The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields
Open accessAbstract
We report a noninvasive strategy for electrically stimulating neurons at depth. By delivering to the brain multiple electric fields at frequencies too high to recruit neural firing, but which differ by a frequency within the dynamic range of neural firing, we can electrically stimulate neurons throughout a region where interference between the multiple fields results in a prominent electric field envelope modulated at the difference frequency. We validated this temporal interference (TI) concept via modeling and physics experiments, and verified that neurons in the living mouse brain could follow the electric field envelope. We demonstrate the utility of TI stimulation by stimulating neurons in the hippocampus of living mice without recruiting neurons of the overlying cortex. Finally, we show that by altering the currents delivered to a set of immobile electrodes, we can steerably evoke different motor patterns in living mice.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Electrical stimulation of excitable tissue: design of efficacious and safe protocols
Merrill, D. R., Bikson, M., & Jefferys, J. G. R. (2005) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2004.10.020 · Cited by 2,078
γH2AX: a sensitive molecular marker of DNA damage and repair
Mah, L.-J., El-Osta, A., & Karagiannis, T. C. (2010) · Leukemia · doi:10.1038/leu.2010.6 · Cited by 1,557
Microglia-specific localisation of a novel calcium binding protein, Iba1
Ito, D., Imai, Y., Ohsawa, K., Nakajima, K., Fukuuchi, Y., & Kohsaka, S. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00040-0 · Cited by 1,476
Translational principles of deep brain stimulation
Kringelbach, M. L., Jenkinson, N., Owen, S. L. F., & Aziz, T. Z. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2196 · Cited by 853
Cruz, J. C., Tseng, H.-C., Goldman, J. A., Shih, H., & Tsai, L.-H. (2003) · Neuron · doi:10.1016/s0896-6273(03)00627-5 · Cited by 609
Self-citationHisted, M. H., Bonin, V., & Reid, R. C. (2009) · Neuron · doi:10.1016/j.neuron.2009.07.016 · Cited by 604
Cited by
Interoception and Mental Health: A Roadmap.
Khalsa, S. S., Adolphs, R., Cameron, O. G., Critchley, H. D., Davenport, P. W., Feinstein, J. S., Feusner, J. D., Garfinkel, S. N., Lane, R. D., Mehling, W. E., et al. (2018) · Biological psychiatry. Cognitive neuroscience and neuroimaging · doi:10.1016/j.bpsc.2017.12.004 · Cited by 1,453
Direct effects of transcranial electric stimulation on brain circuits in rats and humans
Vöröslakos, M., Takeuchi, Y., Brinyiczki, K., Zombori, T., Oliva, A., Fernández-Ruiz, A., Kozák, G., Kincses, Z. T., Iványi, B., Buzsáki, G., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-02928-3 · Cited by 735
Harris, S. S., Wolf, F., De Strooper, B., & Busche, M. A. (2020) · Neuron · doi:10.1016/j.neuron.2020.06.005 · Cited by 161
Visual prosthesis: interfacing stimulating electrodes with retinal neurons to restore vision.
Barriga-Rivera, A., Bareket, L., Goding, J., Aregueta-Robles, U. A., & Suaning, G. J. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00620 · Cited by 73
Hell, F., Palleis, C., Mehrkens, J. H., Koeglsperger, T., & Bötzel, K. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00314 · Cited by 75
Metadata
- Authors
- Grossman, N., Bono, D., Dedic, N., Kodandaramaiah, S. B., Rudenko, A., Suk, H.-J., Cassara, A. M., Neufeld, E., Kuster, N., Tsai, L.-H., Pascual-Leone, A., & Boyden, E. S.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2017-06
- Volume
- 169
- Issue
- 6
- Pages
- 1029-1041.e16
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2620619632
- Cited by
- 986
- References
- 6
- FWCI
- 30.41
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields. https://app.cochat.ai/papers/10.1016/j.cell.2017.05.024
- The paper
- Grossman, N., Bono, D., Dedic, N., Kodandaramaiah, S. B., Rudenko, A., Suk, H.-J., Cassara, A. M., Neufeld, E., Kuster, N., Tsai, L.-H., Pascual-Leone, A., & Boyden, E. S. (2017). Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields. Cell. https://doi.org/10.1016/j.cell.2017.05.024
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
