SnapShot: The Noncanonical Inflammasome
Open accessAbstract
This SnapShot depicts how the noncanonical inflammasome pathway is initiated and activated, as well as its effector mechanism in triggering pyroptosis and immune defenses.
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CASP11, CASP4, and CASP5 trigger pyroptosis upon sensing cytosolic LPS in monocytes and other cell types.
“Further experimental observations confirmed that CASP11, CASP4, and CASP5 trigger pyroptosis upon sensing cytosolic LPS [609 622–624], in monocytes as well as in other cell types [609, 625].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [625]
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Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680 · see citing works
Self-citationChemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin
Wang, Y., Gao, W., Shi, X., Ding, J., Liu, W., He, H., Wang, K., & Shao, F. (2017) · Nature · doi:10.1038/nature22393 · Cited by 3,199 · see citing works
Self-citation
- Authors
- Ding, J., & Shao, F.
- Affiliations
- Chinese Academy of Sciences (CN)
- National Institute of Biological Sciences, Beijing (CN)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2017-01
- Volume
- 168
- Issue
- 3
- Pages
- 544-544.e1
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2581042601
- Cited by
- 106
- References
- 0
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 13 · 2023: 18 · 2022: 18 · 2021: 17 · 2020: 10 · 2019: 9 · 2018: 6 · 2017: 2
- FWCI
- 3.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Keywords
- non-canonical inflammasome, inflammasome activation, pyroptosis, immune defense
- MeSH terms
- Animals, Humans, Immunity, Innate, Infections, Signal Transduction, Caspases, Inflammasomes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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