Genomic and transcriptomic features of response to anti-PD-1 therapy in metastatic melanoma

Hugo, Willy, Zaretsky, Jesse M., Sun, Lu, Song, Chunying, Moreno, Blanca Homet, Hu-Lieskovan, Siwen, Berent-Maoz, Beata, Pang, Jia +10 more·2017·Cell

DOI 10.1016/j.cell.2017.01.010

Cited by (494)

Items 201–300 of 494

Host response to immune checkpoint inhibitors contributes to tumor aggressiveness
Irina Khononov, Eyal Jacob, Ella Fremder, Nili Dahan, Michal Harel, Ziv Raviv, Boris Milev Krastev, Yuval Shaked · 2021 · Journal for ImmunoTherapy of Cancer
Correction: A balance score between immune stimulatory and suppressive microenvironments identifies mediators of tumour immunity and predicts pan-cancer survival
Tolga Turan, Sarah Kongpachith, Kyle D. Halliwill, Jessica P Roelands, Wouter Hendrickx, Francesco Maria Marincola, Thomas J. Hudson, Howard J. Jacob, Davide Bedognetti, Josue A. Samayoa et al. · 2020 · British Journal of Cancer
The S100 family is a prognostic biomarker and correlated with immune cell infiltration in pan-cancer
Xiaojie Liang, Xiaoshan Huang, Zihong Cai, Yeling Deng, Dan Liu, Jiayi Hu, Zhihao Jin, Xinyu Zhou, Hongsheng Zhou, Liang Wang · 2024 · Discover Oncology
Melanoma antigens recognized by T cells and their use for immunotherapy
Shigeki Ohta, Aya Misawa, Chaw Kyi‐Tha‐Thu, Naomi Matsumoto, Yoshie Hirose, Yutaka Kawakami · 2023 · Experimental Dermatology
Comparison of different predictive biomarker testing assays for PD-1/PD-L1 checkpoint inhibitors response: a systematic review and network meta-analysis
Haotong Shi, Wenxia Zhang, Lin Zhang, Yawen Zheng, Taotao Dong · 2023 · Frontiers in Immunology
High Expression of PDLIM2 Predicts a Poor Prognosis in Prostate Cancer and Is Correlated with Epithelial-Mesenchymal Transition and Immune Cell Infiltration
Songzhe Piao, Lan Zheng, Hai-Hong Zheng, Mengya Zhou, Qin Feng, Suna Zhou, Mang Ke, Haihua Yang, Xuequan Wang · 2022 · Journal of Immunology Research
Integrated cancer cell-specific single-cell RNA-seq datasets of immune checkpoint blockade-treated patients
M. Gondal, M. Cieslik, A. Chinnaiyan · 2025 · Scientific Data
Early immune evasion in colorectal cancer: interplay between stem cells and the tumor microenvironment
Norihiro Goto, Judith Agudo, Ömer H. Yilmaz · 2025 · Trends in cancer
Myeloid Maturity: ATRA to Enhance Anti–PD-1?
