Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia

Sykes, David B., Kfoury, Youmna S., Mercier, François E., Wawer, Mathias J., Law, Jason M., Haynes, Mark K., Lewis, Timothy A., Schajnovitz, Amir, Jain, Esha, Lee, Dongjun, Meyer, Hanna, Pierce, Kerry A., Tolliday, Nicola J., Waller, Anna, Ferrara, Steven J., Eheim, Ashley L., Stoeckigt, Detlef, Maxcy, Katrina L., Cobert, Julien M., Bachand, Jacqueline, Szekely, Brian A., Mukherjee, Siddhartha, Sklar, Larry A., Kotz, Joanne D., Clish, Clary B., Sadreyev, Ruslan I., Clemons, Paul A., Janzer, Andreas, Schreiber, Stuart L., Scadden, David T.·2016·Cell
DOI 10.1016/j.cell.2016.08.057

Cited by (516)

Items 401–500 of 516

  1. Structural and molecular basis for allosteric regulation and catalytic coupling of human phosphoribosylformylglycinamidine synthase
    Nandini Sharma, Weijie Zhou, Jarrod B. French · 2026 · Nature Communications
  2. Structural Basis for Potent Inhibition of Human DHODH by Quinoline-4-carboxylic Acid Derivatives
    Jéssika de Oliveira Viana, Tayná Rodrigues Olegário, Marília Cecília da Silva, Rodrigo Cristiano, Euzébio Guimarães Barbosa, Aline Dias da Purificação, Marina Sena Mendes, Diogo F. Boerin, Maria Cristina Nonato, Karen C. Weber et al. · 2026 · ACS Omega
  3. DHODH Drives Sunitinib Resistance Via a Non‐Enzymatic Mechanism by Inhibiting TRIM28 Ubiquitination and Consequent VEGFA Activation in RCC
    Shijie Qian, Shihang Pu, Zhipeng Xu, Yiheng Ding, L L Jin, Baochao Li, Qi Li, Xiaohai Xi, Zengjun Wang, Jiajun Xing et al. · 2026 · Advanced Science
  4. Dynamic control of nucleotide metabolism in physiology and disease
    Dohun Kim, Gerta Hoxhaj · 2026 · Nature Cell Biology
  5. DHODH is a synthetic lethal target in PIK3CA-mutant colorectal cancer
    Jun Liang, Xi Liu, Ziyun Ni, Sen Zhang, Xiangli He, Lili Wang, Y Huang, Zhaomin Xu, Zhongyu Xu, J P Qian et al. · 2026 · Cell Reports
  6. DHODH is the key target of the KDM4 inhibitor QC6352 in glioblastoma stem cells
    Jayden Sterling, Jacinda Holtsmark, George L. Joun, Matthew S. Graus, Tian Y. Du, Mani Kuchibhotla, Terrance G. Johns, Antoine deWeck, Lipin Loo, G. Gregory Neely et al. · 2026 · Nature Chemical Biology
  7. Radiosynthesis of [ 18 F]brequinar for in vivo PET imaging of hDHODH for potential studies of acute myeloid leukemia and cancers
    Vinay Kumar Banka, Stefano Sainas, Elena Martino, Jiacheng Wang, Marco L. Lolli, Yu‐Shin Ding · 2024 · RSC Medicinal Chemistry
  8. Pushing differentiation
    M. Teresa Villanueva · 2016 · Nature reviews. Cancer
  9. Discovery of a novel series of hDHODH inhibitors with anti-pulmonary fibrotic activities
    Kuan Lu, Yanfang Zhao, Guodong Wu, Hao Hu, Mingzhong Wang, Guowei Gong, Yuyang Jiang · 2019 · Bioorganic Chemistry
  10. Resistance to differentiation affects ribo- and deoxyribonucleotide pools and sensitivity to pyrimidine metabolism antagonists in HL60 cells
    Godefridus J. Peters, Albert LEYVA, Gilberto Schwartsmann · 2020 · Nucleosides Nucleotides & Nucleic Acids
  11. Advances in New Targets for Differentiation Therapy of Acute Myeloid Leukemia
    Jingfang Yao, Mengjie Zhao, Jiangyun Wang, Liuya Wei · 2020 · Journal of cancer research updates
  12. A post-transcriptional program of chemoresistance by AU-rich elements and TTP
    Sooncheol Lee, Douglas Micalizzi, Samuel S Truesdell, Syed IA Bukhari, Myriam Boukhali, Jennifer Lombardi-Story, Yasutaka Kato, Min-Kyung Choo, Ipsita Dey‐Guha, Benjamin T. Nicholson et al. · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
