Molecular mechanisms regulating NLRP3 inflammasome activation

The Inflammasome

Martinon, F., Burns, K., & Tschopp, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00599-3 · Cited by 6,066 · see citing works

A role for mitochondria in nlrp3 inflammasome activation

Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602 · see citing works

The Inflammasomes

Schroder, K., & Tschopp, J. (2010) · Cell · doi:10.1016/j.cell.2010.01.040 · Cited by 5,475 · see citing works

Gout-associated uric acid crystals activate the NALP3 inflammasome

Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A., & Tschopp, J. (2006) · Nature · doi:10.1038/nature04516 · Cited by 5,326 · see citing works

Autophagy and Viruses: Adversaries or Allies?

Dong, X., & Levine, B. (2013) · Journal of Innate Immunity · doi:10.1159/000346388 · Cited by 4,441 · see citing works

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

Duewell, P., Kono, H., Rayner, K. J., Sirois, C. M., Vladimer, G., Bauernfeind, F. G., Abela, G. S., Franchi, L., Nuñez, G., Schnurr, M., et al. (2010) · Nature · doi:10.1038/nature08938 · Cited by 4,026 · see citing works

Immunological and inflammatory functions of the interleukin-1 family

Dinarello, C. A. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132612 · Cited by 3,466 · see citing works

Cryopyrin activates the inflammasome in response to toxins and ATP

Mariathasan, S., Weiss, D. S., Newton, K., McBride, J., O'Rourke, K., Roose-Girma, M., Lee, W. P., Weinrauch, Y., Monack, D. M., & Dixit, V. M. (2006) · Nature · doi:10.1038/nature04515 · Cited by 3,080 · see citing works

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

Hornung, V., Bauernfeind, F., Halle, A., Samstad, E. O., Kono, H., Rock, K. L., Fitzgerald, K. A., & Latz, E. (2008) · Nature Immunology · doi:10.1038/ni.1631 · Cited by 3,065 · see citing works

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

Nakahira, K., Haspel, J. A., Rathinam, V. A. K., Lee, S.-J., Dolinay, T., Lam, H. C., Englert, J. A., Rabinovitch, M., Cernadas, M., Kim, H. P., et al. (2011) · Nature Immunology · doi:10.1038/ni.1980 · Cited by 3,049 · see citing works

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

Thornberry, N., Bull, H., Calaycay, J., Chapman, K., Howard, A., Kostura, M., Miller, D. K., Molineaux, S., Weidner, J., Auniņš, J., et al. (1992) · Nature · doi:10.1038/356768a0 · Cited by 2,725 · see citing works

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

Zhou, R., Tardivel, A., Thorens, B., Choi, I., & Tschopp, J. (2010) · Nature Immunology · doi:10.1038/ni.1831 · Cited by 2,708 · see citing works

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

Dostert, C., Pétrilli, V., Van Bruggen, R., Steele, C., Mossman, B. T., & Tschopp, J. (2008) · Science · doi:10.1126/science.1156995 · Cited by 2,658 · see citing works

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

Halle, A., Hornung, V., Petzold, G. C., Stewart, C. R., Monks, B. G., Reinheckel, T., Fitzgerald, K. A., Latz, E., Moore, K. J., & Golenbock, D. T. (2008) · Nature Immunology · doi:10.1038/ni.1636 · Cited by 2,441 · see citing works

The Inflammasomes: Guardians of the Body

Martinon, F., Mayor, A., & Tschopp, J. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132715 · Cited by 2,436 · see citing works

Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis

Shimada, K., Crother, T. R., Karlin, J., Dagvadorj, J., Chiba, N., Chen, S., Ramanujan, V. K., Wolf, A. J., Vergnes, L., Ojcius, D. M., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.009 · Cited by 2,282 · see citing works

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

Muñoz-Planillo, R., Kuffa, P., Martínez-Colón, G. J., Smith, B. L., Rajendiran, T. M., & Núñez, G. (2013) · Immunity · doi:10.1016/j.immuni.2013.05.016 · Cited by 2,167 · see citing works

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

Saitoh, T., Fujita, N., Jang, M. H., Uematsu, S., Yang, B., Satoh, T., Omori, H., Noda, T., Yamamoto, N., Komatsu, M., et al. (2008) · Nature · doi:10.1038/nature07383 · Cited by 2,020 · see citing works

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

Wen, H., Gris, D., Lei, Y. L., Jha, S., Zhang, L., Huang, M. T.-H., Brickey, W. J., & Ting, J. P. ‐. (2011) · Nature Immunology · doi:10.1038/ni.2022 · Cited by 1,811 · see citing works

Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome

Hoffman, H. M., Mueller, J. L., Broide, D. H., Wanderer, A. A., & Kolodner, R. D. (2001) · Nature Genetics · doi:10.1038/ng756 · Cited by 1,679 · see citing works

The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

Davis, B. K., Wen, H., & Ting, J. P.-Y. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101405 · Cited by 1,618 · see citing works

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

Kayagaki, N., Wong, M. T., Stowe, I. B., Ramani, S. R., Gonzalez, L. C., Akashi‐Takamura, S., Miyake, K., Zhang, J., Lee, W. P., Muszyński, A., et al. (2013) · Science · doi:10.1126/science.1240248 · Cited by 1,545 · see citing works

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

Eisenbarth, S. C., Colegio, O. R., O’Connor, W., Sutterwala, F. S., & Flavell, R. A. (2008) · Nature · doi:10.1038/nature06939 · Cited by 1,542 · see citing works

Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration

Pétrilli, V, Papin, S., Dostert, C., Mayor, A., Martinon, F., & Tschopp, J. (2007) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402195 · Cited by 1,445 · see citing works

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

Shi, C.-S., Shenderov, K., Huang, N.-N., Kabat, J., Abu-Asab, M., Fitzgerald, K. A., Sher, A., & Kehrl, J. H. (2012) · Nature Immunology · doi:10.1038/ni.2215 · Cited by 1,367 · see citing works

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

Lu, A., Magupalli, V. G., Ruan, J., Yin, Q., Atianand, M. K., Vos, M. R., Schröder, G. F., Fitzgerald, K. A., Wu, H., & Egelman, E. H. (2014) · Cell · doi:10.1016/j.cell.2014.02.008 · Cited by 1,353 · see citing works

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

Hagar, J. A., Powell, D. A., Aachoui, Y., Ernst, R. K., & Miao, E. A. (2013) · Science · doi:10.1126/science.1240988 · Cited by 1,261 · see citing works

Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme

Gu, Y., Kuida, K., Tsutsui, H., Ku, G., Hsiao, K., Fleming, M. A., Hayashi, N., Higashino, K., Okamura, H., Nakanishi, K., et al. (1997) · Science · doi:10.1126/science.275.5297.206 · Cited by 1,159 · see citing works

The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP

Lee, G., Subramanian, N., Kim, A. I., Aksentijevich, I. A., Goldbach‐Mansky, R. T., Sacks, D. B., Germain, R. N., Kastner, D. L., & Chae, J. J. (2012) · Nature · doi:10.1038/nature11588 · Cited by 1,077 · see citing works

Sensing and reacting to microbes through the inflammasomes

Franchi, L., Muñoz-Planillo, R., & Núñez, G. (2012) · Nature Immunology · doi:10.1038/ni.2231 · Cited by 1,013 · see citing works

Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

Iyer, S. S., He, Q., Janczy, J. R., Elliott, E. I., Zhong, Z., Olivier, A. K., Sadler, J. J., Knepper-Adrian, V., Han, R., Qiao, L., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.001 · Cited by 939 · see citing works

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

Groß, O., Poeck, H., Bscheider, M., Dostert, C., Hannesschläger, N., Endres, S., Hartmann, G., Tardivel, A., Schweighoffer, E., Tybulewicz, V. L. J., et al. (2009) · Nature · doi:10.1038/nature07965 · Cited by 922 · see citing works

Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

Misawa, T., Takahama, M., Kozaki, T., Lee, H., Zou, J., Saitoh, T., & Akira, S. (2013) · Nature Immunology · doi:10.1038/ni.2550 · Cited by 863 · see citing works

Nox proteins in signal transduction

Brown, D. I., & Griendling, K. (2009) · Free Radical Biology & Medicine · doi:10.1016/j.freeradbiomed.2009.07.023 · Cited by 841 · see citing works

Salidroside Attenuates Ventilation Induced Lung Injury via SIRT1-Dependent Inhibition of NLRP3 Inflammasome

Wang, Y., Xu, C.-F., Liu, Y.-J., Mao, Y.-F., Lv, Z., Li, S.-Y., Zhu, X.-Y., & Jiang, L. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000477112 · Cited by 825 · see citing works

Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation

Harris, J., Hartman, M., Roche, C., Zeng, S. G., O'Shea, A., Sharp, F. A., Lambe, E. M., Creagh, E. M., Golenbock, D. T., Tschopp, J., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.202911 · Cited by 794 · see citing works

ATP Activates a Reactive Oxygen Species-dependent Oxidative Stress Response and Secretion of Proinflammatory Cytokines in Macrophages

Cruz, C. M., Rinna, A., Forman, H. J., Ventura, A. L. M., Persechini, P. M., & Ojcius, D. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608083200 · Cited by 786 · see citing works

Novel role of PKR in inflammasome activation and HMGB1 release

Lü, B., Nakamura, T., Inouye, K., Li, J., Tang, Y., Lundbäck, P., Valdés‐Ferrer, S. I., Olofsson, P. S., Kalb, T. H., Roth, J., et al. (2012) · Nature · doi:10.1038/nature11290 · Cited by 772 · see citing works

Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity.