Daniel J. Olson, Jason J. Luke · 2023 · Clinical Cancer Research
MTDH associates with m6A RNA methylation and predicts cancer response for immune checkpoint treatment
Fen Zhang, Huimei Huang, Yuexiang Qin, Chang‐Han Chen, Li She, Juncheng Wang, Donghai Huang, Qinglai Tang, Yong Liu, Gangcai Zhu et al. · 2021 · iScience
Pericyte mediates the infiltration, migration, and polarization of macrophages by CD163/MCAM axis in glioblastoma
Hao Zhang, Nan Zhang, Wantao Wu, Zeyu Wang, Ziyu Dai, Xisong Liang, Liyang Zhang, Yun Peng, Peng Luo, Jian Zhang et al. · 2022 · iScience
Comprehensive analysis of glycoprotein VI-mediated platelet activation signaling pathway for predicting pan-cancer survival and response to anti-PD-1 immunotherapy
Shuzhao Chen, Limei Zhang, Lezong Chen, Qianqian Huang, Yun Wang, Liang Yang · 2023 · Computational and Structural Biotechnology Journal
Tumor‐associated macrophages as treatment targets in glioma
Yichen Peng, Feng Chen, Shenglan Li, Xiu Liu, Can Wang, Chunna Yu, Wenbin Li · 2020 · Brain Science Advances
Monitoring T Cells Responses Mounted by Therapeutic Cancer Vaccines
Kue Peng Lim, Nur Syafinaz Zainal · 2021 · Frontiers in Molecular Biosciences
Genome instability and crosstalk with the immune response
Roman M. Chabanon, F.X. Danlos, Kaïssa Ouali, Sophie C. Postel-Vinay · 2025 · Genome Medicine
Comprehensive Analysis of the Immunogenomics of Triple-Negative Breast Cancer Brain Metastases From LCCC1419
Eric D. Routh, Amanda E.D. Van Swearingen, Maria J. Sambade, Steven P. Vensko II, Marni B. McClure, Mark G. Woodcock, Shengjie Chai, Luz Andrea Cuaboy, Amy Wheless, Amy Garrett et al. · 2022 · Frontiers in Oncology
MYC Induces Immunotherapy and IFNγ Resistance Through Downregulation of JAK2
Ettai Markovits, Ortal Harush, Erez N. Baruch, Eldad David Shulman, Assaf Debby, Orit Itzhaki, Liat Anafi, Artem Danilevsky, Noam Shomron, Guy Ben‐Betzalel et al. · 2023 · Cancer Immunology Research
The loss of neoantigens is an important reason for immune escape in multiple myeloma patients with high intratumor heterogeneity
Yue Wang, Jiadai Xu, Tianwei Lan, Chi Zhou, Peng Liu · 2023 · Cancer Medicine
Integrated Germline and Somatic Features Reveal Divergent Immune Pathways Driving Response to Immune Checkpoint Blockade
Timothy J. Sears, Meghana S. Pagadala, Andrea Castro, Ko-Han Lee, JungHo Kong, Kairi Tanaka, Scott Michael Lippman, Maurizio Zanetti, Hannah K. Carter · 2024 · Cancer Immunology Research
Integrative multi-omics analysis reveals the role of tumor-associated endothelial cells and their signature in prognosis of intrahepatic cholangiocarcinoma
Hao Jiang, Biao Gao, Zihe Meng, Yafei Wang, Tianyu Jiao, Junfeng Li, X. H. Li, Yinbiao Cao, Xianzhou Zhang, Chonghui Li et al. · 2024 · Journal of Translational Medicine
In vivo armed macrophages curb liver metastasis through tumor-reactive T-cell rejuvenation
Marco Notaro, Maristella Borghetti, Chiara Bresesti, Giovanna Giacca, Thomas Kerzel, Carl Mirko Mercado, Stefano Beretta, Marco Monti, Ivan Merelli, Silvia Iaia et al. · 2025 · Nature Communications
MAPKinase inhibition after failure of immune checkpoint blockade in patients with advanced melanoma – An evaluation of the multicenter prospective skin cancer registry ADOREG
Sophia Kreft, Valerie Glutsch, Anne Zaremba, Patrick Schummer, Peter Mohr, Imke Grimmelmann, Ralf Gutzmer, Friedegund Elke Meier, Claudia Pföhler, Michael Sachse et al. · 2022 · European Journal of Cancer
Mechanisms of Resistance to PD-1 Checkpoint Blockade
Justin C. Moser, Siwen Hu‐Lieskovan · 2020 · Drugs
GTF2IRD1 overexpression promotes tumor progression and correlates with less CD8+ T cells infiltration in pancreatic cancer
Hongkai Zhuang, Chuanzhao Zhang, Baohua Hou · 2020 · Bioscience Reports
Effector T cells under hypoxia have an altered transcriptome similar to tumor-stressed T cells found in non-responsive melanoma patients
Mate Z Nagy, Lourdes Plaza-Rojas, Justin C. Boucher, Elena Kostenko, Anna L Austin, Ahmad A. Tarhini, Zhihua Chen, Dongliang Du, Awino Maureiq E. Ojwang’, Joshua Saul Davis et al. · 2025 · Journal for ImmunoTherapy of Cancer
Profiling with senescence-associated secretory phenotype score identifies GDC-0879 as a small molecule sensitizing glioblastoma to anti-PD1
Yang Liu, Yuan Feng, Lin Li Cheng, Yangxi Xu, Anhua Wu, Peng Cheng · 2025 · Cell Death and Disease
Can Immune Suppression and Epigenome Regulation in Placenta Offer Novel Insights into Cancer Immune Evasion and Immunotherapy Resistance?
