Genomic and transcriptomic features of response to anti-PD-1 therapy in metastatic melanoma
Hugo, Willy, Zaretsky, Jesse M., Sun, Lu, Song, Chunying, Moreno, Blanca Homet, Hu-Lieskovan, Siwen, Berent-Maoz, Beata, Pang, Jia +10 more·2017·Cell
Cited by (494)
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- A novel pyroptosis-regulated gene signature for predicting prognosis and immunotherapy response in hepatocellular carcinomaBaozhu Zhang, Zhan Wang · 2022 · Frontiers in Molecular Biosciences
- neoepiscope improves neoepitope prediction with multi-variant phasingMary Ann Wood, Austin Nguyen, Adam J. Struck, Kyle Ellrott, Abhinav Nellore, Reid F. Thompson · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
- Pre-treatment DNA methylome and transcriptome profiles correlate with melanoma response to anti-PD1 immunotherapySultana Mehbuba Hossain, Grégory Gimenez, Peter A. Stockwell, Robert J. Weeks, Suzan N. Almomani, Gregory T. Jones, Magdalena Ratajska, Mathew Shuen, Basharat Ahmad Bhat, Janusz Ryś et al. · 2025 · Cancer Letters
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- Small-cell lung cancer: anatomy of an immune-cold tumorDavid Millrine, Kathryn Simpson, Fiona Helen Blackhall, Caroline Dive · 2025 · Trends in cancer
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- Somatic structural variants drive distinct modes of oncogenesis in melanomaJake R. Conway, Riaz Gillani, Jett P. Crowdis, Brendan Michael Reardon, Jihye Park, Seunghun Han, Breanna M. Titchen, Mouadh Benamar, Rizwan Haq, Eliezer M. Van Allen · 2024 · Journal of Clinical Investigation
- Immune Checkpoint Inhibitors in Triple Negative Breast Cancer: What is the Evidence?Nora Chok, Samer Chokr · 2018 · Journal of Neoplasm
- Biomarkers of response to immune checkpoint inhibitors for metastatic castration resistant prostate cancer: looking for the needle in the haystackHusam A. Alqaisi, Esmail Mutahar Al-Ezzi, Aaron Richard Hansen · 2020 · Annals of Translational Medicine
- Computational Characterizing Necroptosis Reveals Implications for Immune Infiltration and Immunotherapy of Hepatocellular CarcinomaJun Wei Zhu, Tenghui Han, Shoujie Zhao, Yejing Zhu, Shouzheng Ma, Fenghua Xu, Tingting Bai, Yuxin Tang, Yungang Xu, Lei Liu · 2022 · Frontiers in Oncology
- Modification of m5C regulators in sarcoma can guide different immune infiltrations as well as immunotherapyShusheng Wu, Mengge Li, Rixin Su, Hao Shen, Yifu He, Yangfan Zhou · 2023 · Frontiers in Surgery
- Development a m6A regulators characterized by the immune cell infiltration in stomach adenocarcinoma for predicting the prognosis and immunotherapy responseGuodong Shi, Yang Li, H.-J. Gao, Yucheng Wei, Yuanyong Wang · 2023 · Aging
- Integrated analysis identities Rho GTPases related molecular map in patients with gastric carcinomaShaowei Ma, Ying Wang, Weibo Li, Shaofan Qiu, Xiangyu Zhang, Ren Niu, Fangchao Zhao, Yu Zheng · 2023 · Scientific Reports
- Circadian rhythm related genes identified through tumorigenesis and immune infiltration-guided strategies as predictors of prognosis, immunotherapy response, and candidate drugs in skin cutaneous malignant melanomaChengling Liu, Xingchen Liu, Pengjuan Cao, Haiming Xin, Xin Li, Sailing Zhu · 2025 · Frontiers in Immunology
- Crosstalk of angiogenesis-related subtypes, establishment of a prognostic signature and immune infiltration characteristics in colorectal adenocarcinomaGuoliang Cui, Jinhui Liu, Manli Wang · 2022 · Frontiers in Immunology
