The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
The Landscape of Mouse Meiotic Double-Strand Break Formation, Processing, and Repair
Open accessAbstract
SUMMARY Heritability and genome stability are shaped by meiotic recombination, which is initiated via hundreds of DNA double-strand breaks (DSBs). The distribution of DSBs throughout the genome is not random, but mechanisms molding this landscape remain poorly understood. Here we exploit genome-wide maps of mouse DSBs at unprecedented nucleotide resolution to uncover previously invisible spatial features of recombination. At fine scale, we reveal a stereotyped hotspot structure—DSBs occur within narrow zones between methylated nucleosomes—and identify relationships between SPO11, chromatin, and the histone methyltransferase PRDM9. At large scale, DSB formation is suppressed on non-homologous portions of the sex chromosomes via the DSB-responsive kinase ATM, which also shapes the autosomal DSB landscape at multiple size scales. We also provide a genome-wide analysis of exonucleolytic DSB resection lengths and elucidate spatial relationships between DSBs and recombination products. Our results paint a comprehensive picture of features governing successive steps in mammalian meiotic recombination.
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Cites
Fast and accurate short read alignment with Burrows-Wheeler transform
Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607
MEME-ChIP: motif analysis of large DNA datasets
Machanick, P., & Bailey, T. L. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr189 · Cited by 1,806
Atm-Deficient Mice: A Paradigm of Ataxia Telangiectasia
Barlow, C., Hirotsune, S., Paylor, R., Liyanage, M., Eckhaus, M., Collins, F., Shiloh, Y., Crawley, J. N., Ried, T., Tagle, D., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)80086-0 · Cited by 1,458
Combining evidence using p-values: application to sequence homology searches.
Bailey, T. L., & Gribskov, M. (1998) · Bioinformatics · doi:10.1093/bioinformatics/14.1.48 · Cited by 1,253
Meiotic Recombination: The Essence of Heredity
Hunter, N. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016618 · Cited by 780
High-resolution mapping of meiotic crossovers and non-crossovers in yeast
Mancera, E., Bourgon, R., Brozzi, A., Huber, W., & Steinmetz, L. M. (2008) · Nature · doi:10.1038/nature07135 · Cited by 613
Meiotic recombination in mammals: localization and regulation
Baudat, F., Imai, Y., & de Massy, B. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3573 · Cited by 583
SHRiMP: Accurate Mapping of Short Color-space Reads
Rumble, S. M., Lacroute, P., Dalca, A. V., Fiume, M., Sidow, A., & Brudno, M. (2009) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000386 · Cited by 575
Pan, J., Sasaki, M., Kniewel, R., Murakami, H., Blitzblau, H. G., Tischfield, S. E., Zhu, X., Neale, M. J., Jasin, M., Socci, N. D., et al. (2011) · Cell · doi:10.1016/j.cell.2011.02.009 · Cited by 549
Self-citationGenetic recombination is directed away from functional genomic elements in mice
Brick, K., Smagulova, F., Khil, P., Camerini-Otero, R. D., & Petukhova, G. V. (2012) · Nature · doi:10.1038/nature11089 · Cited by 414
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Self-citationCharacterizing mutagenic effects of recombination through a sequence-level genetic map
Halldorsson, B. V., Palsson, G., Stefansson, O. A., Jonsson, H., Hardarson, M. T., Eggertsson, H. P., Gunnarsson, B., Oddsson, A., Halldorsson, G. H., Zink, F., et al. (2019) · Science · doi:10.1126/science.aau1043 · Cited by 361
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Huang, Y., Li, L., An, G., Yang, X., Cui, M., Song, X., Lin, J., Zhang, X., Yao, Z., Wan, C., et al. (2023) · Nature Cell Biology · doi:10.1038/s41556-023-01232-7 · Cited by 59
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Metadata
- Authors
- Lange, J., Yamada, S., Tischfield, S. E., Pan, J., Kim, S., Zhu, X., Socci, N. D., Jasin, M., & Keeney, S.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2016-10
- Volume
- 167
- Issue
- 3
- Pages
- 695-708.e16
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2531301510
- Cited by
- 285
- References
- 45
- FWCI
- 13.09
- Type
- journal article
- Language
- en
- Open access
- bronze
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