Sultana Mehbuba Hossain, Chiemi F. Lynch‐Sutherland, Aniruddha Chatterjee, Erin C. Macaulay, Michael Roger Eccles · 2021 · Epigenomes
Genomic and molecular alterations associated with primary resistance to immune checkpoint inhibitors
Jyoti Dhar Malhotra, Subhajyoti De, Kim Nguyen, Percy P. Lee, Victoria Meucci Villaflor · 2024 · Cancer Immunology Immunotherapy
Targeting pyroptosis reverses KIAA1199-mediated immunotherapy resistance in colorectal cancer
Lisha Li, Lei Zhao, Diwei Zhou et al. · 2025 · Journal for ImmunoTherapy of Cancer
Activating antiviral immune responses potentiates immune checkpoint inhibition in glioblastoma models
Deepa Seetharam, Jay S. Chandar, Christian Kieran Ramsoomair, Jelisah Desgraves, Alexandra Alvarado Medina, Anna Jane Hudson, Ava Amidei, Jesús Castro, Vaidya Govindarajan, Sarah Wang et al. · 2025 · Journal of Clinical Investigation
Mechanisms of primary and acquired resistance to PD-1/PD-L1 blockade and the emerging role of gut microbiome
Renrui Zou, Yaomin Wang, F. Ye, X. Zhang, Min Wang, Shiyun Cui · 2021 · Clinical & Translational Oncology
Upregulation of SLC12A3 and SLC12A9 Mediated by the HCP5/miR-140-5p Axis Confers Aggressiveness and Unfavorable Prognosis in Uveal Melanoma
Congcong Yan, Xiaojuan Hu, Xiaoyan Liu · 2023 · Laboratory Investigation
Identification of Pyroptosis-Relevant Signature in Tumor Immune Microenvironment and Prognosis in Skin Cutaneous Melanoma Using Network Analysis
Yun Zhu, Dan Han, Hongjue Duan, Qi Rao, Yike Qian, Qiaoyun Chen, Xiao Du, Huanyu Ni, Siliang Wang · 2023 · Stem Cells International
Immune cell profiling in the age of immune checkpoint inhibitors: implications for biomarker discovery and understanding of resistance mechanisms
Su Yin Lim, Helen Rizos · 2018 · Mammalian Genome
Status of Immune Oncology: Challenges and Opportunities
Alessandra Cesano, Francesco Maria Marincola, Magdalena Thurin · 2019 · Methods in molecular biology
Multi-Omics and Informatics Analysis of FFPE Tissues Derived from Melanoma Patients with Long/Short Responses to Anti-PD1 Therapy Reveals Pathways of Response
Saurabh K. Garg†, Eric A. Welsh, Bin Fang, Yuliana Hernandez, Trevor A Rose, Jhanelle E. Gray, John M. Koomen, Anders Berglund, James J. Mulé, Joseph Markowitz · 2020 · Cancers
Crosstalk of Redox-Related Subtypes, Establishment of a Prognostic Model and Immune Responses in Endometrial Carcinoma
Rui Geng, Jiahang Song, Zihang Zhong, Senmiao Ni, Wen Liu, Zhiqiang He, Shilin Gan, Qinghao Huang, Hao Yu, Jianling Bai et al. · 2022 · Cancers
Computed Tomography‐Based Radiomics and Genomics Analyses for Survival Prediction of Stage III Unresectable Non‐Small Cell Lung Cancer Treated With Definitive Chemoradiotherapy and Immunotherapy
Yuxin Geng, Tianwen Yin, Yikun Li, Kaixing He, Bingwen Zou, Jinming Yu, Xiao Sun, Tao Zhang, Feifei Teng · 2025 · Molecular Carcinogenesis
A hypoxia related long non-coding RNA signature could accurately predict survival outcomes in patients with bladder cancer
