Genomic and transcriptomic features of response to anti-PD-1 therapy in metastatic melanoma

Hugo, Willy, Zaretsky, Jesse M., Sun, Lu, Song, Chunying, Moreno, Blanca Homet, Hu-Lieskovan, Siwen, Berent-Maoz, Beata, Pang, Jia +10 more·2017·Cell

Cited by (494)

Items 301–400 of 494

  1. A novel pyroptosis-regulated gene signature for predicting prognosis and immunotherapy response in hepatocellular carcinoma
    Baozhu Zhang, Zhan Wang · 2022 · Frontiers in Molecular Biosciences
  2. neoepiscope improves neoepitope prediction with multi-variant phasing
    Mary Ann Wood, Austin Nguyen, Adam J. Struck, Kyle Ellrott, Abhinav Nellore, Reid F. Thompson · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
  3. Pre-treatment DNA methylome and transcriptome profiles correlate with melanoma response to anti-PD1 immunotherapy
    Sultana Mehbuba Hossain, Grégory Gimenez, Peter A. Stockwell, Robert J. Weeks, Suzan N. Almomani, Gregory T. Jones, Magdalena Ratajska, Mathew Shuen, Basharat Ahmad Bhat, Janusz Ryś et al. · 2025 · Cancer Letters
  4. Multimodal Approach Predicts Relapse upon Cessation of Immune Checkpoint Inhibitors in Advanced Melanoma
    Ka‐Won Noh, Yuri Tolkach, Doris Helbig, Vincenzo Mitchell Barroso, Yannick Foerster, Max S. Schlaak, Tilo Biedermann, Reinhard Büttner, Oana‐Diana Persa · 2025 · Clinical Cancer Research
  5. The Impact of JAK1 Pathogenic Variants and MHC-I Expression on Response to Immune Checkpoint Inhibition in Endometrial Cancer
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  6. Small-cell lung cancer: anatomy of an immune-cold tumor
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  7. PD-L1-targeted photodynamic therapy orchestrates checkpoint blockade and immunogenic cell death for synergistic cancer immunotherapy
    Sijin Liu, Zhaoting Yang, Biao Wang, Shuyu Huan, Zixi Li, Xunbin Wei, Guoquan Liu · 2026 · Redox Biology
  8. Somatic structural variants drive distinct modes of oncogenesis in melanoma
    Jake R. Conway, Riaz Gillani, Jett P. Crowdis, Brendan Michael Reardon, Jihye Park, Seunghun Han, Breanna M. Titchen, Mouadh Benamar, Rizwan Haq, Eliezer M. Van Allen · 2024 · Journal of Clinical Investigation
  9. Immune Checkpoint Inhibitors in Triple Negative Breast Cancer: What is the Evidence?
    Nora Chok, Samer Chokr · 2018 · Journal of Neoplasm
  10. Biomarkers of response to immune checkpoint inhibitors for metastatic castration resistant prostate cancer: looking for the needle in the haystack
    Husam A. Alqaisi, Esmail Mutahar Al-Ezzi, Aaron Richard Hansen · 2020 · Annals of Translational Medicine
  11. Computational Characterizing Necroptosis Reveals Implications for Immune Infiltration and Immunotherapy of Hepatocellular Carcinoma
    Jun Wei Zhu, Tenghui Han, Shoujie Zhao, Yejing Zhu, Shouzheng Ma, Fenghua Xu, Tingting Bai, Yuxin Tang, Yungang Xu, Lei Liu · 2022 · Frontiers in Oncology
  12. Modification of m5C regulators in sarcoma can guide different immune infiltrations as well as immunotherapy
    Shusheng Wu, Mengge Li, Rixin Su, Hao Shen, Yifu He, Yangfan Zhou · 2023 · Frontiers in Surgery
  13. Development a m6A regulators characterized by the immune cell infiltration in stomach adenocarcinoma for predicting the prognosis and immunotherapy response
    Guodong Shi, Yang Li, H.-J. Gao, Yucheng Wei, Yuanyong Wang · 2023 · Aging
  14. Integrated analysis identities Rho GTPases related molecular map in patients with gastric carcinoma
    Shaowei Ma, Ying Wang, Weibo Li, Shaofan Qiu, Xiangyu Zhang, Ren Niu, Fangchao Zhao, Yu Zheng · 2023 · Scientific Reports
  15. Circadian rhythm related genes identified through tumorigenesis and immune infiltration-guided strategies as predictors of prognosis, immunotherapy response, and candidate drugs in skin cutaneous malignant melanoma
    Chengling Liu, Xingchen Liu, Pengjuan Cao, Haiming Xin, Xin Li, Sailing Zhu · 2025 · Frontiers in Immunology
  16. Crosstalk of angiogenesis-related subtypes, establishment of a prognostic signature and immune infiltration characteristics in colorectal adenocarcinoma
