Inhibition of dihydroorotate dehydrogenase overcomes differentiation blockade in acute myeloid leukemia

Sykes, David B., Kfoury, Youmna S., Mercier, François E., Wawer, Mathias J., Law, Jason M., Haynes, Mark K., Lewis, Timothy A., Schajnovitz, Amir +22 more·2016·Cell
DOI 10.1016/j.cell.2016.08.057

Cited by (516)

Items 501–516 of 516

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  4. BindingDB Entry 50015476: Design, Synthesis, and Biological Evaluation of a Novel Series of Teriflunomide Derivatives as Potent Human Dihydroorotate Dehydrogenase Inhibitors for Malignancy Treatment.
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  5. BindingDB Entry 50009023: Discovery and synthesis of novel indole derivatives-containing 3-methylenedihydrofuran-2(3H)-one as irreversible LSD1 inhibitors.
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  6. BindingDB Entry 50022826: Identification of isoquinolinone DHODH inhibitor isosteres.
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  7. BindingDB Entry 50019783: Discovery of Alternative Binding Poses through Fragment-Based Identification of DHODH Inhibitors.
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  8. BindingDB Entry 50010583: Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability.
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  9. BindingDB Entry 50048029: Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia.
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  10. BindingDB Entry 50015991: Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-
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  11. BindingDB Entry 50015418: Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-
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  12. BindingDB Entry 50011749: Cerpegin-derived furo[3,4-c]pyridine-3,4(1H,5H)-diones enhance cellular response to interferons by de novo pyrimidine biosynthesis inhibition.
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  13. BindingDB Entry 50019934: Discovery of potent human dihydroorotate dehydrogenase inhibitors based on a benzophenone scaffold.
    BindingDB · 2024 · UC San Diego
  14. BindingDB Entry 50001475: Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors.
    BindingDB · 2020 · UC San Diego
  15. BindingDB Entry 50002707: Design, Synthesis, and Biological Evaluation of 4-Quinoline Carboxylic Acids as Inhibitors of Dihydroorotate Dehydrogenase.
    BindingDB · 2020 · UC San Diego
  16. BindingDB Entry 50010748: Bifunctional Naphtho[2,3-
    BindingDB · 2021 · UC San Diego