Facai Zhang, Xiaoming Wang, Huan Hu, Yubo Yang, Jiahao Wang, Yin Tang, Dengxiong Li, Yunjin Bai, Ping Han · 2021 · Bioengineered
Ferroptosis Patterns Correlate with Immune Microenvironment Characterization in Gastric Cancer
Xiaotao Jiang, Fan Liu, Peng Liu, Yanhua Yan, Shaoyang Lan, Kunhai Zhuang, Yufeng Liu, Kailin Jiang, Yuancheng Huang, Kechao Nie et al. · 2021 · International Journal of General Medicine
A Genomic Signature Reflecting Fibroblast Infiltration Into Gastric Cancer Is Associated With Prognosis and Treatment Outcomes of Immune Checkpoint Inhibitors
Yi Lu, Dan Li, Yixin Cao, Leqian Ying, Tao Qing, Fen Xiong, Zhangmin Hu, Yufei Yang, Xuehan Qiao, Peng Chen et al. · 2022 · Frontiers in Cell and Developmental Biology
Integrated in silico analysis of LRP2 mutations to immunotherapy efficacy in pan-cancer cohort
Chunbo Li, Yan Ding, Xuyin Zhang, Keqin Hua · 2022 · Discover Oncology
Unravelling Tumour Microenvironment in Melanoma at Single-Cell Level and Challenges to Checkpoint Immunotherapy
Xinyu Bai, Camelia Y. J. Quek · 2022 · Genes
Genomic and epigenomic perspectives of T-cell exhaustion in cancer
Anliang Xia, Jincheng Wang, Kun Yang, Dong Ji, Zheng‐Ming Huang, Yong Xu · 2018 · Briefings in Functional Genomics
The Cellular Tumor Immune Microenvironment of Childhood Solid Cancers: Informing More Effective Immunotherapies
Malcolm Holterhus, Bianca Altvater, Sareetha Kailayangiri, Claudia Rössig · 2022 · Cancers
Construction and comprehensive analysis of a novel prognostic signature associated with pyroptosis molecular subtypes in patients with pancreatic adenocarcinoma
Qian Huang, Xingyu Peng, Qingqing Li, Jinfeng Zhu, Ju Xue, Hua Jiang · 2023 · Frontiers in Immunology
Mechanism of resistance to immune checkpoint inhibitors
Manu Raj Pandey, Marc S. Ernstoff · 2019 · Cancer Drug Resistance
Cell Death Modalities in Therapy of Melanoma
Meng Wang, Jiahui Zhao, Ming-Xuan Tang, Meng Li, Hu Zhao, Zhongyu Li, Andong Liu · 2025 · International Journal of Molecular Sciences
Pseudohypoxic stabilization of HIF1α via cyclophilin D suppression promotes melanoma metastasis
Hye‐Kyung Park, Sung Hu, So Yeon Kim, Sora Yoon, Nam Gu Yoon, Ji Hye Lee, Wonyoung Choi, Sun‐Young Kong, Jong Heon Kim, Dougu Nam et al. · 2025 · Signal Transduction and Targeted Therapy
Caspase-8 contributes to an immuno-hot microenvironment by promoting phagocytosis via an ecto-calreticulin-dependent mechanism
Zhihua Gong, Qingzhu Jia, Jinming Guo, Chongyi Li, Shouxia Xu, Zheng Jin, Han Chu, Yisong Y. Wan, Bo Zhu, Yi Zhou · 2023 · Experimental Hematology and Oncology
Aggrephagy-related patterns in tumor microenvironment, prognosis, and immunotherapy for acute myeloid leukemia: a comprehensive single-cell RNA sequencing analysis
Yan Pan, Yingjian Wang, Mengsi Hu, Shoufang Xu, Feiyu Jiang, Yetao Han, Fangjian Chen, Zhiwei Liu · 2023 · Frontiers in Oncology