Perregaux, D. G., & Gabel, C. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36591-2 · Cited by 760 · see citing works

NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases

Abderrazak, A., Syrovets, T., Couchie, D., Hadri, K. E., Friguet, B., Simmet, T., & Rouis, M. (2015) · Redox Biology · doi:10.1016/j.redox.2015.01.008 · Cited by 737 · see citing works

Mechanism of NLRP3 inflammasome activation

Sutterwala, F. S., Haasken, S., & Cassel, S. L. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12458 · Cited by 736 · see citing works

Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes

Lee, H., Kim, J.-J., Kim, H. J., Shong, M., Ku, B. J., & Jo, E. (2012) · Diabetes · doi:10.2337/db12-0420 · Cited by 730 · see citing works

Inflammasome recognition of influenza virus is essential for adaptive immune responses

Ichinohe, T., Lee, H. K., Ogura, Y., Flavell, R. A., & Iwasaki, A. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20081667 · Cited by 682 · see citing works

The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation

Subramanian, N., Natarajan, K., Clatworthy, M. R., Wang, Z., & Germain, R. N. (2013) · Cell · doi:10.1016/j.cell.2013.02.054 · Cited by 675 · see citing works

Influenza virus activates inflammasomes via its intracellular M2 ion channel

Ichinohe, T., Pang, I. K., & Iwasaki, A. (2010) · Nature Immunology · doi:10.1038/ni.1861 · Cited by 632 · see citing works

Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome

Bauernfeind, F., Bartok, E., Rieger, A., Franchi, L., Núñez, G., & Hornung, V. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100613 · Cited by 617 · see citing works

The interleukin‐1 receptor/Toll‐like receptor superfamily: 10 years of progress

O'Neill, L. A. J. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00701.x · Cited by 612 · see citing works

Redox regulation of mitochondrial function

Handy, D. E., & Loscalzo, J. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4123 · Cited by 588 · see citing works

Mitochondrial Reactive Oxygen Species Induces NLRP3-Dependent Lysosomal Damage and Inflammasome Activation

Heid, M. E., Keyel, P. A., Kamga, C., Shiva, S., Watkins, S. C., & Salter, R. D. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301490 · Cited by 570 · see citing works

Prion-like Polymerization Underlies Signal Transduction in Antiviral Immune Defense and Inflammasome Activation

Cai, X., Chen, J., Xu, H., Liu, S., Jiang, Q., Halfmann, R., & Chen, Z. J. (2014) · Cell · doi:10.1016/j.cell.2014.01.063 · Cited by 567 · see citing works

The Inflammasome Mediates UVB-Induced Activation and Secretion of Interleukin-1β by Keratinocytes

Feldmeyer, L., Keller, M., Niklaus, G., Hohl, D., Werner, S., & Beer, H.-D. (2007) · Current Biology · doi:10.1016/j.cub.2007.05.074 · Cited by 544 · see citing works

Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome

Sharp, F. A., Ruane, D., Claass, B., Creagh, E. M., Harris, J., Malyala, P., Singh, M., O’Hagan, D. T., Pétrilli, V., Tschopp, J., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804897106 · Cited by 536 · see citing works

GBP5 Promotes NLRP3 Inflammasome Assembly and Immunity in Mammals

Shenoy, A. R., Wellington, D. A., Kumar, P., Kassa, H. T., Booth, C. J., Cresswell, P., & MacMicking, J. D. (2012) · Science · doi:10.1126/science.1217141 · Cited by 512 · see citing works

Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

Walle, L., Opdenbosch, N. V., Jacques, P., Fossoul, A., Verheugen, E., Vogel, P., Beyaert, R., Elewaut, D., Kanneganti, T., van Loo, G., et al. (2014) · Nature · doi:10.1038/nature13322 · Cited by 499 · see citing works

Mechanisms of inflammasome activation: recent advances and novel insights

Vanaja, S. K., Rathinam, V. A. K., & Fitzgerald, K. A. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.12.009 · Cited by 499 · see citing works

Blocking IL-1 in systemic inflammation

Dinarello, C. A. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050640 · Cited by 494 · see citing works

Where the endoplasmic reticulum and the mitochondrion tie the knot: The mitochondria-associated membrane (MAM)

Raturi, A., & Simmen, T. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.04.013 · Cited by 448 · see citing works

Emerging inflammasome effector mechanisms

Lamkanfi, M. (2011) · Nature reviews. Immunology · doi:10.1038/nri2936 · Cited by 435 · see citing works

NLRP3 inflammasomes link inflammation and metabolic disease

De Nardo, D., & Latz, E. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.05.004 · Cited by 425 · see citing works

Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock

Mao, K., Chen, S., Chen, M., Ma, Y., Wang, Y., Huang, B., He, Z., Zeng, Y., Hu, Y., Sun, S., et al. (2013) · Cell Research · doi:10.1038/cr.2013.6 · Cited by 397 · see citing works

The receptor NLRP3 is a transcriptional regulator of TH2 differentiation

Bruchard, M., Rébé, C., Dérangère, V., Togbe, D., Ryffel, B., Boidot, R., Humblin, É., Hamman, A., Chalmin, F., Berger, H., et al. (2015) · Nature Immunology · doi:10.1038/ni.3202 · Cited by 394 · see citing works

Mitochondria: diversity in the regulation of the NLRP3 inflammasome

Gurung, P., Lukens, J. R., & Kanneganti, T.-D. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.11.008 · Cited by 393 · see citing works

The NLRP3 inflammasome in health and disease: the good, the bad and the ugly

Menu, P., & Vince, J. E. (2011) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2011.04440.x · Cited by 387 · see citing works

Targeting the NLRP3 inflammasome in chronic inflammatory diseases: current perspectives

Doyle, S., Ozaki, E., & Campbell, M. (2015) · Journal of Inflammation Research · doi:10.2147/jir.s51250 · Cited by 382 · see citing works

TRPM2 links oxidative stress to NLRP3 inflammasome activation

Zhong, Z., Zhai, Y., Liang, S., Mori, Y., Han, R., Sutterwala, F. S., & Qiao, L. (2013) · Nature Communications · doi:10.1038/ncomms2608 · Cited by 374 · see citing works

Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex

Man, S. M., Hopkins, L., Nugent, E., Cox, S., Glück, I. M., Tourlomousis, P., Wright, J. A., Cicuta, P., Monie, T. P., & Bryant, C. E. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1402911111 · Cited by 351 · see citing works

Differential Expression of NLRP3 among Hematopoietic Cells

Guarda, G., Zenger, M., Yazdi, A. S., Schroder, K., Ferrero, I., Menu, P., Tardivel, A., Mattmann, C., & Tschopp, J. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002720 · Cited by 350 · see citing works

A Critical Role for Hemolysins and Bacterial Lipoproteins in Staphylococcus aureus-Induced Activation of the Nlrp3 Inflammasome

Muñoz-Planillo, R., Franchi, L., Miller, L. S., & Núñez, G. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900729 · Cited by 335 · see citing works

RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway

Wang, X., Jiang, W., Yan, Y., Gong, T., Han, J., Tian, Z., & Zhou, R. (2014) · Nature Immunology · doi:10.1038/ni.3015 · Cited by 323 · see citing works

Aspergillus fumigatus Stimulates the NLRP3 Inflammasome through a Pathway Requiring ROS Production and the Syk Tyrosine Kinase