  13. Macrophage-secreted Pyrimidine Metabolites Confer Chemotherapy Resistance in Acute Myeloid Leukemia (AML)
    Chuqi Wang, Yuhan Wang, Camillo Benetti, Xiao Xian Lin, Enes Dasdemir, Petra Hyroššová, Jordan Yong Ming Tan, Edward Ayoub, Karanpreet Singh Bhatia, Fang Qi Lim et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  14. Multiomic analysis of clonal development reveals new regulators of leukemic cell growth
    Gracia M. Bonilla, Alexander Morris, Sharmistha Kundu, Anthony Ducasse, Grace Kirkpatrick, Nathan Elias Jeffries, Kashish Chetal, Emma Yvanovich, Jelena Milosevic, Ting Zhao et al. · 2026 · Genes & Development
  15. Intracellular Membrane Organization in Mycobacteria
    Jennifer M. Hayashi · 2021 · ScholarWorks@UMassAmherst (University of Massachusetts Amherst)
  16. The complexity of stem cell transplants: can we improve our understanding?
    Andrea Paolo Bacigalupo, Francesca Bonifazi · 2018 · Haematologica
  17. CHCHD4 regulates a proliferation-EMT switch in tumour cells, through respiratory complex I mediated metabolism
    Luke W. Thomas, Cinzia Esposito, Jenna M. Stephen, Ana S.H. Costa, Christian Frezza, Thomas S. Blacker, György Szabadkai, Margaret A. Ashcroft · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  18. Investigating the Mechanism and Species-Specificity of Thalidomide Derivatives
    Emma C. Fink · 2018 · Digital Access to Scholarship at Harvard (DASH) (Harvard University)
  19. Seeing the Future
    Jonathan Hoggatt · 2017 · The Hematologist
  20. A Preliminary Study on the Impact of UCK2 Knockdown in DLD-1 Colorectal Cells Treated with DHODH Inhibitor
    Mohamad Fairus Abdul Kadir, Puteri Shafinaz Abdul‐Rahman, Kavitha Nellore, Shatrah Othman · 2021 · Sains Malaysiana
  21. A network-based approach to integrate nutrient environment in the prediction of synthetic lethality in cancer metabolism
    Iñigo Apaolaza, Edurne San José‐Eneriz, Luis V. Valcárcel, Xabier Agirre, Felipe Prósper, Francisco J. Planes · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  22. Inhibition of pyrimidine biosynthesis targets protein translation in AML
    Joan So, Alexander Charles Lewis, Lorey K. Smith, Kym L. Stanley, Lizzy Pijpers, Pilar M. Domínguez, Simon J. Hogg, Stephin J. Vervoort, Ricky W. Johnstone, Gabrielle McDonald et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  23. In vivo metabolomic study uncovers distinct metabolic phenotypes of host tissues and predicts oxidative state of acute myeloid leukemia
    Guillaume Cognet, Lucille Stuani, Thomas Farge, Mathilde Gotanègre, Maud Heuillet, Lara Gales, Amandine Rocher, Nina Lager-Lachaud, Claudie Bosc, Marie Sabatier et al. · 2021 · Research Square
  24. Erythrinin C, From The Root of Pueraria Peduncularis, is a Potential Antagonist Against DHODH, A Therapeutic Target in Acute Myeloid Leukemia: An In Silico Study
    Toluwalase Abolarinwa · 2021 · ChemRxiv
  25. Analysis of teriflunomide therapy on EAE
    Dannheim Jasemin · 2022
  26. SHy-Cam: A Single-Shot Hyperspectral Phasor Camera for Fast, Multi-Color Fluorescence Microscopy
    Pu Wang, Masahiro Kitano, Kevin Keomanee-Dizon, Thai V. Truong, Scott E. Fraser, Francesco Cutrale · 2022 · Research Square
  27. A Comperehensive Drug Repurposing Study for Covid19 Treatment: Novel Putative DHODH Inhibitors Show Association to Serotonin-Dopamine Receptors
