Venkatachalam, Ashwini Jambhekar, Galit Lahav · 2022 · Current Opinion in Cell Biology
A single-shot hyperspectral phasor camera for fast, multi-color fluorescence microscopy
Pu Wang, Masahiro Kitano, Kevin Keomanee-Dizon, Thai V. Truong, Scott E. Fraser, Francesco Cutrale · 2023 · Cell Reports Methods
Synthesis, structure–activity relationship and binding mode analysis of 4-thiazolidinone derivatives as novel inhibitors of human dihydroorotate dehydrogenase
Fanxun Zeng, Tiantian Qi, Chunyan Li, Tingfang Li, Honglin Li, Shiliang Li, Lili Zhu, Xiaoyong Xu · 2017 · MedChemComm
Design, Synthesis, and Biological Evaluation of a Novel Series of Teriflunomide Derivatives as Potent Human Dihydroorotate Dehydrogenase Inhibitors for Malignancy Treatment
Chungen Li, Xiaowei Yang, Yuan Luo, Huan Liu, Xi Zoë Zhong, Xia Zhou, Ting Zeng, Lei Tao, Yue Zhou, Kun Gou et al. · 2021 · Journal of Medicinal Chemistry
Teriflunomide Loaded SPION Nanoparticles Induced Apoptosis in MDA-MB-231 Breast Cancer Cells
Tina Rabizadeh, Reyhaneh Varshochian, Athar Mahdieh, Mahsa Rezaei, Negin Pazouki, Mahsa Zardkanlou, Shiva Irani, Rassoul Dinarvand · 2022 · Journal of Cluster Science
The oncogenic control of nucleotide synthesis
Olivia Vidal-Cruchez, Issam Ben‐Sahra · 2026 · Oncogenesis
DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation
Nicholas J. Mullen, Surendra Kumar Shukla, Ravi Kumar Thakur, Sai Sundeep Kollala, Dezhen Wang, Nina V. Chaika, Juan F. Santana, William R. Miklavcic, Drew A. LaBreck, Jayapal Reddy Mallareddy et al. · 2024 · eLife
Combined epigenetic and metabolic treatments overcome differentiation blockade in acute myeloid leukemia
Barry M. Zee, Kamrine E. Poels, Cong-Hui Yao, Kimihito Cojin Kawabata, Gongwei Wu, Cihangir Duy, William D. Jacobus, Elizabeth Senior, Jennifer E. Endress, Ashwini Jambhekar et al. · 2021 · iScience
Identification of Dihydroorotate Dehydrogenase Inhibitors─Indoluidins─That Inhibit Cancer Cell Growth
Makoto Kawatani, Harumi Aono, Takeshi Shimizu, Shouta Ohkura, Sayoko Hiranuma, Makoto Muroi, Naoko Ogawa, Tomokazu Ohishi, Shun‐ichi Ohba, Manabu Kawada et al. · 2021 · ACS Chemical Biology
ML390 inhibits enterovirus 71 replication by targeting de novo pyrimidine biosynthesis pathway
Qingyu Yang, Chengyuan Wu, Guangyan Zhu, Fuli Ren, Binbin Lin, Rui Huang, Xujuan Hu, Dingran Zhao, Ke Peng, Ying Wu et al. · 2022 · Antiviral Research
Synergistic effects of the KDM4C inhibitor SD70 and the menin inhibitor MI ‐503 against MLL::AF9‐driven acute myeloid leukaemia
Wenqi Zhu, Yiyi Ding, Wanling Huang, Nini Guo, Qian Ren, Nan Wang, Xiaotong Ma · 2024 · British Journal of Haematology
Enhanced Response of Acute Monocytic Leukemia Cells to Low-dose Cytarabine by 1,25-dihydroxyvitamin D3
Hao Guo, Sheng‐Yan Lin, Wenxiang Ren, Qian Lei, Zhichao Chen, Lu Zhang, Qiubai Li · 2018 · Current Medical Science
The evolution of leukaemia from pre‐leukaemic and leukaemic stem cells
Liran I. Shlush, Tzah Feldman · 2021 · Journal of Internal Medicine
Genome-scale integration of transcriptome and metabolome unveils squalene synthase and dihydrofolate reductase as targets against AML cells resistant to chemotherapy
Effrosyni Karakitsou, Carles Foguet, Miriam G. Contreras Mostazo, Nina Kurrle, Frank Schnütgen, Martin Michaelis, Jindrich Jr. Cinatl, Silvia Marín, Marta Cascante · 2021 · Computational and Structural Biotechnology Journal