    Guoliang Cui, Jinhui Liu, Manli Wang · 2022 · Frontiers in Immunology
  17. Assessment of genetic diversity in Narbon vetch (Vicia narbonensis L.) germplasm using morphological and molecular markers
    Siwar Bouabid, Houda Chennaoui Kourda, A. Boussaha · 2018 · Australian Journal of Agricultural Research
  18. Intrinsic immune evasion patterns predict temozolomide sensitivity and immunotherapy response in lower-grade gliomas
    Zewei Tu, Qiankun Ji, Qing Han, Xiaoyan Long, Jingying Li, Lei Wu, Kai Huang, Xingen Zhu · 2022 · BMC Cancer
  19. Deep and lasting response and acquired resistance to BRAFV600E targeting in a low-grade ovarian cancer patient
    Sandro Anchisi, Anita Wolfer, Bettina Bisig · 2023 · Cancer Biology & Therapy
  20. Combined MEK and STAT3 inhibition reprograms stromal inflammation to overcome immunotherapy resistance in pancreatic cancer
    Jashodeep Datta, Xizi Dai, Anna Bianchi, Iago De Castro Silva, Siddharth Mehra, Vanessa T. Garrido, Purushottam Lamichhane, Samara P. Singh, Zhiqun Zhou, Austin R. Dosch et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  21. Targeting ZNF638 activates antiviral immune responses and potentiates immune checkpoint inhibition in glioblastoma
    Deepa Seetharam, Jay S. Chandar, Christian Kieran Ramsoomair, Jelisah Desgraves, Alexandra Alvarado Medina, Anna Jane Hudson, Ava Amidei, Jesús Castro, Vaidya Govindarajan, Sarah Wang et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  22. m6A modification patterns are associated with copy number burden and tumor immune landscape in thyroid cancer
    Liangliang Cai, Tingting Liu, Hujia Hua, Xingyu Jiang, Qian Li · 2023 · BMC Endocrine Disorders
  23. Enhanced Prediction of Immune Checkpoint Blockade Response in Melanoma Using Ensemble Learning and a Hybrid Feature Selection Technique
    Basant Badwy, Nagia M. Ghanem, Karim Banawan, Nour Eldin Ismail · 2024 · IEEE Access
  24. Identification of SURF4 and RALGAPA1 as promising therapeutic targets in glioblastoma and pan-cancer through integrative multi-omics, CRISPR-Cas9 screening and prognostic meta-analysis
    Fei Wang, Yuxuan Chen, Run Huang, Dengfeng Lu, Juyi Zhang, Yanbo Yang, Hanhan Dang, Meirong Liu, Zhouqing Chen, Xiaoou Sun et al. · 2025 · Cancer Immunology Immunotherapy
  25. Integrated Single-Cell and Bulk RNA Sequencing Analysis Identifies a Regulated Cell Death-Related Gene Signature for Predicting Prognosis and Therapeutic Responses in Cutaneous Melanoma
    Jie Tang, Shixing Zhu, Linyu Zhu · 2025 · Journal of Immunotherapy
  26. Harnessing Anoikis-Related Gene Signatures for Immunotherapy Precision: A Machine Learning-Driven Predictive and Prognostic Model
    Xuxiang Chen, Kaile Wang, Shuang Zhou, Jin Huang, Haihang Zhang, Chenmou Huang, Changcheng Yang, Jiangzheng Zeng · 2026 · ACS Omega
  27. Integrating Machine Learning and Mendelian Randomization Determined a Functional Neurotrophin-Related Gene Signature in Patients with Lower-Grade Glioma
    Cong Zhang, Guichuan Lai, Jielian Deng, Kangjie Li, Liuyi Chen, Xiaoni Zhong, Biao Xie · 2024 · Molecular Biotechnology
  28. Grainyhead-like-2, an epithelial master programmer, promotes interferon induction and suppresses breast cancer recurrence
    Ian MacFawn, Joshua C. Farris, Phillip M. Pifer, Naira V. Margaryan, Halima Akhter, Lei Wang, Sebastian A. Dziadowicz, James Denvir, Gangqing Hu, Steven M. Frisch · 2024 · Molecular Immunology
  29. Immunogenic cell death signatures from on-treatment tumor specimens predict immune checkpoint therapy response in metastatic melanoma
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  30. A regularized Cox hierarchical model for incorporating annotation information in predictive omic studies
    Dixin Shen, Juan Pablo Lewinger, Eric S. Kawaguchi · 2024 · BioData Mining
  31. A comprehensive investigation of associations between cell death pathways and molecular and clinical features in pan-cancer
    Yin He, Xiaosheng Wang · 2024 · Clinical & Translational Oncology