    Burak Berber, Osman Doluca · 2020 · ChemRxiv
  28. Erythrinin C, From The Root of Pueraria Peduncularis, is a Potential Antagonist Against DHODH, A Therapeutic Target in Acute Myeloid Leukemia: An In Silico Study
    Toluwalase Abolarinwa · 2021 · ChemRxiv
  29. EIF4A inhibition targets bioenergetic homeostasis in AML and synergizes with cytarabine and venetoclax
    Katie Fooks, Gabriela Galicia-Vázquez, Alejandro Schcolnik‐Cabrera, Victor Gife, Zaynab Nouhi, William W. L. Poon, Vincent Mingyi Luo, Raquel S. Aloyz, Alexandre Orthwein, Laura Hulea et al. · 2022 · Research Square
  30. Identification of second generation benzylidene chromanone analogues as novel, potent DHODH inhibitors in acute myeloid leukemia cells
    Mohammad Abohassan, Mesfer Mohammad Al Shahrani, Prasanna Rajagopalan · 2022 · Journal of Biomolecular Structure and Dynamics
  31. Differentiation Therapy
    Sai‐Juan Chen, Xiao‐Jing Yan, Guang‐Biao Zhou, Chen Hui Zhu · 2022 · Wiley eBooks
  32. DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation
    Nicholas J. Mullen, Surendra Kumar Shukla, Ravi Kumar Thakur, Sai Sundeep Kollala, Dezhen Wang, Nina V. Chaika, Drew A. LaBreck, Jayapal Reddy Mallareddy, David H. Price, Amarnath Natarajan et al. · 2023 · eLife
  33. Utilizing a dual endogenous reporter system to identify functional regulators of aberrant stem cell and differentiation activity in colorectal cancer
    Sándor Spisák, David J. Chen, Pornlada Likasitwatanakul, Khoa Tat Doan, Zhixin Li, Pratyusha Bala, Laura Vízkeleti, Viktória Tisza, Pushpamail De Silva, Marios Giannakis et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  34. Cell of origin epigenetic priming determines susceptibility to Tet2 mutation
    Giulia Schiroli, Vinay K. Kartha, Fabiana M. Duarte, Trine Ahn Kristiansen, Christina Mayerhofer, Rojesh Shrestha, Andrew Earl, Yan Hu, Tristan Tay, Catherine Rhee et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  35. Differentiating Acute Myeloid Leukemia Stem Cells/Blasts
    Pierre Schembri-Wismayer, Lucienne Gatt, Analisse Cassar · 2023 · Elsevier eBooks
  36. Mitohormesis : la clé de voûte de la résistance thérapeutique des cellules cancéreuses
    Emeline Boët, Estelle Saland, Sarah J. Skuli, Emmanuel Griessinger, Jean‐Emmanuel Sarry · 2024 · Comptes Rendus Biologies
  37. Developing a novel therapeutic strategy against cancer stem cell heterogeneity and plasticity
    Tôru Kondo · 2024 · Cancer Heterogeneity and Plasticity
  38. Effects of selective lactate dehydrogenase A inhibitors and their mechanism in neoplastic and non-neoplastic cells
    Marika Frańczak · 2024
  39. Inhibition of DHODH Activates Pyroptosis and cGAS-STING Pathways to Enhance NK cell Infiltration Mediated Anti-tumor Immunity in Melanoma
    Yongrui Hai, Ruizhuo Lin, Weike Liao, Siqing Fu, Renming Fan, Guiquan Ding, Junyan Zhuang, Bingjie Zhang, Yi Liu, Jun-Ke Song et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  40. Azvudine exhibits potent differentiation-inducing effect by targeting the TERT/p21 axis in acute myeloid leukemia
    Chan-Seong Kwon, Jieun Lee, Byeol-Eun Jeon, Tae‐Jin Kim, Sang Hun Lee, Ho‐Jin Shin, Sang‐Woo Kim · 2025 · Biomedicine & Pharmacotherapy
  41. Exploiting genetic and environmental vulnerabilities to target DHODH in CNS tumors
    Eli E. Bar, Julie-Aurore Losman · 2025 · Neuro-Oncology Advances