Sadier, N. S., Padilla, E., Langsley, G., & Ojcius, D. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010008 · Cited by 302 · see citing works

Superoxide dismutase 1 regulates caspase-1 and endotoxic shock

Meissner, F., Molawi, K., & Zychlinsky, A. (2008) · Nature Immunology · doi:10.1038/ni.1633 · Cited by 302 · see citing works

Critical functions of priming and lysosomal damage for NLRP3 activation

Hornung, V., & Latz, E. (2010) · European Journal of Immunology · doi:10.1002/eji.200940185 · Cited by 297 · see citing works

NLRP3/Cryopyrin Is Necessary for Interleukin-1β (IL-1β) Release in Response to Hyaluronan, an Endogenous Trigger of Inflammation in Response to Injury

Yamasaki, K., Muto, J., Taylor, K. R., Cogen, A. L., Audish, D., Bertin, J., Grant, E. P., Coyle, A. J., Misaghi, A., Hoffman, H. M., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m806084200 · Cited by 288 · see citing works

Mitochondrial protein mitofusin 2 is required for NLRP3 inflammasome activation after RNA virus infection

Ichinohe, T., Yamazaki, T., Koshiba, T., & Yanagi, Y. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1312571110 · Cited by 284 · see citing works

Monounsaturated Fatty Acid–Enriched High-Fat Diets Impede Adipose NLRP3 Inflammasome–Mediated IL-1β Secretion and Insulin Resistance Despite Obesity

Finucane, O. M., Lyons, C. L., Murphy, A. M., Reynolds, C. M., Klinger, R. W., Healy, N. P., Cooke, A. A., Coll, R. C., McAllan, L., Nilaweera, K. N., et al. (2015) · Diabetes · doi:10.2337/db14-1098 · Cited by 281 · see citing works

Neisseria gonorrhoeae Activates the Proteinase Cathepsin B to Mediate the Signaling Activities of the NLRP3 and ASC-Containing Inflammasome

Duncan, J. A., Gao, X., Huang, M. T.-H., O’Connor, B. P., Thomas, C. E., Willingham, S. B., Bergstralh, D. T., Jarvis, G. A., Sparling, P. F., & Ting, J. P. ‐. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802696 · Cited by 278 · see citing works

Mitochondrial ROS fuel the inflammasome

Sorbara, M. T., & Girardin, S. E. (2011) · Cell Research · doi:10.1038/cr.2011.20 · Cited by 274 · see citing works

3,4-Methylenedioxy-β-nitrostyrene Inhibits NLRP3 Inflammasome Activation by Blocking Assembly of the Inflammasome

He, Y., Varadarajan, S., Muñoz-Planillo, R., Burberry, A., Nakamura, Y., & Núñez, G. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.515080 · Cited by 272 · see citing works

Inflammasome activation in nadph oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease

Meissner, F., Seger, R. A., Moshous, D., Fischer, A., Reichenbach, J., & Zychlinsky, A. (2010) · Blood · doi:10.1182/blood-2010-01-264218 · Cited by 269 · see citing works

Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation

Ives, A., Nomura, J., Martinon, F., Roger, T., LeRoy, D., Miner, J. N., Simon, G., Busso, N., & So, A. (2015) · Nature Communications · doi:10.1038/ncomms7555 · Cited by 264 · see citing works

ATP release and purinergic signaling: a common pathway for particle-mediated inflammasome activation

Riteau, N., Baron, L., Villeret, B., Guillou, N., Savigny, F., Ryffel, B., Rassendren, F., Bert, M. L., Gombault, A., & Couillin, I. (2012) · Cell Death and Disease · doi:10.1038/cddis.2012.144 · Cited by 258 · see citing works

Reactive oxygen species–independent activation of the IL-1β inflammasome in cells from patients with chronic granulomatous disease

van de Veerdonk, F. L., Smeekens, S. P., Joosten, L. A. B., Kullberg, B. J., Dinarello, C. A., van der Meer, J. W. M., & Netea, M. G. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914795107 · Cited by 248 · see citing works

The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation

Rodgers, M. A., Bowman, J. W., Fujita, H., Orazio, N., Shi, M., Liang, Q., Amatya, R., Kelly, T. J., Iwai, K., Ting, J., et al. (2014) · Journal of Experimental Medicine · doi:10.1084/jem.20132486 · Cited by 247 · see citing works

NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy

Jin, C., Frayssinet, P., Pelker, R. R., Cwirka, D., Hu, B., Vignery, A., Eisenbarth, S. C., & Flavell, R. A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1111101108 · Cited by 241 · see citing works

The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine

Baron, L., Gombault, A., Fanny, M., Villeret, B., Savigny, F., Guillou, N., Panek, C., Bert, M. L., Lagente, V., Rassendren, F., et al. (2015) · Cell Death and Disease · doi:10.1038/cddis.2014.576 · Cited by 221 · see citing works

The Lysosome Rupture-activated TAK1-JNK Pathway Regulates NLRP3 Inflammasome Activation

Okada, M., Matsuzawa, A., Yoshimura, A., & Ichijo, H. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.579961 · Cited by 213 · see citing works

Aryl hydrocarbon receptor negatively regulates NLRP3 inflammasome activity by inhibiting NLRP3 transcription

Huai, W., Zhao, R., Song, H., Zhao, J., Zhang, L., Zhang, L., Gao, C., Han, L., & Zhao, W. (2014) · Nature Communications · doi:10.1038/ncomms5738 · Cited by 211 · see citing works

TLR Agonists Stimulate Nlrp3-Dependent IL-1β Production Independently of the Purinergic P2X7 Receptor in Dendritic Cells and In Vivo

He, Y., Franchi, L., & Núñez, G. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1202737 · Cited by 206 · see citing works

The DHX33 RNA Helicase Senses Cytosolic RNA and Activates the NLRP3 Inflammasome

Mitoma, H., Hanabuchi, S., Kim, T. I., Bao, M., Zhang, Z., Sugimoto, N., & Liu, Y. (2013) · Immunity · doi:10.1016/j.immuni.2013.07.001 · Cited by 204 · see citing works

Human nlrp3 inflammasome activation is nox1-4 independent

van Bruggen, R., Köker, M. Y., Jansen, M., van Houdt, M., Roos, D., Kuijpers, T. W., & van den Berg, T. K. (2010) · Blood · doi:10.1182/blood-2009-10-250803 · Cited by 202 · see citing works

Encephalomyocarditis Virus Viroporin 2B Activates NLRP3 Inflammasome

Ito, M., Yanagi, Y., & Ichinohe, T. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002857 · Cited by 199 · see citing works

Doxorubicin and daunorubicin induce processing and release of interleukin-1β through activation of the NLRP3 inflammasome

Sauter, K. A. D., Wood, L. J., Wong, J. W., Iordanov, M. S., & Magun, B. E. (2011) · Cancer Biology & Therapy · doi:10.4161/cbt.11.12.15540 · Cited by 195 · see citing works

Cutting Edge: CIAS1/Cryopyrin/PYPAF1/NALP3/ CATERPILLER 1.1 Is an Inducible Inflammatory Mediator with NF-κB Suppressive Properties

O’Connor, W., Harton, J. A., Zhu, X., Linhoff, M. W., & Ting, J. P. ‐. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.12.6329 · Cited by 195 · see citing works

NLRP3 inflammasome is required in murine asthma in the absence of aluminum adjuvant

Besnard, A., Guillou, N., Tschopp, J., Erard, F., Couillin, I., Iwakura, Y., Quesniaux, V. F. J., Ryffel, B., & Togbe, D. (2011) · Allergy · doi:10.1111/j.1398-9995.2011.02586.x · Cited by 188 · see citing works

Adenovirus Membrane Penetration Activates the NLRP3 Inflammasome

Barlan, A., Griffin, T., McGuire, K. A., & Wiethoff, C. M. (2010) · Journal of Virology · doi:10.1128/jvi.01265-10 · Cited by 181 · see citing works

Novel Roles for Caspase-8 in IL-1β and Inflammasome Regulation

Gurung, P., & Kanneganti, T. (2014) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.08.025 · Cited by 178 · see citing works

Inflammasomes and host defenses against bacterial infections

Vladimer, G. I., Marty-Roix, R., Ghosh, S., Weng, D., & Lien, E. (2013) · Current Opinion in Microbiology · doi:10.1016/j.mib.2012.11.008 · Cited by 173 · see citing works