Studying Immunotherapy Resistance in a Melanoma Autologous Humanized Mouse Xenograft
J. Jason Morton, Nathaniel Alzofon, Stephen B. Keysar, Tugs-Saikhan Chimed, Julie Reisinger, Loni Perrenoud, Phuong N. Le, Cera Nieto, Karina E. Gomez, Bettina Miller et al. · 2020 · Molecular Cancer Research
Characterization of Immune Infiltration and Construction of a Prediction Model for Overall Survival in Melanoma Patients
Gang Li, Xuran Zhu, Chao Liu · 2021 · Frontiers in Oncology
Genomic Analysis of Response to Neoadjuvant Chemotherapy in Esophageal Adenocarcinoma
Fereshteh Izadi, Benjamin P. Sharpe, Stella Panagio Breininger, Maria Secrier, Jane Gibson, Robert Walker, Saqib Rahman, Ginny Devonshire, Megan A. Lloyd, Zoë S. Walters et al. · 2021 · Cancers
Characterization of m6A Methylation Modification Patterns in Colorectal Cancer Determines Prognosis and Tumor Microenvironment Infiltration
Qingfang Yue, Yuan Zhang, Fei Wang, Fei Cao, Jun Yuan Bai, Xianglong Duan · 2022 · Journal of Immunology Research
Identification of 15 T Cell Restricted Genes Evaluates T Cell Infiltration of Human Healthy Tissues and Cancers and Shows Prognostic and Predictive Potential
Luigi Cari, Francesca De Rosa, Maria Grazia Petrillo · 2019 · International Journal of Molecular Sciences
Classification of gastric cancers based on immunogenomic profiling
Zhixian Liu, Zehang Jiang, Nan Wu, Guoren Zhou, Xiaosheng Wang · 2020 · Translational Oncology
Tumor neoantigens derived from RNA editing events show significant clinical relevance in melanoma patients treated with immunotherapy
Qicheng Lu, Wenhao Zhou, Ligang Fan, Tian Ding, Wei Wang, Xiaodong Zhang · 2023 · Anti-Cancer Drugs
A lactate‐responsive gene signature predicts the prognosis and immunotherapeutic response of patients with triple‐negative breast cancer
Kaixiang Feng, You-Cheng Shao, Jun Li et al. · 2024 · Cancer Innovation
Single-cell RNA sequencing reveals melanoma cell state-dependent heterogeneity of response to MAPK inhibitors
Su Yin Lim, Yingxin Lin, Jenny Lee, Bernadette Pedersen, Ashleigh Stewart, Richard A. Scolyer, Georgina Venetia Long, Jean Yee Hwa Yang, Helen Rizos · 2024 · EBioMedicine
A Distinguished Roadmap of Fibroblast Senescence in Predicting Immunotherapy Response and Prognosis Across Human Cancers
Dongjie Chen, Pengyi Liu, Jiayu Lin, Longjun Zang, Yihao Liu, Shuyu Zhai, Xiongxiong Lu, Yuanchi Weng, Hongzhe Li · 2024 · Advanced Science
DNA methylation regulator-mediated modification patterns and tumor microenvironment characterization in glioma
Haitao Luo, Minhua Ye, Yan Wei Hu, Miaojing Wu, Mengqi Cheng, Xingen Zhu, Kai Huang · 2022 · Aging
A tumor-associated endothelial signature score model in immunotherapy and prognosis across pan-cancers
Shuzhao Chen, Limei Zhang, Mayan Huang, Yang Liang, Yun Wang · 2023 · Frontiers in Pharmacology
Immune Checkpoint Inhibitor Therapy for Metastatic Melanoma: What Should We Focus on to Improve the Clinical Outcomes?