  42. Dynamics of Ribosomal RNA Transcription and Abundance in Normal and Leukemic Hematopoiesis
    Eleanor I. Sams, Victoria K. Feist, Erin M. Gray, Subin S. George, Charles Antony A, Jill A. Henrich, Kiyan Alrobaire, Putzer J. Hung, Yulia Gonskikh, Sydney L. Moore et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  43. Causal Effects of Plasma Metabolites on Leukemia: A Mendelian Randomization Study
    Chang Huang, Yuchen Li, Mengjie Li, Ye Xu, Tong Wang, Nannan Liu, Xinyi Meng, Yu Gao, Xinhui Wang · 2025 · Metabolites
  44. Combinatorial inhibition of LSD1 and Menin induces therapeutic differentiation in AML
    María F. Carrera Rodríguez, Joshua Rico, Manaswini Vijayaraghavan, Fangxue Yan, Austin King, Ricardo Petroni, Nicolae Adrian Leu, Haley Goodrow, Kathrin Maria Bernt, Gerald M. McGeehan et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  45. TP53-dependent antitumor effects of DHODH Inhibition in nasopharyngeal carcinoma
    Xingchen Dong, Yaoting Zhang, Zhicun Zhang, Ting Liu, Dongsheng Gu · 2025 · Discover Oncology
  46. Additional file 3 of 5-aminoimidazole-4-carboxamide ribonucleoside induces differentiation in a subset of primary acute myeloid leukemia blasts
    Vilma Dembitz, Hrvoje Lalić, Ivan Kodvanj, Barbara Tomić, Batinic, Josip, Klara Dubravčić, Drago Batinić, Antonio Bedalov, Dora Višnjić · 2020 · Figshare
  47. Additional file 4 of 5-aminoimidazole-4-carboxamide ribonucleoside induces differentiation in a subset of primary acute myeloid leukemia blasts
    Vilma Dembitz, Hrvoje Lalić, Ivan Kodvanj, Barbara Tomić, Batinic, Josip, Klara Dubravčić, Drago Batinić, Antonio Bedalov, Dora Višnjić · 2020 · Figshare
  48. Additional file 1 of EIF4A inhibition targets bioenergetic homeostasis in AML MOLM-14 cells in vitro and in vivo and synergizes with cytarabine and venetoclax
    Katie Fooks, Gabriela Galicia-Vázquez, Victor Gife, Alejandro Schcolnik‐Cabrera, Zaynab Nouhi, William W. L. Poon, Vincent Mingyi Luo, Rys, Ryan N., Raquel S. Aloyz, Alexandre Orthwein et al. · 2023 · Figshare
  49. Additional file 2 of 5-aminoimidazole-4-carboxamide ribonucleoside induces differentiation in a subset of primary acute myeloid leukemia blasts
    Vilma Dembitz, Hrvoje Lalić, Ivan Kodvanj, Barbara Tomić, Batinic, Josip, Klara Dubravčić, Drago Batinić, Antonio Bedalov, Dora Višnjić · 2020 · Figshare
  50. Additional file 1 of 5-aminoimidazole-4-carboxamide ribonucleoside induces differentiation in a subset of primary acute myeloid leukemia blasts
    Vilma Dembitz, Hrvoje Lalić, Ivan Kodvanj, Barbara Tomić, Batinic, Josip, Klara Dubravčić, Drago Batinić, Antonio Bedalov, Dora Višnjić · 2020 · Figshare
  51. Additional file 5 of 5-aminoimidazole-4-carboxamide ribonucleoside induces differentiation in a subset of primary acute myeloid leukemia blasts
    Vilma Dembitz, Hrvoje Lalić, Ivan Kodvanj, Barbara Tomić, Batinic, Josip, Klara Dubravčić, Drago Batinić, Antonio Bedalov, Dora Višnjić · 2020 · Figshare
  52. Partial differentiation induction of leukemia cells co-opts NK cells to erode leukemic stemness
    Jiang Zhu, Juan Chen, Siyi Wang, Rui-Xue Feng, Mengxi Wang, Xiangzhen Liu, Shijun Chen, Jianmin Dai, Hezhou Guo, Xiaoyao Wang et al. · 2026 · Research Square
  53. hENT Inhibition Prevents Pyrimidine-Driven Resistance to DHODH Inhibition in Malignant Rhabdoid Tumors