Dietary saturated fatty acids prime the NLRP 3 inflammasome via TLR 4 in dendritic cells—implications for diet‐induced insulin resistance

Reynolds, C. M., McGillicuddy, F. C., Harford, K. A., Finucane, O. M., Mills, K. H. G., & Roche, H. M. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200058 · Cited by 168 · see citing works

The inflammasome in pathogen recognition and inflammation

Sutterwala, F. S., Ogura, Y., & Flavell, R. A. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.1206755 · Cited by 166 · see citing works

Role of lysosome rupture in controlling Nlrp3 signaling and necrotic cell death

Lima, H., Jacobson, L. S., Goldberg, M. F., Chandran, K., Diaz‐Griffero, F., Lisanti, M. P., & Brojatsch, J. (2013) · Cell Cycle · doi:10.4161/cc.24903 · Cited by 164 · see citing works

Caspase-4 Is Required for Activation of Inflammasomes

Sollberger, G., Strittmatter, G. E., Kistowska, M., French, L. E., & Beer, H. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1101620 · Cited by 163 · see citing works

Human respiratory syncytial virus viroporin SH: a viral recognition pathway used by the host to signal inflammasome activation

Triantafilou, K., Kar, S., Vakakis, E., Kotecha, S., & Triantafilou, M. (2012) · Thorax · doi:10.1136/thoraxjnl-2012-202182 · Cited by 161 · see citing works

Activation of the NLRP3 Inflammasome by Group B Streptococci

Costa, A., Gupta, R., Signorino, G., Malara, A., Cardile, F., Biondo, C., Midiri, A., Galbo, R., Trieu‐Cuot, P., Papasergi, S., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102543 · Cited by 156 · see citing works

TLR-induced PAI-2 expression suppresses IL-1β processing via increasing autophagy and NLRP3 degradation

Chuang, S.-Y., Yang, C.-H., Chou, C.-C., Chiang, Y.-P., Chuang, T., & Hsu, L.-C. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1306556110 · Cited by 154 · see citing works

The expanding role of NLR s in antiviral immunity

Lupfer, C. R., & Kanneganti, T. (2013) · Immunological Reviews · doi:10.1111/imr.12089 · Cited by 151 · see citing works

Immunologic manifestations of autophagy

Deretic, V. P., Kimura, T., Timmins, G. S., Moseley, P. L., Chauhan, S., & Mandell, M. A. (2015) · Journal of Clinical Investigation · doi:10.1172/jci73945 · Cited by 146 · see citing works

MDP-induced interleukin-1β processing requires Nod2 and CIAS1/NALP3

Pan, Q., Mathison, J. C., Fearns, C., Kravchenko, V. V., Correia, J. D. S., Hoffman, H. M., Kobayashi, K. S., Bertin, J., Grant, E. P., Coyle, A. J., et al. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.1006627 · Cited by 145 · see citing works

Rhinovirus-Induced Calcium Flux Triggers NLRP3 and NLRC5 Activation in Bronchial Cells

Triantafilou, K., Kar, S., van Kuppeveld, F. J. M., & Triantafilou, M. (2013) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2013-0032oc · Cited by 141 · see citing works

Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome

Yang, C.-S., Kim, J.-J., Kim, T. S., Lee, P. Y., Kim, S. Y., Lee, H.-M., Shin, D., Nguyen, L. T., Lee, M., Jin, H. S., et al. (2015) · Nature Communications · doi:10.1038/ncomms7115 · Cited by 135 · see citing works

Coordinated Host Responses during Pyroptosis: Caspase-1–Dependent Lysosome Exocytosis and Inflammatory Cytokine Maturation

Bergsbaken, T., Fink, S. L., den Hartigh, A. B., Loomis, W. P., & Cookson, B. T. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100477 · Cited by 135 · see citing works

Lysosomes Integrate Metabolic-Inflammatory Cross-talk in Primary Macrophage Inflammasome Activation

Weber, K., & Schilling, J. D. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.531202 · Cited by 133 · see citing works

NLRP3 Inflammasome and Host Protection against Bacterial Infection

Kim, J.-J., & Jo, E. (2013) · Journal of Korean Medical Science · doi:10.3346/jkms.2013.28.10.1415 · Cited by 124 · see citing works

A Key Role for Redox Signaling in Rapid P2X7 Receptor-Induced IL-1β Processing in Human Monocytes

Hewinson, J., Moore, S., Glover, C., Watts, A. G., & Mackenzie, A. B. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.12.8410 · Cited by 122 · see citing works

Cell stress increases ATP release in NLRP3 inflammasome-mediated autoinflammatory diseases, resulting in cytokine imbalance

Carta, S., Penco, F., Lavieri, R., Martini, A., Dinarello, C. A., Gattorno, M., & Rubartelli, A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1424741112 · Cited by 121 · see citing works

Megalin/Cubulin-Lysosome-mediated Albumin Reabsorption Is Involved in the Tubular Cell Activation of NLRP3 Inflammasome and Tubulointerstitial Inflammation

Liu, D., Wen, Y., Tang, T., Lv, L., Tang, R., Liu, H., Ma, K., Crowley, S. D., & Liu, B. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.662064 · Cited by 112 · see citing works

Secreted aspartic proteases of C andida albicans activate the NLRP 3 inflammasome

Pietrella, D., Pandey, N., Gabrielli, E., Pericolini, E., Perito, S., Kasper, L., Bistoni, F., Cassone, A., Hube, B., & Vecchiarelli, A. (2012) · European Journal of Immunology · doi:10.1002/eji.201242691 · Cited by 111 · see citing works

CARD8 is a negative regulator for NLRP3 inflammasome, but mutant NLRP3 in cryopyrin-associated periodic syndromes escapes the restriction

Ito, S., Hara, Y., & Kubota, T. (2014) · Arthritis Research & Therapy · doi:10.1186/ar4483 · Cited by 111 · see citing works

IKKα negatively regulates ASC-dependent inflammasome activation

Martin, B. N., Wang, C., Willette‐Brown, J., Herjan, T., Gulen, M. F., Zhou, H., Bulek, K., Franchi, L., Sato, T., Alnemri, E. S., et al. (2014) · Nature Communications · doi:10.1038/ncomms5977 · Cited by 110 · see citing works

Zinc depletion regulates the processing and secretion of IL-1β

Summersgill, H. R., England, H., López‐Castejón, G., Lawrence, C. B., Luheshi, N., Pahle, J., Mendes, P., & Brough, D. (2014) · Cell Death and Disease · doi:10.1038/cddis.2013.547 · Cited by 109 · see citing works

Tripartite-Motif Protein 30 Negatively Regulates NLRP3 Inflammasome Activation by Modulating Reactive Oxygen Species Production

Hu, Y., Mao, K., Zeng, Y., Chen, S., Tao, Z., Yang, C., Sun, S., Wu, X., Meng, G., & Sun, B. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001099 · Cited by 108 · see citing works

Nucleotide-Binding Oligomerization Domain-Like Receptors and Inflammasomes in the Pathogenesis of Non-Microbial Inflammation and Diseases

Mason, D. R., Beck, P. L., & Muruve, D. A. (2011) · Journal of Innate Immunity · doi:10.1159/000334247 · Cited by 106 · see citing works

Caspase-1 activation by NLRP3 inflammasome dampens IL-33-dependent house dust mite-induced allergic lung inflammation

Madouri, F., Guillou, N., Fauconnier, L., Marchiol, T., Rouxel, N., Chenuet, P., Ledru, A., Apétoh, L., Ghiringhelli, F., Chamaillard, M., et al. (2015) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjv012 · Cited by 104 · see citing works

Control of antiviral immunity by pattern recognition and the microbiome

Pang, I. K., & Iwasaki, A. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01073.x · Cited by 103 · see citing works

Disease-associated mutations in CIAS1 induce cathepsin B–dependent rapid cell death of human THP-1 monocytic cells

Fujisawa, A., Kambe, N., Saito, M. K., Nishikomori, R., Tanizaki, H., Kanazawa, N., Adachi, S., Heike, T., Sagara, J., Suda, T., et al. (2006) · Blood · doi:10.1182/blood-2006-07-033597 · Cited by 101 · see citing works

Defects in Mitochondrial Clearance Predispose Human Monocytes to Interleukin-1β Hypersecretion

van der Burgh, R., Nijhuis, L., Pervolaraki, K., Compeer, E. B., Jongeneel, L. H., van Gijn, M. E., Coffer, P. J., Murphy, M. P., Mastroberardino, P. G., Frenkel, J., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.536920 · Cited by 92 · see citing works