- Assessment of genetic diversity in Narbon vetch (Vicia narbonensis L.) germplasm using morphological and molecular markersSiwar Bouabid, Houda Chennaoui Kourda, A. Boussaha · 2018 · Australian Journal of Agricultural Research
- Intrinsic immune evasion patterns predict temozolomide sensitivity and immunotherapy response in lower-grade gliomasZewei Tu, Qiankun Ji, Qing Han, Xiaoyan Long, Jingying Li, Lei Wu, Kai Huang, Xingen Zhu · 2022 · BMC Cancer
- Deep and lasting response and acquired resistance to BRAFV600E targeting in a low-grade ovarian cancer patientSandro Anchisi, Anita Wolfer, Bettina Bisig · 2023 · Cancer Biology & Therapy
- Combined MEK and STAT3 inhibition reprograms stromal inflammation to overcome immunotherapy resistance in pancreatic cancerJashodeep Datta, Xizi Dai, Anna Bianchi, Iago De Castro Silva, Siddharth Mehra, Vanessa T. Garrido, Purushottam Lamichhane, Samara P. Singh, Zhiqun Zhou, Austin R. Dosch et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Targeting ZNF638 activates antiviral immune responses and potentiates immune checkpoint inhibition in glioblastomaDeepa Seetharam, Jay S. Chandar, Christian Kieran Ramsoomair, Jelisah Desgraves, Alexandra Alvarado Medina, Anna Jane Hudson, Ava Amidei, Jesús Castro, Vaidya Govindarajan, Sarah Wang et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- m6A modification patterns are associated with copy number burden and tumor immune landscape in thyroid cancerLiangliang Cai, Tingting Liu, Hujia Hua, Xingyu Jiang, Qian Li · 2023 · BMC Endocrine Disorders
- Enhanced Prediction of Immune Checkpoint Blockade Response in Melanoma Using Ensemble Learning and a Hybrid Feature Selection TechniqueBasant Badwy, Nagia M. Ghanem, Karim Banawan, Nour Eldin Ismail · 2024 · IEEE Access
- Identification of SURF4 and RALGAPA1 as promising therapeutic targets in glioblastoma and pan-cancer through integrative multi-omics, CRISPR-Cas9 screening and prognostic meta-analysisFei Wang, Yuxuan Chen, Run Huang, Dengfeng Lu, Juyi Zhang, Yanbo Yang, Hanhan Dang, Meirong Liu, Zhouqing Chen, Xiaoou Sun et al. · 2025 · Cancer Immunology Immunotherapy
- Integrated Single-Cell and Bulk RNA Sequencing Analysis Identifies a Regulated Cell Death-Related Gene Signature for Predicting Prognosis and Therapeutic Responses in Cutaneous MelanomaJie Tang, Shixing Zhu, Linyu Zhu · 2025 · Journal of Immunotherapy
- Harnessing Anoikis-Related Gene Signatures for Immunotherapy Precision: A Machine Learning-Driven Predictive and Prognostic ModelXuxiang Chen, Kaile Wang, Shuang Zhou, Jin Huang, Haihang Zhang, Chenmou Huang, Changcheng Yang, Jiangzheng Zeng · 2026 · ACS Omega
- Integrating Machine Learning and Mendelian Randomization Determined a Functional Neurotrophin-Related Gene Signature in Patients with Lower-Grade GliomaCong Zhang, Guichuan Lai, Jielian Deng, Kangjie Li, Liuyi Chen, Xiaoni Zhong, Biao Xie · 2024 · Molecular Biotechnology
- Grainyhead-like-2, an epithelial master programmer, promotes interferon induction and suppresses breast cancer recurrenceIan MacFawn, Joshua C. Farris, Phillip M. Pifer, Naira V. Margaryan, Halima Akhter, Lei Wang, Sebastian A. Dziadowicz, James Denvir, Gangqing Hu, Steven M. Frisch · 2024 · Molecular Immunology
- Immunogenic cell death signatures from on-treatment tumor specimens predict immune checkpoint therapy response in metastatic melanomaHuancheng Zeng, Qiongzhi Jiang, Rendong Zhang · 2024 · Scientific Reports