    Marjolein M G Kes, Giulia Perticari, Jolanda Kooiman, Nadia Anderson, Jeroen W. A. Jansen, Esther A. Zaal, Celia R. Berkers, Jarno Drost · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  54. Proof-of-Principle for Selective Enhancement of Nucleotide Imbalance in Cancer Cells
    James R. Henderson, Kevin Alan Peterson, Lisa Michelle Carter, David Bruce Hall · 2025 · Archive of International Journal of Cancer and Allied Science
  55. Design, synthesis and biological evaluation of thiadiazole derivatives as human dihydroorotate dehydrogenase (hDHODH) inhibitors and anticancer agents
    Pinky Gehlot, Sunil Kumar, Abu Sufiyan Chhipa, Anam Sami, Snehal Patel, Tejal A Mehta, Vivek Kumar Vyas · 2026 · Journal of Molecular Structure
  56. The EAAT1 aspartate/glutamate transporter is dispensable for acute myeloid leukemia cell growth and response to therapy
    Hernán A. Tirado, Nithya Balasundaram, Jean Jacobs, Fleur Leguay, Lotfi Laaouimir, Nick van Gastel · 2026 · PLoS ONE
  57. Multi-omics integration reveals that pyrimidine metabolism in lung adenocarcinoma drives an immunosuppressive microenvironment
    Miaoyan Liu, Houqiang Li, Shenghan Xu, Yike Zhou, Min Yao, Jiahai Shi, Lou Zhong · 2026 · iScience
  58. Neuronal Differentiation of GBM-Initiating Cells Combined with Elimination of Undifferentiated Cells Preserves Motor Function
    Zhenzhong Chen, Peilin Zou, Tôru Kondo · 2026 · Cells
  59. Synthèse de petites molécules interférant avec des microARN oncogènes pour l’induction de la différenciation des cellules souches du glioblastome
    Chloé Maucort · 2020 · theses.fr (ABES)
  60. Etude des adaptations métaboliques tissulaires et systémiques dans les leucémies aigues myéloides
    Guillaume Cognet · 2021 · theses.fr (ABES)
  61. Etude in vivo du rôle du métabolisme énergétique et mitochondrial dans la résistance thérapeutique des leucémies aiguës myéloïdes
    Claudie Bosc · 2020 · theses.fr (ABES)
  62. Nucleic acid metabolism as therapeutic target in cancer: a comprehensive analysis of folate cycle, nucleotide synthesis, and clinical applications
    Jacinta DSouza, Harish Kundaikar · 2026 · Elsevier eBooks
  63. KDM6 Enzymes are the Mechanistic Targets of Mutant IDH that Dictate Replication Stress Sensitivity
    Alexander C.-Y. Tsai, Mathew D. Lin, Vineshkumar Thidil Puliyappadamba, Dorothy M. Junginger, Victoria G. Donovan, Eleanor G. Kaplan, Laura M. Drepanos, Hiroaki Wakimoto, Daniel P. Cahill, Julie A. Losman et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  64. Cytoplasmic retention of IRF3 binding Vimentin competitively with ERK1/2 mitigates acute myeloid leukemia through TFEB nuclear translocation
    Manman Geng, Aili He, Qiaoyan Jin, Dongxia Liang, Xiaoyu Ren, Xiaomeng Li, Yanglong Guan, Chongyu Zhang, Yaqi Lu, Zhang Jing et al. · 2026 · Cell Communication and Signaling
  65. Dihydroorotate dehydrogenase: A multifunctional target in cancer, infectious diseases, and immune disorders
    Xiaoying Guan, Jinchun Li, Xiaoli Guan, Cuirong Hao, Yajie Zhang, Hong Yan · 2026 · The International Journal of Biochemistry & Cell Biology
  66. Novel noscapine derivative induces AML differentiation by dual-engaging DHODH and mitochondrial lipids to trigger a metabolic–epigenetic–transcriptional cascade
    Shuting Shen, Defeng Li, Youping Zhang, Shiwei Li, Lei Li, Wenhao Shen, Yujie Ma, Wenhao Zhang, Rong Tao, Wei Wang et al. · 2026 · Acta Pharmaceutica Sinica B