Xanthine oxidoreductase: A journey from purine metabolism to cardiovascular excitation-contraction coupling

Agarwal, A., Banerjee, A., & Banerjee, U. C. (2011) · Critical Reviews in Biotechnology · doi:10.3109/07388551.2010.527823 · Cited by 91 · see citing works

LRRFIP2 negatively regulates NLRP3 inflammasome activation in macrophages by promoting Flightless-I-mediated caspase-1 inhibition

Jin, J., Yu, Q., Han, C., Hu, X., Xu, S., Wang, Q., Wang, J., Li, N., & Cao, X. (2013) · Nature Communications · doi:10.1038/ncomms3075 · Cited by 90 · see citing works

Mitochondria-targeted drugs enhance Nlrp3 inflammasome-dependent IL-1β secretion in association with alterations in cellular redox and energy status

Jabaut, J., Ather, J. L., Taracanova, A., Poynter, M. E., & Ckless, K. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.01.025 · Cited by 89 · see citing works

Carbon monoxide negatively regulates NLRP3 inflammasome activation in macrophages

Jung, S. S., Moon, J., Xu, J., Ifedigbo, E., Ryter, S. W., Choi, A. M. K., & Nakahira, K. (2015) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00400.2014 · Cited by 84 · see citing works

Negative regulation of the inflammasome: keeping inflammation under control

Pedraza‐Alva, G., Pérez‐Martínez, L., Valdez‐Hernández, L., Meza‐Sosa, K. F., & Ando‐Kuri, M. (2015) · Immunological Reviews · doi:10.1111/imr.12294 · Cited by 76 · see citing works

RNA and β-Hemolysin of Group B Streptococcus Induce Interleukin-1β (IL-1β) by Activating NLRP3 Inflammasomes in Mouse Macrophages

Gupta, R., Ghosh, S., Monks, B. G., DeOliveira, R. B., Tzeng, T.-C. J., Kalantari, P., Nandy, A., Bhattacharjee, B., Chan, J., Ferreira, F., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.c114.548982 · Cited by 75 · see citing works

Inflammasome activation via intracellular NLRs triggered by bacterial infection

Koizumi, Y., Toma, C., Higa, N., Nohara, T., Nakasone, N., & Suzuki, T. (2011) · Cellular Microbiology · doi:10.1111/j.1462-5822.2011.01707.x · Cited by 69 · see citing works

Evaluation of Nod-Like Receptor (NLR) Effector Domain Interactions

Wagner, R. N., Proell, M., Kufer, T. A., & Schwarzenbacher, R. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004931 · Cited by 68 · see citing works

NADPH Oxidase Biology and the Regulation of Tyrosine Kinase Receptor Signaling and Cancer Drug Cytotoxicity

Paletta-Silva, R., Rocco-Machado, N., & Meyer‐Fernandes, J. R. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14023683 · Cited by 63 · see citing works

TLR4 Activation Under Lipotoxic Conditions Leads to Synergistic Macrophage Cell Death through a TRIF-Dependent Pathway

Schilling, J. D., Machkovech, H. M., He, L. N., Diwan, A., & Schaffer, J. E. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1202208 · Cited by 61 · see citing works

G Protein Signaling Modulator-3 Inhibits the Inflammasome Activity of NLRP3

Giguère, P. M., Gall, B., Ezekwe, E., Laroche, G., Buckley, B. K., Kébaïer, C., Wilson, J. E., Ting, J. P. ‐., Siderovski, D. P., & Duncan, J. A. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.578393 · Cited by 35 · see citing works

Albumin impairs renal tubular tight junctions via targeting the NLRP3 inflammasome.

Zhuang, Y.-B., Hu, C., Ding, G., Zhang, Y., Huang, S., Jia, Z., & Zhang, A.-H. (2015) · AJP - Renal Physiology · doi:10.1152/ajprenal.00509.2014 · Cited by 35 · see citing works

Class II essential for CD4 survival

Kirberg, J., von Boehmer, H., Brocker, T., Rodewald, H.-R., & Takeda, S. (2001) · Nature Immunology · doi:10.1038/84229 · Cited by 17 · see citing works

Reactive Oxygen Species in Metabolic and Inflammatory Signaling

Forrester, S. J., Kikuchi, D. S., Hernandes, M. S., Xu, Q., & Griendling, K. K. (2018) · Circulation Research · doi:10.1161/circresaha.117.311401 · Cited by 2,081 · see citing works

Nrf2 signaling pathway: pivotal roles in inflammation

Ahmed, S. M. U., Luo, L., Namani, A., Wang, X. J., & Tang, X. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.11.005 · Cited by 1,794 · see citing works

Inflammatory mechanisms in patients with chronic obstructive pulmonary disease

Barnes, P. J. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.05.011 · Cited by 1,697 · see citing works

FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation

Hu, J. J., Liu, X., Xia, S., Zhang, Z., Zhang, Y., Zhao, J., Ruan, J., Luo, X., Lou, X., Bai, Y., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0669-6 · Cited by 1,145 · see citing works

Triggering and resolution of inflammation in NASH

Schuster, S., Cabrera, D., Arrese, M., & Feldstein, A. E. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0009-6 · Cited by 943 · see citing works

Mitochondria as a therapeutic target for common pathologies

Murphy, M. P., & Hartley, R. C. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.174 · Cited by 832 · see citing works

Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity

He, H., Jiang, H., Chen, Y., Ye, J., Wang, A., Wang, C., Liu, Q., Liang, G., Deng, X., Jiang, W., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04947-6 · Cited by 827 · see citing works

Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders

Jiang, H., He, H., Chen, Y., Huang, W., Cheng, J., Ye, J., Wang, A., Tao, J., Wang, C., Liu, Q., et al. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20171419 · Cited by 771 · see citing works

Reactive oxygen species (ROS) in macrophage activation and function in diabetes

Rendra, E., Riabov, V., Mossel, D. M., Sevastyanova, T., Harmsen, M. C., & Kzhyshkowska, J. (2019) · Immunobiology · doi:10.1016/j.imbio.2018.11.010 · Cited by 636 · see citing works

The NLRP3 Inflammasome Pathway: A Review of Mechanisms and Inhibitors for the Treatment of Inflammatory Diseases

Blevins, H. M., Xu, Y., Biby, S., & Zhang, S. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.879021 · Cited by 587 · see citing works

Tranilast directly targets NLRP3 to treat inflammasome‐driven diseases

Huang, Y., Jiang, H., Chen, Y., Wang, X., Yang, Y., Tao, J., Deng, X., Liang, G., Zhang, H., Jiang, W., et al. (2018) · EMBO Molecular Medicine · doi:10.15252/emmm.201708689 · Cited by 521 · see citing works

Cellular and molecular mechanisms of asthma and COPD

Barnes, P. J. (2017) · Clinical Science · doi:10.1042/cs20160487 · Cited by 511 · see citing works

Pyroptosis-Induced Inflammation and Tissue Damage

Vasudevan, S. O., Behl, B., & Rathinam, V. A. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101781 · Cited by 412 · see citing works

Melatonin prevents endothelial cell pyroptosis via regulation of long noncoding RNA MEG3/miR‐223/NLRP3 axis

Zhang, Y., Liu, X., Bai, X., Yuan, L., Li, Z., Fu, J., Li, M., Zhao, T., Yang, H., Xu, R., et al. (2017) · Journal of Pineal Research · doi:10.1111/jpi.12449 · Cited by 395 · see citing works

Mitochondria-associated membranes (MAMs) and inflammation

Missiroli, S., Patergnani, S., Caroccia, N., Pedriali, G., Perrone, M., Previati, M., Wieckowski, M. R., & Giorgi, C. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0027-2 · Cited by 389 · see citing works

CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation

Tang, T., Lang, X., Xu, C., Wang, X., Gong, T., Yang, Y., Cui, J., Bai, L., Wang, J., Jiang, W., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00227-x · Cited by 364 · see citing works

HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1β production via suppressing the NF-κB pathway and ROS production

Yu, X., Lan, P., Hou, X., Han, Q., Lü, N., Li, T., Jiao, C., Zhang, J., Zhang, C., & Tian, Z. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.12.018 · Cited by 357 · see citing works

Mitochondria as a Cellular Hub in Infection and Inflammation

Andrieux, P., Chevillard, C., Cunha-Neto, E., & Nunes, J. P. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111338 · Cited by 346 · see citing works