  32. Machine learning derived development and validation of extracellular matrix related signature for predicting prognosis in adolescents and young adults glioma
    Pancheng Wu, Yi Zheng, Wei Wu, Beichen Zhang, Yichang Wang, Min Zhou, Ziyi Liu, Zhao Wang, Maode Wang, Jia Wang · 2025 · Scientific Reports
  33. Local therapy overcomes primary resistance to target-immunotherapy combination in unresectable hepatocellular carcinoma
    Xiangqi Chen, Mingjian Piao, Zixiang Zhou, Shanshan Wang, Shuofeng Li, Nan Zhang, Boyu Sun, Kai Liu, Xu Yang, Xiaobo Yang et al. · 2025 · Cancer Immunology Immunotherapy
  34. Functional Genome Profiling to Understand Cancer Immune Responsiveness
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  36. Innovative molecular subtypes of multiple signaling pathways in colon cancer and validation of FMOD as a prognostic-related marker
    Zhujiang Dai, Xiang Peng, Xuewei Cui, Yuegui Guo, Jie Zhang, Xia Shen, Chen‐Ying Liu, Yun Liu · 2023 · Journal of Cancer Research and Clinical Oncology
  37. Pyroptosis‐related gene signatures are associated with prognosis and tumor microenvironment infiltration in head and neck cancer
    Yan Long, Yadong Wu, Juxiang Peng, Jukun Song, Na Li · 2023 · Health Science Reports
  38. ECT2 promotes the occurrence and is a prognostic biomarker of head and neck squamous cell carcinoma
    Shixiong Peng, Jinhang Wang, Naiheng Hei · 2024 · Journal of Cancer
  39. Long‑term response to ipilimumab after nivolumab failure in a case of anorectal melanoma with an intermediate tumor mutation burden and negative for PD‑L1 expression
    Hitomi Sakai, Masayuki Takeda, Kazuko Sakai, Kazuto Nishio, Kazuhiko Nakagawa · 2020 · Molecular and Clinical Oncology
  40. Pathogenesis of Zika Virus Infection via Rectal Route
    Laura E. Martínez, Gustavo Garcia, Deisy A. Contreras, Danyang Gong, Ren Sun, Vaithilingaraja Arumugaswami · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
  41. Persistent cell proliferation signals correlates with increased glycolysis in tumor hypoxia microenvironment across cancer types
    Jinfen Wei, Kaitang Huang, Meiling Hu, Zixi Chen, Yunmeng Bai, Shudai Lin, Hongli Du · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  42. Genomic analysis of response to neoadjuvant chemotherapy in esophageal adenocarcinoma
    Fereshteh Izadi, Benjamin P. Sharpe, Stella Panagio Breininger et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  43. Faculty Opinions recommendation of Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade.
    Jordan Berlin · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  44. Is tumor mutational burden predictive of response to immunotherapy?
    Carino Gurjao, Dina I. Tsukrov, Maxim Imakaev, Lovelace J. Luquette, Leonid A. Mirny · 2024 · eLife
  45. Unraveling the Single-Cell Spatial Landscapes of Melanoma Brain Metastases
    Artuer Manukyan, Kristin Peters, Helena Radbruch, Florian Roßner, Felicitas Geserick, Florian Roßner, Annika Lehmann, Janine Altmüller, Thomas Conrad, Janine Altmüller et al. · 2025 · medRxiv
  46. A Framework to Predict the Molecular Classification and Prognosis of Breast Cancer Patients and Characterize the Landscape of Immune Cell Infiltration
    Kun Zheng, Zhiyong Luo, Yilu Zhou, Lili Zhang, Yali Wang, Xiuqiong Chen, Shuo Yao, Huihua Xiong, Xianglin Yuan, Yanmei Zou et al. · 2022 · Computational and Mathematical Methods in Medicine
  47. Integrative bioinformatics and in vitro exploration of EVI2A expression: unraveling its immunological and prognostic implications in kidney renal clear cell carcinoma
    RONG LIU, Sheng Li, Situ Xiong, Fucun Zheng, Xiangpeng Zhan, JIN ZENG, Bin Fu, Songhui Xu, SHAOXING ZHU, Ru Chen · 2024 · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
  48. Transcriptomic signatures in peripheral CD4+T-lymphocytes may reflect melanoma staging and immunotherapy responsiveness prior to ICI initiation
    Eleni Palli, Matthieu D. Lavigne, Panagiotis Verginis, Themis Alissafi, Amalia N. Anastasopoulou, Georgios Lyrarakis, John M. Kirkwood, Helen J Gogas, Dimitrios C. Ziogas · 2025 · Frontiers in Immunology