Sultana Mehbuba Hossain, Kevin Ly, Yih Jian Sung, Antony W. Braithwaite, Kunyu Li · 2024 · International Journal of Molecular Sciences
Mining of immunological and prognostic-related biomarker for cervical cancer based on immune cell signatures
Nana Wang, Abiyasi Nanding, Xiaocan Jia et al. · 2022 · Frontiers in Immunology
Epigenetic control of CD1D expression as a mechanism of resistance to immune checkpoint therapy in poorly immunogenic melanomas
Mona Meng Wang, Saara A. Koskela, Arfa Mehmood, Miriam Langguth, Eleftheria Maranou, Carlos R. Figueiredo · 2023 · Frontiers in Immunology
HLApollo: A superior transformer model for pan-allelic peptide-MHC-I presentation prediction, with diverse negative coverage, deconvolution and protein language features
William John Thrift, Nicolas Lounsbury, Quade Broadwell, Amy J. Heidersbach, Emily C. Freund, Yassan Abdolazimi, Qui T. Phung, Jieming Chen, Aude-Hélène Capietto, Ann-Jay Tong et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
Spatially Resolved Transcriptomics: Revealing Tumor Microenvironment Heterogeneity to Advance Cancer Immunotherapy
Dan Liu, Lu Xin Xiao, Yaojiong Wu, Chensirong Yue, Mengmeng Li, Yu Sun, Chaoyong James Yang · 2025 · Small Methods
Palmitate-induced mitochondrial damage restricts histone acetylation in CD8 T cells to impair antitumor immunity
Silvia Tiberti, Sara Gennari, M A Romeo, Ilir Sheraj, Mohamed Faisal Kassir, Juan Fernández-García, Carina B. Nava Lauson, Roberta Noberini, Carlotta Catozzi, Tiziano Dallavilla et al. · 2026 · Science Immunology
RePhine: An Integrative Method for Identification of Drug Response-Related Transcriptional Regulators
Xujun Wang, Zhengtao Zhang, Wenyi Qin, Shiyi Liu, Cong Liu, Georgi Z. Genchev, Lijian Hui, Hongyu Zhao, Hui Juan Lu · 2021 · Genomics Proteomics & Bioinformatics
Quantification of ferroptosis pattern in bladder carcinoma and its significance on immunotherapy
Cheng Xu, Yinhuai Wang, Yijian Li, Wentao Liu · 2022 · Scientific Reports
Novel exosome-related risk signature as prognostic biomarkers in glioblastoma
Mingyan Ding, Qiang Xu, Xiuying Jin, Zhezhu Han, Hao Jiang, Honghua Sun, Yongmin Jin, Zhengri Piao, Songnan Zhang · 2023 · Frontiers in Immunology
The potential of BRAF-associated non-coding RNA as a therapeutic target in melanoma
Luigi Fattore, Rita Mancini, Paolo A. Ascierto · 2018 · Expert Opinion on Therapeutic Targets
Response and recurrence correlates in individuals treated with neoadjuvant anti-PD-1 therapy for resectable oral cavity squamous cell carcinoma
S Liu, Hannah M. Knochelmann, Shirley H. Lomeli, A Hong, M Richardson, Z Yang, RJ Lim, Y Wang, Camelia Dumitras, Kostyantyn Krysan et al. · 2021 · immuneACCESS
IFN-γ Approaches in Tumor Suppression, Its Challenges, and Future Directions: A Review of Recent Advances
Mohammad Reza Ataherian, Nasim Hafezi, Elaheh Ferdosi-Shahandashti, Fatemeh Sarina Abdinia · 2025 · Journal of Interferon & Cytokine Research
UFMylation: A supervisor of the HIF1α pathway and a potential therapeutic target for anti-PD-1 combination therapy in hypoxic tumors
Yongkang Zou, Zhaoxiang Wang, Qiang Jiang, Xia Kong, Xiaohe Ma, Zhengyan Liang, Zhiguo Wang, Beiying Chen, Jiao Yuan, Jiayue Wen et al. · 2025 · Proceedings of the National Academy of Sciences
Immune tumor board: integral part in the multidisciplinary management of cancer patients treated with cancer immunotherapy
