The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Molecular mechanisms influencing efficiency of RNA interference in insects
Abstract
RNA interference (RNAi) is an endogenous, sequence‐specific gene‐silencing mechanism elicited by small RNA molecules. RNAi is a powerful reverse genetic tool, and is currently being utilized for managing insects and viruses. Widespread implementation of RNAi‐based pest management strategies is currently hindered by inefficient and highly variable results when different insect species, strains, developmental stages, tissues, and genes are targeted. Mechanistic studies have shown that double‐stranded ribonucleases (dsRNases), endosomal entrapment, deficient function of the core machinery, and inadequate immune stimulation contribute to limited RNAi efficiency. However, a comprehensive understanding of the molecular mechanisms limiting RNAi efficiency remains elusive. Recent advances in dsRNA stability in physiological tissues, dsRNA internalization into cells, the composition and function of the core RNAi machinery, as well as small‐interfering RNA/double‐stranded RNA amplification and spreading mechanisms are reviewed to establish a global understanding of the obstacles impeding wider understanding of RNAi mechanisms in insects. © 2018 Society of Chemical Industry
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Cites
A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila
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Towards the elements of successful insect RNAi
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Self-citationSilencing of Aphid Genes by dsRNA Feeding from Plants
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Metadata
- Authors
- Cooper, A. M., Silver, K., Zhang, J., Park, Y., & Zhu, K. Y.
- Venue
- Pest Management Science
- Publisher
- Wiley
- Published
- 2018-08-13
- Volume
- 75
- Issue
- 1
- Pages
- 18-28
- ISSN
- 1526-498X (ISSN-L)
- 1526-4998
- OpenAlex
- W2808824133
- Cited by
- 435
- References
- 45
- FWCI
- 8.87
- Type
- journal article
- Language
- en
- Open access
- closed
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