  49. Interpretable Differential Abundance Signature (iDAS)
    Lijia Yu, Yingxin Lin, Xiangnan Xu, Pengyi Yang, Jean Yee Hwa Yang · 2025 · Small Methods
  50. UBE2N as a novel prognostic and therapeutic biomarker of lung adenocarcinoma
    Haofeng Yin, Yibo Xue, Chen Wang, Yanqin Wu, Yuchen Guo, Chunzhen Li, Yunyan Zhang, Shulei Yin, Tiejun Zhao · 2025 · Frontiers in Immunology
  51. Targeting Tumor‐Immune Microenvironment with Organoid and Organ‐on‐a‐Chip: An Updated Review
    Sahar Madani, Joseph Benjamin Holman, Muhammad Umer Rajput, Syed Wajahat Ali, Zhengdi Shi, Bensheng Qiu, Anqing Zhang, Chengpan Li, Weiping Ding · 2025 · Advanced Materials Technologies
  52. Integrating single-cell and bulk transcriptomes with machine learning reveals a CAF signature for immunotherapy response in dMMR endometrial cancer
    Lu Zhang, Quan Zhang, Mengjie Yang, Mengyao Xu, Qiyuan Li, Qionghua Chen · 2026 · Discover Oncology
  53. Inferring Phenotypes of Single Cells Based on the Expression Profiles of Phenotype-Associated Marker Genes in Bulks and Single Cells
    Yin He, Rongzhuo Long, Li Zhao, Xiaosheng Wang · 2026 · Interdisciplinary Sciences Computational Life Sciences
  54. CDCSI: a machine learning-based interpretable cell death and cellular senescence index for prognosis improvement, immune landscape characterization, and therapeutic response prediction in head and neck squamous cell carcinoma
    Xiaoqin Luo, Xian He · 2026 · Frontiers in Immunology
  55. Single-cell profiling of gastric cancer ascites reveals an epithelial-immune dual phenotype signature predictive for anti-PD-1 immunotherapy responses
    Tianbing Xu, Muyang Yang, Jing Huang, Lisen Lu, Deqiang Deng, Xiujuan Shi, Yao Sun, Jonathan F. Lovell, Z.B Lin, Y B Zheng et al. · 2026 · BMC Medicine
  56. Résistance primaire et résistance acquise aux inhibiteurs PD-1
    Daniele Grazziotin Soares, Jean‐Pierre Lotz · 2017 · ONCOLOGIE
  57. Clinical Significance and Immune Landscape of Recurrence-Associated Ferroptosis Signature in Early-Stage Lung Adenocarcinoma
    Lilan Yi, Ping Cheong Huang, Yinfang Gu, Guowu Wu, Xiaofang Zou, Longhua Guo, Chunling Wen, Junlin Zhu, Dongdong Zhao · 2022 · Frontiers in Oncology
  58. Biomarkers for Melanoma
    Dirk Schadendorf, Keith T. Flaherty, Lyn M. Duncan, Mohammed Kashani–Sabet, Selma Ugurel · 2020 · Springer eBooks
  59. Identification of N7-methylguanosine-related miRNAs as potential biomarkers for prognosis and drug response in breast cancer
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  60. Molecular Landscape and Prognostic Value in the Post-Translational Ubiquitination, SUMOylation and Neddylation in Osteosarcoma: A Transcriptome Study
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  61. Novel Methods to Overcome Acquired Resistance to Immunotherapy
    Xianda Zhao, Ce Yuan, John Markus Rieth, Dechen Wangmo, Subbaya Subramanian · 2019 · Resistance to targeted anti-cancer therapeutics
  62. Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response
    Meghana S. Pagadala, Victoria H. Wu, Eva Pérez‐Guijarro et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  63. Decoding molecular programs in melanoma brain metastases
    Josefine Radke, Elisa Schumann, Julia Onken, Randi Koll, Güliz Acker, Bohdan Bodnar, Carolin Senger, Sascha Tierling, Markus Möbs, Peter Vajkoczy et al. · 2022 · medRxiv
  64. Neural Induction: the General Principle for Embryogenesis and Tumorigenesis
    Ying Cao · 2022 · Preprints.org
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  78. Combination oral immunotherapy with IL-10 and IL-12 effectively treats colon tumors via synergistic effects on IL-17 producing T cells and colon epithelial barrier integrity.
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  81. A quest through diagnostics and predictive tools and the exploration of new treatment strategies in clinical trials to improve cancer therapy
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