Heinz Philipp Laubli, Stefan Dirnhofer, Alfred Zippelius · 2018 · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin
Genomics-based immuno-oncology: bridging the gap between immunology and tumor biology
Renzo G. DiNatale, A. Ari Hakimi, Timothy An-thy Chan · 2020 · Human Molecular Genetics
Characterization of the CpG island methylator phenotype subclass in papillary thyroid carcinoma
Pengfei Gu, Yunjie Zeng, Weike Ma, Wei Zhang, Yu Liu, Fengli Guo, Xian-Hui Ruan, Jia-Dong Chi, Xiangqian Zheng, Ming Gao · 2022 · Frontiers in Endocrinology
The impact of BRAF mutation status on clinical outcomes with anti‐PD‐1 monotherapy versus combination ipilimumab/nivolumab in treatment‐naïve advanced stage melanoma
Vincent The-Luc Ma, Stephanie Daignault‐Newton, Jessica J. Waninger, Sara N. Journey, Zoey Chopra, Alangoya Tezel, Bruce G. Redman, Leslie Anne Fecher, Michael D. Green, Ajjai Shivaram Alva et al. · 2020 · Pigment Cell & Melanoma Research
Mesenchymal traits at the convergence of tumor-intrinsic and -extrinsic mechanisms of resistance to immune checkpoint blockers
Paola Trono, Antonella Sistigu, Belinda Palermo, Gennaro Ciliberto, Paola Nisticò · 2017 · Emerging Topics in Life Sciences
Integrated cancer cell-specific single-cell RNA-seq datasets of immune checkpoint blockade-treated patients
M. Gondal, M. Cieslik, A. Chinnaiyan · 2024 · bioRxiv
Size matters: integrating tumour volume and immune activation signatures predicts immunotherapy response
Su Yin Lim, Inês Pires da Silva, Nurudeen Adedayo Adegoke · 2024 · Molecular Cancer
Construction of a novel lipid drop-mitochondria-associated genetic profile for predicting the survival and prognosis of lung adenocarcinoma
Ruijuan Cai, Hongsheng Lin, Qianwen Cheng, Qiyuan Mao, Chuchu Zhang, Ying Tan · 2024 · Discover Oncology
Identifying treatment options for BRAFV600 wild-type metastatic melanoma: A SU2C/MRA genomics-enabled clinical trial
P. LoRusso, A. Sekulic, J. Sosman, W. Liang, J. Carpten, David W. Craig, D. Solit, A. Bryce, J. Kiefer, Jessica Aldrich et al. · 2021 · PLoS ONE
Characterizing T-cell dysfunction and exclusion signatures in malignant peripheral nerve sheath tumors reveals susceptibilities to immunotherapy
Archis R. Bhandarkar, Shaan Bhandarkar, Dusica Babovic‐Vuksanovic · 2023 · Journal of Neuro-Oncology
Immunotherapeutic Strategies for Intra-cranial Metastatic Melanoma - a Meta-analysis and Systematic Review
Hiu Kwan Carolyn Tang, Ankit Rohit Rao, Christina Peters, Tanvi Ambulkar, Michael FX Ho, Bo Wang, Poulam M. Patel · 2024 · Journal of Cancer
REVIEW OF APPROACHES TO IMMUNOTHERAPY IN ONCOLOGY
И. Л. Царев, Alexander Melerzanov · 2017 · Research and Practical Medicine Journal
Prognostic Value of Programmed Death Ligand-1 in Discriminating Patients With Lymph Node–Negative, p53–Wild-Type, or Low-BRCA1/2-Expression Pancreatic Ductal Adenocarcinoma
Xianlong Chen, Yue Zhang, Shengwei Mo, Heng Ma, Zhaohui Lu, Shuangni Yu, Jie Chen · 2022 · Archives of Pathology & Laboratory Medicine
Immune characteristics and genetic markers of esophageal cancer by single-cell analysis: implications for immunotherapy
Bing Xu, Ihsuan Tseng, Xiaofei Zhang, Hui Chen, Eleonor Rivin del Campo, Jiaying Deng, Dashan Ai, Xumeng Fang, Xinchen Sun, Kuaile Zhao et al. · 2023 · Journal of Thoracic Disease
Biomarkers of resistance to immune checkpoint inhibitors in non-small-cell lung cancer: myth or reality?