New insights into the evasion of host innate immunity by Mycobacterium tuberculosis

Chai, Q., Wang, L., Liu, C. H., & Ge, B. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-0502-z · Cited by 336 · see citing works

Manganese salts function as potent adjuvants

Zhang, R., Wang, C., Guan, Y., Wei, X., Sha, M., Yi, M., Jing, M., Lv, M., Guo, W., Xu, J., et al. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-021-00669-w · Cited by 321 · see citing works

Mitochondria and microbiota dysfunction in COVID-19 pathogenesis

Saleh, J., Peyssonnaux, C., Singh, K. K., & Edeas, M. A. (2020) · Mitochondrion · doi:10.1016/j.mito.2020.06.008 · Cited by 304 · see citing works

Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson’s disease

Sarkar, S., Malovic, E., Harischandra, D. S., Ghaisas, S., Panicker, N., Charli, A., Palanisamy, B. N., Rokad, D., Jin, H., Anantharam, V., et al. (2017) · npj Parkinson s Disease · doi:10.1038/s41531-017-0032-2 · Cited by 283 · see citing works

STING-dependent sensing of self-DNA drives silica-induced lung inflammation

Benmerzoug, S., Rose, S., Bounab, B., Gosset, D., Duneau, L., Chenuet, P., Mollet, L., Bert, M. L., Lambers, C., Geleff, S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07425-1 · Cited by 282 · see citing works

Protein kinase D at the Golgi controls NLRP3 inflammasome activation

Zhang, Z., Mészáros, G., He, W., Xu, Y., Magliarelli, H. D. F., Mailly, L., Mihlan, M., Liu, Y., Gámez, M. P., Goginashvili, A., et al. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20162040 · Cited by 279 · see citing works

Spotlight on the NLRP3 inflammasome pathway

Groslambert, M., & Py, B. F. (2018) · Journal of Inflammation Research · doi:10.2147/jir.s141220 · Cited by 267 · see citing works

The Crosstalk between Nrf2 and Inflammasomes

Hennig, P., Garstkiewicz, M., Grossi, S., Filippo, M. D., French, L. E., & Beer, H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020562 · Cited by 256 · see citing works

The Crohn’s Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy

Mehto, S., Jena, K. K., Nath, P., Chauhan, S., Kolapalli, S. P., Das, S. K., Sahoo, P. K., Jain, A., Taylor, G. A., & Chauhan, S. (2019) · Molecular Cell · doi:10.1016/j.molcel.2018.11.018 · Cited by 238 · see citing works

Immunological mechanisms and therapeutic targets of fatty liver diseases

Wang, H., Mehal, W. Z., Nagy, L. E., & Rotman, Y. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-00579-3 · Cited by 222 · see citing works

miR-21 and miR-146a: The microRNAs of inflammaging and age-related diseases

Olivieri, F., Prattichizzo, F., Giuliani, A., Matacchione, G., Rippo, M. R., Sabbatinelli, J., & Bonafè, M. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101374 · Cited by 221 · see citing works

Danger Signals and Inflammasomes: Stress-Evoked Sterile Inflammation in Mood Disorders

Fleshner, M., Frank, M., & Maier, S. F. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.125 · Cited by 216 · see citing works

Depression and sterile inflammation: essential role of danger associated molecular patterns

Franklin, T. C., Xu, C., & Duman, R. S. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.10.025 · Cited by 204 · see citing works

NLRP3 Inflammasome as a Molecular Marker in Diabetic Cardiomyopathy

Luo, B., Huang, F., Liu, Y., Liang, Y., Wei, Z., Ke, H., Zeng, Z., Huang, W., & He, Y. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00519 · Cited by 213 · see citing works

Lonicerin targets EZH2 to alleviate ulcerative colitis by autophagy-mediated NLRP3 inflammasome inactivation

Lv, Q., Xing, Y., Liu, J., Dong, D., Liu, Y., Qiao, H., Zhang, Y., & Hu, L. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.03.011 · Cited by 213 · see citing works

Origin and Consequences of Necroinflammation

Sarhan, M., Land, W. G., Tonnus, W., Hugo, C., & Linkermann, A. (2018) · Physiological Reviews · doi:10.1152/physrev.00041.2016 · Cited by 210 · see citing works

Mitochondria-Targeted Drugs

Zinovkin, R. A., & Zamyatnin, A. A. (2019) · Current Molecular Pharmacology · doi:10.2174/1874467212666181127151059 · Cited by 209 · see citing works

Post-translational regulation of inflammasomes

Yang, J., Liu, Z., & Xiao, T. S. (2016) · Cellular and Molecular Immunology · doi:10.1038/cmi.2016.29 · Cited by 201 · see citing works

Crosstalk between Oxidative Stress and Inflammatory Liver Injury in the Pathogenesis of Alcoholic Liver Disease

Yang, Y. M., Cho, Y. E., & Hwang, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020774 · Cited by 199 · see citing works

Loganin Attenuates High Glucose-Induced Schwann Cells Pyroptosis by Inhibiting ROS Generation and NLRP3 Inflammasome Activation

Cheng, Y., Chu, L., Chen, J., Hsieh, S., Chang, Y., Dai, Z., & Wu, B. (2020) · Cells · doi:10.3390/cells9091948 · Cited by 192 · see citing works

Cellular Innate Immunity: An Old Game with New Players

Gasteiger, G., D’Osualdo, A., Schubert, D. A., Weber, A. N. R., Bruscia, E. M., & Hartl, D. (2016) · Journal of Innate Immunity · doi:10.1159/000453397 · Cited by 191 · see citing works

The DNA Repair Nuclease MRE11A Functions as a Mitochondrial Protector and Prevents T Cell Pyroptosis and Tissue Inflammation

Li, Y., Shen, Y., Jin, K., Wen, Z., Cao, W., Wu, B., Wen, R. M., Tian, L., Berry, G. J., Goronzy, J. J., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.06.016 · Cited by 188 · see citing works

The mechanism of NLRP3 inflammasome activation and its pharmacological inhibitors

Zhan, X., Li, Q., Xu, G., Xiao, X., & Bai, Z. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1109938 · Cited by 191 · see citing works

The involvement of NLRP3 inflammasome in the treatment of Alzheimer’s disease

Feng, Y.-S., Tan, Z., Wu, L., Dong, F., & Zhang, F. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101192 · Cited by 184 · see citing works

Resolvin D1 delivery to lesional macrophages using antioxidative black phosphorus nanosheets for atherosclerosis treatment

He, Z., Chen, W., Hu, K., Luo, Y., Zeng, W., He, X., Li, T., Ouyang, J., Li, Y., Xie, L., et al. (2024) · Nature Nanotechnology · doi:10.1038/s41565-024-01687-1 · Cited by 190 · see citing works

The Hallmarks of Flavonoids in Cancer

Ponte, L. G. S., Pavan, I. C. B., Mancini, M. C. S., da Silva, L. G. S., Morelli, A. P., Severino, M. B., Bezerra, R. M. N., & Simabuco, F. M. (2021) · Molecules · doi:10.3390/molecules26072029 · Cited by 184 · see citing works

CD36 promotes NLRP3 inflammasome activation via the mtROS pathway in renal tubular epithelial cells of diabetic kidneys

Hou, Y., Wang, Q., Han, B., Chen, Y., Qiao, X., & Wang, L. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03813-6 · Cited by 185 · see citing works

Recent Advances of the NLRP3 Inflammasome in Central Nervous System Disorders

Zhou, K., Shi, L., Wang, Y., Chen, S., & Zhang, J. (2016) · Journal of Immunology Research · doi:10.1155/2016/9238290 · Cited by 175 · see citing works

Intestinal dysbiosis augments liver disease progression via NLRP3 in a murine model of primary sclerosing cholangitis

Liao, L., Schneider, K. M., Gálvez, E. J. C., Frissen, M., Marschall, H., Su, H., Hatting, M., Wahlstrom, A. M., Haybaeck, J., Puchas, P., et al. (2019) · Gut · doi:10.1136/gutjnl-2018-316670 · Cited by 175 · see citing works

Development of an Acrylate Derivative Targeting the NLRP3 Inflammasome for the Treatment of Inflammatory Bowel Disease

Cocco, M., Pellegrini, C., Martínez‐Banaclocha, H., Giorgis, M., Marini, E., Costale, A., Miglio, G., Fornai, M., Antonioli, L., López‐Castejón, G., et al. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b01624 · Cited by 172 · see citing works

The lipid peroxidation product 4-hydroxynonenal inhibits NLRP3 inflammasome activation and macrophage pyroptosis

Hsu, C. G., Chávez, C. L., Zhang, C., Sowden, M. P., Chen, Y., & Berk, B. C. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-00966-5 · Cited by 173 · see citing works

Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells.