  67. Iron-driven regulation of nucleotide synthesis reveals metabolic vulnerabilities in colorectal cancer
    Luke Villareal, Yanshan Liang, Young‐Yon Kwon, Sheng Tony Hui, Xiang Xue · 2026 · Genes & Diseases
  68. The mitochondria-targeting compound PTC299 enhances megakaryocyte and platelet production
    X Wang, Meijuan Xia, Yifei Cai, Ziqi Huo, Yao Zhong, Pei Su, Cuicui Liu, Hongtao Wang, Xiangchun Shen, Fei Wang et al. · 2026 · Stem Cells Translational Medicine
  69. Lysyl oxidase inhibition disrupts mitochondrial homeostasis to create vulnerability to ferroptosis in TNBC
    Özge Saatci, Bürge Ulukan, Metin Çetįn, Hellen Kuasne, Constanza Martinez, Elif Perçin, Natalia Oleinik, Matthew T. Savoca, Ali Nehme, Aldo Hernández-Corchado et al. · 2026 · Cell Reports Medicine
  70. Combined inhibition of de novo pyrimidine synthesis and ATR promotes ATF4‐mediated cell death in TP53 ‐deficient ALL
    Kari J. T. Grünewald, Marjolein M G Kes, Gawin R. Stoll, Willem P. J. Cox, Dorette van Ingen Schenau, Enzo M. Scutigliani, Emmely M. Wagener, Ziqin Tang, Senna Visser, Jolanda Kooiman et al. · 2026 · HemaSphere
  71. OTUD6A promotes de novo pyrimidine synthesis by deubiquitinating and stabilizing CAD in cervical cancer
    Liming Liao, Lizhou Zeng, Yiliang Zhao, Zihao Guo, Tong Zeng, Ronghui Yang, Yu Xu, Xuesong Wu, Hongkun Wu, Mengyao Chen et al. · 2026 · Oncogene
  72. NLRP3 inflammasome activation is associated with type 1 inflammation and neutrophil activation in pyoderma gangrenosum across human and murine models
    T. Araki, Akihiko Uchiyama, Rimu Takata, Keiji Kosaka, Mayu Ohtaka, Shintaro Saito, Takayuki Shuto, Akiko Sekiguchi, Sachiko Ogino, Yoko Yokoyama et al. · 2026 · JID Innovations
  73. Exploring the Role of the LCN2–DHODH Interaction in Mitochondrial Ferroptosis During Sepsis-Induced Myocardial Injury and LPS-Induced HL-1 Cardiomyocyte Injury
    Lu Li, Yuping Li, Yixuan Hao, Mengjie Yu, Shicheng Xia, Jiahui Wang, Hongwei Ye, Qin Feng Gao · 2026 · International Journal of Molecular Sciences
  74. B7-H3 (CD276) regulates myeloid-derived suppressor cell differentiation in pulmonary fibrosis
    Francina Gonzalez De Los Santos, Alyssa Rosek, Akira Ando, Sem Hin Phan, Navin R. Mahadevan, Tianju Liu · 2026 · Frontiers in Immunology
  75. Ribosomal RNA transcription in normal and leukemic hematopoiesis
    Jill A. Henrich, Eleanor I. Sams, Vikram R. Paralkar · 2026 · Current topics in developmental biology/Current Topics in Developmental Biology
  76. Dihydroorotate dehydrogenase inhibitors are potent antiviral agents against henipaviruses and arenaviruses
    Yuanyuan Li, Jing Ma, Ryan Bott, Laura K. McMullan, Michael K. Lo, Payel Chatterjee, Mike Flint, Jessica R. Spengler, Kevin A. Kunz, Malaika D. Argade et al. · 2026 · Antiviral Research
  77. SAMUDRA Report, No.54, November 2009
    2009 · AquaDocs (United Nations Educational, Scientific and Cultural Organization)
  78. SAMUDRA Report No. 60, November 2011
    2011 · AquaDocs (United Nations Educational, Scientific and Cultural Organization)
  79. Samudra Report No.86, November 2021
    2021 · AquaDocs (United Nations Educational, Scientific and Cultural Organization)
  80. SAMUDRA Report, No. 48, November 2007
    2007 · AquaDocs (United Nations Educational, Scientific and Cultural Organization)
  81. SAMUDRA Report No.33, November 2002
    2002 · AquaDocs (United Nations Educational, Scientific and Cultural Organization)
