The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Circulating Immune Cells Mediate a Systemic RNAi-Based Adaptive Antiviral Response in Drosophila
Open accessAbstract
Effective antiviral protection in multicellular organisms relies on both cell autonomous and systemic immunity. Systemic immunity mediates the spread of antiviral signals from infection sites to distant uninfected tissues. In arthropods, RNA interference (RNAi) is responsible for antiviral defense. Here we show that flies have a sophisticated systemic RNAi-based immunity mediated by macrophage-like haemocytes. Haemocytes take up dsRNA from infected cells and, through endogenous transposon reverse transcriptases, produce virus-derived complementary DNAs (vDNA). These vDNAs template de novo synthesis of secondary viral siRNAs (vsRNA) which are secreted in exosome-like vesicles. Strikingly, exosomes containing vsRNAs, purified from haemolymph of infected flies, confers passive protection against virus challenge in naïve animals. Thus, similar to vertebrates, insects use immune cells to generate immunological memory, in the form of stable vDNAs, that generate systemic immunity, which is mediated by the vsRNA-containing exosomes.
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Cites
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.
Langmead, B., Trapnell, C., Pop, M., & Salzberg, S. L. (2009) · Genome Biology · doi:10.1186/gb-2009-10-3-r25 · Cited by 21,849
Turturici, G., Tinnirello, R., Sconzo, G., & Geraci, F. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00228.2013 · Cited by 483
A role for retrotransposon LINE-1 in fetal oocyte attrition in mice
Malki, S., van der Heijden, G. W., O’Donnell, K. A., Martin, S. L., & Bortvin, A. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.04.027 · Cited by 215
Cited by
Welsh, J. A., Goberdhan, D. C. I., O'Driscoll, L., Buzas, E. I., Blenkiron, C., Bussolati, B., Cai, H., Di Vizio, D., Driedonks, T. A. P., Erdbrügger, U., et al. (2024) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12404 · Cited by 4,663
Li, W., Liu, Y., Zhang, P., Tang, Y., Zhou, M., Jiang, W., Zhang, X., Wu, G., & Zhou, Y. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b17620 · Cited by 455
Molecular mechanisms influencing efficiency of RNA interference in insects
Cooper, A. M., Silver, K., Zhang, J., Park, Y., & Zhu, K. Y. (2019) · Pest Management Science · doi:10.1002/ps.5126 · Cited by 435
In vivo antagonistic role of the Human T-Cell Leukemia Virus Type 1 regulatory proteins Tax and HBZ
Akkouche, A., Moodad, S., Hleihel, R., Skayneh, H., Chambeyron, S., El Hajj, H., & Bazarbachi, A. (2021) · PLOS Pathogens · doi:10.1371/journal.ppat.1009219 · Cited by 20
Metadata
- Authors
- Tassetto, M., Kunitomi, M., & Andino, R.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2017-04
- Volume
- 169
- Issue
- 2
- Pages
- 314-325.e13
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2604845045
- Cited by
- 291
- References
- 3
- FWCI
- 12.14
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Tassetto, M., Kunitomi, M., & Andino, R. (2017). Circulating Immune Cells Mediate a Systemic RNAi-Based Adaptive Antiviral Response in Drosophila. Cell. https://doi.org/10.1016/j.cell.2017.03.033
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