Sarkar, S., Rokad, D., Malovic, E., Luo, J., Harischandra, D. S., Jin, H., Anantharam, V., Huang, X., Lewis, M., Kanthasamy, A., et al. (2019) · Science Signaling · doi:10.1126/scisignal.aat9900 · Cited by 171 · see citing works

Molecular pathways linking adipose innervation to insulin action in obesity and diabetes mellitus

Guilherme, A., Henriques, F. D. S., Bedard, A. H., & Czech, M. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0165-y · Cited by 173 · see citing works

Cellular and molecular regulation of innate inflammatory responses

Liu, J., & Cao, X. (2016) · Cellular and Molecular Immunology · doi:10.1038/cmi.2016.58 · Cited by 171 · see citing works

SARS-CoV-2 Entry Receptor ACE2 Is Expressed on Very Small CD45− Precursors of Hematopoietic and Endothelial Cells and in Response to Virus Spike Protein Activates the Nlrp3 Inflammasome

Ratajczak, M. Z., Bujko, K., Ciechanowicz, A. K., Sielatycka, K., Cymer, M., Marlicz, W. M., & Kucia, M. (2020) · Stem Cell Reviews and Reports · doi:10.1007/s12015-020-10010-z · Cited by 170 · see citing works

Transplantation and Damage-Associated Molecular Patterns (DAMPs)

Land, W. G., Agostinis, P., Gasser, S., Garg, A. D., & Linkermann, A. (2016) · American Journal of Transplantation · doi:10.1111/ajt.13963 · Cited by 166 · see citing works

The P2X7 Receptor: Central Hub of Brain Diseases

Andrejew, R., Oliveira-Giacomelli, Á., Ribeiro, D. E., Glaser, T., Arnaud-Sampaio, V. F., Lameu, C., & Ulrich, H. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00124 · Cited by 162 · see citing works

Pirfenidone ameliorates lipopolysaccharide-induced pulmonary inflammation and fibrosis by blocking NLRP3 inflammasome activation

Li, Y., Li, H., Liu, S., Pan, P., Su, X., Tan, H., Wu, D., Zhang, L., Song, C., Dai, M., et al. (2018) · Molecular Immunology · doi:10.1016/j.molimm.2018.05.003 · Cited by 160 · see citing works

Gypenosides improve diabetic cardiomyopathy by inhibiting ROS ‐mediated NLRP 3 inflammasome activation

Zhang, H., Chen, X., Zong, B., Yuan, H., Wang, Z., Wei, Y., Wang, X., Liu, G., Zhang, J., Li, S., et al. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13743 · Cited by 158 · see citing works

Major pathogenic mechanisms in vascular dementia: Roles of cellular stress response and hormesis in neuroprotection

Calabrese, V., Giordano, J., Signorile, A., Ontario, M. L., Castorina, S., Pasquale, C. D., Eckert, G. P., & Calabrese, E. J. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23925 · Cited by 156 · see citing works

Mitochondria: the indispensable players in innate immunity and guardians of the inflammatory response

Mohanty, A., Tiwari-Pandey, R., & Pandey, N. R. (2019) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-019-00507-9 · Cited by 157 · see citing works

The NLRP3 inflammasome modulates glycolysis by increasing PFKFB3 in an IL-1β-dependent manner in macrophages

Finucane, O. M., Sugrue, J. A., Rubio‐Araiz, A., Guillot‐Sestier, M., & Lynch, M. A. (2019) · Scientific Reports · doi:10.1038/s41598-019-40619-1 · Cited by 155 · see citing works

Strategies for Targeting the NLRP3 Inflammasome in the Clinical and Preclinical Space

Schwaid, A. G., & Spencer, K. B. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c01307 · Cited by 152 · see citing works

TLRs/NLRs: Shaping the landscape of host immunity

Dolasia, K., Bisht, M. K., Pradhan, G., Udgata, A., & Mukhopadhyay, S. (2017) · International Reviews of Immunology · doi:10.1080/08830185.2017.1397656 · Cited by 146 · see citing works

Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology

Ribeiro, D. E., Oliveira-Giacomelli, Á., Glaser, T., Arnaud-Sampaio, V. F., Andrejew, R., Dieckmann, L., Baranova, J., Lameu, C., Ratajczak, M. Z., & Ulrich, H. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00965-3 · Cited by 145 · see citing works

Microglial inflammation and phagocytosis in Alzheimer's disease: Potential therapeutic targets

Nizami, S., Hall‐Roberts, H., Warrier, S., Cowley, S. A., & Di Daniel, E. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14618 · Cited by 147 · see citing works

Immunological dimensions of neuroinflammation and microglial activation: exploring innovative immunomodulatory approaches to mitigate neuroinflammatory progression

Laurindo, L. F., Dias, J. A., Araújo, A. C., Pomini, K. T., Galhardi, C. M., Detregiachi, C. R. P., Haber, L. S. D. A., Roque, D. D., Bechara, M. D., de Castro, M. V. M., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1305933 · Cited by 149 · see citing works

Glial Contribution to Excitatory and Inhibitory Synapse Loss in Neurodegeneration

Henstridge, C. M., Tzioras, M., & Paolicelli, R. C. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00063 · Cited by 145 · see citing works

Stress-induced NLRP3 inflammasome activation negatively regulates fear memory in mice

Dong, Y., Li, S., Lu, Y., Li, X., Liao, Y., Peng, Z., Li, Y., Hou, L., Yuan, Z., & Cheng, J. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01842-0 · Cited by 146 · see citing works

Cell death in chronic inflammation: breaking the cycle to treat rheumatic disease

Anderton, H., Wicks, I. P., & Silke, J. (2020) · Nature Reviews Rheumatology · doi:10.1038/s41584-020-0455-8 · Cited by 145 · see citing works

Echinatin effectively protects against NLRP3 inflammasome–driven diseases by targeting HSP90

Xu, G., Fu, S., Zhan, X., Wang, Z., Zhang, P., Shi, W., Qin, N., Chen, Y., Wang, C., Niu, M., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.134601 · Cited by 143 · see citing works

Mitochondria as a target for neuroprotection: role of methylene blue and photobiomodulation

Yang, L., Youngblood, H. A., Wu, C., & Zhang, Q. (2020) · Translational Neurodegeneration · doi:10.1186/s40035-020-00197-z · Cited by 143 · see citing works

NLRP3 inflammasome: a key player in the pathogenesis of life-style disorders

Ramachandran, R., Manan, A., Kim, J., & Choi, S. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01261-8 · Cited by 142 · see citing works

Stress-induced blood brain barrier disruption: Molecular mechanisms and signaling pathways

Welcome, M. O., & Mastorakis, N. E. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104769 · Cited by 139 · see citing works

Roles of PRR-Mediated Signaling Pathways in the Regulation of Oxidative Stress and Inflammatory Diseases

Li, P., & Chang, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147688 · Cited by 139 · see citing works

New Insights on NLRP3 Inflammasome: Mechanisms of Activation, Inhibition, and Epigenetic Regulation

Kodi, T., Sankhe, R., Gopinathan, A., Nandakumar, K., & Kishore, A. (2024) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-024-10101-5 · Cited by 138 · see citing works

Mitochondria as a centrally positioned hub in the innate immune response

Sandhir, R., Halder, A., & Sunkaria, A. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.10.020 · Cited by 135 · see citing works

Bacteroides fragilis restricts colitis-associated cancer via negative regulation of the NLRP3 axis

Shao, X., Sun, S., Zhou, Y., Wang, H., Yu, Y., Hu, T., Yao, Y., & Zhou, C. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.10.002 · Cited by 134 · see citing works

Mechanisms of immune response to inorganic nanoparticles and their degradation products

Mohammapdour, R., & Ghandehari, H. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.114022 · Cited by 135 · see citing works

Inhibitors of the NLRP3 inflammasome pathway as promising therapeutic candidates for inflammatory diseases (Review)

Zhang, X., Wang, Z., Zheng, Y., Yu, Q., Zeng, M., Bai, L., Yang, L., Guo, M., Jiang, X., & Gan, J. (2023) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2023.5238 · Cited by 132 · see citing works