Virtual-freezing fluorescence imaging flow cytometry
Hideharu Mikami, Makoto Kawaguchi, Chun‐Jung Huang, Hiroki Matsumura, Takeaki Sugimura, Kangrui Huang, Cheng Lei, Shunnosuke Ueno, Taichi Miura, Takuro Ito et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
Histone chaperones coupled to DNA replication and transcription control divergent chromatin elements to maintain cell fate
Reuben Franklin, Brian Zhang, Jonah Frazier, Meijuan Chen, Brian T. Do, Sally Padayao, Kun Wu, Matthew G. Vander Heiden, Christopher R. Vakoc, Jae‐Seok Roe et al. · 2025 · Genes & Development
A Phenotypic Screen Identifies a Compound Series That Induces Differentiation of Acute Myeloid Leukemia Cells In Vitro and Shows Antitumor Effects In Vivo
Laia Josa‐Culleré, Katrina S. Madden, Thomas J. Cogswell, Thomas Jackson, Tom S. Carter, Douzi Zhang, Graham P. Trevitt, Stephen G. Davies, Paresh Vyas, Graham M. Wynne et al. · 2021 · Journal of Medicinal Chemistry
New Insights into the Interaction of Class II Dihydroorotate Dehydrogenases with Ubiquinone in Lipid Bilayers as a Function of Lipid Composition
Juan Manuel Orozco Rodriguez, Hanna Pauliina Wacklin, Luke A. Clifton, Oliver Bogojevic, Anna E. Leung, Giovanna Fragneto, Wolfgang Knecht · 2022 · International Journal of Molecular Sciences
All-trans retinoic acid induces differentiation in primary acute myeloid leukemia blasts carrying an inversion of chromosome 16
Vilma Dembitz, Hrvoje Lalić, Barbara Tomić, Tomislav Smoljo, Josip Batinić, Klara Dubravčić, Drago Batinić, Antonio Bedalov, Dora Višnjić · 2021 · International Journal of Hematology
A Patent Review of Human Dihydroorotate Dehydrogenase (hDHODH) Inhibitors as Anticancer Agents and their Other Therapeutic Applications (1999-2022)
Pinky Gehlot, Vivek Kumar Vyas · 2023 · Recent Patents on Anti-Cancer Drug Discovery
GPAM mediated lysophosphatidic acid synthesis regulates mitochondrial dynamics in acute myeloid leukemia
Hidetoshi Irifune, Yu Kochi, Toshihiro Miyamoto, Teppei Sakoda, Koji Kato, Yuya Kunisaki, Koichi Akashi, Yoshikane Kikushige · 2023 · Cancer Science
Antipyrimidine effects of five different pyrimidine de novo synthesis inhibitors in three head and neck cancer cell lines
Godefridus J. Peters · 2018 · Nucleosides Nucleotides & Nucleic Acids
Identification of dihydroorotate dehydrogenase as a protein target of ginkgolic acid by molecular docking and dynamics
Pan Yu, Dong‐Dong Li, Lei Wang, Lihu Zhang, Fuliang Cao, Xianying Fang, Linguo Zhao · 2020 · Journal of Molecular Structure
Selective eradication of pluripotent stem cells by inhibiting DHODH activity
Tôru Kondo · 2020 · Stem Cells
Guanine nucleotide biosynthesis blockade impairs MLL complex formation and sensitizes leukemias to menin inhibition
Xiangguo E. Shi, Minhua Li, Zian Liu, Jonathan Tiessen, Yuan Li, Jing Zhou, Yudan Zhu, Swetha Mahesula, Ding Qing, Lin Tan et al. · 2025 · Nature Communications
Comprehensive multi-omics analysis of nucleotide metabolism: elucidating the role and prognostic significance of UCK2 in bladder cancer
Yadong Guo, Ziyou Lin, Wentao Zhang, Haotian Chen, Yuxin Chen, Yongqiang Liu, Zezhi Shan, Shiyu Mao, Xudong Yao · 2025 · Functional & Integrative Genomics