Ivan Pourmir, Benoit Gazeau, Hortense de Saint Basile, Elizabeth Fabre · 2020 · Cancer Drug Resistance
Screening responsive or resistant biomarkers of immune checkpoint inhibitors based on online databases
Zhen Xiang, Yingyan Yu · 2019 · Frontiers of Medicine
Plasma proteomic biomarkers identify non-responders and reveal biological insights about the tumor microenvironment in melanoma patients after PD1 blockade
Arnav Mehta, Marijana Ručević, Emmett Sprecher, Milan Parikh, Jiajia Chen, Dennie Tompers Frederick, Elliot C. Woods, Lynn Bi, David Lieb, Lina Hultin‐Rosenberg et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
Multi-omics profiling highlights karyopherin subunit alpha 2 as a promising biomarker for prognosis and immunotherapy respond in pediatric and adult adrenocortical carcinoma
Yi‐Hao Chen, Shumin Fang, Chuanfan Zhong, Shanshan Mo, Yongcheng Shi, Xiaohui Ling, Fengping Liu, Weide Zhong, Junhong Deng, Zhong Dong et al. · 2024 · Annals of Medicine
Super-high tumor mutational burden predicts complete remission following immunotherapy: from Peto’s paradox to druggable cancer hallmark
Ming Zheng · 2025 · Journal for ImmunoTherapy of Cancer
Comprehensive Characterization of the Immune Microenvironment Based on Nested Resampling Machine Learning Framework Identifies TRAF3 Interacting Protein 3 as a Promising Regulator to Improve the Resistance to Immunotherapy in Glioma
Yan-Bo Yang, Fei Wang, Yu-Lian Zhang, Run Huang, Chuan-Peng Zhang, Lu Zhao, Han-Han Dang, Xin-Yu Tao, Yue Lu, Dengfeng Lu et al. · 2025 · Advancement of science
Identification of the relationship between single-cell N6-methyladenosine regulators and the infiltrating immune cells in esophageal carcinoma
Yunyi Bian, Guoshu Bi, Guangyao Shan · 2023 · Heliyon
Molecular map of cGAS-STING pathway-related genes in bladder cancer: the perspective toward immune microenvironment and prognosis
Wei Dong, Ying Liu, Ying Yuan, Yishuai Li, Fangchao Zhao, Xuebo Qin · 2024 · Aging
Comprehensive analysis reveals the prognostic and immunogenic characteristics of DNA methylation regulators in lung adenocarcinoma
Jing Huang, Chujian Huang, Can Huang · 2024 · Respiratory Research
Phase II Study of Niraparib in Patients With Advanced Melanoma With Homologous Recombination Pathway Gene Mutations
Kevin B. Kim, Pierre‐Yves Desprez, David de Semir et al. · 2025 · JCO Precision Oncology