- A regularized Cox hierarchical model for incorporating annotation information in predictive omic studiesDixin Shen, Juan Pablo Lewinger, Eric S. Kawaguchi · 2024 · BioData Mining
- A comprehensive investigation of associations between cell death pathways and molecular and clinical features in pan-cancerYin He, Xiaosheng Wang · 2024 · Clinical & Translational Oncology
- Machine learning derived development and validation of extracellular matrix related signature for predicting prognosis in adolescents and young adults gliomaPancheng Wu, Yi Zheng, Wei Wu, Beichen Zhang, Yichang Wang, Min Zhou, Ziyi Liu, Zhao Wang, Maode Wang, Jia Wang · 2025 · Scientific Reports
- Local therapy overcomes primary resistance to target-immunotherapy combination in unresectable hepatocellular carcinomaXiangqi Chen, Mingjian Piao, Zixiang Zhou, Shanshan Wang, Shuofeng Li, Nan Zhang, Boyu Sun, Kai Liu, Xu Yang, Xiaobo Yang et al. · 2025 · Cancer Immunology Immunotherapy
- Functional Genome Profiling to Understand Cancer Immune ResponsivenessEna Wang, Davide Bedognetti, Francesco Maria Marincola · 2019 · Methods in molecular biology
- A novel fatty-acid metabolism-based classification for triple negative breast cancerXia Yang, Wen Tang, Yongtao He, Huimin An, Jin Wang · 2023 · Aging
- Innovative molecular subtypes of multiple signaling pathways in colon cancer and validation of FMOD as a prognostic-related markerZhujiang Dai, Xiang Peng, Xuewei Cui, Yuegui Guo, Jie Zhang, Xia Shen, Chen‐Ying Liu, Yun Liu · 2023 · Journal of Cancer Research and Clinical Oncology
- Pyroptosis‐related gene signatures are associated with prognosis and tumor microenvironment infiltration in head and neck cancerYan Long, Yadong Wu, Juxiang Peng, Jukun Song, Na Li · 2023 · Health Science Reports
- ECT2 promotes the occurrence and is a prognostic biomarker of head and neck squamous cell carcinomaShixiong Peng, Jinhang Wang, Naiheng Hei · 2024 · Journal of Cancer
- Long‑term response to ipilimumab after nivolumab failure in a case of anorectal melanoma with an intermediate tumor mutation burden and negative for PD‑L1 expressionHitomi Sakai, Masayuki Takeda, Kazuko Sakai, Kazuto Nishio, Kazuhiko Nakagawa · 2020 · Molecular and Clinical Oncology
- Pathogenesis of Zika Virus Infection via Rectal RouteLaura E. Martínez, Gustavo Garcia, Deisy A. Contreras, Danyang Gong, Ren Sun, Vaithilingaraja Arumugaswami · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
- Persistent cell proliferation signals correlates with increased glycolysis in tumor hypoxia microenvironment across cancer typesJinfen Wei, Kaitang Huang, Meiling Hu, Zixi Chen, Yunmeng Bai, Shudai Lin, Hongli Du · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Genomic analysis of response to neoadjuvant chemotherapy in esophageal adenocarcinomaFereshteh Izadi, Benjamin P. Sharpe, Stella Panagio Breininger et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Faculty Opinions recommendation of Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade.Jordan Berlin · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Is tumor mutational burden predictive of response to immunotherapy?Carino Gurjao, Dina I. Tsukrov, Maxim Imakaev, Lovelace J. Luquette, Leonid A. Mirny · 2024 · eLife
- Unraveling the Single-Cell Spatial Landscapes of Melanoma Brain MetastasesArtuer Manukyan, Kristin Peters, Helena Radbruch, Florian Roßner, Felicitas Geserick, Florian Roßner, Annika Lehmann, Janine Altmüller, Thomas Conrad, Janine Altmüller et al. · 2025 · medRxiv