Design, synthesis, and biological evaluation of novel substituted benzamide derivatives bearing a 1,2,3-triazole moiety as potent human dihydroorotate dehydrogenase inhibitors
Kuan Lu, Lude Cai, Xue Zhang, Guodong Wu, Congjun Xu, Yanfang Zhao, Ping Gong · 2017 · Bioorganic Chemistry
Identification of a dihydroorotate dehydrogenase inhibitor that inhibits cancer cell growth by proteomic profiling
Makoto Kawatani, Harumi Aono, Sayoko Hiranuma, Takeshi Shimizu, Makoto Muroi, Toshihiko Nogawa, Tomokazu Ohishi, Shun‐ichi Ohba, Manabu Kawada, Kanami Yamazaki et al. · 2023 · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
HOXA9 Regulome and Pharmacological Interventions in Leukemia
Sajesan Aryal, Rui Lu · 2024 · Advances in experimental medicine and biology
Differentiation of Cancer Stem Cells by Using Synthetic Small Molecules: Toward New Therapeutic Strategies against Therapy Resistance
Chloé Maucort, Audrey Di Giorgio, Stéphane Azoulay, Maria Duca · 2020 · ChemMedChem
The Role of Metabolism in the Development of Personalized Therapies in Acute Myeloid Leukemia
Vilma Dembitz, Paolo Gallipoli · 2021 · Frontiers in Oncology
Application of High Throughput Technologies in the Development of Acute Myeloid Leukemia Therapy: Challenges and Progress
Wei Xiang, Yi Hui Lam, Giridharan Periyasamy, Charles T. H. Chuah · 2022 · International Journal of Molecular Sciences
A tubulin binding molecule drives differentiation of acute myeloid leukemia cells
Thomas Jackson, Aini Vuorinen, Laia Josa‐Culleré, Katrina S. Madden, Daniel Conole, Thomas J. Cogswell, Isabel V. L. Wilkinson, Laura M. Kettyle, Douzi Zhang, Alison O’Mahony et al. · 2022 · iScience
Discovery of potent human dihydroorotate dehydrogenase inhibitors based on a benzophenone scaffold
Chungen Li, Yue Zhou, Jing Xu, Xia Zhou, Song Liu, Zongkai Huang, Zhiqiang Qiu, Ting Zeng, Kun Gou, Lei Tao et al. · 2022 · European Journal of Medicinal Chemistry
Hox‐driven conditional immortalization of myeloid and lymphoid progenitors: Uses, advantages, and future potential
Shranjit S. Lail, Corey R. Arnold, Luiz Gustavo Nogueira de Almeida, Neil T. McKenna, Jose A. Chiriboga, Antoine Dufour, Amy L. Warren, Robin M. Yates · 2022 · Traffic
Bring on the brequinar: an approach to enforce the differentiation of myeloid-derived suppressor cells
Natalie K. Horvat, Gregory B. Lesinski · 2022 · Journal of Clinical Investigation
FISH-Flow to quantify nascent and mature ribosomal RNA in mouse and human cells
Charles Antony A, Patrick Somers, Erin M. Gray, Maxim Pimkin, Vikram R. Paralkar · 2023 · STAR Protocols
Blockade of de novo pyrimidine biosynthesis triggers autophagic degradation of oncoprotein FLT3-ITD in acute myeloid leukemia
Hui Ma, Jiayan Cui, Zehui Liu, Wenqing Fang, Sisi Lu, Shuying Cao, Yuanyuan Zhang, Jian Chen, Lixue Lu, Qiong Xie et al. · 2023 · Oncogene
JNK1 as a signaling node in VDR-BRAF induction of cell death in AML
Xuening Wang, William K Beute, Jonathan S. Harrison, George P. Studzinski · 2017 · The Journal of Steroid Biochemistry and Molecular Biology
5-aminoimidazole-4-carboxamide ribonucleoside induces differentiation in a subset of primary acute myeloid leukemia blasts
Vilma Dembitz, Hrvoje Lalić, Ivan Kodvanj, Barbara Tomić, Josip Batinić, Klara Dubravčić, Drago Batinić, Antonio Bedalov, Dora Višnjić · 2020 · BMC Cancer