  82. SAMUDRA Report No.42, November 2005
    2005 · AquaDocs (United Nations Educational, Scientific and Cultural Organization)
  83. SAMUDRA Report No. 57, November 2010
    2010 · AquaDocs (United Nations Educational, Scientific and Cultural Organization)
  84. SAMUDRA Report No. 63, November 2012
    2012 · AquaDocs (United Nations Educational, Scientific and Cultural Organization)
  85. SAMUDRA Report No.8, November 1993
    1993 · AquaDocs (United Nations Educational, Scientific and Cultural Organization)
  86. SAMUDRA Report No.36, November 2003
    2003 · AquaDocs (United Nations Educational, Scientific and Cultural Organization)
  87. SAMUDRA Report No.39, November 2004
    2004 · AquaDocs (United Nations Educational, Scientific and Cultural Organization)
  88. SAMUDRA Report No.45, November 2006
    2006 · AquaDocs (United Nations Educational, Scientific and Cultural Organization)
  89. SAMUDRA Report No.51, November 2008
    2008 · AquaDocs (United Nations Educational, Scientific and Cultural Organization)
  90. Exploring mitochondrial central dogma in cancer from a metabolic perspective
    Shengjie Zhang, Beisi Han, Lu Chen, Lingchao Chen, Tianshi Wang, Miao Lin, Jun Liu, Yiping Wang · 2026 · Clinical Cancer Bulletin
  91. In Cellulo Observation of De Novo -Synthesized Nucleotide by Spectral Tracing of Glutamine-Derived Nitrogen Metabolism (QN-STIM) in Cancer Cells
    Jiro Karlo, Surya Pratap Singh · 2026 · Analytical Chemistry
  92. A NanoBiT-based high-throughput assay system for monitoring osteoclast fusion
    Muneaki Yoshino, Sumire Hanahira, Momoka Nakatani, Wataru Fujii, Norihiro Ishida‐Kitagawa, Takuya Ogawa, Keiichiro Yogo · 2026 · Analytical Biochemistry
  93. Pharmacologically Targeting DHODH-Dependent Pyrimidine Metabolism with HSA-Conjugated BRQ Suppresses Leukemogenesis
    Xiaoxu Zhang, Changhao Tian, Yang Ding, Lei Dong, Jia Hui Yu, Rui Su, Min Gao · 2026 · Cancers
  94. Protocol for ribosome-protected fragment isolation from rare leukemia cell populations
    Christina Mayerhofer, Ernst Mayerhofer, Dan Li, Trine Ahn Kristiansen, Tobias F. Feuchtinger, David T. Scadden · 2026 · STAR Protocols
  95. Cholinergic signals regulate acute myeloid leukemia and chemotherapy response
    Simón Méndez‐Ferrer, Yexuan Zhu, Michelle Buri, Claire Fielding, Xiaochi MA, José A. Bejarano-García, Benian Uzun, Thomas Henderson, Harpreet Kaur Mandhair, Julius Schmiegelow et al. · 2026 · Research Square
  96. BindingDB Entry 50022034: Discovery of JNJ-74856665: A Novel Isoquinolinone DHODH Inhibitor for the Treatment of AML.
    BindingDB · 2025 · UC San Diego
  97. BindingDB Entry 50016438: Recent advances of human dihydroorotate dehydrogenase inhibitors for cancer therapy: Current development and future perspectives.
    BindingDB · 2023 · UC San Diego
  98. BindingDB Entry 50012107: Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1).
    BindingDB · 2022 · UC San Diego
  99. BindingDB Entry 50015235: Discovery of Orally Available Retinoic Acid Receptor-Related Orphan Receptor γ-t/Dihydroorotate Dehydrogenase Dual Inhibitors for the Treatment of Refractory Inflammatory Bowel Disease.
    BindingDB · 2023 · UC San Diego
  100. BindingDB Entry 50014340: Exploring Marine-Derived Ascochlorins as Novel Human Dihydroorotate Dehydrogenase Inhibitors for Treatment of Triple-Negative Breast Cancer.
    BindingDB · 2022 · UC San Diego