- A Framework to Predict the Molecular Classification and Prognosis of Breast Cancer Patients and Characterize the Landscape of Immune Cell InfiltrationKun Zheng, Zhiyong Luo, Yilu Zhou, Lili Zhang, Yali Wang, Xiuqiong Chen, Shuo Yao, Huihua Xiong, Xianglin Yuan, Yanmei Zou et al. · 2022 · Computational and Mathematical Methods in Medicine
- Integrative bioinformatics and in vitro exploration of EVI2A expression: unraveling its immunological and prognostic implications in kidney renal clear cell carcinomaRONG LIU, Sheng Li, Situ Xiong, Fucun Zheng, Xiangpeng Zhan, JIN ZENG, Bin Fu, Songhui Xu, SHAOXING ZHU, Ru Chen · 2024 · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
- Transcriptomic signatures in peripheral CD4+T-lymphocytes may reflect melanoma staging and immunotherapy responsiveness prior to ICI initiationEleni Palli, Matthieu D. Lavigne, Panagiotis Verginis, Themis Alissafi, Amalia N. Anastasopoulou, Georgios Lyrarakis, John M. Kirkwood, Helen J Gogas, Dimitrios C. Ziogas · 2025 · Frontiers in Immunology
- Interpretable Differential Abundance Signature (iDAS)Lijia Yu, Yingxin Lin, Xiangnan Xu, Pengyi Yang, Jean Yee Hwa Yang · 2025 · Small Methods
- UBE2N as a novel prognostic and therapeutic biomarker of lung adenocarcinomaHaofeng Yin, Yibo Xue, Chen Wang, Yanqin Wu, Yuchen Guo, Chunzhen Li, Yunyan Zhang, Shulei Yin, Tiejun Zhao · 2025 · Frontiers in Immunology
- Targeting Tumor‐Immune Microenvironment with Organoid and Organ‐on‐a‐Chip: An Updated ReviewSahar Madani, Joseph Benjamin Holman, Muhammad Umer Rajput, Syed Wajahat Ali, Zhengdi Shi, Bensheng Qiu, Anqing Zhang, Chengpan Li, Weiping Ding · 2025 · Advanced Materials Technologies
- Integrating single-cell and bulk transcriptomes with machine learning reveals a CAF signature for immunotherapy response in dMMR endometrial cancerLu Zhang, Quan Zhang, Mengjie Yang, Mengyao Xu, Qiyuan Li, Qionghua Chen · 2026 · Discover Oncology
- Inferring Phenotypes of Single Cells Based on the Expression Profiles of Phenotype-Associated Marker Genes in Bulks and Single CellsYin He, Rongzhuo Long, Li Zhao, Xiaosheng Wang · 2026 · Interdisciplinary Sciences Computational Life Sciences
- CDCSI: a machine learning-based interpretable cell death and cellular senescence index for prognosis improvement, immune landscape characterization, and therapeutic response prediction in head and neck squamous cell carcinomaXiaoqin Luo, Xian He · 2026 · Frontiers in Immunology
- Single-cell profiling of gastric cancer ascites reveals an epithelial-immune dual phenotype signature predictive for anti-PD-1 immunotherapy responsesTianbing Xu, Muyang Yang, Jing Huang, Lisen Lu, Deqiang Deng, Xiujuan Shi, Yao Sun, Jonathan F. Lovell, Z.B Lin, Y B Zheng et al. · 2026 · BMC Medicine
- Résistance primaire et résistance acquise aux inhibiteurs PD-1Daniele Grazziotin Soares, Jean‐Pierre Lotz · 2017 · ONCOLOGIE
- Clinical Significance and Immune Landscape of Recurrence-Associated Ferroptosis Signature in Early-Stage Lung AdenocarcinomaLilan Yi, Ping Cheong Huang, Yinfang Gu, Guowu Wu, Xiaofang Zou, Longhua Guo, Chunling Wen, Junlin Zhu, Dongdong Zhao · 2022 · Frontiers in Oncology
- Biomarkers for MelanomaDirk Schadendorf, Keith T. Flaherty, Lyn M. Duncan, Mohammed Kashani–Sabet, Selma Ugurel · 2020 · Springer eBooks
- Identification of N7-methylguanosine-related miRNAs as potential biomarkers for prognosis and drug response in breast cancerD. Dai, Hongkai Zhuang, Mao Shu, Lezi Chen, Long Chen, Hongmei Wu, Bo Chen · 2024 · Heliyon