Fluoxetine Inhibits NLRP3 Inflammasome Activation: Implication in Depression

Du, R., Tan, J., Sun, X., Lu, M., Ding, J., & Hu, G. (2016) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw037 · Cited by 128 · see citing works

Ketogenic Diet Improves Brain Ischemic Tolerance and Inhibits NLRP3 Inflammasome Activation by Preventing Drp1-Mediated Mitochondrial Fission and Endoplasmic Reticulum Stress

Guo, M. A., Wang, X., Zhao, Y., Yang, Q., Ding, H., Dong, Q., Chen, X., & Cui, M. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00086 · Cited by 129 · see citing works

New Insights into the Mechanisms of Pyroptosis and Implications for Diabetic Kidney Disease

Lin, J., Cheng, A., Cheng, K. Y., Deng, Q., Zhang, S., Lan, Z., Wang, W., & Chen, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197057 · Cited by 131 · see citing works

Roles of mitochondrial ROS and NLRP3 inflammasome in multiple ozone-induced lung inflammation and emphysema

Li, F., Xu, M., Wang, M., Wang, L., Wang, H., Zhang, H., Chen, Y., Gong, J., Zhang, J. J., Adcock, I. M., et al. (2018) · Respiratory Research · doi:10.1186/s12931-018-0931-8 · Cited by 125 · see citing works

Crosstalk Between Dysfunctional Mitochondria and Inflammation in Glaucomatous Neurodegeneration

Jassim, A. H., Inman, D. M., & Mitchell, C. H. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.699623 · Cited by 124 · see citing works

Attenuation of mechanical pain hypersensitivity by treatment with Peptide5, a connexin-43 mimetic peptide, involves inhibition of NLRP3 inflammasome in nerve-injured mice

Tonkin, R. S., Bowles, C., Perera, C. J., Keating, B. A., Makker, P. G. S., Duffy, S. S., Lees, J. G., Tran, C., Don, A. S., Fath, T., et al. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.10.016 · Cited by 124 · see citing works

IL-1β mediates lung neutrophilia and IL-33 expression in a mouse model of viral-induced asthma exacerbation

Persson, I. M., Menzel, M., Ramu, S., Cerps, S., Akbarshahi, H., & Uller, L. (2018) · Respiratory Research · doi:10.1186/s12931-018-0725-z · Cited by 122 · see citing works

Bergapten inhibits NLRP3 inflammasome activation and pyroptosis via promoting mitophagy

Luo, T., Jia, X., Feng, W.-D., Wang, J., Xie, F., Kong, L., Wang, X., Lian, R., Liu, X., Chu, Y.-J., et al. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01094-7 · Cited by 122 · see citing works

Association of Inflammatory Responses and ECM Disorganization with HMGB1 Upregulation and NLRP3 Inflammasome Activation in the Injured Rotator Cuff Tendon

Thankam, F. G., Roesch, Z. K., Dilisio, M. F., Radwan, M. M., Kovilam, A. N., Gross, R. M., & Agrawal, D. K. (2018) · Scientific Reports · doi:10.1038/s41598-018-27250-2 · Cited by 121 · see citing works

Inhibiting pannexin-1 alleviates sepsis-induced acute kidney injury via decreasing NLRP3 inflammasome activation and cell apoptosis

Huang, G., Bao, J., Shao, X., Zhou, W., Wu, B., Ni, Z., & Wang, L. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117791 · Cited by 121 · see citing works

AIM2 Inflammasome Is Critical for Influenza-Induced Lung Injury and Mortality

Zhang, H., Luo, J., Alcorn, J. F., Chen, K., Fan, S., Pilewski, J. M., Liu, A., Chen, W., Kolls, J. K., & Wang, J. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1600714 · Cited by 122 · see citing works

Interaction between autophagy and the NLRP3 inflammasome

Cao, Z., Wang, Y., Long, Z., & He, G. (2019) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmz098 · Cited by 119 · see citing works

Gut microbiota regulates chronic ethanol exposure-induced depressive-like behavior through hippocampal NLRP3-mediated neuroinflammation

Yao, H., Zhang, D., Yu, H., Yuan, H., Shen, H., Lan, X., Liu, H., Chen, X., Meng, F., Wu, X., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01841-y · Cited by 119 · see citing works

Pannexin1 as mediator of inflammation and cell death

Yanguas, S. C., Willebrords, J., Johnstone, S. R., Maes, M., Decrock, E., Bock, M. D., Leybaert, L., Cogliati, B., & Vinken, M. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.10.006 · Cited by 119 · see citing works

The Mechanism of the NLRP3 Inflammasome Activation and Pathogenic Implication in the Pathogenesis of Gout

Kim, S. (2022) · Journal of Rheumatic Diseases · doi:10.4078/jrd.2022.29.3.140 · Cited by 118 · see citing works

Hydrogen sulfide inhibits NLRP3 inflammasome activation and reduces cytokine production both in vitro and in a mouse model of inflammation

Castelblanco, M., Lugrin, J., Ehirchiou, D., Nasi, S., Ishii, I., So, A. K.-L., Martinon, F., & Busso, N. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.806869 · Cited by 112 · see citing works

Huangkui capsule alleviates renal tubular epithelial–mesenchymal transition in diabetic nephropathy via inhibiting NLRP3 inflammasome activation and TLR4/NF-κB signaling

Han, W.-B., Ma, Q., Liu, Y., Wu, W., Tu, Y., Huang, L., Long, Y., Wang, W., Yee, H.-Y., Wan, Z.-Y., et al. (2018) · Phytomedicine · doi:10.1016/j.phymed.2018.12.021 · Cited by 114 · see citing works

NLRP inflammasomes in health and disease

Xu, Z., Kombe, A. J. K., Deng, S., Zhang, H., Wu, S., Ruan, J., Zhou, Y. Y., & Jin, T. (2024) · Molecular Biomedicine · doi:10.1186/s43556-024-00179-x · Cited by 120 · see citing works

Inhibiting NLRP3 inflammasome activation prevents copper-induced neuropathology in a murine model of Wilson’s disease

Dong, J., Wang, X., Xu, C., Gao, M., Wang, S., Zhang, J. C., Tong, H., Wang, L., Han, Y., Cheng, N., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03397-1 · Cited by 113 · see citing works

Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction

Li, Q., Feng, H., Wang, H., Wang, Y., Mou, W., Xu, G., Zhang, P., Li, R., Shi, W., Wang, Z., et al. (2021) · EMBO Reports · doi:10.15252/embr.202153499 · Cited by 111 · see citing works

MicroRNA 223 3p Negatively Regulates the NLRP3 Inflammasome in Acute and Chronic Liver Injury

Calvente, C. J., Pilar, H. D., Tameda, M., Johnson, C. D., & Feldstein, A. E. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.09.013 · Cited by 111 · see citing works

Ketone Body 3‐Hydroxybutyrate Ameliorates Atherosclerosis via Receptor Gpr109a‐Mediated Calcium Influx

Zhang, S., Li, Z., Zhang, Y., Jin, C., Li, Y., Wu, F., Wang, W., Cui, Z. J., & Chen, G. (2021) · Advanced Science · doi:10.1002/advs.202003410 · Cited by 110 · see citing works

The NLRP3 inflammasome: contributions to inflammation-related diseases

Chen, Y., Ye, X., Escames, G., Lei, W., Zhang, X., Li, M., Jing, T., Yao, Y., Qiu, Z., Wang, Z., et al. (2023) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-023-00462-9 · Cited by 492 · see citing works

Negative regulators and their mechanisms in NLRP3 inflammasome activation and signaling

Kim, J. K., Jin, H. S., Suh, H., & Jo, E. (2017) · Immunology and Cell Biology · doi:10.1038/icb.2017.23 · Cited by 53 · see citing works

The Signaling Pathways Regulating NLRP3 Inflammasome Activation

Chen, M.-Y., Ye, X.-J., He, X.-H., & Ouyang, D.-Y. (2021) · Inflammation · doi:10.1007/s10753-021-01439-6 · Cited by 154 · see citing works

NLRP3 inflammasome: activation, regulation, and role in diseases

Zhou, R., Yan, Y., Jiang, W., & Jiang, H. (2017) · Scientia Sinica Vitae · doi:10.1360/n052016-00360 · Cited by 10 · see citing works

New progress on the activation mechanisms of NOD-like receptor, pyrin domain-containing 3 inflammasome

Wang, W., & Ma, Y. (2015) · Int J Immunol · doi:10.3760/cma.j.issn.1673-4394.2015.04.010