- Molecular Landscape and Prognostic Value in the Post-Translational Ubiquitination, SUMOylation and Neddylation in Osteosarcoma: A Transcriptome StudyChenguang Jia, Xiaowei Yao, Zhaoliang Dong · 2024 · Journal of Inflammation Research
- Novel Methods to Overcome Acquired Resistance to ImmunotherapyXianda Zhao, Ce Yuan, John Markus Rieth, Dechen Wangmo, Subbaya Subramanian · 2019 · Resistance to targeted anti-cancer therapeutics
- Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy responseMeghana S. Pagadala, Victoria H. Wu, Eva Pérez‐Guijarro et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Decoding molecular programs in melanoma brain metastasesJosefine Radke, Elisa Schumann, Julia Onken, Randi Koll, Güliz Acker, Bohdan Bodnar, Carolin Senger, Sascha Tierling, Markus Möbs, Peter Vajkoczy et al. · 2022 · medRxiv
- Neural Induction: the General Principle for Embryogenesis and TumorigenesisYing Cao · 2022 · Preprints.org
- 513 Overcoming hedgehog mediated anti-PD-1 resistance in melanoma through prostaglandin inhibitionNicholas C. DeVito, Y‐Van Nguyen, Nagendra Sastry Yarla, Michael P. Plebanek, Balamayooran Theivanthiran, Michael Aksu, Vaibhav Jain, Brent Allen Hanks · 2022 · Regular and Young Investigator Award Abstracts
- TREM1 + regulatory myeloid cells expand in steatohepatitis-HCC and associate with poor prognosis and therapeutic resistance to immune checkpoint blockadeJulie Giraud, Domitille Chalopin, Eloïse Ramel, Thomas Boyer, Atika Zouine, Marie‐Alix Derieppe, Nicolas Larmonier, Olivier Adotévi, Brigitte Le Bail, Jean‐Frédéric Blanc et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Overcoming tumor hypoxiaAlexander Marie-Madeleine Adrianus van der Wiel · 2023
- Guadecitabine plus ipilimumab in unresectable melanoma: five-year follow-up and correlation with integrated, multiomic analysis in the NIBIT-M4 trialTeresa Noviello, Anna Maria Di Giacomo, Francesca Pia Caruso et al. · 2023 · medRxiv
- Construction of a mitochondria genes-based model for prognosis prediction, drug guidance and immune feature analysis in ovarian serous cystadenocarcinomaDongsheng Shen, Chenghao Wu, Zhongyue Ding · 2023 · Research Square
- Is tumor mutational burden predictive of response to immunotherapy?Carino Gurjao, Dina I. Tsukrov, Maxim Imakaev, Lovelace J. Luquette, Leonid A. Mirny · 2023 · eLife
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- Combination oral immunotherapy with IL-10 and IL-12 effectively treats colon tumors via synergistic effects on IL-17 producing T cells and colon epithelial barrier integrity.Neal Bhutiani · 2018
- Comparative analysis of sfRNA in the genome of pre-epidemic and epidemic Zika viruses for host interacting proteins potentially related to the recent epidemicPerumal Arumugam Desingu · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
- Sex-based mutational landscape confers sensitivity to checkpoint blockade immunotherapy in cutaneous melanomaMingming Jia, Tian H. Chi · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
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- TMB detection from primary and metastatic lesions should be considered separately: a pan-cancer study.Xiaoling Shang, Chenglong Zhao, Haining Yu · 2020
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- Identification of the Relationships between Tumor Mutation Burden with Immune Infiltrates in Liver Hepatocellular Carcinoma家麟 曲 · 2021 · Advances in Clinical Medicine
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